The influence of genetic and environmental factors among MDMA users in cognitive performance

This study is aimed to clarify the association between MDMA cumulative use and cognitive dysfunction, and the potential role of candidate genetic polymorphisms in explaining individual differences in the cognitive effects of MDMA. Gene polymorphisms related to reduced serotonin function, poor competency of executive control and memory consolidation systems, and high enzymatic activity linked to bioactivation of MDMA to neurotoxic metabolites may contribute to explain variations in the cognitive impact of MDMA across regular users of this drug. Sixty ecstasy polydrug users, 110 cannabis users and 93 non-drug users were assessed using cognitive measures of Verbal Memory (California Verbal Learning Test, CVLT), Visual Memory (Rey-Osterrieth Complex Figure Test, ROCFT), Semantic Fluency, and Perceptual Attention (Symbol Digit Modalities Test, SDMT). Participants were also genotyped for polymorphisms within the 5HTT, 5HTR2A, COMT, CYP2D6, BDNF, and GRIN2B genes using polymerase chain reaction and TaqMan polymerase assays. Lifetime cumulative MDMA use was significantly associated with poorer performance on visuospatial memory and perceptual attention. Heavy MDMA users (>100 tablets lifetime use) interacted with candidate gene polymorphisms in explaining individual differences in cognitive performance between MDMA users and controls. MDMA users carrying COMT val/val and SERT s/s had poorer performance than paired controls on visuospatial attention and memory, and MDMA users with CYP2D6 ultra-rapid metabolizers performed worse than controls on semantic fluency. Both MDMA lifetime use and gene-related individual differences influence cognitive dysfunction in ecstasy users.

Fiscal Regime Shifts in Portugal

We estimate changes in fiscal policy regimes in Portugal with a Markov Switching regression of fiscal policy rules for the period 1978-2007, using a new dataset of fiscal quarterly series. We find evidence of a deficit bias, while repeated reversals of taxes making the budget procyclical. Economic booms have typically been used to relax tax pressure, especially during elections. One-off measures have been preferred over structural ones to contain the deficit during economic crises. The EU fiscal rules prompted temporary consolidation, but did not permanently change the budgeting process.

Similar problems, different solutions: Comparing refuse collection in the Netherlands and Spain

Local public service provision can vary greatly because of differences in institutional arrangements, public service markets, and national traditions regarding government intervention. In this paper we compare the procedures adopted by the local governments of the Netherlands and Spain in arranging for the provision of solid waste collection. We find that Spain faces a consolidation problem, opting more frequently to implement policies of privatization and cooperation, at the expense of competition. By contrast, the Netherlands has, on average, larger municipalities, resorting somewhat less to privatization and cooperation, and more to competition. The two options - cooperation and competition - have their merits when striving to strike a balance between transaction costs and scale economies. The choices made in organizational reform seem to be related to several factors, among which the nature of the political system and the size of municipalities appear to be relevant.

Lifestyles positius i reserva cognitiva : Implicacions cognitives, clíniques i biològiques

La reserva cognitiva és un concepte hipotètic actual que sembla presentar la clau per a fer front al repte de les malalties neurodegeneratives. Aquesta es defineix com aquelles capacitats funcionals del cervell que ajuden a la persona a tolerar un major dany cerebral sense presentar manifestació clínica al respecte. La estreta relació del concepte amb els hàbits positius de les persones (lifestyles) la converteix en una variable independent per a la intervenció, prevenció i promoció de la salut. Els canvis morfològics del cervell i la consolidació de circuits neuronals més robustos i eficients semblen explicar els mecanismes de funcionament de la reserva cognitiva. Aquesta revisió defineix el concepte de reserva cognitiva i els models que l'expliquen, troba formes de mesurar-la i representar-la, i evidencia la seva relació amb els lifestyles positius mitjançant estudis epidemiològics i de neuroimatge, per tal de comprendre millor el concepte i enfocar-lo en una línia futura d'investigació.

Identidad territorial y promoción turística: la organización de eventos como estrategia de creación, consolidación y difusión de la imagen de marca del territorio

Gertakizun baten antolaketa paradigmatikoa da in situ bizi izandako lurraldeirudien eraikuntza-prozesuan. Parte-hartzaileen imaginario kolektiboan finkatzeko helburuaz antolatutako gertakizunak direla eta, fabrikatutako lurralde-irudiek – turistikoak zein bestelakoak– sustapen turistikorako alternatiba bitxia planteatzen dute, gertakizunaren kudeaketa-estrategian bertan dagoena. Izan ere, gertakizunak, berez, lurraldearen sustapenerako estrategia garrantzitsua adierazten du; are gehiago, irudien katalizatzaile ere bihur daiteke, eta bere osotasunean hiri-marka bat finkatzeko gai diren imaginarioak sor ditzake. Artikulu honetan, identitate-posizionamenduari eta lurralde-sustapenari dagokienean, gertakizun baten antolaketak eskeintzen dituen aukerak ezagutarazten dira.

Fiscal sustainability across government tiers: an assessment of soft budget constraints

This paper analyses how fiscal adjustment comes about when both central and sub-national governments are involved in consolidation. We test sustainability of public debt with a fiscal rule for both the federal and regional government. Results for the German Länder show that lower tier governments bear a relatively smaller part of the burden of debt consolidation, if they consolidate at all. Most of the fiscal adjustment occurs via central government debt. In contrast, both the US federal and state levels contribute to consolidation of public finances.

Fases estacionárias monolíticas para separações cromatográficas

Monolithic stationary phases represent a new generation of chromatographic separation media. These phases consist of a continuous separation bed prepared by in situ polymerization or consolidation inside the column tubing. In recent years, their simple preparation procedure, unique properties and excellent performance have attracted quite remarkable attention in liquid chromatography and capillary electrochromatography. This review summarizes the preparation, characterization and applications of monolithic stationary phases. The analytical potential of these columns is demonstrated with separations involving various families of compounds in different separation modes.

Façamos Químicos: a "certidão de nascimento" dos cursos de química de nível superior no Brasil

This work presents a brief retrospective of José de Freitas Machado's prominent role in the creation, development and consolidation of Chemistry undergraduate courses in Brazil. Freitas Machado defended in many occasions the importance of chemical studies for the economic development of this country. We analyze, here, his important paper "Façamos Químicos" [Let's Make Chemists] (1917), seminal for the implantation of Industrial Chemistry undergraduate courses in Brazil.

Obtenção de titânio metálico com porosidade controlada por metalurgia do pó

Titanium is an attractive material for structural and biomedical applications because of its excellent corrosion resistance, biocompatibility and high strength-to-weight ratio. The high reactivity of titanium in the liquid phase makes it difficult to produce it by fusion. Powder metallurgy has been shown to be an adequate technique to obtain titanium samples at low temperatures and solid-phase consolidation. The production of compacts with different porosities obtained by uniaxial pressing and vacuum sintering is briefly reviewed. Powder particle size control has been shown to be very important for porosity control. Sample characterization was made using scanning electron microscopy (SEM) images.

Química de (nano)materiais

An overview of different aspects related to Materials and Nanomaterials Chemistry is presented and discussed. The insertion of this field in Brazil is evaluated on the basis of the communications presented on the 30th Annual Meeting of the Brazilian Chemical Society (SBQ). The importance of the Materials Chemistry Division of SBQ for the growth and consolidation of Materials Chemistry in Brazil is also discussed.

Estudio sobre la construcción autorregulada del portafolio en el grado de Enfermería

Introduction. This study presents the results of the implementation process of portfolio in the course of four consecutive years. The plan includes three phases (initiation, development and consolidation). The sample is 480 students studying the first year of nursing at the University of Girona. The objective is to evaluate the effectiveness of the instrument and achieve its construction in a self-regulated process. Subjects and methods. The proposed methodology is based on the sequential triangulation between methods. The study of the same empirical unit it’s used two investigation strategies, quantitative and qualitative. Study 1: quantitative, descriptive, longitudinal and prospective. The statistical analysis of paired data for continuous variables that follow a normaldistribution is made with t Student-Fisher test. The correlation between two numerical variables is used the Pearson correlation index. Study 2: qualitative, uses the discussion groups and topics. For textual data analysis is used Atlas.ti. Results. The final score for students who prepare the portfolio is higher (7.78) than the score who do not prepare (7) (p ≤ 0.001). A significant correlation exists between the portfolio score and final score (p ≤ 0.001). The trend study showsa greater sensitivity of the instrument assessment. Conclusion. The final design of the portfolio is characterized by mixed, flexible and encourages the student reflection and empowers the reflection on the continuum of learning

Fitoprodutos e desenvolvimento econômico

Natural products have been, historically, very important for Brazil. Coffee, sugar and soy were some examples that prove this economical significance. A project that involves phytoproducts should be guide by three main axis: agriculture management for the plants; pharmaceutical; support the national industry and academy. In Brazil, pharmaceutical products contribute negatively to the commerce balance showing an enormous technological dependence in this economical sector. The consolidation of the phytoproduct's chain in Brazil could contribute for the development of the pharmaceutical sector in order to help all domains in natural products area.

Hans Viertler: professor, cientista, gestor e amigo

Hans Viertler, a visionary, an example of institutional commitment, a great scientist, excellent and dedicated teacher, highly respected as a professional and admired for his leadership, wisdom, generosity, good humor, professional capacity, and balance. A life dedicated to the consolidation of Chemistry in Brazil, the teaching chemistry, the IQ-USP, the Brazilian Chemical Society (SBQ) and the CRQ-fourth region. Hans, a friend with a heart bigger than himself!

Unitizing in Supply Chain – Case SECU Container

The aim of this thesis is to analyze how increasing the level of unitizing affects to the costs in the transport system of a Finnish paper and board company. The parts of the supply chain where costs are analyzed are limited to domestic inland transport and port operations. Supply Chain management is important aspect of modern day companies’ strategies. Intermodal transport and different transport systems are the key items which are studied in the theory part of this thesis. In the case study the payload simulations for SECU container (Stora Enso Cargo Unit) stuffed in mills sites are base of the cost analyze of this thesis. Thesis also makes a glance for the restrictions and development trends in Finnish railroads. In analyze SECU containers are moved up to the mill site for stuffing. This increases the level of unitizing in supply chain. Analyze is made for three variation of current traffic lines. Analyze shows that when idea of intermodalism is well used there is considerable cost savings to gather in pre-transportation and port operations. But also effects to mill sites and destination ports needs to be take under considering. In analyze the effects of increased axle weight for SECU container transportation in Finnish railroads is studied. When transport unit is stuffed in earliest possible point supply chain and unloaded the last possible point the savings made in chain can be considerable. In case study of this thesis almost 40% savings in total costs could be reached in pre transportation and port operations when unitizing level is increased in supply chain.

Hiljaisen tiedon ja osaamisen jakamisen psykologiset esteet ja kannustimet

Kestävä kilpailuetu perustuu yhä enemmän resurssien, erityisesti tiedon luovaan hyödyntämiseen ja yhdistämiseen muiden resurssien kanssa. Hiljaisen tiedon ja osaamisen tehokkaan jakamisen avulla on mahdollista rakentaa organisaatiolle pysyvää kilpailukykyä. Tämän kvalitatiivisin menetelmin suoritetun tutkimuksen päätavoite on selvittää yksilön hiljaisen tiedon ja osaamisen jakamiseen vaikuttavia psykologisia esteitä ja kannustimia. Tavoitteena on myös selvittää tiedon arvoa yksilölle ja löytää keinoja tehostaa hiljaisen tiedon ja osaamisen jakamista Vakuutusyhtiössä. Tutkimuksen aineisto perustuu Vakuutusyhtiössä tehtyihin puolistrukturoituihin haastatteluihin. Teoreettinen viitekehys perustuu pääosin Herzbergin kaksifaktoriteoriaan.