The big shrink.

Apropiado para niños de seis años, pertenece al género obras de teatro para introducir a los niños en una variedad de textos. Contiene la motivación de historias del capítulo sobre mundos de fantasía, que están llenas de humor, acción y sorpresa. Para lectura guiada. Mr Mulch, un maestro de escuela con poderes especiales personaje central en esta historia, advierte a la clase de no tocar nada, pero Sam y Jason no se enteran.

The Big book of people skills games.

Este libro ofrece una serie de juegos y actividades para realizar en grupo que facilitan el desarrollo de distintas áreas de la comunicación en el ámbito profesional y personal (conocer gente nueva, desarrollar habilidades de atención o resolver situaciones complicadas con clientes o trabajadores). El objetivo de las actividades propuestas es la mejora de la relación cliente-empleado, la reducción del absentismo laboral y fomentar un ambiente de trabajo más positivo y productivo, contribuyendo al crecimiento y al éxito de la empresa.

Comparison of speech processor MAP minimum (T) and maximum (C) levels with psychophysical thresholds and maximum acceptable loudness levels in users of the Nucleus 22 cochlear implant system

This paper discusses the Nucleus 22 cochlear implant.

Narration for instructional video: operation and maintenance of the Nucleus 22 Channel Cochlear Implant

This paper presents the narration for an educational video on cochlear implants and the implantation process aimed at parents and teachers of hearing-impaired children.

Common errors made by clinic patients responding to the W-22 and NU-6 word lists

This paper presents a study of common errors made during speech discrimination testing.

Representación de la sociedad de la información como cotidianidad tecnificada e incomunicación: estudio de "The big bang theory"

Este trabajo de investigación pretende demostrar, a través de un producto televisivo como es The Big Bang Theory, que la sociedad contemporánea experimenta la comunicación y otros procesos de forma distinta a los modelos tradicionales, principalmente por la irrupción de la tecnología en la vida cotidiana. La comunicación, a través de la propuesta de la Escuela de Palo Alto, debe entenderse como un sistema de intercambio no solo de información sino de otros elementos que permiten construir relaciones incluso en la confusión que la caracteriza. El imperativo de que “lo importante es comunicar” es el hilo conductor de este estudio académico donde los personajes de esta serie de situación, o sitcom, a pesar de ser catalogados como seres digitales ensimismados en los aparatos electrónicos, le permiten al espectador reconocer los comportamientos y vínculos actuales.

“So the big rocks we put in the jar”: using situated reasoning to coordinate design activity

Ways in which situated reasoning featured in the course of action in the setting of a pair-programming software design exercise is examined, and how interactionally design was accomplished as a coordinated activity in situ.

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9 A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2.

Thermal behavior of the Cu-22.55 at.%Al alloy with small Ag additions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of Ag addition on phase transitions of the Cu-22.26 at.%Al-9.93 at.%Mn alloy

The phase transitions that occur in the Cu-22.26 at.%Al-9.93 at.%Mn and Cu-22.49 at.%Al-10.01 at.%Mn-1.53 at.%Ag alloys after slow cooling were studied using differential scanning calorimetry at different heating rates, microhardness changes with temperature, magnetization changes with temperature, scanning electron microscopy and energy dispersion X-ray spectroscopy. The results indicated that the presence of Ag does not modify the transition sequence of Cu-Al-Mn alloy, introduces a new transition due to the (Ag-Cu)-rich precipitates dissolution at about 800 K, and changes the mechanism of DO 3 phase dissolution. This mechanistic change was analyzed and a sequence of phase transitions was proposed for the reaction. © 2013 Elsevier B.V.

Circadian-rhythm of the endopeptidase 22.19 (ec 3.4.22.19) in the rat-brain

The endopeptidase 22.19 (EC 3.4.22.19) has been associated with the metabolism of neuropeptides by its ability to convert small enkephalin-containing peptides (8 to 13 amino acids) into enkephalins. In addition, this enzyme cleaves the Arg8-Arg9 bond of neurotensin and the Phe5-Ser6 bond of bradykinin. We analyzed the circadian variation of endopeptidase 22.19 in the whole and individual areas of the rat brain. Endopeptidase 22.19 activity was analyzed by high-performance liquid chromatography (HPLC) using bradykinin as an operative substrate. Enzymatic specific activities were analyzed by rhythmometric methods and indicate a circadian fluctuation of endopeptidase 22.19 specific activity (mU of enzyme/mg of protein) in the whole brain [p < 0.001, mesor (M) = 7.62, amplitude (A) = 2.89, and acrophase (phi) = 23:08 h], striatum (p < 0.001, M = 2.92, A = 0.62, phi-23:03 h), hypothalamus (p < 0.001, M = 3.15, A = 0.86, phi-01:12 h), periaqueductal gray matter (p < 0.005, M = 2.62, A = 0.34, phi = 22:35 h), and cerebellum (p < 0.0 14, M = 4.27, A = 0.88, phi = 17:12 h). The circadian rhythmicity in endopeptidase 22.19 specific activity suggests that light may have an effect on the peptidase activity in whole brain and in areas of the central nervous system and may be essential for the mechanisms of circadian fluctuations of neuropeptides in the brain.

Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up

Postmenopausal women with hormone receptor-positive early breast cancer have persistent, long-term risk of breast-cancer recurrence and death. Therefore, trials assessing endocrine therapies for this patient population need extended follow-up. We present an update of efficacy outcomes in the Breast International Group (BIG) 1-98 study at 8·1 years median follow-up.