Group portrait, 50th Anniversary of the Saxony-Anhalt chapter of German Engineers; Bernburg Portraits Groups

Caption: Zur Erinnerung an das fuenfzigjaehrige Gruendungsfest Saechsisch Anhaltinischen Bezirksvereins Deutscher Ingenieure am 11. und 12. Mai 1912 in Bernburg.

Portrait from the Golden Wedding Anniversary celebration of Heinrich and Helena Valentin; Berlin Portraits Groups

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GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors

Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk. We have conducted a genome-wide association scan to discover genetic variants affecting BCHE activity, and to clarify whether the associations between BCHE activity and cardiometabolic risk factors are caused by variation in BCHE or whether BCHE variation is secondary to the metabolic abnormalities. We measured serum BCHE in adolescents and adults from three cohorts of Australian twin and family studies. The genotypes from approximately 2.4 million single-nucleotide polymorphisms (SNPs) were available in 8791 participants with BCHE measurements. We detected significant associations with BCHE activity at three independent groups of SNPs at the BCHE locus (P = 5.8 x 10(-262), 7.8 x 10(-47), 2.9 x 10(-12)) and at four other loci: RNPEP (P = 9.4 x 10(-16)), RAPH1-ABI2 (P = 4.1 x 10(-18)), UGT1A1 (P = 4.0 x 10(-8)) and an intergenic region on chromosome 8 (P = 1.4 x 10(-8)). These loci affecting BCHE activity were not associated with metabolic risk factors. On the other hand, SNPs in genes previously associated with metabolic risk had effects on BCHE activity more often than can be explained by chance. In particular, SNPs within FTO and GCKR were associated with BCHE activity, but their effects were partly mediated by body mass index and triglycerides, respectively. We conclude that variation in BCHE activity is due to multiple variants across the spectrum from uncommon/large effect to common/small effect, and partly results from (rather than causes) metabolic abnormalities.

Albert Einstein with Coriolano Alberini and unidentified men; Buenos Aires, Argentina Portraits Groups; Men

Dedication: Al Prof. Alberto Einstein, maestro y amigo, signed Coriolano Alberini, Dean of the Faculty of Philosophy and Literature of the University of Buenos Aires

Albert Einstein, Paul Langevin, Princesse de Noeille, and Paul Painleve; Paris Portraits Groups

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Albert Einstein with unidentified group Portraits Groups

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Albert Einstein with Robert Andrews Millikan, Albert Michelson and unidentified men; Pasadena, California Portraits Groups; Men

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Albert Einstein and unidentified man Portraits Groups; Men

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Unidentified Group on Beach at Swinemuende Portraits; Groups

Album 4

Heymann; Unidentified others on Beach; Swinemuende Portraits; Groups

Album 4

Members of Chewra Kadischa (Burial Society) of the Klaus Synagogue, Mannheim, taken one day before the November Pogrom (Kristallnacht) Portraits; Groups; Men

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