Altered adhesion molecules expression on peripheral blood mononuclear cells from patients with systemic sclerosis and clinical correlations
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
19/10/2012
19/10/2012
2009
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Resumo |
The aim of the study was to evaluate the expressions of adhesion molecules (AM) on peripheral blood mononuclear cells (PBMNC) from systemic sclerosis (SSc) patients. Thirty-one SSc patients (ACR) and 20 normal subjects were selected for the study. PBMNC were analyzed for LFA-1 alpha, LFA-1 beta, ICAM-3, ICAM-1, and l-selectin expressions. ICAM-3 expression was decreased while ICAM-1 was increased on SSc PBMNC, compared to controls (p = 0.04 and 0.003, respectively). A positive association was found between LFA-1 alpha (r = 0.37, p = 0.03), LFA-1 beta (r = 0.38, p = 0.002), ICAM-3 (r = 0.42, p = 0.01), and l-selectin (r = 0.38, p = 0.03) expressions and greater number of immunosuppressive drugs taken by SSc patients. Also, anti-centromeric positive SSc patients had lower expressions of LFA-1 alpha, LFA-1 beta, ICAM-3, and l-selectin. Lower expression of ICAM-3 and higher expression of ICAM-1 suggest that AMs may be involved in the pathogenesis of scleroderma. |
Identificador |
CLINICAL RHEUMATOLOGY, v.28, n.7, p.847-851, 2009 0770-3198 http://producao.usp.br/handle/BDPI/21598 10.1007/s10067-009-1124-0 |
Idioma(s) |
eng |
Publicador |
SPRINGER |
Relação |
Clinical Rheumatology |
Direitos |
restrictedAccess Copyright SPRINGER |
Palavras-Chave | #Adhesion molecules #ICAM-1 #ICAM-3 #Pathogenesis #Scleroderma #Systemic sclerosis #L-SELECTIN #LOCALIZED SCLERODERMA #INVOLVEMENT #LYMPHOCYTES #RECEPTOR #SERA #SKIN #Rheumatology |
Tipo |
article original article publishedVersion |