No longitudinal mitochondrial DNA sequence changes in HIV-infected individuals with and without lipoatrophy

The potential for mitochondrial (mt) DNA mutation accumulation during antiretroviral therapy (ART), and preferential accumulation in patients with lipoatrophy compared with control participants, remains controversial. We sequenced the entire mitochondrial genome, both before ART and after ART exposure, in 29 human immunodeficiency virus (HIV)-infected Swiss HIV Cohort Study participants initiating a first-line thymidine analogue-containing ART regimen. No accumulation of mtDNA mutations or deletions was detected in 13 participants who developed lipoatrophy or in 16 control participants after significant and comparable ART exposure (median duration, 3.3 and 3.7 years, respectively). In HIV-infected persons, the development of lipoatrophy is unlikely to be associated with accumulation of mtDNA mutations detectable in peripheral blood.

"Leiomyomatoid angiomatous neuroendocrine tumor" (LANT) of the pituitary reflects idiosyncratic angiogenesis in adenomas of the gonadotroph cell lineage.

Based on a single-case observation, the descriptive label "leiomyomatoid angiomatous neuroendocrine tumor" (LANT) has been tentatively applied to what was perceived as a possible novel type of dual-lineage pituitary neoplasm with biphasic architecture. We report on two additional examples of an analogous phenomenon encountered in male patients, aged 59 years (Case 1) and 91 years (Case 2). Both tumors were intra- and suprasellar masses, measuring 5.6 cm × 4.4 cm × 3.4 cm, and 2.7 cm × 2 cm × 1.7 cm, respectively. Histologically, Case 1 was an FSH-cell adenoma interwoven by vascularized connective tissue septa that tended to exhibit incremental stages of adventitial overgrowth. The epithelial component of Case 2 corresponded to an LH-cell adenoma, and lay partitioned by a maze of paucicellular to hyalinized vascular axes. Irrespective of architectural variations, perivascular spindle cells exhibited immunopositivity for vimentin, muscular actin, and smooth muscle actin. Conversely, negative results were obtained for CD34, EMA, S100 protein, GFAP, and TTF-1. Ultrastructural study failed to reveal metaplastic cell forms involving transitional features between adenohypophyseal-epithelial and mesenchymal-contractile phenotype. We propose that LANT be regarded as a peculiar reflection of maladaptive angiogenesis in some pituitary adenomas, rather than a genuine hybrid neoplasm. While no mechanistic clue is forthcoming to account for this distinctive pattern, hemodynamic strain through direct arterial - rather than portal - supply of the adenoma's capillary bed may be one such explanatory factor. The apparent predilection of the LANT pattern for macroadenomas of the gonadotroph cell lineage remains unexplained.

Fratris Didaci Stellæ Ordinis Minorum, in sacrosanctum Iesu Christi Domini Nostri Euangelium secundum Lucam Enarrationum : tomus secundus.

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Fratris Didaci Stellæ Ordinis Minorum, in sacrosanctum Iesu Christi Domini Nostri Euangelium secundum Lucam Enarrationum : tomus secundus.

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Manual de confessores y penitentes, que contiene quasi todas las dudas que en las confessiones suelen ocurrir, de los pecados ... : con cinco comentarios de vsuras, cambios, symonia mental, defension del proximo, de hurto notable, [et] irregularidad /compuesto por el Doctor Martin de Azpilcueta nauarro ... ; con su reportorio copiosissimo

Colofón en 3D8r y en L5v de la segunda secuencia

Manual de confessores y penitentes, que contiene quasi todas las dudas que en las confessiones suelen ocurrir, de los pecados ... : con cinco comentarios de vsuras, cambios, symonia mental, defension del proximo, de hurto notable, [et] irregularidad /compuesto por el Doctor Martin de Azpilcueta nauarro ... ; con su reportorio copiosissimo

Colofón en 3D8r y en L5v de la segunda secuencia

Libro de las excelencias, y vida de S. Iuan Euangelista

Datos de mención de resp. de ed. preceden a mención de ed

El paso del Ebro en Castejón de Navarra. Notas para su historia

El río Ebro confiere a su paso por Navarra un carácter fisiográfico singular. Las comarcas de La Ribera y Tierra Estella son también distritos administrativos seculares: Merindad de Estella y Merindad de Tudela. El río determina una notable frontera a lo largo del borde suroeste navarro. Ésta ha sido fijada en su emplazamiento actual a lo largo de la historia. Sin embargo, la llamada Ribera Baja, mantiene navarras ambas márgenes. El paso del puente -acaso romano- de Tudela y la influencia de tan importante ciudad la ha preservado desde tiempos medievales frente a los intereses de los reinos vecinos durante la edad media. La influencia de esta región en las comunicaciones peninsulares es notable. Para explicar la permeabilidad de comunicaciones es necesario acudir a otros pasos, de menor orden e importancia, pero de contribución decisiva en las comunicaciones del reino con la Meseta y Castilla.

O EVANGELHO SEGUNDO DOSTOIÉVSKI UMA ABORDAGEM INTERTEXTUAL DA IMAGEM DE CRISTO NO ROMANCE O IDIOTA

No romance O Idiota, Dostoiévski cria, por meio do príncipe Míchkin, uma personagem com as características do Cristo. Sabe-se que a Bíblia, principalmente o Novo Testamento, acompanhou o escritor desde sua infância até o momento de sua morte. O primeiro capítulo, dedicado ao referencial teórico da pesquisa, lida com o universo da linguagem. Tanto o texto literário quanto a literatura bíblica procedem do mito. Neste sen-tido, religião e literatura se tocam e se aproximam. O segundo capítulo foi escrito na intenção de mostrar como o Cristo e os Evangelhos são temas, motivos e imagens recorrentes na obra de Dostoiévski. A literatura bíblica está presente, com mais ou menos intensidade, em diversas das principais obras do escritor russo e não somente em O Idiota. A hipótese de que Dostoiévski cria um Cristo e um Evangelho por meio de O Idiota é demonstrada na análise do romance, no terceiro capítulo. A tese proposta é: Dostoiévski desenvolve um evangelho literário, por meio de Míchkin, misto de um Cristo russo, ao mesmo tempo divino e humano, mas também idiota e quixotesco. Na dinâmica intertextual entre os Evangelhos bíblicos e O Idiota, entre Cristo e Míchkin, a literatura e o sagrado se revelam, como uma presença divina. Nas cenas e na estruturação do enredo que compõe o romance, Cristo se manifesta nas ações de Míchkin, na luz, na beleza, mas também na tragicidade de uma trajetória deslocada e antinômica. O amor e a compaixão ganham forma e vida na presen-ça do príncipe, vazio de si, servo de todos.

De Teodomiro a Tudmīr: los primeros tiempos desde la arqueología (s. VII-IX)

Trabajo realizado en el marco del proyecto de investigación HAR2009-11441, Lectura arqueológica del uso social del espacio. Análisis transversal de la Protohistoria al Medievo en el Mediterráneo Occidental, financiado por el Ministerio de Ciencia e Innovación.

European Union Bailouts and Credibility. Jean Monnet/Robert Schuman Paper Series Vol. 15 No. 4, October 2015

Since the Great Recession started, there have been eight bailouts to EU Member States, which approximate cost to the EU has been of around 380 billion euros. The aim of this paper is to analyze the legal-constitutional issues that this major bailing out operation has brought about. The conclusion is that the EU was not only ill-prepared from an economic perspective to make bailouts; it was also ill-prepared from a constitutional perspective as well, above all if one understands law, as this paper does, as a credibility device. Absent further reforms and clarifications, the current EU system of bailout governance may be prone to generate important credibility problems in the future.

Modus concionandi, et explanatio in Psalm. cxxxvj. Super flumina Babylonis / Didaco Stella Minorita auctore.

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Tratado de la vanidad de el mundo /

Mode of access: Internet.

Meditaciones devotissimas del amor de Dios /

Mode of access: Internet.