EuroPineDB: a high-coverage web database for maritime pine transcriptome

Pinus pinaster is an economically and ecologically important species that is becoming a woody gymnosperm model. Its enormous genome size makes whole-genome sequencing approaches are hard to apply. Therefore, the expressed portion of the genome has to be characterised and the results and annotations have to be stored in dedicated databases.

Gromov hyperbolicity of periodic planar graphs

The study of hyperbolic graphs is an interesting topic since the hyperbolicity of a geodesic metric space is equivalent to the hyperbolicity of a graph related to it. The main result in this paper is a very simple characterization of the hyperbolicity of a large class of periodic planar graphs.

Asymptotic values of quasiregular maps

Suslin analytic sets characterize the sets of asymptotic values of entire holomorphic functions. By a theorem of Ahlfors, the set of asymptotic values is finite for a function with finite order of growth. Quasiregular maps are a natural generalization of holomorphic functions to dimensions n ≥ 3 and, in fact, many of the properties of holomorphic functions have counterparts for quasiregular maps. It is shown that analytic sets also characterize the sets of asymptotic values of quasiregular maps in Rn, even for those with finite order of growth. Our construction is based on Drasin's quasiregular sine function

Quasi-isometries and isoperimetric inequalities

We consider the stability of isoperimetric inequalities under quasi-isometries between Riemann surfaces. Kanai observed that quasi-isometries preserve isoperimetric inequalities on complete Riemannian manifolds with finite geometry: positive injectivity radius and Ricci curvature bounded from below (see [2]). In [1], it is shown that the linear isoperimetric inequality is a quasi-isometric invariant for planar Riemann surfaces (genus zero surfaces) with vanishing injectivity radius. Moreover, it is proved that non-linear isoperimetric inequalities can only hold for Riemann surfaces with positive injectivity radius, and hence, by Kanai's observation, preserved by quasi-isometries. In this talk we present an overview on isoperimetric inequalities and give some of the ideas of the proofs of the results cited above.

Youth participation in development planning: case study of Sayausí (Rural Parish) Cuenca-Ecuador

Young people now represent the highest percentage of the world population. Soon, they will be seniors and they will take decisions for a more orderly and equitable world. For this reason, the participation of young people in development planning is very important and many countries are trying to promote it through various measures. This article analyzes the trajectory of youth participation in the Latin American region and specifically the profile of youth participation in Ecuador, country in which the Constitution recognizes the strategic role of youth in development. The case study of Sayausí rural parish in canton Cuenca is analyzed, through surveys, interviews and an Empowerment Evaluation workshop to young people and decentralized government. The results obtained allow to propose strategies to help improve the participation of youth in the community.

Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm).

Mutations in 12 genes regulating Drosophila melanogaster mushroom body (MB) development were each studied in two genetic backgrounds. In all cases, brain structure was qualitatively or quantitatively different after replacement of the "original" genetic background with that of the Canton Special wild-type strain. The mushroom body miniature gene (mbm) was investigated in detail. mbm supports the maintenance of MB Kenyon cell fibers in third instar larvae and their regrowth during metamorphosis. Adult mbm1 mutant females are lacking many or most Kenyon cell fibers and are impaired in MB-mediated associative odor learning. We show here that structural defects in mbm1 are apparent only in combination with an X-linked, dosage-dependent modifier (or modifiers). In the Canton Special genetic background, the mbm1 anatomical phenotype is suppressed, and MBs develop to a normal size. However, the olfactory learning phenotype is not fully restored, suggesting that submicroscopic defects persist in the MBs. Mutant mbm1 flies with full-sized MBs have normal retention but show a specific acquisition deficit that cannot be attributed to reductions in odor avoidance, shock reactivity, or locomotor behavior. We propose that polymorphic gene interactions (in addition to ontogenetic factors) determine MB size and, concomitantly, the ability to recognize and learn odors.

Acute Synaptic Activity Causes Differential miRNA Expression in The Drosophila melanogaster Larval Central Nervous System

The primary goal of this thesis was to determine if spaced synaptic stimulation induced the differential expression of microRNAs (miRNAs) in the Drosophila melanogaster central nervous system (CNS). Prior to attaining this goal, we needed to identify and validate a spaced stimulation paradigm that could induce the formation of new synaptic growth at a model synapse, the larval neuromuscular junction (NMJ). Both Channelrhodopsin- and high potassium-based stimulation paradigms adapted from (Ataman, et al. 2008) were tested. Once validation of these paradigms was complete, we sought to characterize the miRNA expression profile of the larval CNS by miRNA array. Following attainment of these data, we used quantitative real-time PCR (RT-qPCR) to determine if acute synaptic stimulation caused the differential expression of neuronal miRNAs. We found that upon high potassium spaced training in a wild type (Canton S) genotype, 5 miRNAs showed significant differential expression when normalized to a validated reference gene, the U1 snRNA. Moreover, absolute quantification of our RT-qPCR study implicated one miRNA: miR-958 as being significantly regulated by activity. Investigation into potential targets for miR-958 revealed it to be a potential regular of Dlar, a protein tyrosine phosphatase implicated in synapse development. This investigation provides the foundation to directly test our underlying hypothesis that, following spaced training, differential expression of miRNAs alters the translation of proteins required to induce and maintain these structural changes at the synapse.

Vida Triste y Buen Vivir según personas adultas mayores en Otavalo, Ecuador

El presente trabajo se basa en el diagnóstico inicial previo de un proyecto de cooperación con una entidad social del Cantón de Otavalo (Ecuador), para incluir la actividad física y el juego en su programa de atención integral de Personas Adultas Mayores (PAM) en situación de indigencia. Para conocer el contexto de la población del servicio, sus experiencias previas y sus expectativas, se realizó una investigación basada en sus historias de vida. A su vez, se analizaron las políticas públicas del Buen Vivir y las políticas específicas para personas adultas mayores, analizando la legislación vigente y efectuando entrevistas en profundidad a informantes clave. Con enfoque interdisciplinar, se exponen reflexiones sobre elementos constitutivos de la Vida Triste y Buen Vivir, se destaca la importancia de la intervención integral en la promoción del Buen Vivir de PAM a partir de su pasado, sus puntos de vista y recursos de apoyo del territorio.

Student notebook of Samuel Dunbar, 1721-1722

This leather-bound volume contains substantial transcriptions copied by Samuel Dunbar from textbooks while he was a student at Harvard in 1721 and 1722. There is a general index to texts at the end of the volume. Dunbar's notebook provides a window into the state of higher education in the eighteenth century and offers a firsthand account of academic life at Harvard College. Notably, he often indicated the number of days spent copying texts into his book.

Student notes of Elijah Dunbar, 1792-1793

Three unlined pages with notes written by Harvard undergraduate Elijah Dunbar. The documents consist of two pages of chemistry notes compiled in September 1792 when Dunbar was a junior and an undated, untitled list of theological themes. The chemistry notes include a summary of the discipline and a set of laws regarding the "affinity of composition." The verso of the second page was later annotated: "Borrow- He that discerneth Youth & Beau[ty] Elij. Dunar 2'd 1793. Rec'd David Tappan, Professor of Divinity in the University--Elijah Dunbar, jun." followed by a list of students identified as "Alchemists" in the "Ridiculous Society": Joseph Perkins, Isaac Braman, William Biglow, and Elijah Dunbar. The second document is an untitled list of 27 theological themes beginning "1. Doctrine of the Trinity," and ending "27. Family worship," and may refer to sermon or lecture topics.

Pearl River Estuary Region : North, Guangdong Sheng, China, 1749 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'entrée de la riviere de Canton : dressée sur les observations les plus récentes, par N.B., Ingr. ordre. de la Marine ; J.V. Schley direx. It was published by Pierre de Hondt in 1749. Scale [ca. 1:475,000]. Covers the Zhujiang Kou region, Guangdong Sheng, China. Map in French and Dutch.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Asia North Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, selected buildings and fortification, shoreline features, and more. Relief shown pictorially.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Pearl River Estuary Region : South, Guangdong Sheng, China, 1749 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte des isles qui sont a l'embouchure de la riviere de Canton : dressée sur les observations des navigateurs, par N.B., Ingr. ordre. de la Marine ; J.V. Schley, direx. It was published by Pierre de Hondt in 1749. Scale [ca. 1:500,000]. Covers the Zhujiang Kou region, Guangdong Sheng, China. Map in French and Dutch. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Asia North Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, selected buildings and fortification, shoreline features, and more. Relief shown pictorially.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Norfolk County, Massachusetts, 1858 (Image 1 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the county of Norfolk, Massachusetts, based upon the details of the trigonometrical survey of the state; the details from actual surveys under the direction of Henry F. Walling. Supt. of the state map. It was published by Smith & Bumstead in 1858. Scale [ca. 1:40,000]. This layer is image 1 of 4 total images, representing the northwest portion of the four sheet source map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Norfolk County, Massachusetts, 1858 (Image 4 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the county of Norfolk, Massachusetts, based upon the details of the trigonometrical survey of the state; the details from actual surveys under the direction of Henry F. Walling. Supt. of the state map. It was published by Smith & Bumstead in 1858. Scale [ca. 1:40,000]. This layer is image 4 of 4 total images, representing the northeast portion of the four sheet source map.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.