De historie van den Waldensen : ghedeelt in drie deelen där van het eerste handelt van hunnen oorspronck suyver Gheloove ende vervolgingen die sy door geheel Europa, gedürende den tijt van meer als 450. jaren hebben gheleden. Het tweede vervat de historie van de Waldensen, anders genämt de Albigensen. Het derde begrijpt de leere ende discipline welcke sy onderlinghe ghemeyn ghehadt hebben Midsgaders de wederlegginghe vande leere van ... nne weder-partije. ... Vergadert wt d'autheuren, der welcker namen hier nä ghestelt worden, ende in de Fransoysche tale beschreven,

Mode of access: Internet.

Drey curieuse chymische tractätlein, das erste, betitult: Güldene rose, [das ist, einfältige beschreibung des allergrössesten, von dem allmächtigsten schopffer himmels und der erden Jehovah in die natur gelegten, und dessen freunden unhd auserwählten zugetheilten geheimnisses, als speigels der göttlichen und natürlichen weissheit.] Das andere Brunn der weisheit und erkänntnis der natur, von einem unvergleichlichen philosopho gegraben. Das dritte Blut der natur, [oder: Entdeckung des allergeheimsten schatzes derer weisen, seyende nichts anders, als der rothe lebens-safft davon alle geschöpfe nach dem willen des Allmächtigen herstammen, erhalten und fortgepflanzet werden.]

[Each tract has special t.-p.: Güldene rose ... ans licht gebracht durch J.R.V.M.D.--Brunnen der weissheit ... geöffnet durch Anonymum von Schwartzfuss.--Das blut der natur ... hervorgegeben von Anonymus von Schwarzfuss.]

A history of municipal government in Liverpool, from the earliest times to the Municipal Reform Act of 1835 ... Part I: A narrative introduction, by Ramsay Muir ... Part II: A collection of charters, leases, and other documents, transcribed, translated and edited with illustrative material, by Edith M. Platt ...

Mode of access: Internet.

The poems of Allan Ramsay. With glossary, life of the author, and remarks on his poems.

Chalmer's edition of 1800, with new title-pages prefixed to the original ones, mistakes corrected, and an appendix (v. 2, 14 p.) of poems not found in that edition. The life is by Chalmers, the "Remarks on the genius and writings of Allan Ramsay" by Lord Woodhouselee. cf. Introductory note, p. iv.-not in this ed.

The poems of Allan Ramsay.

Chalmer's edition of 1800, with new title-pages prefixed to the original ones, mistakes corrected, and an appendix (v. 2, 14 p.) of poems not found in that edition. The life is by Chalmers, the "Remarks on the genius and writings of Allan Ramsay" by Lord Woodhouselee. cf. Introductory note, p. iv.

Monthly air temperatures, snow density and snow and ice thickness at Malcolm Ramsay Lake, North America

In northern regions where observational data is sparse, lake ice models are ideal tools as they can provide valuable information on ice cover regimes. The Canadian Lake Ice Model was used to simulate ice cover for a lake near Churchill, Manitoba, Canada throughout the 2008/2009 and 2009/2010 ice covered seasons. To validate and improve the model results, in situ measurements of the ice cover through both seasons were obtained using an upward-looking sonar device Shallow Water Ice Profiler (SWIP) installed on the bottom of the lake. The SWIP identified the ice-on/off dates as well as collected ice thickness measurements. In addition, a digital camera was installed on shore to capture images of the ice cover through the seasons and field measurements were obtained of snow depth on the ice, and both the thickness of snow ice (if present) and total ice cover. Altering the amounts of snow cover on the ice surface to represent potential snow redistribution affected simulated freeze-up dates by a maximum of 22 days and break-up dates by a maximum of 12 days, highlighting the importance of accurately representing the snowpack for lake ice modelling. The late season ice thickness tended to be under estimated by the simulations with break-up occurring too early, however, the evolution of the ice cover was simulated to fall between the range of the full snow and no snow scenario, with the thickness being dependant on the amount of snow cover on the ice surface.

Hans-Christoph Koller: Bildung anders denken, Einführung in die Theorie transformatorischer Bildungsprozesse. Stuttgart: Kohlhammer 2012 [Rezension]

Rezension von: Hans-Christoph Koller: Bildung anders denken, Einführung in die Theorie transformatorischer Bildungsprozesse, Stuttgart: Kohlhammer 2012 (194 S.; ISBN 978-3-17-021980-9)

Changing the metaphor : the potential of online communities in teacher professional development

Belonging to an online community offers teachers the opportunity to exchange ideas, make connections with a wider peer group and form collaborative networks. The increasing popularity of teacher professional communities means that we need to understand how they work and determine the role they may play in teacher professional development. This chapter will map data from a doctoral study to a recentlydeveloped model of professional development to offer a new perspective of how online communities can add to a teacher’s personal and professional growth and, in so doing, add to the small number of studies in this field. This chapter will conclude with a call for a revision of the way we approach professional development in the 21st century and suggest that old models and metaphors are hindering the adoption of more effective means of professional development for teachers.

Vom Prosumer zum Produser : Ein neues Verständnis nutzergesteuerter Inhaltserschaffung

Alvin Tofflers Bild des Prosumers beeinflußt weiterhin maßgeblich unser Verständnis vieler heutzutage als „Social Media“ oder „Web 2.0“ beschriebener nutzergesteuerter, kollaborativer Prozesse der Inhaltserstellung. Ein genauerer Blick auf Tofflers eigene Beschreibung seines Prosumermodells offenbart jedoch, daß es fest im Zeitalter der Massenmedienvorherrschaft verankert bleibt: der Prosumer ist eben nicht jener aus eigenem Antrieb aktive, kreative Ersteller und Weiterbearbeiter neuer Inhalte, wie er heutzutage in Projekten von der Open-Source-Software über die Wikipedia bis hin zu Second Life zu finden ist, sondern nur ein ganz besonders gut informierter, und daher in seinem Konsumverhalten sowohl besonders kritischer als auch besonders aktiver Konsument. Hochspezialisierte, High-End-Konsumenten etwa im Hi-Fi- oder Automobilbereich stellen viel eher das Idealbild des Prosumers dar als das für Mitarbeiter in oft eben gerade nicht (oder zumindest noch nicht) kommerziell erfaßten nutzergesteuerten Kollaborationsprojekten der Fall ist. Solches von Tofflers in den 70ern erarbeiteten Modells zu erwarten, ist sicherlich ohnehin zuviel verlangt. Das Problem liegt also nicht bei Toffler selbst, sondern vielmehr in den im Industriezeitalter vorherrschenden Vorstellungen eines recht deutlich in Produktion, Distribution, und Konsum eingeteilten Prozesses. Diese Dreiteilung war für die Erschaffung materieller wie immaterieller Güter durchaus notwendig – sie ist selbst für die konventionellen Massenmedien zutreffend, bei denen Inhaltsproduktion ebenso aus kommerziellen Gründen auf einige wenige Institutionen konzentriert war wie das für die Produktion von Konsumgütern der Fall ist. Im beginnenden Informationszeitalter, beherrscht durch dezentralisierte Mediennetzwerke und weithin erhaltbare und erschwingliche Produktionsmittel, liegt der Fall jedoch anders. Was passiert, wenn Distribution automatisch erfolgt, und wenn beinahe jeder Konsument auch Produzent sein kann, anstelle einer kleinen Schar von kommerziell unterstützten Produzenten, denen bestenfallls vielleicht eine Handvoll von nahezu professionellen Prosumern zur Seite steht? Was geschieht, wenn sich die Zahl der von Eric von Hippel als ‚lead user’ beschriebenen als Produzenten aktiven Konsumenten massiv ausdehnt – wenn, wie Wikipedias Slogan es beschreibt, ‚anyone can edit’, wenn also potentiell jeder Nutzer aktiv an der Inhaltserstellung teilnehmen kann? Um die kreative und kollaborative Beteiligung zu beschreiben, die heutzutage nutzergesteuerte Projekte wie etwa die Wikipedia auszeichnet, sind Begriffe wie ‚Produktion’ und ‚Konsum’ nur noch bedingt nützlich – selbst in Konstruktionen wie 'nutzergesteuerte Produktion' oder 'P2P-Produktion'. In den Nutzergemeinschaften, die an solchen Formen der Inhaltserschaffung teilnehmen, haben sich Rollen als Konsumenten und Benutzer längst unwiederbringlich mit solchen als Produzent vermischt: Nutzer sind immer auch unausweichlich Produzenten der gemeinsamen Informationssammlung, ganz egal, ob sie sich dessens auch bewußt sind: sie haben eine neue, hybride Rolle angenommen, die sich vielleicht am besten als 'Produtzer' umschreiben lassen kann. Projekte, die auf solche Produtzung (Englisch: produsage) aufbauen, finden sich in Bereichen von Open-Source-Software über Bürgerjournalismus bis hin zur Wikipedia, und darüberhinaus auch zunehmend in Computerspielen, Filesharing, und selbst im Design materieller Güter. Obwohl unterschiedlich in ihrer Ausrichtung, bauen sie doch auf eine kleine Zahl universeller Grundprinzipien auf. Dieser Vortrag beschreibt diese Grundprinzipien, und zeigt die möglichen Implikationen dieses Übergangs von Produktion (und Prosumption) zu Produtzung auf.

Kallikrein-related peptidase 4 activation of protease-activated receptor family members and association with prostate cancer

Two areas of particular importance in prostate cancer progression are primary tumour development and metastasis. These processes involve a number of physiological events, the mediators of which are still being discovered and characterised. Serine proteases have been shown to play a major role in cancer invasion and metastasis. The recently discovered phenomenon of their activation of a receptor family known as the protease activated receptors (PARs) has extended their physiological role to that of signaling molecule. Several serine proteases are expressed by malignant prostate cancer cells, including members of the kallikreinrelated peptidase (KLK) serine protease family, and increasingly these are being shown to be associated with prostate cancer progression. KLK4 is highly expressed in the prostate and expression levels increase during prostate cancer progression. Critically, recent studies have implicated KLK4 in processes associated with cancer. For example, the ectopic over-expression of KLK4 in prostate cancer cell lines results in an increased ability of these cells to form colonies, proliferate and migrate. In addition, it has been demonstrated that KLK4 is a potential mediator of cellular interactions between prostate cancer cells and osteoblasts (bone forming cells). The ability of KLK4 to influence cellular behaviour is believed to be through the selective cleavage of specific substrates. Identification of relevant in vivo substrates of KLK4 is critical to understanding the pathophysiological roles of this enzyme. Significantly, recent reports have demonstrated that several members of the KLK family are able to activate PARs. The PARs are relatively new members of the seven transmembrane domain containing G protein coupled receptor (GPCR) family. PARs are activated through proteolytic cleavage of their N-terminus by serine proteases, the resulting nascent N-terminal binds intramolecularly to initiate receptor activation. PARs are involved in a number of patho-physiological processes, including vascular repair and inflammation, and a growing body of evidence suggests roles in cancer. While expression of PAR family members has been documented in several types of cancers, including prostate, the role of these GPCRs in prostate cancer development and progression is yet to be examined. Interestingly, several studies have suggested potential roles in cellular invasion through the induction of cytoskeletal reorganisation and expression of basement membrane-degrading enzymes. Accordingly, this program of research focussed on the activation of the PARs by the prostate cancer associated enzyme KLK4, cellular processing of activated PARs and the expression pattern of receptor and agonist in prostate cancer. For these studies KLK4 was purified from the conditioned media of stably transfected Sf9 insect cells expressing a construct containing the complete human KLK4 coding sequence in frame with a V5 epitope and poly-histidine encoding sequences. The first aspect of this study was the further characterisation of this recombinant zymogen form of KLK4. The recombinant KLK4 zymogen was demonstrated to be activatable by the metalloendopeptidase thermolysin and amino terminal sequencing indicated that thermolysin activated KLK4 had the predicted N-terminus of mature active KLK4 (31IINED). Critically, removal of the pro-region successfully generated a catalytically active enzyme, with comparable activity to a previously published recombinant KLK4 produced from S2 insect cells. The second aspect of this study was the activation of the PARs by KLK4 and the initiation of signal transduction. This study demonstrated that KLK4 can activate PAR-1 and PAR-2 to mobilise intracellular Ca2+, but failed to activate PAR-4. Further, KLK4 activated PAR-1 and PAR-2 over distinct concentration ranges, with KLK4 activation and mobilisation of Ca2+ demonstrating higher efficacy through PAR-2. Thus, the remainder of this study focussed on PAR-2. KLK4 was demonstrated to directly cleave a synthetic peptide that mimicked the PAR-2 Nterminal activation sequence. Further, KLK4 mediated Ca2+ mobilisation through PAR-2 was accompanied by the initiation of the extra-cellular regulated kinase (ERK) cascade. The specificity of intracellular signaling mediated through PAR-2 by KLK4 activation was demonstrated by siRNA mediated protein depletion, with a reduction in PAR-2 protein levels correlating to a reduction in KLK4 mediated Ca2+mobilisation and ERK phosphorylation. The third aspect of this study examined cellular processing of KLK4 activated PAR- 2 in a prostate cancer cell line. PAR-2 was demonstrated to be expressed by five prostate derived cell lines including the prostate cancer cell line PC-3. It was also demonstrated by flow cytometry and confocal microscopy analyses that activation of PC-3 cell surface PAR-2 by KLK4 leads to internalisation of this receptor in a time dependent manner. Critically, in vivo relevance of the interaction between KLK4 and PAR-2 was established by the observation of the co-expression of receptor and agonist in primary prostate cancer and prostate cancer bone lesion samples by immunohistochemical analysis. Based on the results of this study a number of exciting future studies have been proposed, including, delineating differences in KLK4 cellular signaling via PAR-1 and PAR-2 and the role of PAR-1 and PAR-2 activation by KLK4 in prostate cancer cells and bone cells in prostate cancer progression.