Advanced morphological and biochemical magnetic resonance imaging of cartilage repair procedures in the knee joint at 3 Tesla

Morphological and biochemical magnetic resonance imaging (MRI) is due to high field MR systems, advanced coil technology, and sophisticated sequence protocols capable of visualizing articular cartilage in vivo with high resolution in clinical applicable scan time. Several conventional two-dimensional (2D) and three-dimensional (3D) approaches show changes in cartilage structure. Furthermore newer isotropic 3D sequences show great promise in improving cartilage imaging and additionally in diagnosing surrounding pathologies within the knee joint. Functional MR approaches are additionally able to provide a specific measure of the composition of cartilage. Cartilage physiology and ultra-structure can be determined, changes in cartilage macromolecules can be detected, and cartilage repair tissue can thus be assessed and potentially differentiated. In cartilage defects and following nonsurgical and surgical cartilage repair, morphological MRI provides the basis for diagnosis and follow-up evaluation, whereas biochemical MRI provides a deeper insight into the composition of cartilage and cartilage repair tissue. A combination of both, together with clinical evaluation, may represent a desirable multimodal approach in the future, also available in routine clinical use.

Pupil phase apodization for achromatic imaging of extra-solar planets

Direct imaging of extra-solar planets in the visible and infrared region has generated great interest among scientists and the general public as well. However, this is a challenging problem. Diffculties of detecting a planet (faint source) are caused, mostly, by two factors: sidelobes caused by starlight diffraction from the edge of the pupil and the randomly scattered starlight caused by the phase errors from the imperfections in the optical system. While the latter diffculty can be corrected by high density active deformable mirrors with advanced phase sensing and control technology, the optimized strategy for suppressing the diffraction sidelobes is still an open question. In this thesis, I present a new approach to the sidelobe reduction problem: pupil phase apodization. It is based on a discovery that an anti-symmetric spatial phase modulation pattern imposed over a pupil or a relay plane causes diffracted starlight suppression sufficient for imaging of extra-solar planets. Numerical simulations with specific square pupil (side D) phase functions, such as ... demonstrate annulling in at least one quadrant of the diffraction plane to the contrast level of better than 10^12 with an inner working angle down to 3.5L/D (with a = 3 and e = 10^3). Furthermore, our computer experiments show that phase apodization remains effective throughout a broad spectrum (60% of the central wavelength) covering the entire visible light range. In addition to the specific phase functions that can yield deep sidelobe reduction on one quadrant, we also found that a modified Gerchberg-Saxton algorithm can help to find small sized (101 x 101 element) discrete phase functions if regional sidelobe reduction is desired. Our simulation shows that a 101x101 segmented but gapless active mirror can also generate a dark region with Inner Working Distance about 2.8L/D in one quadrant. Phase-only modulation has the additional appeal of potential implementation via active segmented or deformable mirrors, thereby combining compensation of random phase aberrations and diffraction halo removal in a single optical element.

The NACIR Project: New Applications for CPV'S: A fast way to improve reliability and Technology progress

The main goal of this proposal is to join together the owners of the most advanced CPV technology, with respect to the state of the art, in order to research from its leading position new applications for CPV systems. In addition to opening up new markets, it will unveil possible sources of failure in new environments outside Europe, in order to assure component reliability. The proposed project will also try to improve the current technology of the industrial partners (ISOFOTON and CONCENTRIX) by accelerating the learning curve that CPV must follow in order to reach the competitive market, and lowering the cost under the current flat panel PV significantly within 3-4 years. The use of CPV systems in remote areas, together with harsher radiation, ambient and infrastructure conditions will help to increase the rate of progress of this technology. In addition, the ISFOC s contribution, which brings together seven power plants from seven CPV technologies up to 3 MWpeak, will allow creating the most complete database of components and systems performance to be generated as well as the effects of radiation and meteorology on systems operations. Finally, regarding the new applications for CPV subject, the project will use a CPV system sized 25 kWp in a stand-alone station in Egypt (NWRC) for the first time for water pumping and irrigation purposes. In a similar way ISOFOTON will connect up to 25 kWp CPV to the Moroccan ONE utility grid. From the research content point of view of this project, which is directly addressed by the scope of the call, the cooperative research between UPM, FhG-ISE and the two companies will be favoured by the fact that all are progressing in similar directions: developing two-stage optics CPV systems. In addition to these technology improvements the UPM is very interested in developing a new concept of module, recently patented, which will fulfil all required characteristics of a good CPV with less components and reducing cost.

Multiprotocol Android Application for Smart Control and Monitoring in Buildings

This paper presents a multiprotocol mobile application for building automation which supports and enables the integration of the most representative control technologies such as KNX, LonWorks and X-10. The application includes a real-time monitoring service. Finally, advanced control functionalities based on gestures recognition and predefined scenes have been implemented. This application has been developed and tested in the Energy Efficiency Research Facility located at CeDInt-UPM, where electrical loads, blinds and HVAC and lighting systems can be controlled.

El vidrio y la luz en la envolvente contemporánea

Los arquitectos se han sentido progresivamente inclinados a incorporar superficies de vidrio cada vez mayores en sus proyectos de arquitectura, en correspondencia con una percepción socio-cultural del vidrio vinculada al progreso, la contemporaneidad y el bienestar, así como por la versatilidad de este material para expresar aspectos de la identidad del proyecto, establecer comunicación con el entorno y actuar como un escaparate para las tecnologías emergentes. A pesar de esta receptividad para acoger los sistemas tecnológicos más avanzados, la envolvente de vidrio contemporánea muy raramente integra tecnología avanzada para el control de la luz natural. Desde la arquitectura, el proyecto de la luz natural a través de la superficie de vidrio se ha explorado muy escasamente, aún cuando en las últimas tres décadas se haya producido una gran diversidad de soluciones tecnológicas para este propósito. Uno de los motivos principales para esta falta de sinergia es la inconsistencia conceptual que impulsa a los procesos proyectuales de la arquitectura y a los desarrollos tecnológicos para la sostenibilidad. Por un lado, las especificaciones de las tecnologías del control de la luz natural se determinan fundamentalmente desde una perspectiva científica de la eficiencia, que no tiene en consideración otros intereses y preocupaciones arquitectónicos. Por otro lado, la práctica arquitectónica no ha asimilado un pensamiento técnico en torno a la luz natural que lo determine como un agente clave del proceso proyectual, incluso cuando la sostenibilidad se perfile como la fuerza que ha de liderar la arquitectura del futuro y, en este sentido, sea una prioridad absoluta minimizar las consecuencias económicas y ecológicas del impacto negativo del vidrio. Por medio del escrutinio de valores culturales, proyectuales, funcionales y ecológicos, esta tesis aborda el estudio del precario diálogo transdisciplinar entre la evolución de la envolvente de vidrio en la arquitectura contemporánea y el desarrollo de soluciones tecnológicas para el proyecto de la luz natural, e identifica sus principales puntos de divergencia como los temas centrales desde los que proyectar con vidrio en una arquitectura sostenible futura. Desde una perspectiva energética, este ejercicio es un paso crítico para concienciar sobre la gravedad de la situación presente y establecer los cimientos para líneas de intervención esenciales para hacer a ambos mundos converger. Desde la óptica arquitectónica, este estudio representa además de una oportunidad para entender los potenciales proyectuales de estas tecnologías y reflexionar sobre la relación vidrio-luz, un escenario desde el que comprender el estatus incongruente de la sostenibilidad tecnológica en la arquitectura actual, contribuyendo a que se genere una contextualización recíproca entre la investigación en energía y la práctica de la arquitectura futura. ABSTRACT Architects are increasingly demanded to incorporate extensive glazed areas in buildings in correspondence with a socio-cultural perception of glass linked with progress, contemporaneity and welfare, as well as for this material’s versatility to express identity features, establish communication with its environment, and perform as a showroom for emergent technologies. Despite this disposition to take cutting-edge technology in, the contemporary glass envelope very scarcely integrates advanced daylight control technology. From an architectural standpoint, the exploration of the manipulation of natural light through the glass surface has been very swallow, even though a wide range of technical solutions has being produced in the last three decades for this purpose. One of the core issues behind this inconsistency is the lack of established synergy between architectural design processes and sustainable technological developments. From one side, the specifications of daylighting technologies are primarily determined by a scientific perspective of efficiency and disregard fundamental architectural concerns and interests. From another, architectural practice does not conceive sustainable technologies as key active agents in the design process, despite the fact the concept of sustainability is constantly regarded as the driving force of the leading-edge architecture of the future, and in this sense, it becomes an absolute priority to minimize the ecological and economical consequences of glass decisive impact in buildings. Through the scrutiny of cultural, functional and ecological values, this thesis analyses the precarious transdisciplinary dialogue between the evolution of the glass envelope in contemporary architecture and the development of daylighting technological solutions, and identifies the core affairs necessary to a sustainable integration of glass facades into future architecture. From an energy point of view, this exercise is a critical step to raise awareness about the severity of the present situation, and to establish the underpinnings for new lines of intervention essential to make both worlds efficiently converge. Architecturally speaking, in addition to the opportunity to understand the design potentials of these technologies and reflect on the relationship glasslight, this study contributes with a scenario from which generate the reciprocal contextualization of energy building research to future architectural practices.

Toward mass production of microtextured microdevices: linking rapid prototyping with microinjection molding

The possibility of manufacturing textured materials and devices, with surface properties controlled from the design stage, instead of being the result of machining processes or chemical attacks, is a key factor for the incorporation of advanced functionalities to a wide set of micro and nanosystems. Recently developed high-precision additive manufacturing technologies, together with the use of fractal models linked to computer-aided design tools, allow for a precise definition and control of final surface properties for a wide set of applications, although the production of larger series based on these resources is still an unsolved challenge. However, rapid prototypes, with controlled surface topography, can be used as original masters for obtaining micromold inserts for final large-scale series manufacture of replicas using microinjection molding. In this study, an original procedure is presented, aimed at connecting rapid prototyping with microinjection molding, for the mass production of two different microtextured microsystems, linked to tissue engineering tasks, using different thermoplastics as ultimate materials.

Eliminación de nutrientes mediante tratamientos biopelícula : corrientes actuales y necesidades de investigación

Los tratamientos biopelícula fueron unos de los primeros tratamientos biológicos que se aplicaron en las aguas residuales. Los tratamientos biopelícula presentan importantes ventajas frente a los cultivos en suspensión, sin embargo, el control de los tratamientos biopelícula es complicado y su modelización también. Las bases teóricas del comportamiento de las biopelículas empezaron a desarrollarse fundamentalmente a partir de los años 80. Dado que el proceso es complejo con ecuaciones de difícil resolución, estas conceptualizaciones han sido consideradas durante años como ejercicios matemáticos más que como herramientas de diseño y simulación. Los diseños de los reactores estaban basados en experiencias de plantas piloto o en comportamientos empíricos de determinadas plantas. Las ecuaciones de diseño eran regresiones de los datos empíricos. La aplicabilidad de las ecuaciones se reducía a las condiciones particulares de la planta de la que provenían los datos empíricos. De tal forma que existía una gran variedad y diversidad de ecuaciones empíricas para cada tipo de reactor. La investigación médica durante los años 90 centró su atención en la formación y eliminación de las biopelículas. Gracias al desarrollo de nuevas prácticas de laboratorio que permitían estudiar el interior de las biopelículas y gracias también al aumento de la capacidad de los ordenadores, la simulación del comportamiento de las biopelículas tomó un nuevo impulso en esta década. El desarrollo de un tipo de biopelículas, fangos granulares, en condiciones aerobias realizando simultaneamente procesos de eliminación de nutrientes ha sido recientemente patentado. Esta patente ha recibido numerosos premios y reconocimientos internacionales tales como la Eurpean Invention Award (2012). En 1995 se descubrió que determinadas bacterias podían realizar un nuevo proceso de eliminación de nitrógeno denominado Anammox. Este nuevo tipo de proceso de eliminación de nitrógeno tiene el potencial de ofrecer importantes mejoras en el rendimiento de eliminación y en el consumo de energía. En los últimos 10 años, se han desarrollado una serie de tratamientos denominados “innovadores” de eliminación de nutrientes. Dado que no resulta posible el establecimiento de estas bacterias Anammox en fangos activos convencionales, normalmente se recurre al uso de cultivos biopelícula. La investigación se ha centrado en el desarrollo de estos procesos innovadores en cultivos biopelícula, en particular en los fangos granulares y MBBR e IFAs, con el objeto de establecer las condiciones bajo las cuales estos procesos se pueden desarrollar de forma estable. Muchas empresas y organizaciones buscan una segunda patente. Una cuestión principal en el desarrollo de estos procesos se encuentra la correcta selección de las condiciones ambientales y de operación para que unas bacterias desplacen a otras en el interior de las biopelículas. El diseño de plantas basado en cultivos biopelícula con procesos convencionales se ha realizado normalmente mediante el uso de métodos empíricos y semi-empíricos. Sin embargo, los criterios de selección avanzados aplicados en los Tratamientos Innovadores de Eliminación de Nitrógeno unido a la complejidad de los mecanismos de transporte de sustratos y crecimiento de la biomasa en las biopelículas, hace necesario el uso de herramientas de modelización para poder conclusiones no evidentes. Biofilms were one of the first biological treatments used in the wastewater treatment. Biofilms exhibit important advantages over suspended growth activated sludge. However, controlling biofilms growth is complicated and likewise its simulation. The theoretical underpinnings of biofilms performance began to be developed during 80s. As the equations that govern the growth of biofilms are complex and its resolution is challenging, these conceptualisations have been considered for years as mathematical exercises instead of practical design and simulation tools. The design of biofilm reactors has been based on performance information of pilot plants and specific plants. Most of the times, the designing equations were simple regressions of empirical data. The applicability of these equations were confined to the particular conditions of the plant from where the data came from. Consequently, there were a wide range of design equations for each type of reactor During 90s medical research focused its efforts on how biofilm´s growth with the ultimate goal of avoiding it. Thanks to the development of new laboratory techniques that allowed the study the interior of the biofilms and thanks as well to the development of the computers, simulation of biofilms’ performance had a considerable evolution during this decade. In 1995 it was discovered that certain bacteria can carry out a new sort of nutrient removal process named Anammox. This new type of nutrient removal process potentially can enhance considerably the removal performance and the energy consumption. In the last decade, it has been developed a range of treatments based on the Anammox generally named “Innovative Nutrient Removal Treatments”. As it is not possible to cultivate Anammox bacteria in activated sludge, normally scientists and designers resort to the use of biofilms. A critical issue in the development of these innovative processes is the correct selection of environment and operation conditions so as to certain bacterial population displace to others bacteria within the biofilm. The design of biofilm technology plants is normally based on the use of empirical and semi-empirical methods. However, the advanced control strategies used in the Innovative Nutrient Removal Processes together with the complexity of the mass transfer and biomass growth in biofilms, require the use of modeling tools to be able to set non evident conclusions.

Liquefied gaseous fuels safety and environmental control assessment program : a status report /

May 1979.

Evaluation of environmental control technologies for magnetic fields /

August 1978.

State-of-the-art hydrogen sulfide control for geothermal energy systems, 1979 /

Contract no.: W-7405-ENG-48.

Proceedings of the U.S. Department of Energy Environmental Control Symposium, November 28-30, 1978, Washington, D.C. /

"DOE/EV-0046."

Technology of instrumentation.

Mode of access: Internet.

Robust multivariable control of complex biological processes

This paper addresses advanced control of a biological nutrient removal (BNR) activated sludge process. Based on a previously validated distributed parameter model of the BNR activated sludge process, we present robust multivariable controller designs for the process, involving loop shaping of plant model, robust stability and performance analyses. Results from three design case studies showed that a multivariable controller with stability margins of 0.163, 0.492 and 1.062 measured by the normalised coprime factor, multiplicative and additive uncertainties respectively give the best results for meeting performance robustness specifications. The controller robustly stabilises effluent nutrients in the presence of uncertainties with the behaviour of phosphorus accumulating organisms as well as to effectively attenuate major disturbances introduced as step changes. This study also shows that, performance of the multivariable robust controller is superior to multi-loops SISO PI controllers for regulating the BNR activated sludge process in terms of robust stability and performance and controlling the process using inlet feed flowrate is infeasible. (C) 2003 Elsevier Ltd. All rights reserved.

Integrated manufacturing, empowerment, and company performance

There is controversy over whether integrated manufacturing (IM), comprising advanced manufacturing technology, just-in-time inventory control and total quality management, empowers or deskills shop floor work. Moreover, both IM and empowerment are promoted on the assumption that they enhance competitiveness. We examine these issues in a study of 80 manufacturing companies. The extent of use of IM was positively associated with empowerment (i.e., job enrichment and employee skill enhancement), but, with the minor exception of AMT, bore little relationship with subsequent company performance. In contrast, the extent of empowerment within companies predicted the subsequent level of company performance controlling for prior performance, with the effect on productivity mediating that on profit. Copyright © 2004 John Wiley & Sons, Ltd.

A new DEA model for technology selection in the presence of ordinal data

This paper suggests a data envelopment analysis (DEA) model for selecting the most efficient alternative in advanced manufacturing technology in the presence of both cardinal and ordinal data. The paper explains the problem of using an iterative method for finding the most efficient alternative and proposes a new DEA model without the need of solving a series of LPs. A numerical example illustrates the model, and an application in technology selection with multi-inputs/multi-outputs shows the usefulness of the proposed approach. © 2012 Springer-Verlag London Limited.