Les mécanismes sous-jacents aux effets pathologiques cardiaques de l’angiotensine II dans le remodelage électrique et contractile entre les sexes

L’insuffisance cardiaque (IC) est associée à un taux de mortalité et d’hospitalisations élevé causant un fardeau économique important. Les deux causes majeures de décès de l’IC sont les arythmies ventriculaires létales et les sidérations myocardiques. Il est maintenant reconnu que l’angiotensine II (ANGII) est l'un des principaux médiateurs de l’IC. Ses effets délétères découlent de l’activation du récepteur de type 1 de l’ANGII (AT1) et entraînent le développement d’hypertrophie. Toutefois, son rôle dans la genèse d’arythmies demeure incompris. De ce fait, l'étude des mécanismes électriques et contractiles sous-jacents aux effets pathologiques de l’ANGII s’avère essentielle afin de mieux comprendre et soigner cette pathologie. Il est souvent perçu que les femmes sont protégées envers les maladies cardiovasculaires. Cependant, le nombre total de femmes décédant d’IC est plus grand que le nombre d’hommes. Également, l’impact des facteurs de risque diffère entre chaque sexe. Ces différences existent, mais les mécanismes sous-jacents sont encore peu connus. De plus, les femmes reçoivent fréquemment un diagnostic ou un traitement inapproprié en raison d’un manque d’information sur les différences entre les sexes dans la manifestation d’une pathologie. Ce manque de données peut découler du fait que les sujets de sexe féminin sont souvent sous-représentés dans les essais cliniques ou la recherche fondamentale ce qui a grandement limité l’avancement de nos connaissances sur ~50 % de la population. Ainsi, il semble plus que nécessaire d’approfondir notre compréhension des différences entre les sexes, notamment dans la progression de l’IC. L’utilisation d’un modèle de souris transgénique surexprimant le récepteur AT1 (souris AT1R) a permis d’étudier les changements électriques, structurels et contractiles avant et après le développement d’hypertrophie. Premièrement, chez les souris AT1R mâles, un ralentissement de la conduction ventriculaire a été observé indépendamment de l’hypertrophie. Ce résultat était expliqué par une réduction de la densité du courant Na+, mais pas de l’expression du canal. Ensuite, le rôle des protéines kinases C (PKC) dans la régulation du canal Na+ par l’ANGII a été exploré. Les évidences ont suggéré que la PKCα était responsable de la modulation de la diminution du courant Na+ chez les souris AT1R mâles et dans les cardiomyocytes humains dérivés de cellules souches induites pluripotentes (hiPSC-CM) en réponse à un traitement chronique à l’ANGII. Ensuite, les différences entre les sexes ont été comparées chez la souris AT1R. Une plus grande mortalité a été constatée chez les femelles AT1R suggérant qu’elles sont plus sensibles à la surexpression de AT1R. Le remodelage électrique ventriculaire a donc été comparé entre les souris AT1R des deux sexes. Les courants ioniques étaient altérés de façon similaire entre les sexes excluant ainsi leur implication dans la mortalité plus élevée chez les femelles. Ensuite, l’homéostasie calcique et la fonction cardiaque ont été étudiées. Il a été démontré que les femelles développaient une hypertrophie et une dilatation ventriculaire plus sévère que les mâles. De plus, les femelles AT1R avaient de petits transitoires calciques, une extrusion du Ca2+ plus lente ainsi qu’une augmentation de la fréquence des étincelles Ca2+ pouvant participer à des troubles contractiles et à la venue de post-dépolarisations précoces. En conclusion, l’ANGII est impliquée dans le remodelage électrique, structurel et calcique associé à l'émergence de l’IC. De surcroît, ces altérations affectent plus sévèrement les femelles soulignant la présence de différences entre les sexes dans le développement de l’IC.

Beyond the Convent Walls: The Local and Japan-wide Activities of Daihongan’s Nuns in the Early Modern Period (c. 1550–1868)

This dissertation examines the social and financial activities of Buddhist nuns to demonstrate how and why they deployed Buddhist doctrines, rituals, legends, and material culture to interact with society outside the convent. By examining the activities of the nuns of the Daihongan convent (one of the two administrative heads of the popular pilgrimage temple, Zenkōji) in Japan’s early modern period (roughly 1550 to 1868) as documented in the convent’s rich archival sources, I shed further light on the oft-overlooked political and financial activities of nuns, illustrate how Buddhist institutions interacted with the laity, provide further nuance to the discussion of how Buddhist women navigated patriarchal sectarian and secular hierarchies, and, within the field of Japanese history, give voice to women who were active outside of the household unit around which early modern Japanese society was organized.

Zenkōji temple, surrounded by the mountains of Nagano, has been one of Japan’s most popular pilgrimage sites since the medieval period. The abbesses of Daihongan, one Zenkōji’s main sub-temples, traveled widely to maintain connections with elite and common laypeople, participated in frequent country-wide displays of Zenkōji’s icon, and oversaw the creation of branch temples in Edo (now Tokyo), Osaka, Echigo (now Niigata), and Shinano (now Nagano). The abbesses of Daihongan were one of only a few women to hold the imperially sanctioned title of eminent person (shōnin 上人) and to wear purple robes. While this means that this Pure Land convent was in some ways not representative of all convents in early modern Japan, Daihongan’s position is particularly instructive because the existence of nuns and monks in a single temple complex allows us to see in detail how monastics of both genders interacted in close quarters.

This work draws heavily from the convent’s archival materials, which I used as a guide in framing my dissertation chapters. In the Introduction I discuss previous works on women in Buddhism. In Chapter 1, I briefly discuss the convent’s history and its place within the Zenkōji temple complex. In Chapter 2, I examine the convent’s regular economic bases and its expenditures. In Chapter 3, I highlight Daihongan’s branch temples and discuss the ways that they acted as nodes in a network connecting people in various areas to Daihongan and Zenkōji, thus demonstrating how a rural religious center extended its sphere of influence in urban settings. In Chapter 4, I discuss the nuns’ travels throughout the country to generate new and maintain old connections with the imperial court in Kyoto, confraternities in Osaka, influential women in the shogun’s castle, and commoners in Edo. In Chapter 5, I examine the convent’s reliance upon irregular means of income such as patronage, temple lotteries, loans, and displays of treasures, and how these were needed to balance irregular expenditures such as travel and the maintenance or reconstruction of temple buildings. Throughout the dissertation I describe Daihongan’s inner social structure comprised of abbesses, nuns, and administrators, and its local emplacement within Zenkōji and Zenkōji’s temple lands.

Exploring these themes sheds light on the lives of Japanese Buddhist nuns in this period. While the tensions between freedom and agency on the one hand and obligations to patrons, subordination to monks, or gender- and status-based restrictions on the other are important, and I discuss them in my work, my primary focus is on the nuns’ activities and lives. Doing so demonstrates that nuns were central figures in ever-changing economic and social networks as they made and maintained connections with the outside world through Buddhist practices and through precedents set centuries before. This research contributes to our understanding of nuns in Japan’s early modern period and will participate in and shape debates on the roles of women in patriarchal religious hierarchies.

Global Factors Affecting Women's Participation in Leadership

This dissertation is a multi-level, cross-cultural study of women in leadership conducted with both macro-society data and individual-level data aggregated to the country level. The research questions are, “What macro and micro forces are hindering or advancing women into business or political leadership?” “How do these forces impact the level of women’s involvement in business and political leadership in a particular country?” Data was collected from 10 secondary sources, available for 213 countries, and includes about 300 variables for business leadership (N=115) and political leadership (N=181). To date, most women in leadership research has been Western- or US- based, and little rigorous empirical, multi-level research has been done across countries. The importance of cross-cultural studies on women in leadership stems from the potential to better understand why some countries have more women in positions of both business and political leadership; and the factors that affect women’s involvement in such positions in different countries. A “Levels of Women’s Participation in Leadership” country model is tested using cluster and discriminant analyses. Results indicate that the factors that affect women’s participation in leadership in countries with fewer women leaders are different from the factors that affect women’s participation in countries with high levels of participation. This dissertation proposes that initiatives to increase participation of women in leadership need to consider the relevant factors that significantly affect countries at certain Levels of Women’s Participation in Leadership.

Nuevas perspectivas historiográficas sobre mujeres, género y antifascismos en Argentina

Los estudios sobre mujeres y género en relación con el antifascismo llevados a cabo en el ámbito académico en distintos países han revelado una variedad de desarrollos en el mundo. En el caso argentino, las investigaciones han demostrado que el antifascismo, caracterizado por una gran heterogeneidad de manifestaciones, movilizó a amplias capas de la sociedad de diversas maneras y en distintos períodos. El presente artículo, orientado a establecer el estado actual de la historiografía, explora en primer lugar los avances realizados en los campos respectivos de los estudios de género y el antifascismo en la Argentina en las últimas décadas. Indaga luego la manera en que una serie de trabajos recientes ha incorporado los aportes de ambos campos, mostrando las posibilidades ofrecidas por el entrecruzamiento entre género y antifascismo. Finalmente, el texto concluye ofreciendo una agenda de investigación con orientaciones para futuros trabajos

Nuevas perspectivas historiográficas sobre mujeres, género y antifascismos en Argentina

Los estudios sobre mujeres y género en relación con el antifascismo llevados a cabo en el ámbito académico en distintos países han revelado una variedad de desarrollos en el mundo. En el caso argentino, las investigaciones han demostrado que el antifascismo, caracterizado por una gran heterogeneidad de manifestaciones, movilizó a amplias capas de la sociedad de diversas maneras y en distintos períodos. El presente artículo, orientado a establecer el estado actual de la historiografía, explora en primer lugar los avances realizados en los campos respectivos de los estudios de género y el antifascismo en la Argentina en las últimas décadas. Indaga luego la manera en que una serie de trabajos recientes ha incorporado los aportes de ambos campos, mostrando las posibilidades ofrecidas por el entrecruzamiento entre género y antifascismo. Finalmente, el texto concluye ofreciendo una agenda de investigación con orientaciones para futuros trabajos

Nuevas perspectivas historiográficas sobre mujeres, género y antifascismos en Argentina

Los estudios sobre mujeres y género en relación con el antifascismo llevados a cabo en el ámbito académico en distintos países han revelado una variedad de desarrollos en el mundo. En el caso argentino, las investigaciones han demostrado que el antifascismo, caracterizado por una gran heterogeneidad de manifestaciones, movilizó a amplias capas de la sociedad de diversas maneras y en distintos períodos. El presente artículo, orientado a establecer el estado actual de la historiografía, explora en primer lugar los avances realizados en los campos respectivos de los estudios de género y el antifascismo en la Argentina en las últimas décadas. Indaga luego la manera en que una serie de trabajos recientes ha incorporado los aportes de ambos campos, mostrando las posibilidades ofrecidas por el entrecruzamiento entre género y antifascismo. Finalmente, el texto concluye ofreciendo una agenda de investigación con orientaciones para futuros trabajos

Media diversity as a guarantee to cultural diversity: the promotion of identities from an international law approach

This article deals with several international instruments which provide legal guarantees for media diversity, which is essential for the promotion of cultural diversity. Based on several articles of the Convention of cultural diversity, the General Comment of the Committee on Economic, Social and Cultural Rights No. 21 on the right to take part in cultural life, as well as the work of the UN Independent Expert on Cultural Rights, this article aims to identify legal tools for the establishing of measures promoting cultural diversity in the media. This article looks at the case study of Honduran Garifuna community radios. It emphasizes the importance of taking into account the economic aspects of cultural and communicational rights.

Eclipses, razón y superstición en las vidas de Nicias y Dión de Plutarco

A partir de un abordaje retórico-literario, nuestro objetivo es indagar las representaciones discursivas de los elementos supersticiosos en la biografía de Nicias y en la de Dión. Tomaremos como ejemplo el eclipse de luna narrado en Nicias 23 y reiterado en Dión 24, para demostrar que mediante la repetición del ejemplo en dos contextos distintos Plutarco nos invita a reflexionar sobre la superstición de un modo más atractivo que la mera exposición teórica de doctrinas filosóficas.

Latina Super-heroines: Hot Tamales in Tights vs. Women Warriors, Wrestlers and Guerrilla Fighters of La Raza

The year 1977 saw the making of the first Latino superhero by a Latino artist. From the 1980s onwards it is also possible to find Latina super-heroines, whose number and complexity has kept increasing ever since. Yet, the representations of spandexed Latinas are still few. For that reason, the goal of this paper is, firstly, to gather a great number of Latina super-heroines and, secondly, to analyze the role that they have played in the history of American literature and art. More specifically, it aims at comparing the spandexed Latinas created by non-Latino/a artists and mainstream comic enterprises with the Latina super-heroines devised by Latino/a artists. The conclusion is that whereas the former tend to conceive heroines within the constraints of the logic of Girl Power, the latter choose to imbue their works with a more daring political content and to align their heroines with the ideologies of Feminism and Postcolonialism.

Pratiquer l’égalité entre les femmes et les hommes au sein des organisations : étude de cas des ONG au Mali.

Cette thèse analyse les pratiques d’égalité entre les femmes et les hommes au sein des organisations non gouvernementales (ONG) maliennes qui ont reçu du financement canadien. En effet, l’aide publique au développement a subi des transformations majeures depuis les années 1950. L’une de ces transformations a été le rôle important joué par les ONG dans les années 1990, à la suite de l’adoption des politiques d’ajustements structurels et de la fin de la monopolisation par l’État en ce qui a trait à l’aide publique pour les projets de développement. Entre autres, les ONG ont été sollicitées pour promouvoir les politiques d’égalité entre hommes et femmes. L’importance des ONG dans l’aide publique au développement a créé des relations de dépendances vis-à-vis des bailleurs de fonds qui imposent des conditionnalités. Nos résultats ont montré que les bailleurs de fonds exigent l’égalité entre les sexes en ce qui concerne les bénéficiaires des programmes, mais, paradoxalement, ne l’exigent pas à l’intérieur des ONG et dans leurs ressources humaines. En analysant la composition du personnel de huit ONG maliennes, nos résultats montrent que 34 % du personnel sont des femmes alors que 66 % sont des hommes, ce qui démontre un déséquilibre assez important en matière de parité. Cependant, une analyse plus fine nous indique que les pratiques d’égalité entre femmes et hommes dans les structures et dans la gestion des ressources humaines diffèrent d’une ONG à une autre. Ces pratiques dépendent beaucoup de la volonté et des valeurs des gestionnaires. Notre recherche a fait ressortir plusieurs explications de cette disparité au niveau de l’emploi des femmes. Les raisons souvent mentionnées étaient : 1) la nécessité d’avoir du personnel compétent, 2) la conciliation famille-travail, 3) le contexte socioculturel, 4) l’interprétation de la religion musulmane en matière d’égalité. En effet, nos résultats ont démontré que sous l’influence des bailleurs de fonds les ONG se sont professionnalisées, que l’impact de la professionnalisation a été différent selon le genre et que celle-ci s’est faite aux dépens des femmes. Ainsi, certains gestionnaires, quel que soit leur sexe, préfèrent recruter plus d’hommes parce qu’ils les jugent plus compétents.Nos résultats confirment la théorie du plafond de verre qui met en exergue le fait que les femmes ont de la difficulté à accéder à des postes de responsabilité. Nos résultats ont aussi démontré qu’au Mali, le contexte socioculturel et la religion jouent un grand rôle dans les relations sociales et surtout en ce qui concerne la place des femmes au sein de la société.

Assessing the Knowledge and Attitude Among Somali Men In King County Towards Female Genital Mutilation

Thesis (Master's)--University of Washington, 2016-06

Age-Specific Fertility Dynamics: Sub-Saharan African Fertility in a Global Context

Thesis (Ph.D.)--University of Washington, 2016-08

Les internats de rééducation au Québec : un cas type, l'Institut Val du Lac (1944-1972)

L'historique de l'Institut Val du Lac est avant tout l'histoire du premier centre de rééducation spécialisé pour enfants déficients mentaux au Québec. Bien que sa clientèle du début ait été constituée majoritairement d'enfants illégitimes pseudo-déficients, Val du Lac se présente comme la première alternative aux hôpitaux psychiatriques de la province qui vers le milieu du 20e siècle reçoivent le trop plein d'enfants des crèches surpeuplées. Ces jeunes qui présentent des caractéristiques de déficience intellectuelle légère du fait d'un trop long séjour en institution et du manque de stimulis qui en découle, Val du Lac les accueillera pour les aider tant au plan affectif qu'intellectuel et pour tenter de les réintégrer dans la société. L'Institut, malgré des débuts difficiles, est avant-gardiste. Elle crée de nouvelles méthodes thérapeutiques de rééducation et collabore avec plusieurs centres européens et américains. Toute l'organisation de la vie des jeunes est inspirée d'une réelle pensée clinique qui vise à l'épanouissement dans un cadre de vie le plus normalisant possible en vue d'une réintégration future dans la société. L'aspect physique de Val du Lac se présente même comme un petit village: on y retrouve une école, une église, une ferme, des pavillons d'enfants et d'éducateurs, etc. Comme toile de fond, on voit le développement des services offerts aux enfants déficients mentaux qui s'améliore graduellement grâce, entre autres, à l'intervention grandissante de l'État dans le domaine social, à l'éclosion des connaissances en sciences sociales, spécialement en psychoéducation, et aussi à la distinction qui sera établie entre la déficience mentale et la mésadaptation sociale.

Reproducing Women: Female Bodily Narratives and English Patriarchies, 1600-1660

During the early Stuart period, England’s return to male monarchal rule resulted in the emergence of a political analogy that understood the authority of the monarch to be rooted in the “natural” authority of the father; consequently, the mother’s authoritative role within the family was repressed. As the literature of the period recognized, however, there would be no family unit for the father to lead without the words and bodies of women to make narratives of dynasty and legitimacy possible. Early modern discourse reveals that the reproductive roles of men and women, and the social hierarchies that grow out of them, are as much a matter of human design as of divine or natural law. Moreover, despite the attempts of James I and Charles I to strengthen royal patriarchal authority, the role of the monarch was repeatedly challenged on stage and in print even prior to the British Civil Wars and the 1649 beheading of Charles I. Texts produced at moments of political crisis reveal how women could uphold the legitimacy of familial and political hierarchies, but they also disclose patriarchy’s limits by representing “natural” male authority as depending in part on women’s discursive control over their bodies. Due to the epistemological instability of the female reproductive body, women play a privileged interpretive role in constructing patriarchal identities. The dearth of definitive knowledge about the female body during this period, and the consequent inability to fix or stabilize somatic meaning, led to the proliferation of differing, and frequently contradictory, depictions of women’s bodies. The female body became a site of contested meaning in early modern discourse, with men and women struggling for dominance, and competitors so diverse as to include kings, midwives, scholars of anatomy, and female religious sectarians. Essentially, this competition came down to a question of where to locate somatic meaning: In the opaque, uncertain bodies of women? In women’s equally uncertain and unreliable words? In the often contradictory claims of various male-authored medical treatises? In the whispered conversations that took place between women behind the closed doors of birthing rooms? My dissertation traces this representational instability through plays by William Shakespeare, John Ford, Thomas Middleton, and William Rowley, as well as in monstrous birth pamphlets, medical treatises, legal documents, histories, satires, and ballads. In these texts, the stories women tell about and through their bodies challenge and often supersede male epistemological control. These stories, which I term female bodily narratives, allow women to participate in defining patriarchal authority at the levels of both the family and the state. After laying out these controversies and instabilities surrounding early modern women’s bodies in my first chapter, my remaining chapters analyze the impact of women’s words on four distinct but overlapping reproductive issues: virginity, pregnancy, birthing room rituals, and paternity. In chapters 2 and 3, I reveal how women construct the inner, unseen “truths” of their reproductive bodies through speech and performance, and in doing so challenge the traditional forms of male authority that depend on these very constructions for coherence. Chapter 2 analyzes virginity in Thomas Middleton and William Rowley’s play The Changeling (1622) and in texts documenting the 1613 Essex divorce, during which Frances Howard, like Beatrice-Joanna in the play, was required to undergo a virginity test. These texts demonstrate that a woman’s ability to feign virginity could allow her to undermine patriarchal authority within the family and the state, even as they reveal how men relied on women to represent their reproductive bodies in socially stabilizing ways. During the British Civil Wars and Interregnum (1642-1660), Parliamentary writers used Howard as an example of how the unruly words and bodies of women could disrupt and transform state politics by influencing court faction; in doing so, they also revealed how female bodily narratives could help recast political historiography. In chapter 3, I investigate depictions of pregnancy in John Ford’s tragedy, ‘Tis Pity She’s a Whore (1633) and in early modern medical treatises from 1604 to 1651. Although medical texts claim to convey definitive knowledge about the female reproductive body, in actuality male knowledge frequently hinged on the ways women chose to interpret the unstable physical indicators of pregnancy. In Ford’s play, Annabella and Putana take advantage of male ignorance in order to conceal Annabella’s incestuous, illegitimate pregnancy from her father and husband, thus raising fears about women’s ability to misrepresent their bodies. Since medical treatises often frame the conception of healthy, legitimate offspring as a matter of national importance, women’s ability to conceal or even terminate their pregnancies could weaken both the patriarchal family and the patriarchal state that the family helped found. Chapters 4 and 5 broaden the socio-political ramifications of women’s words and bodies by demonstrating how female bodily narratives are required to establish paternity and legitimacy, and thus help shape patriarchal authority at multiple social levels. In chapter 4, I study representations of birthing room gossip in Thomas Middleton’s play, A Chaste Maid in Cheapside (1613), and in three Mistris Parliament pamphlets (1648) that satirize parliamentary power. Across these texts, women’s birthing room “gossip” comments on and critiques such issues as men’s behavior towards their wives and children, the proper use of household funds, the finer points of religious ritual, and even the limits of the authority of the monarch. The collective speech of the female-dominated birthing room thus proves central not only to attributing paternity to particular men, but also to the consequent definition and establishment of the political, socio-economic, and domestic roles of patriarchy. Chapter 5 examines anxieties about paternity in William Shakespeare’s The Winter’s Tale (1611) and in early modern monstrous birth pamphlets from 1600 to 1647, in which children born with congenital deformities are explained as God’s punishment for the sexual, religious, and/or political transgressions of their parents or communities. Both the play and the pamphlets explore the formative/deformative power of women’s words and bodies over their offspring, a power that could obscure a father’s connection to his children. However, although the pamphlets attempt to contain and discipline women’s unruly words and bodies with the force of male authority, the play reveals the dangers of male tyranny and the crucial role of maternal authority in reproducing and authenticating dynastic continuity and royal legitimacy. My emphasis on the socio-political impact of women’s self-representation distinguishes my work from that of scholars such as Mary Fissell and Julie Crawford, who claim that early modern beliefs about the female reproductive body influenced textual depictions of major religious and political events, but give little sustained attention to the role female speech plays in these representations. In contrast, my dissertation reveals that in such texts, patriarchal society relies precisely on the words women speak about their own and other women’s bodies. Ultimately, I argue that female bodily narratives were crucial in shaping early modern culture, and they are equally crucial to our critical understanding of sexual and state politics in the literature of the period.

A crítica às mulheres no fr. 7 de Semónides de Amorgos

O poema de Semónides de Amorgos sobre as mulheres (Fr. 7 West) é o mais extenso fragmento preservado da poesia iâmbica grega da época arcaica. Nele o poeta apresenta uma reflexão pessimista de cariz misógino sobre o carácter feminino, numa narrativa original que cataloga dez tipos de mulher, oito baseadas em modelos animais (a porca, a raposa, a cadela, a burra, a doninha, a égua, a macaca e a abelha) e dois em elementos da natureza (a terra e o mar). Pretende-se demonstrar, neste estudo, que essa caracterização tipológica era inovadora e respondia a uma dupla finalidade: satírica e humorística. Uma vez que o poema se destinaria a um contexto simpótico, um espaço tipicamente masculino, a mulher e a sua natureza constituiriam uma temática que levaria o homem a reflectir, de um modo simultaneamente sério e divertido, sobre a sua própria condição.