977 resultados para Private Key


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Tutkimuksella selvitettiin eri tekijöiden merkitystä hammaslääkärien tehdessä uraansa koskevia valintoja lähtien ammatinvalinnasta. Tutkimuksessa verrattiin erilaisissa työpaikoissa toimivien hammaslääkärien sekä hammaslääketieteen opiskelijoiden odotuksia ja kokemuksia. Tutkimus tehtiin kyselynä postitse lähetetyin lomakkein. Kyselyyn osallistui 350 hammaslääkäriä ja 115 opiskelijaa. Kiinnostus lääketieteeseen ja työn konkreettisuus olivat keskeisimmät syyt lähteä hammaslääketiedettä opiskelemaan. Suurin osa sekä hammaslääkäreistä että opiskelijoista valitsisi vähintään todennäköisesti saman ammatin uudelleen, hammaslääkäreistä yksityishammaslääkärit useimmin. 69 % hammaslääkäreistä oli aloittanut työuransa terveyskeskuksessa, opiskelijoista 46 % toivoi työpaikkaa yksityissektorilta ja 37 % terveyskeskuksesta. Hammaslääkärit kokivat työn mielekkyyden, positiivisen kaiun, työn ja elämän reunaehtojen sekä taloudellisen turvallisuuden vaikuttaneen ensimmäiseen työpaikkaan menoon vähemmän kuin opiskelijat arvioivat niiden vaikuttavan. Työssä tärkeänä sekä hammaslääkärit että opiskelijat pitivät hyviä työolosuhteita ja mielekästä työn sisältöä. Toimiva yhteistyö työparin kanssa oli myös erittäin tärkeää. Hammaslääkärit pitivät hyviä työoloja ja autonomiaa tärkeämpinä kuin opiskelijat, joille puolestaan uralla eteneminen ja työajan joustot olivat tärkeämpiä. Hammaslääkärit arvostivat työtä ja työssä suoriutumista sekä hyvää työpaikkaa enemmän kuin opiskelijat. Parhaiten työssään toteutuvana suhteessa asian merkitykseen hammaslääkärit kokivat autonomian ja huonoiten ilmapiirin. Naiset kokivat asioiden toteutumisessa enemmän puutteita kuin miehet. Työpaikkaansa heikosti sitoutuneita oli 8 %, joista valtaosa terveyskeskushammaslääkäreitä. Heikosti sitoutuneet kokivat sitoutuneita huonompina varsinkin työilmapiirin, työolosuhteet ja mahdollisuuden uralla etenemiseen. Hammaslääkärit olivat halukkaampia jatkokoulutukseen kuin kokivat siihen olevanmahdollisuuksia; 25 % oli harkinnut erikoistumista, mutta luopunut ajatuksesta, ja20 % halusi erikoistua, mutta koki siihen käytännön esteitä. Jatkossa tulisi tarkemmin analysoida ja toistettavin tutkimuksin seurata hammaslääkärien urakokemuksia ja valintoja sekä koetun työssä vallitsevan tilanteen ja asioiden merkityksen välistä suhdetta. Myös opiskelijoiden urasuunnitelmia ja arvostuksia tulisi tutkia säännöllisin väliajoin.

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Tutkimuksen tavoite on selvittää mitkä tekijät vaikuttavat asiakkaan luottamuksen kokemukseen palveluntarjoajaa kohtaan ei kasvokkain tarjottavissa terveyspalveluissa. Tutkimusongelman käsittelyssä kiinnitetään erityisesti huomiota luottamuksen rakentumisen dynamiikkaan ja aikaulottuvuuteen sekä yksityisen palveluntarjoajan maineeseen yhtenä luottamuksen kokemusta selittavänä tekijänä. Kirjailisuuskatsauksessa on määritelty paääkäsitteet maine ja luottamus sekä niiden alakasitteita. Lähteinä on käytetty luottamusta käsittelevää kirjallisuutta useilta eri tieteenaloilta. Case tutkimus on suoritettu laadullisin menetelmin kirjallisuuskatsauksessa esitetyn viitekehyksen ja aikaisemman tutkimuksen pohjalta. Primaariaineisto on kerätty fokusryhmäkeskusteluilia. Aineistoa on pyritty anatysoimaan mahdollisimman yksityiskohtaisesti tutkimuskysymyksen kontekstissa. Analyysin pohjalta tehtyjä tulkintoja on verrattu aikaisempaan tutkimukseen. Case tutkimus osoitti, etta positiivisten odotusten ja suomalaista terveydenhuollon järjestelmää kohtaan tunnetun luottamuksen ansiosta suhtautuminen terveydenhuollon palveluntarjoajaa kohtaan on lähtokohtaisesti luottavainen. Luottamuksen rakentumisen ensivaiheessa nopea luottamus perustuu aikaisemmista kokemuksista siirrettyyn luottamukseen ja stereotypioihin. Seuraavassa vaiheessa luottamus henkilöityy hoitajaan. Luottamus syvenee positiivisten kokemusten ja odotusten täyttymyksen myötä koskemaan myös palveluntarjoajaa. Luottamuksen rakentumisen tärkeimmiksi tekijöiksi nousivat yrityksen maine sosiaalisessa mediassa, suosittelijat, yrityksen asema terveydenhuollon järjestelmässä sekä hoitajien kyvykkyys, kompetenssi, empatiakyky ja potilaan ymmärtäminen.

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Background: As a result of the growing number of interventions that are now performed in the context of maternity care, health authorities have begun to examine the possible repercussions for service provision and for maternal and neonatal health. In Spain the Strategy Paper on Normal Childbirth was published in 2008, and since then the authorities in Catalonia have sought to implement its recommendations. This paper reviews the current provision of maternity care in Catalonia. Methods: This was a descriptive study. Hospitals were grouped according to their source of funding (public or private) and were stratified (across four strata) on the basis of the annual number of births recorded within their respective maternity service. Data regarding the distribution of obstetric professionals were taken from an official government survey of hospitals published in 2010. The data on obstetric interventions (caesarean, use of forceps, vacuum or non-specified instruments) performed in 2007, 2010 and 2012 were obtained by consulting discharge records of 44 public and 20 private hospitals, which together provide care in 98% of all births in Catalonia. Proportions and confidence intervals were calculated for each intervention performed in all full-term (3742 weeks) singleton births. Results: Analysis of staff profiles according to the stratification of hospitals showed that almost all the hospitals had more obstetricians than midwives among their maternity care staff. Public hospitals performed fewer caesareans [range between 19.20% (CI 18.84-19.55) and 28.14% (CI 27.73-28.54)] than did private hospitals [range between 32.21% (CI 31.78-32.63) and 39.43% (CI 38.98-39.87)]. The use of forceps has decreased in public hospitals. The use of a vacuum extractor has increased and is more common in private hospitals. Conclusions: Caesarean section is the most common obstetric intervention performed during full-term singleton births in Catalonia. The observed trend is stable in the group of public hospitals, but shows signs of a rise among private institutions. The number of caesareans performed in accredited public hospitals covers a limited range with a stable trend. Among public hospitals the highest rate of caesareans is found in non-accredited hospitals with a lower annual number of births.

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Background: As a result of the growing number of interventions that are now performed in the context of maternity care, health authorities have begun to examine the possible repercussions for service provision and for maternal and neonatal health. In Spain the Strategy Paper on Normal Childbirth was published in 2008, and since then the authorities in Catalonia have sought to implement its recommendations. This paper reviews the current provision of maternity care in Catalonia. Methods: This was a descriptive study. Hospitals were grouped according to their source of funding (public or private) and were stratified (across four strata) on the basis of the annual number of births recorded within their respective maternity service. Data regarding the distribution of obstetric professionals were taken from an official government survey of hospitals published in 2010. The data on obstetric interventions (caesarean, use of forceps, vacuum or non-specified instruments) performed in 2007, 2010 and 2012 were obtained by consulting discharge records of 44 public and 20 private hospitals, which together provide care in 98% of all births in Catalonia. Proportions and confidence intervals were calculated for each intervention performed in all full-term (3742 weeks) singleton births. Results: Analysis of staff profiles according to the stratification of hospitals showed that almost all the hospitals had more obstetricians than midwives among their maternity care staff. Public hospitals performed fewer caesareans [range between 19.20% (CI 18.84-19.55) and 28.14% (CI 27.73-28.54)] than did private hospitals [range between 32.21% (CI 31.78-32.63) and 39.43% (CI 38.98-39.87)]. The use of forceps has decreased in public hospitals. The use of a vacuum extractor has increased and is more common in private hospitals. Conclusions: Caesarean section is the most common obstetric intervention performed during full-term singleton births in Catalonia. The observed trend is stable in the group of public hospitals, but shows signs of a rise among private institutions. The number of caesareans performed in accredited public hospitals covers a limited range with a stable trend. Among public hospitals the highest rate of caesareans is found in non-accredited hospitals with a lower annual number of births.

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We hypothesized that the analysis of mRNA level and activity of key enzymes in amino acid and carbohydrate metabolism in a feeding/fasting/refeeding setting could improve our understanding of how a carnivorous fish, like the European seabass (Dicentrarchus labrax), responds to changes in dietary intake at the hepatic level. To this end cDNA fragments encoding genes for cytosolic and mitochondrial alanine aminotransferase (cALT; mALT), pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) were cloned and sequenced. Measurement of mRNA levels through quantitative real-time PCR performed in livers of fasted seabass revealed a significant increase in cALT (8.5-fold induction)while promoting a drastic 45-fold down-regulation of PK in relation to the levels found in fed seabass. These observations were corroborated by enzyme activity meaning that during food deprivation an increase in the capacity of pyruvate generation happened via alanine to offset the reduction in pyruvate derived via glycolysis. After a 3-day refeeding period cALT returned to control levels while PK was not able to rebound. No alterations were detected in the expression levels of G6PDH while 6PGDH was revealed to be more sensitive specially to fasting, as confirmed by a significant 5.7-fold decrease in mRNA levels with no recovery after refeeding. Our results indicate that in early stages of refeeding, the liver prioritized the restoration of systemic normoglycemia and replenishment of hepatic glycogen. In a later stage, once regular feeding is re-established, dietary fuel may then be channeled to glycolysis and de novo lipogenesis.

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We hypothesized that the analysis of mRNA level and activity of key enzymes in amino acid and carbohydrate metabolism in a feeding/fasting/refeeding setting could improve our understanding of how a carnivorous fish, like the European seabass (Dicentrarchus labrax), responds to changes in dietary intake at the hepatic level. To this end cDNA fragments encoding genes for cytosolic and mitochondrial alanine aminotransferase (cALT; mALT), pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) were cloned and sequenced. Measurement of mRNA levels through quantitative real-time PCR performed in livers of fasted seabass revealed a significant increase in cALT (8.5-fold induction)while promoting a drastic 45-fold down-regulation of PK in relation to the levels found in fed seabass. These observations were corroborated by enzyme activity meaning that during food deprivation an increase in the capacity of pyruvate generation happened via alanine to offset the reduction in pyruvate derived via glycolysis. After a 3-day refeeding period cALT returned to control levels while PK was not able to rebound. No alterations were detected in the expression levels of G6PDH while 6PGDH was revealed to be more sensitive specially to fasting, as confirmed by a significant 5.7-fold decrease in mRNA levels with no recovery after refeeding. Our results indicate that in early stages of refeeding, the liver prioritized the restoration of systemic normoglycemia and replenishment of hepatic glycogen. In a later stage, once regular feeding is re-established, dietary fuel may then be channeled to glycolysis and de novo lipogenesis.

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Aim of the Thesis is to study and understand the theoretical concept of Metanational corporation and understand how the Web 2.0 technologies can be used to support the theory. Empiric part of the study compares the theory to the case company’s current situation Goal of theoretical framework is to show how the Web 2.0 technologies can be used in the three levels of the Metanational corporation. In order to do this, knowledge management and more accurately knowledge transferring is studied to understand what is needed from the Web 2.0 technologies in the different functions and operations of the Metanational corporation. Final synthesis of the theoretical framework is to present a model where the Web 2.0 technologies are placed on the levels of the Metanational corporation. Empirical part of the study is based on interviews made in the case company. Aim of the interviews is to understand the current state of the company related to the theoretical framework. Based on the interviews, the differences between the theoretical concept and the case company are presented and studied. Finally the study presents the found problem areas, and where the adoption of the Web 2.0 tools is seen as beneficiary, based on the interviews and theoretical framework.

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Climate innovations, that cover both technological applications and process and service innovations, play a key role in climate change mitigation. The purpose of this study was to examine how the Finnish innovation system could be enhanced with governmental measures so that the diffusion of climate innovations could be speeded up. During the study, it became evident that the governmental measures need to support the whole innovation chain, which comprises of research, development, demonstration and deployment. Only this can lead to the successful birth and diffusion of low carbon innovations. The study found that the strengths of the Finnish innovation system are research and development, and the current national innovation policies strongly support these activities. However, these have been emphasised at the expense of the demonstration and deployment. Consequently, the biggest bottlenecks in the Finnish innovation landscape are the lack of pilot and demonstration projects and slow commercialisation, thus the high price of the innovation. To meet with the challenge, the government should firstly promote strict greenhouse gas emission reduction targets. This would boost up the innovation activities, which would also lower the prices of the innovations. To speed up the commercialisation process, measures that stimulate the domestic market, such as feed-in-tariffs and public procurements, are needed. Special attention should also be paid to the measures that could shift the traditional closed innovation chain towards open innovation. This means that the product development should involve experts from several fields such as the user and marketing experts to speed up the commercialisation. In addition, efficient innovation co-operation between both private and public sector is essential. Finally, as the domestic resources are not adequate for producing all the innovations needed, the domestic innovation activities should be focused on a few sectors, and at the same time promote efficient import policies.

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The physical education curriculum stresses the importance of improving students’ key motor skills. This idea agrees with the contributions of research into motor development concerning the important role these skills play in child development. In order to facilitate this improvement is essential to know the different basic aspects of how these key motor skills evolve as well as the essential factors related to the characteristics and conditions of educational practice

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In an article recently published in Química Nova, entitled "Chemistry Without Borders" ("Química Sem Fronteiras") [Pinto, A. C.; Zucco, C.; Galembeck, F.; Andrade, J. B.; Vieira, P. C. Quim. Nova 2012, 35, 2092], the authors highlighted the important aspects of science and technology with special emphasis on the field of Chemistry and its contributions toward a more prosperous Brazil of future. As a second step in that direction, this article extends the discussion of a key issue for the country in the framework of the chemistry community through the so called position papers in strategic areas. This document is a part of the contribution of the Brazilian Chemical Society to the World Science Forum to be held in Rio de Janeiro in November 2013. In this context, the present paper provides a brief discussion on neglected tropical diseases (NTDs) with emphasis on the current challenges and opportunities towards the development and evolution of the field. NTDs leads to illness, long-term disability or death, and has severe social, economic and psychological consequences for millions of men, women, and children worldwide. In most cases, the available treatments are inadequate and extremely limited in terms of efficacy and safety, leading to an urgent demand for new drugs. In addition to the traditional challenges involved in any drug discovery process, it is widely recognized that there is an innovation gap and a lack of investment for research and development (R&D) in the area of NTDs. In the last few decades, methods toward combating, eradication, prevention, and treatment of NTDs have been repeatedly emphasized in the major international agendas. Developments in these strategies and alliances have continued to have an essential impact, particularly in the area of drug discovery, both in Brazil and globally and should be encouraged and supported. Several examples of international activities dedicated to the reduction of the devastating global impact of NTDs can be provided. Despite the beneficial developments in the past 30 years, NTDs continue to devastate poor communities in remote and vulnerable areas, in large part, due to market failures and public policies. Recent studies have shown that among 756 new drugs approved between 2000 and 2011, only four new chemical entities (NCEs) were identified for the treatment of malaria, while none were developed against NTDs or tuberculosis. Furthermore, only 1.4% of approximately 150,000 clinical trials were registered for neglected diseases, with a smaller number of trials for NCEs. Establishment and strengthening of global strategies involving the triad "government-academia-industry" is fundamental to the success in R&D of new drugs for NTDs. National and international public-private initiatives that aim to create, encourage, and invest in R&D projects have been implemented and therefore are of utmost importance to successfully integrate Brazil into this new paradigm. It is essential to lay the foundation for mechanisms that will intensify investments in infrastructure, training, and qualification of personnel with an ultimate strategic vision that foresees continuity. Our research group has made significant contributions to the development of this field with the goal of forging new frontiers while tackling both current and future challenges that include indispensable elements such as innovation and integration.

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Appearance of trust in regional, co-operative networks In our times, the value of social networks has been widely acknowledged. One can say that it is important for private persons to get networked, whilst it is even a must for companies and organizations in business life. This doctor's thesis examines three co-operative regional networks. Networks are located in Western Uusimaa (Länsi-Uusimaa) region in southernmost Finland, and they had both public organizations and private companies as participants (later called ‘players’). Initially, all of them were co-financed from public funds, and two of them are still operational while writing this. The main target of these networks has been to act as learning networks. The learning network stands for an ensemble of research and development units and workplaces constituting a common forum for learning. The main focus in this study has been on qualitative and structural characteristics of the networks, and how they are relating with intrinsic trust. In addition to the development of trust, it has been studied, at what level organizational learning within the networks takes place, and lastly, what kind of factors facilitate the development of social capital. The theoretical framework for the study is built on analysing trust and social capital. It is a 'mission impossible' to find single definitions for such major concepts. In this study, from the research questions' point of view it has been more relevant to concentrate on the aspects of networking and the relationships between the participating organizations. The total view in this study is very network-centric, and therefore those theories which have similar point of view have been prioritized. Such is the theory about structural holes by Ronald S. Burt (1992). It has been widely applied; especially his views on constraints affecting players in networks. The purpose of this study has not been to create new theories or to analyse and compare thoroughly the existing theoretical trends. Instead, the existing theories have provided the study with conceptual tools, which have been utilized for supporting the empirical results. The aim has been to create an explanatory case study consisting relevant discussion on the relationship between the network characteristics and the appearance of trust. The conceptual categorization for confidence vs. trust created by Niklas Luhmann (1979) is another important theoretical building block. In most cases, co-operation in networks is initiated by people already trusting in each other and willing to work together. However, personal trust is not sufficient in the long run to sustain the co-operation within the network: more abstract systemic trust described by Luhmann must also emerge. In the networks with different structures and at different development phases, these forms of trust appear at different levels. In this study, Luhmann’s systemic trust as a term has been replaced by the concept of 'trust in network as a system'. Structural characteristics of a network (density, centrality, structural holes etc.) have been selected to explain the creation of social capital and trust. The ability to adapt new information is essential for the development of social capital. Qualitative analysis for development phase has been used, and the Learning Network Maturity Test by Leenamaija Otala (2000) and her work have been applied. Thus, the qualitative characteristics and the structural characteristics of the networks are utilized together, when the creation of social capital and appearance of trust are assessed. Social Network Analysis, questionnaires and interviews have been the research methods. Quantitative and qualitative data have been combined. There is a similarity in viewpoints to research data with Extensive Case Study method, in which different cases are searched by exploring various cases and comparing certain common features between them and generic models. Development of trust, social capital and organizational learning has been explained in the study by comparing the networks in hand. Being a case study, it doesn't have targets to provide with general results and findings like conventional surveys. However, in this work phenomena and mechanisms related to them are interpreted from the empirical data. Key finding of this study is that the networks with high structural equality and clear target setting enable building trust to the network as a system. When systemic trust is present, e.g. changes in personnel involved in the co-operation won't hinder the network from remaining operational. On the other hand, if the players are not well motivated to co-operate, if the network is extremely centralized structurally, or if the network has players holding very much more beneficial position compared to the others, systemic trust won't develop: trust tends to remain at the personal level, and is directed to some players only. Such networks won't generate results and benefits to its players, and most probably they won’t live very long. In other words, learning networks cannot solely be based on willingness to learn, but also on willingness to co-operate.

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Tämän työn tarkoituksena on hahmottaa pk-yrityksien työllistämismahdollisuuksia teollisuuden rakennemuutoksen karsiessa suurteollisuuden työpaikkoja. Tutkimuksessa selvitetään työllistämistä estäviä ja vaikeuttavia tekijöitä pk-yrityksissä sekä pyritään löytämään niihin liittyviä kehittämisehdotuksia. Tutkimus on kirjallisuuspohjainen katsaus, johon liittyy haastattelututkimus, jossa kohderyhmänä ovat julkisen sektorin edustajat ja toisena osapuolena yksityisen sektorin yrittäjät. Tutkimuksen työn pääongelmana on kartoittaa työllistämisesteitä pk-yrityksissä ja etsiä kehittämistoimenpiteitä, joilla työllistämismahdollisuuksien edistämiseksi. Lisäksi etsitään keinoja edistää yrittäjyyttä erityisesti työllisyyden näkökulmasta. Yrittäjyys ja pk-yritykset ovat voimavara, jonka kasvu- ja kehitysongelmia pienentämällä voidaan merkittävästi vaikuttaa uusien työpaikkojen syntymiseen. Työn alaongelmia ovat: irtisanomissuoja, keskitetty työmarkkinajärjestelmä ja ay-liike, työaikamääräykset, työvoimakustannukset ja paikallisen sopimisen puutteellisuus. Muita työllistämisen ongelmia ovat mm. ammattitaitoisen työvoiman saanti, työttömyysturva ja ensimmäisen työntekijän palkkaaminen. Työn lopputuloksina esitetään mm. irtisanomissuojan heikentämistä, ay-liikkeen saamista mukaan paikalliseen sopimiseen ja joustoihin, työaikamääräysten joustoja, työvoimakustannuksista verotuksen kannustavammaksi rakentamista ja sova-maksujen porrastamista pk-yrityksille oikealla tavalla ja paikallisen sopimisen vahvistamista. Lisäksi työttömyys-turvaa tulee muuttaa kannustavammaksi, ammattitaitoisen työvoiman saantia edistää ja ensimmäisen työntekijän palkkaamista on tuettava.

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Tämän työn tarkoituksena on hahmottaa pk-yrityksien työllistämismahdollisuuksia teollisuuden rakennemuutoksen karsiessa suurteollisuuden työpaikkoja. Tutkimuksessa selvitetään työllistämistä estäviä ja vaikeuttavia tekijöitä pk-yrityksissä sekä pyritään löytämään niihin liittyviä kehittämisehdotuksia. Tutkimus on kirjallisuuspohjainen katsaus, johon liittyy haastattelututkimus, jossa kohderyhmänä ovat julkisen sektorin edustajat ja toisena osapuolena yksityisen sektorin yrittäjät. Tutkimuksen työn pääongelmana on kartoittaa työllistämisesteitä pk-yrityksissä ja etsiä kehittämistoimenpiteitä, joilla työllistämismahdollisuuksien edistämiseksi. Lisäksi etsitään keinoja edistää yrittäjyyttä erityisesti työllisyyden näkökulmasta. Yrittäjyys ja pk-yritykset ovat voimavara, jonka kasvu- ja kehitysongelmia pienentämällä voidaan merkittävästi vaikuttaa uusien työpaikkojen syntymiseen. Työn alaongelmia ovat: irtisanomissuoja, keskitetty työmarkkinajärjestelmä ja ay-liike, työaikamääräykset, työvoimakustannukset ja paikallisen sopimisen puutteellisuus. Muita työllistämisen ongelmia ovat mm. ammattitaitoisen työvoiman saanti, työttömyysturva ja ensimmäisen työntekijän palkkaaminen. Työn lopputuloksina esitetään mm. irtisanomissuojan heikentämistä, ay-liikkeen saamista mukaan paikalliseen sopimiseen ja joustoihin, työaikamääräysten joustoja, työvoimakustannuksista verotuksen kannustavammaksi rakentamista ja sova-maksujen porrastamista pk-yrityksille oikealla tavalla ja paikallisen sopimisen vahvistamista. Lisäksi työttömyysturvaa tulee muuttaa kannustavammaksi, ammattitaitoisen työvoiman saantia edistää ja ensimmäisen työntekijän palkkaamista on tuettava.