Avaliação da expressão de citoqueratinas na citologia esfoliativa da mucosa bucal de pacientes fumantes

The present study compared the expression of cytokeratins CK6, CK16 and CK19 and pan-cytokeratin (PAN) in oral mucosa cells between smokers and nonsmokers in order to determine the stage of cell differentiation and to consequently infer proliferative activity and expressions indicative of a potential for malignant differentiation. Thirty smokers and 30 non-smokers seen at the clinics of FOSJC-UNESP were screened. Smears were obtained from the left lateral border of the tongue with a cytobrush and slides were processed for immunohistochemistry using the antibodies reported Conventional microscopy was used for qualitative analysis. The results were analyzed statistically by the Z test, Fisher's exact test and comparison of two proportions (plus-4 confidence interval method). The expression of CK6 (p=0.002), CK16 (p=0.003), CK19 (p=0.0001) and PAN (p=0.008) was higher in oral mucosa smears from smokers compared to non- smokers. ln conclusion, increased epithelial proliferation is observed in the oral mucosa of smokers as demonstrated by the increased expression of CK6 and CKJ6, and these cells present alterations in epithelial maturation

Associação do treinamento resistido e aeróbico em pacientes com doença pulmonar crônica

Introduction: The pulmonary rehabilitation (PR) is composed of aerobic and resisted exercises that improve the functional capacity to the exercise, life quality and decrease respiratory symptoms in subjects with chronic pulmonary disease. Objective: Assess the effects of a combined PR program in the cardiorespiratory function and peripheral muscle strength in subjects with chronic pulmonary disease. Method: Patients with chronic pulmonary disease were submitted to the PR program, which was developed on 24 sessions of 60 minutes (three times per week). The program was composed of aerobic exercises (two times per week) and resisted exercises (once a week). Before and after the PR the patients were submitted to manovacuometry in order to measure the maximum inspiratory pressure (MIP) and the maximum expiratory pressure (MEP), ventilometry, peek expiratory flow (PEF), six minute walking test (6MWT) and one maximum repetition (1RM). The data are presented in absolute frequency, percentage and mean±standard deviation. The t Student test was used to compare data before and after the PR and the ANOVA test to compare before, after and predicted distances in the 6MWT (p<0.05). Results: Seven patients were part of this study, 85.70% of women, 71.40% with pulmonary emphysema diagnosis. The mean age was 69.43±5.59 years old, the height was 1.61±0.07 m, the mean weight was 66.20±8.40 kg and the body mass index mean was 25.50±2.48 kg/m². From the variables assessed, the MEP increased from 79.71±13.69 to 84.42±12.83 cmH2O (p=0,03), the PEF increase from 255.71±66.3 to 320.00±93.63 l/min (p=0,03) and the distance in the 6MWT from 415.28±47.90 to 483,79±79,77 m (p=0,02). The load in the 1RM test in the reverse peck deck exercise (before - - 17.10±8.10kg; after – 210.40±9.00kg), knee in leg extension machine (before – 17.10±9.50kg; after – 26.40±13.10kg) and hip extensors (right before – 48.60±22.10kg; after – 62.90±19.30kg; and left before – 46.40±20.10kg; after – 62.10±18.20kg) increased significantly (p<0,05). Conclusion: After the PR program there was improvement in the expiratory muscular strength, in the lower limbs strength and in the functional capacity. Besides that, there was a reduction in the airflow obstruction of the subjects with chronic pulmonary disease.

Busca de antígenos para diagnóstico da leishmaniose visceral canina: potencial uso e aplicação da proteína rLc36

Pós-graduação em Biotecnologia - IQ

A produção científica sobre diagnóstico de enfermagem NANDA no Brasil: revisão integrativa da literatura-UNESP – Botucatu

Concern about the identity of nursing professionals has existed since Florence Nightingale. The exercise of the nursing profession must be based on scientific principles so that the actual health problems of a given community can be assessed and actions targeted at improving the population’s quality of life can be designed from such assessments. This problem assessment is referred to as Nursing Diagnosis. NANDA defines diagnosis as “a clinical judgment about individual, family or community responses to actual or potential health problems/life processes. Nursing diagnosis provides the basis for selection of nursing interventions to achieve outcomes for which nurses are accountable”. The present study aimed at investigating the scientific production on Nursing Diagnosis (NANDA). This is an literature review. For data collection, an instrument that addressed the following items was used: identification of original articles and evaluation of their objectives, methodological characteristics, results and conclusion. In the present review, 15 articles that met the inclusion criteria were analyzed. They were all authored by nurses. Four articles addressed obstetrics, puerperium and neonatology, and the diagnosis of an unsatisfactory breastfeeding process was observed in 100% of cases. As regards chronic diseases, four articles were found, and two exclusively addressed diabetes, with a main diagnosis of an ineffective control of the therapeutic regimen. Three articles addressed the elderly, and the main diagnosis found was hindered mobility in more than 90% of cases. As regards, sexually transmitted diseases, one article was found with three diagnoses with 100% for disturbed sleep patterns, infection risk and ineffective protection. As to patients with sequelae, two articles were identified, and the diagnoses found were hindered physical mobility, with 100%; self-care deficit for... (Complete abstract click electronic access below)

Anatomia de folhas, brácteas e escapos de Paepalanthus Sect. Diphyomene Ruhland (Eriocaulaceae, Poales)

As Eriocaulaceae brasileiras encontram-se distribuídas principalmente nos campos rupestres que se estendem de Minas Gerais à Bahia, na Cadeia do Espinhaço. Paepalanthus Mart. é o maior gênero da família e apresenta cerca de 450 espécies, sendo que Paepalanthus sect. Diphyomene Ruhl. possui cerca de 20 espécies que já pertenceram a diversas categorias taxonômicas. Com o objetivo de correlacionar a anatomia e a taxonomia desta seção, além de levantar caracteres diagnósticos para suas espécies, foi estudada a anatomia de folhas, brácteas e escapos. Folhas e brácteas de Paepalanthus sect. Diphyomene apresentam diferenças na forma e no espessamento das células epidérmicas; no espessamento do mesofilo; na disposição dos feixes vasculares; presença ou ausência de hipoderme; diferente forma e composição de parede das células da extensão de bainha do feixe vascular; forma e constituição da margem e presença ou ausência de parênquima aqüífero na face adaxial. No escapo, foram observadas diferenças quanto ao número e contorno de costelas e extensão da medula. Assim, a proposta de divisão de P. sect. Diphyomene em duas categorias é corroborada. São caracteres diagnósticos para as espécies: presença de parênquima aquífero na face adaxial e ausência de extensão de bainha do feixe vascular em folhas de Paepalanthus urbanianus; presença de feixes vasculares distribuídos em ordem decrescente de tamanho em direção à margem em folhas e brácteas e contorno triangular do escapo em P. flaccidus, presença de nove costelas em escapos de P. acanthophyllus e dez em P. macer. Foi elaborada uma chave de identificação das espécies de Paepalanthus sect. Diphyomene com base nas características anatômicas levantadas

Diagnóstico da gestão e do gerenciamento dos resíduos eletroeletrônicos gerados no campus da Faculdade de Engenharia de Guaratinguetá/Unesp

Currently, in Brazil, the quantity and quality of new types of wastes, discarded without criteria in urban areas, has been responsible for considerable impacts on public health and the environment. According to a report prepared by the Institute of Applied Economic Research (IPEA), the country loses about U.S. $ 8 billion annually, due lack of waste recycling, which go directly into landfills or dumps. Among these solid wastes are waste electrical and electronic equipment (WEEE), whose characteristics are complex, by having in its composition substances of high value-added and other health hazards which require different treatment of household waste. Aiming to fill the gap in Brazilian environmental legislation, on 02/08/2010, was sanctioned the National Policy Solid Waste (Law No. 12,305), already regulated on 23/12/2010 (Decree No 7404), whose based on the following principles:reduction of waste generation and toxicity of shared responsibility, proper planning management, social inclusion of waste pickers and sustainable production and consumption. Given the above, this work presented here, aims generally present a diagnosis of the current situation of electronic waste generated in the Faculty of Engineering, Campus Guaratinguetá, FEG / UNESP, to provide data for management and management of these waste, based on sustainability, the economic losses and minimizing environmental impacts and public health related to the flow and the improper disposal of these wastes

Estudo da dose efetiva, razão sinal-ruído e razão contraste-ruído em tomografia computadorizada de múltiplos detetores

Since discovery, computed tomography is a widely used diagnostic modality. However, this modality imparts relatively high doses to the patients and with fast technological advancement, it is necessary optimize the doses used and ensure the quality of the images through a quality assurance program. This work intended to compare Computed Tomography Dose Index (CTDIW) and effective dose with components of image quality: the Contrast-to-Noise Ratio (CNR) and Signal-to-Noise Ratio (SNR), and a quality factor (Q) deduced by the Rose model for two groups of computed tomography units. The first group was composed by equipments with 10 up to 16 slices and the second one presented 40 up to 320 slices detectors, for the protocols of head and abdomen. It was realized a comparison between different selectable parameters in the protocol of a Philips Brilliance 16, too. The results of the first group to CTDIW, effective dose, SNR and CNR showed variations of 28%, 33%, 37% and 32% respectively for head protocol, and 21%, 27%, 43% and 37% respectively for abdomen protocol. The results of the group 2 to CTDIW, effective dose, SNR and CNR showed variations of 15%, 26%, 36% and 34% respectively for the head protocol, and 8%, 13%, 50% and 60% respectively for abdomen protocol. The comparison between both groups demonstrated similar levels of doses impartation to patients though having so many different configurations, if the uncertainties associated with this measurement were considered. The results of the comparison between different parameters in the Philips Brilliance 16 scanner were in agreement with expected

Necrose Asséptica da cabeça do fêmur

Legg-Calvé-Perthes disease is a non-inflammatory aseptic necrosis of the head of the femur that is found in both young animals and humans before the gap in the femur head closes. In the fields of both human and veterinary medicine the cause of this condition is not known for certain. Various factors have been put forward in the literature as being responsible for the incidence of this condition such as: abnormalities in coagulation, changes in blood flow in the arteries, a septic obstruction in the draining of the epiphysis or the upper parts of the femur, trauma, growth cycle, hyperactivity in a child, genetic influences and dietary factors. Case histories in dogs show that the first stages of the condition progress slowly but that limping or putting weight on the limb worsens at 6 to 8 weeks. Some owners talk about a sharp onset in clinical lameness. Other clinical symptoms may include irritability, loss of appetite and knawing at the hair surrounding the affected hip. In the course of physical examination manipulating the hip joint will cause pain to the animal. The advanced stages of the disease may result in restricted amplitude of movement, muscular atrophy and fracturing. In humans the clinical signs are similar, although progression of the disease is slower so that it can be diagnosed at an earlier stage. In veterinary medicine the diagnosis is, in the main, based on case history, clinical symptoms, physical examination and certain related procedures such as radiography. The various diagnoses include physical trauma and dislocation of the medial patella. In human medicine many people have been correctly diagnosed. Whatsmore, there is a range of related procedures that are virtually not available to veterinary medicine such as magnetic nuclear resonance, that show up necroses with great clarity before radiography and cintilography do, and is considered... (Complete abstract click electronic access below)

Controle de Qualidade em Raios X Odontológico Periapical

The purpose of this work is to provide quality control requirements and security in dental x-rays in order to obtain good quality image which allows the correct diagnosis, which reduces the dose to the patient, mainly due to the repetition of tests, and decreasing cost. The requirements apply to related activities to quality control and procedures using ionizing radiation for diagnostic imaging in dentistry by evaluating a minimum set of parameters to be tested or verified. Quality control follows the Ordinance No. 453 of the Ministry of Health of 06.01.1998, SS Resolution No. 625 of 12.14.1994 and Resolution No. 64 of the Health Surveillance Center – Department of Health of Sao Paulo and National Health Surveillance Agency – Ministry of Health of Brazil. This study was conducted in the city of Marilia, Sao Paulo, along with the Company P&R Consulting and Medical Physics, in a dental clinic of the University UNIMAR in the x-ray equipment used on that site. The physical parameters of the device were tested with the aid of ionization chambers to measure rates of radiation, electrometer to measure rates of time, kV and doses, radiographic films and positioning devices. Finally, this work demonstrates the need and importance of quality control, which one ensures the proper use of x-ray machines, maintaining efficiency and at the same time it reduces the risks to the patient, to the dentist and to the general public

Cálculo estrutural de barreiras: Desenvolvimento de um programa computacional de interface online

This study aimed to develop a computer program which systematizes the structural shielding design calculation in diagnostic radiology facilities. For this purpose methodology of the National Council of Radiation Protection and Measurements (NCRP 147[5]) was used. By comparative statistics studies, it was verified if reference parameters values suggested by the US publication correspond to the average national values. The World Wide Web was chosen because of its characteristics as a powerful mean of communication, especially in terms of the wide variety of useful resources and easy access. To compare the reference values of some parameters proposed by NCRP 147 to Brazilian average, studies about the normalized workload per patient, performance of X-ray tube and primary air kerma, unshielded, at one meter from the focal point of the X-ray tube were made. Through this research, relative differences were found. In workload values this differences reached up to 50% in mammography compared to those presented by the NCRP 147; in X-ray tube performance the percentage differences reached 69% in dental radiology, and air kerma results amounted 31% in fluoroscopy. This demonstrates the importance of validation of international protocols to local realities

Métodos diagnóstico de Hiperadrenocorticismo canina

The Hyperadrenocorticism is a disease that occur in dogs between mead to old age, is associated with the higher level of glucocorticoid that result in a corporal reaction. To make a diagnostic of this disease is necessary have a good history and physical examination, the principals complains of the proprietary are polyuria, polydipsia and polyphagia, in some times abdominal enlargement and lethargy. In the physical examination is observed this abdominal enlargement, hepatomegaly, alopecia, in some cases pyoderma and difficult respiratory. From this documents is possible determinate the differential diagnostics and with the tests find the diagnostic of the disease that the animal have. The base methods are hemogram, biochemical, urinalysis, radiographs and ultrasonography it’s possible do tomography and magnetic resonance too. There are confirmation methods too, they are very important, because the others not have documents necessary for the final diagnostic. Those are Urine cortisol to creatinine ratio, dexamethasone suppression test with high dose or low dose and ACTH stimulation test. Despite those tests have high sensibility and specificity, they can result in false positive or false negative, this is one of the causes to do the base methods and together make the veterinary doctor find the solution of the diagnostic and do the adequate treatment

Análise histomorfológica e molecular de lesões granulomatosas sugestivas de tuberculose bovina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Ocorrência de infecção por Leishmania sp. em cães no município de Florianópolis, Santa Catarina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Flora intermediária em mulheres em idade reprodutiva: aspectos inflamatórios, atividade de sialidases e carga bacteriana

Pós-graduação em Patologia - FMB

Pesquisa de genomas virais em primatas não humanos do novo mundo por metagenômica

Pós-graduação em Medicina Veterinária - FMVZ