Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin e: Structure-activity relationship

α-Tocopheryl succinate (α-TOS) is a well-known mitochondrially targeted anticancer compound, however, it is highly hydrophobic and toxic. In order to improve its activity and reduce its toxicity, new surfactant-free biologically active nanoparticles (NP) were synthesized. A methacrylic derivative of α-TOS (MTOS) was prepared and incorporated in amphiphilic pseudoblock copolymers when copolymerized with N-vinylpyrrolidone (VP) by free radical polymerization (poly(VP-co-MTOS)). The selected poly(VP-co-MTOS) copolymers formed surfactant-free NP by nanoprecipitation with sizes between 96 and 220 nm and narrow size distribution, and the in vitro biological activity was tested. In order to understand the structure-activity relationship three other methacrylic monomers were synthesized and characterized: MVE did not have the succinate group, SPHY did not have the chromanol ring, and MPHY did not have both the succinate group and the chromanol ring.

Japonia w życiu i w twórczości Amélie Nothomb

Wydział Neofilologii: Instytut Filologii Romańskiej

Zintegrowane podejście dyskursywne do rozwijania sprawności mownych; przedstawienie celów i założeń projektu badawczego

Celem artykułu jest przedstawienie projektu o charakterze badawczo-wdrożeniowym dotyczącego doskonalenia obcojęzycznych kompetencji mownych (wypowiadanie się i rozumienie wypowiedzi ustnych) na poziomie zaawansowanym i przygotowywanym w Instytucie Filologii Romańskiej UAM. Niniejszy projekt zakłada, że istnieją spore możliwości podniesienia skuteczności i ekonomii kształcenia kompetencji mownych, poprzez zintegrowane podejście do celów kształcenia, a także poprzez wykorzystanie narzędzi internetowych. Podejście to zasadza się na integracji trzech zakresów kształcenia, a mianowicie: (1) doskonalenia umiejętności interakcyjnych w zakresie komunikacji półpublicznej, (2) rozwoju kompetencji medialnej oraz (3) rozwoju wiedzy dot. aktualnej, szeroko pojmowanej problematyki społeczno-kulturowej i krytycznego, zobiektywizowanego myślenia w stosunku do prezentowanych ujęć i naświetleń tej problematyki. W niniejszym omówieniu główny nacisk położony zostanie na uargumentowanie zasadności postulowanego zintegrowanego podejścia dyskursywnego, a także na wykazanie wartości dydaktycznej wybranych audycji medialnych. Zaprezentowane zostaną również główne kierunki pracy dydaktycznej oraz wyniki badania pilotażowego.

Dyskurs pedagogiczny w kształceniu początkowym nauczycieli języków obcych

Wydział Neofilologii: Instytut Filologii Romańskiej

Napięcia tożsamościowe, tematyczne i formalne w dziele Yasminy Khadry

Wydział Neofilologii Instytut Filologii Romańskiej

Mit Ofelii we francuskojęzycznej literaturze belgijskiej doby symbolizmu.

Wydział Neofilologia: Instytut Filologii Romańskiej

Programa Nacional de Joyería. Informe de Gestión - 2002.

25 hojas : Cuadros.

DSpace Basic Tutorial

PDF of powerpoint slides presented at DSUG 2007 Roma

Expression, purification and X-ray crystallographic analysis of the Helicobacter pylori blood group antigen-binding adhesin BabA

Helicobacter pylori is a human pathogen that colonizes about 50% of the world's population, causing chronic gastritis, duodenal ulcers and even gastric cancer. A steady emergence of multiple antibiotic resistant strains poses an important public health threat and there is an urgent requirement for alternative therapeutics. The blood group antigen-binding adhesin BabA mediates the intimate attachment to the host mucosa and forms a major candidate for novel vaccine and drug development. Here, the recombinant expression and crystallization of a soluble BabA truncation (BabA^25-460) corresponding to the predicted extracellular adhesin domain of the protein are reported. X-ray diffraction data for nanobody-stabilized BabA^25-460 were collected to 2.25Å resolution from a crystal that belonged to space group P21, with unit-cell parameters a = 50.96, b = 131.41, c = 123.40Å, α = 90.0, β = 94.8, γ = 90.0°, and which was predicted to contain two BabA^25-460-nanobody complexes per asymmetric unit.

Modelo local de simulación de nivel de napa freática en la Depresión del Salado

p.155-158

Variación del agua edáfica disponible para los cultivos en la Región Oriental de la Argentina

p.141-181

All change!: Romani studies through Romani eyes

The welcome emergence of a Gypsy/Roma/Traveller academic and intellectual community has stimulated new reflections on and reassessments of many of the established ideas surrounding Romani history and culture. New questions are being asked and, in turn, new critical challenges have arisen, in part because, for these individuals, Gypsy identity has never been something exotic and Other, but their own.

The vague, the viral, the parasitic: Piranesi's metropolis

In mid-18th century Giovanni Battista Piranesi’s etchings systematically document the old and new monuments, decrepit buildings and broken down infrastructures of a Rome that continues to inhabit and reinvent its past. His views of Rome offer a devastating account of the blurring of distinctions and articulations that time, use and neglect have imposed on the old differentiations of the urban and the rural, the public and the private, the monumental and the domestic in the 18th century city. Rome becomes for Piranesi the laboratory for a questioning of architecture that places his work well beyond the debate on style and on the origin that dominated the architectural discourse of his time. This paper suggests that Piranesi’s images anticipate the dispersion and sprawl of the city of today, in which the ‘vague’, the ‘viral’ and the ‘parasitic’ become modes of inhabitation and of transient negotiated definition. In the Antichità di Roma, ancient buildings are represented not only in their large scale and magnificence, but also in their decay and reversal to a state of naturalness. These works, together with the acute observations of the Vedute di Roma, provide the materials that are then dislocated, manipulated, cloned and endlessly mutated by Piranesi in the synthesis of the Campo Marzio dell’Antica Roma, in which the historical city is almost entirely dissolved and replaced by an extraordinary congestion of fragments. When they are re-examined on the grounds of contemporary architectural and urban theory, the sites of Piranesi's views reveal anticipations of phenomena that affect the metropolis of today. Political, social and economic conditions have changed dramatically, but the questions asked of architecture in and by these sites challenge the definition of an architecture of style, forms and boundaries - in the 18th century as well as in the 21st -in favour of an architecture of change.

Second site

An exhibition by four artists from Roma/Gypsy/Traveller communities. [From the press release]

The Tamaricetea arceuthoidis: a new class for the continental riparian thickets of the Middle East, Central Asia and the subarid regions of the Lower Volga valley

The new class, the Tamaricetea arceuthoidis, is described covering riparian and intermittent shrubby vegetation of the Irano-Turanian Region in the southwestern and Central Asia and the Lower Volga valley. The dominating species are species of the genus Tamarix that refer high water table in arid and semi-arid habitats with high to moderate salinity. This new class is an ecological analogon of the Nerio-Tamaricetea occurring in the Mediterranean Basin.