Reabilitação biomimética na zona estética: a propósito de um caso clínico

Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

La lectura "palimpsestuosa" en textos e imágenes : Elementos de transtextualidad en dos libros álbum de Anthony Browne

Este trabajo se sumerge en el terreno de la transtextualidad (Genette, 1989) en el análisis de dos libros-álbum del laureado artista inglés Anthony Browne. El libro-álbum es un género relativamente nuevo, fruto de la posmodernidad y terreno fértil para la experimentación, cuya característica principal es la intención cooperativa del texto escrito y la imagen para la construcción de significados, lo que trae aparejado un lector implícito dispuesto a asumir un rol activo para, a partir de lo que expresan tanto lo escrito como lo ilustrado, llegar a co-crear un mensaje. ;La obra de Browne rebosa en referencias, préstamos, alusiones y deudas tanto de las artes visuales como de la literatura. Uno de los mecanismos principales que utiliza tanto en sus textos como en sus imágenes es la puesta en relación de estos con otras obras tanto literarias como visuales, pero también con otros medios (cine, televisión, revistas, periódicos). Tomando como punto de partida una estética cuyo origen es el libro para niños, va más allá, complejiza una invitación a los sentidos y ofrece diferentes capas de significado que serán descodificadas de diversos modos acorde a la experiencia del destinatario, el cual es doble (niños y adultos). ;Nuestro objetivo en este caso es analizar en sus libros En el Bosque (Into the Forest, 2004) y Willy el Soñador (Willy the Dreamer, 1997) el uso de dos mecanismos de la transtextualidad: la intertextualidad y la hipertextualidad (y dentro de esta, principalmente, la parodia). Respecto del primer libro, estudiaremos las conexiones intertextuales establecidas desde el texto escrito y el ilustrado con los cuentos tradicionales como "La Caperucita Roja", "Hansel y Gretel", etc. Y respecto del segundo, observaremos cómo las ilustraciones parodian obras famosas de las artes visuales, muchas de ellas de René Magritte, y hacen guiños sobre relatos muy conocidos como, por ejemplo, Alicia en el país de las maravillas (1863), de Lewis Carrol. ;Desde el ámbito de la Literatura Comparada, en su aspecto abarcativo de otras artes que se relacionan con la literatura, la interpelan e incluso la modifican, proponemos una mirada sobre un género que, debido a su novedad, no ha sido muy estudiado, y una especial atención a la literatura para niños, la cual suele no ser tenida en cuenta en los estudios sobre literatura en general

La lectura "palimpsestuosa" en textos e imágenes : Elementos de transtextualidad en dos libros álbum de Anthony Browne

Este trabajo se sumerge en el terreno de la transtextualidad (Genette, 1989) en el análisis de dos libros-álbum del laureado artista inglés Anthony Browne. El libro-álbum es un género relativamente nuevo, fruto de la posmodernidad y terreno fértil para la experimentación, cuya característica principal es la intención cooperativa del texto escrito y la imagen para la construcción de significados, lo que trae aparejado un lector implícito dispuesto a asumir un rol activo para, a partir de lo que expresan tanto lo escrito como lo ilustrado, llegar a co-crear un mensaje. La obra de Browne rebosa en referencias, préstamos, alusiones y deudas tanto de las artes visuales como de la literatura. Uno de los mecanismos principales que utiliza tanto en sus textos como en sus imágenes es la puesta en relación de estos con otras obras tanto literarias como visuales, pero también con otros medios (cine, televisión, revistas, periódicos). Tomando como punto de partida una estética cuyo origen es el libro para niños, va más allá, complejiza una invitación a los sentidos y ofrece diferentes capas de significado que serán descodificadas de diversos modos acorde a la experiencia del destinatario, el cual es doble (niños y adultos). ;Nuestro objetivo en este caso es analizar en sus libros En el Bosque (Into the Forest, 2004) y Willy el Soñador (Willy the Dreamer, 1997) el uso de dos mecanismos de la transtextualidad: la intertextualidad y la hipertextualidad (y dentro de esta, principalmente, la parodia). Respecto del primer libro, estudiaremos las conexiones intertextuales establecidas desde el texto escrito y el ilustrado con los cuentos tradicionales como "La Caperucita Roja", "Hansel y Gretel", etc. Y respecto del segundo, observaremos cómo las ilustraciones parodian obras famosas de las artes visuales, muchas de ellas de René Magritte, y hacen guiños sobre relatos muy conocidos como, por ejemplo, Alicia en el país de las maravillas (1863), de Lewis Carrol. ;Desde el ámbito de la Literatura Comparada, en su aspecto abarcativo de otras artes que se relacionan con la literatura, la interpelan e incluso la modifican, proponemos una mirada sobre un género que, debido a su novedad, no ha sido muy estudiado, y una especial atención a la literatura para niños, la cual suele no ser tenida en cuenta en los estudios sobre literatura en general

La lectura "palimpsestuosa" en textos e imágenes : Elementos de transtextualidad en dos libros álbum de Anthony Browne

Este trabajo se sumerge en el terreno de la transtextualidad (Genette, 1989) en el análisis de dos libros-álbum del laureado artista inglés Anthony Browne. El libro-álbum es un género relativamente nuevo, fruto de la posmodernidad y terreno fértil para la experimentación, cuya característica principal es la intención cooperativa del texto escrito y la imagen para la construcción de significados, lo que trae aparejado un lector implícito dispuesto a asumir un rol activo para, a partir de lo que expresan tanto lo escrito como lo ilustrado, llegar a co-crear un mensaje. La obra de Browne rebosa en referencias, préstamos, alusiones y deudas tanto de las artes visuales como de la literatura. Uno de los mecanismos principales que utiliza tanto en sus textos como en sus imágenes es la puesta en relación de estos con otras obras tanto literarias como visuales, pero también con otros medios (cine, televisión, revistas, periódicos). Tomando como punto de partida una estética cuyo origen es el libro para niños, va más allá, complejiza una invitación a los sentidos y ofrece diferentes capas de significado que serán descodificadas de diversos modos acorde a la experiencia del destinatario, el cual es doble (niños y adultos). ;Nuestro objetivo en este caso es analizar en sus libros En el Bosque (Into the Forest, 2004) y Willy el Soñador (Willy the Dreamer, 1997) el uso de dos mecanismos de la transtextualidad: la intertextualidad y la hipertextualidad (y dentro de esta, principalmente, la parodia). Respecto del primer libro, estudiaremos las conexiones intertextuales establecidas desde el texto escrito y el ilustrado con los cuentos tradicionales como "La Caperucita Roja", "Hansel y Gretel", etc. Y respecto del segundo, observaremos cómo las ilustraciones parodian obras famosas de las artes visuales, muchas de ellas de René Magritte, y hacen guiños sobre relatos muy conocidos como, por ejemplo, Alicia en el país de las maravillas (1863), de Lewis Carrol. ;Desde el ámbito de la Literatura Comparada, en su aspecto abarcativo de otras artes que se relacionan con la literatura, la interpelan e incluso la modifican, proponemos una mirada sobre un género que, debido a su novedad, no ha sido muy estudiado, y una especial atención a la literatura para niños, la cual suele no ser tenida en cuenta en los estudios sobre literatura en general

DIVULGAÇÃO CIENTÍFICA NAS REVISTAS CIÊNCIA HOJE, SCIENTIFIC AMERICAN BRASIL E SUPERINTERESSANTE: ESTUDO COMPARATIVO

Estudo comparativo que analisa a divulgação científica (DC) praticada pelas revistas Ciência Hoje (CH), Scientific American Brasil (SAB) e Superinteressante (SI), apontando convergências e divergências entre as três publicações. Objetiva-se analisar como as formas de construção textual e o uso de ilustrações nas matérias e nos artigos de capa das revistas CH, SAB e SI podem contribuir ou interferir de maneira efetiva na DC que praticam. Para tanto, são delineados cinco pressupostos básicos: (1) as publicações de análise priorizam nas capas temas pertencentes às Ciências Básicas (CB) em detrimento das Ciências Humanas e Sociais (CHS); (2) no campo amplo das CB há preferência, nas capas das revistas, por temas relacionados à saúde; (3) as temáticas abordadas nas capas das revistas CH, SAB e SI não são, em geral, coincidentes entre si, pois não seguem uma lógica de matérias quentes ; (4) o uso freqüente de elementos explicativos, termos figurados, fontes de informação diversificadas e citações diretas nas construções textuais das matérias e dos artigos de capa das publicações, bem como o uso de ilustrações devidamente contextualizadas, contribuem para tornar os textos mais inteligíveis; (5) as revistas CH, SAB e SI, embora consideradas revistas de DC, apresentam níveis diferenciados de divulgação, em função do perfil de seus leitores. Em consonância com esses pressupostos, são objetivos específicos: a) identificar, dentro das duas amplas categorias (CB e CHS), os temas mais explorados, reunindo-os em subcategorias para identificar mais afinidade / proximidade entre eles; b) examinar, através das formas de construção textual e do uso das ilustrações nas matérias e nos artigos de capa, os critérios utilizados pelas publicações para divulgar ciência e tecnologia (C&T). Para responder os parâmetros estabelecidos nos objetivos apresentados, a metodologia inclui questionário aplicado aos editores das publicações investigadas e análise de conteúdo (AC) da amostra selecionada, que engloba 19 matérias / artigos de capa das revistas CH, SAB e SI, escolhidos entre julho de 2009 e junho de 2010. Os dados coletados e devidamente discutidos permitem confirmar os pressupostos enunciados, vez que, em termos gerais, é evidente que a DC praticada pelas três revistas apresenta mais divergências do que convergências. Isto possibilita estabelecer níveis distintos de divulgação, manifestos na forma como constroem os textos e como utilizam as ilustrações, com maior dificuldade em SAB e CH e com teor mais simplificado em SI.

A CONSTRUÇÃO DE UM DISCURSO SOBRE NUTRIÇÃO E SAÚDE CARDIOVASCULAR: ANÁLISE DA REVISTA SAÚDE É VITAL

A educação em saúde é um tema que requer atenção de todos. O cenário atual da qualidade de saúde da população nos convida a refletir sobre mudanças que visem a construir um panorama mais saudável. Conhecer a trajetória que o alimento, o corpo e a saúde percorreram no decorrer da história nos remete a necessidade de compreender as representações socioeconômicas e culturais que estes conquistaram e como se tornaram mercadorias altamente vendáveis e que despertam o desejo na sociedade de consumidores. Este trabalho tem por objetivo analisar as estratégias discursivas utilizadas nos textos publicados na seção nutrição da Revista Saúde é Vital, cuja temática seja nutrição e doenças cardiovasculares, no sentido de buscar entender como esse discurso construído pode contribuir com o processo de educação nutricional da população. Por meio da análise do discurso da missão, carta ao leitor, capas das revistas, índices de objetividade e subjetividade presentes nas matérias selecionadas constatou-se que as estratégias discursivas contribuem com o processo educativo. No entanto, para que a educação nutricional seja sólida faz-se necessário que o conhecimento não seja fragmentado. Educar não é informar. Educar é ensinar a pensar. Pensar não é ter as informações. Pensar é o que se faz com as informações.

AS MARCAS QUE SE IMPRIMEM NA CAPA DE LIVROS ADAPTADOS PARA O CINEMA E PARA A TELEVISÃO

Este trabalho teve como objetivo os enunciados verbais e/ou não-verbais impressos em capas de livros - escritos por autores brasileiros e adaptados para o cinema ou para a televisão - que associam o livro à produção cinematográfica ou televisiva. Seu objetivo foi verificar se tais enunciados poderiam ou não ser classificados como paratexto - conforme é conceituado por Gerard Genette. A motivação para esta pesquisa surgiu pela constatação de que, em sendo aqueles enunciados construídos a partir de uma obra derivada de um livro, em que medida eles poderiam estar a serviço do texto principal? Para responder a essa questão, os enunciados foram analisados segundo os conceitos da análise do discurso e da análise retórica. Os resultados obtidos na análise permitiram concluir que alguns enunciados não se configuram como paratextuais e, com base nos conceitos da Teoria Crítica, possibilitam compreender, criticamente, os procedimentos editoriais com que o livro se relaciona com os demais produtos midiáticos.(AU)

Estudo in silico das interações da protease NS3-NS2B de DENV-2 com o inibidor peptídico Bz-nKRR-H com finalidades terapêuticas

Dengue virus is an important patogen that causes Dengue desease in all world, and belongs to Flavivirus gender. The virus consists of enveloped RNA with a single strand positive sense, 11Kb genome. The RNA is translated into a polyprotein precursor, wich is cleaved into 3 structural proteins (C, prM e E) and 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B e NS5). The NS3 is a multifunctional protein, that besides to promote the polyprotein precursor cleavage, also have NTPase, helicase and RTPase activity. The NS3 needs a hydrophilic segment of 40 residues from the transmembrane NS2B protein (who acts like cofator) to realize this functions. Actually, there's no vacines available on the market, and the treatment are just symptomatic. The tetrapeptide inhibitor Bz-Nle-Lys-Arg-Arg-H (Ki de 5,8-7,0 M) was showed as a potent inhibitor μ for NS3prot in Dengue virus. That is a inteligent alternative to treat the dengue desease. The present work aimed analyse the interactions of the ligand bounded to the activity site to provid a clear and depth vision of that interaction. For this purpouse, it was conducted an in silico study, by using quantum mechanical calculations based on Density Functional Theory (DFT), with Generalized Gradient approximation (GGA) to describe the effects of exchange and correlation. The interaction energy of each amino acid belonging to the binding site to the ligand was calculated the using the method of molecular fragmentation with conjugated caps (MFCC). Besides energy, we calculated the distances, types of molecular interactions and atomic groups involved. The theoretical models used were satisfactory and show a more accurate description when the dielectric constant = 20 ε and 80 was used. The results demonstrate that the interaction energy of the system reached convergence at 13.5 A. Within a radius of 13,5A the most important residues were identified. Met49, Met84 and Asp81 perform interactions of hydrogen with the ligant. The Asp79 and Asp75 residues present high energy of attraction. Arg54, Arg85 and Lys 131 perform hydrogen interactions with the ligand, however, appear in BIRD graph having high repulsion energy with the inhibitor. The data also emphasizes the importance of residue Tyr161 and the involvement of the catalytic triad composed by Asp75, His51 and Ser135

Caracterização de superfícies seletivas de frequência de periódicas e não-periódicas

The past years have seen a great interest in the use of frequency selective surfaces (FSS), as spatial filters, in many microwave applications. Among these, we highlight applications in telecommunication systems (such as satellite communications and radar), high gain antennas (combined with planar antennas) and (home and industrial) microwave ovens. The FSS is usually composed of two-dimensional periodic arrays, with equally spaced elements, which may be metallic patches (printed on dielectric substrates) or aperture (holes in thin metal surfaces). Using periodic arrays, the FSS have been able to meet the demands of the telecommunications industry. However, new demands are finding technological limitations. In this context, adverse filtering requirements have forced designers to use FSS optimization methods to find specific formats of FSS elements. Another alternative that has been used to increase the selectivity of the FSS is the cascaded FSS, a simple technique that has as main drawback the increased dimensions of the structure, as well as its weight. This work proposes the development of a new class of selective surfaces frequency (FSS) composed of quasi-periodic (or non-periodic) arrangements. The proposed FSS have no array periodicity, in relation with the spatial position of their elements. The frequency responses of these structures were simulated using commercial softwares that implement full-wave methods. For the purpose of validation of this study, FSS prototypes were built and measured, being possible to observe a good agreement between simulated and measured results. The main conclusions of this work are presented, as well as suggestions for future works.

Petrologia das fraturas associadas a feições típicas de dissolução hipogênica na Formação Salitre, Bacia de Irecê, Bahia, Brasil

The recognition of karst reservoirs in carbonate rocks has become increasingly common. However, most karst features are small to be recognized in seismic sections or larger than expected to be investigated with borehole data. One way forward has been the study of analogue outcrops and caves. The present study investigates lithofacies and karst processes, which lead to the generation of the largest system of caves in South America. The study area is located in the Neoproterozoic Una Group in central-eastern Brazil. This province comprises several systems of carbonate caves (Karmann and Sanchéz, 1979), which include the Toca da Boa Vista and Barriguda caves, considered the largest caves in South America (Auler and Smart, 2003). These caves were formed mainly in dolomites of the Salitre Formation, which was deposited in a shallow marine environment in an epicontinental sea (Medeiros and Pereira, 1994). The Salitre Formation in the cave area comprises laminated mud/wakestones, intraclastic grainstones, oncolitic grainstones, oolitic grainstones, microbial laminites, colunar stromatolites, trombolites and fine siliciclastic rocks (marls, shales, and siltites). A thin layer and chert nodules also occur at the top of the carbonate unit. Phosphate deposits are also found. Our preliminary data indicate that folds and associated joints control the main karstification event at the end of the Brasiliano orogeny (740-540 Ma). We recognized five lithofacies in the cave system: (1) Bottom layers of grainstone with cross bedding comprise the main unit affected by speleogenesis, (2) thin grainstone layers with thin siltite layers, (3) microbial laminites layers, (4) layers of columnar stromatolites, and a (5) top layer of siltite. Levels (1) to (3) are affected by intense fracturing, whereas levels (4) and (5) seal the caves and have little fracturing. Chert, calcite and gipsite veins cut across the carbonate units and play a major role in diagenesis. Our preliminary study indicate that hypogenic spelogenesis is the main process of karst development and contributed significantly to the generation of secondary porosity and permeability in the carbonate units.

A predominância do filtro ambiental local na montagem de uma floresta tropical de ambiente estressante

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização e separação física de placas de circuito impresso de computadores obsoletos

The unbridled consumption of electronic equipment associated with fast immersion of new technologies on the market leads to the accelerated growth of electronic waste. Such waste mostly contains printed circuit boards in its structure. Printed circuit boards have many metals, including heavy metals, being highly toxic. Electronic waste is discarded improperly and indiscriminately, usually without any previous treatment and with other municipal waste, contaminating the environment and causing serious problems to human health. Beyond these metals, there are also precious metals and high value-added basis, that can be recovered and recycled, reducing the exploration of natural resources. Thus, due to the high growth potential and reuse of these waste treatment processes, characterization and separation were applied to the printed circuit boards. The printed circuit boards were subjected to physical treatments such as dismantling, crushing, sizing separation, magnetic separation and chemical treatments such as pyrolysis and leaching. Through characterization process (pyrolysis and leaching) the proportions of the components of the granulometric range were determined: 46,08% of metals; 23,32% of polymers and 30,60% of ceramics. It was also observed by particle size separation that metal components tend to concentrate in coarse fractions, while polymeric and ceramic components in fine fractions. From the magnetic separation process was obtained 12,08% of magnetic material and 82,33% of non-magnetic material.

Caracterização do material particulado e avaliação do risco ocupacional e mecanismos moleculares associados à queima artesanal da castanha de caju

Brazil is among the largest cashew nut producers of the world. However, the roasting process is still carried out artisanally, especially in the Brazilian semiarid region. In face of this occupational problem, the aim of this study was to perform a physical-chemical characterization of the particulate matter (PM) emitted by the roasting of cashew nuts, as well as to determine the occupational risk and molecular mechanisms associated. The most evident PM characteristics were the prevalence of fine particles, typical biomass burning morphologies such as tar ball and the presence of the elements K, Cl, S, Ca and Fe. In addition, atmospheric modeling analyses suggest that these particles can reach neighboring regions of the emission source. Polycyclic aromatic hydrocarbons (PAHs) with carcinogenic potential, such as benzo[a]pyrene, dibenz[a,h]anthracene, benzo[a]anthracene, benzo[b]fluoranthene, chrysene, benzo[k]fluoranthene, indeno[1,2,3-c,d]pyrene and benzo[j]fluoranthene were the most abundant PAHs found in the two air monitoring campaigns. Among the identified oxy-PAH the benzanthrone (7H-benz[d,e]anthracen-7-one) had the highest concentration and the evaluation of lifetime cancer risk showed an increase of 12 to 37 cases of cancer for every 10,000 exposed people. Chemical analysis of roasted cashew nuts identified the PAHs: phenanthrene, benzo[g,h,i]perylene, pyrene and benzo[a]pyrene, besides the 3-pentadecilfenol allergen (urushiol analogue) as prevalent. Occupational exposure to PAHs was confirmed by the increase of urinary 1-hydroxypyrene levels and genotoxic effects were evidenced by the increase on micronuclei and nuclear bud frequency in exfoliated buccal mucosa cells among the exposed workers. Other biomarkers of effects such as karyorrhexis, pyknotic, karyolytic, condensed chromatin and binucleated cells also have their frequencies increased when compared to an unexposed control group. The investigation of the molecular mechanisms associated with the PM organic extract showed cytotoxicity in human lung cell lines (A549) at concentrations ≥ 4 nM BaPeq. Using non-cytotoxic doses the extract was able to activate proteins involved in the DNA damage response pathway (Chk1 and p53). Moreover, the specific contribution of the four most representative PAHs in the cashew nut roasting sample showed that benzo[a]pyrene was the most efficient to activate Chk1 and p53. Finally, the organic extract was able to increase persistently the mRNA expression involved in the PAHs metabolism (CYP1A1 and CYP1B1), inflammatory response (IL-8 and TNF-α) and cell cycle arrest (CDKN1A) for DNA repair (DDB2). The high PM concentrations and its biological effects associated warn of the serious harmful effects of artisanal cashew nut roasting and urgent actions should be taken to the sustainable development of this activity.

Caracterização do material particulado e avaliação do risco ocupacional e mecanismos moleculares associados à queima artesanal da castanha de caju

Brazil is among the largest cashew nut producers of the world. However, the roasting process is still carried out artisanally, especially in the Brazilian semiarid region. In face of this occupational problem, the aim of this study was to perform a physical-chemical characterization of the particulate matter (PM) emitted by the roasting of cashew nuts, as well as to determine the occupational risk and molecular mechanisms associated. The most evident PM characteristics were the prevalence of fine particles, typical biomass burning morphologies such as tar ball and the presence of the elements K, Cl, S, Ca and Fe. In addition, atmospheric modeling analyses suggest that these particles can reach neighboring regions of the emission source. Polycyclic aromatic hydrocarbons (PAHs) with carcinogenic potential, such as benzo[a]pyrene, dibenz[a,h]anthracene, benzo[a]anthracene, benzo[b]fluoranthene, chrysene, benzo[k]fluoranthene, indeno[1,2,3-c,d]pyrene and benzo[j]fluoranthene were the most abundant PAHs found in the two air monitoring campaigns. Among the identified oxy-PAH the benzanthrone (7H-benz[d,e]anthracen-7-one) had the highest concentration and the evaluation of lifetime cancer risk showed an increase of 12 to 37 cases of cancer for every 10,000 exposed people. Chemical analysis of roasted cashew nuts identified the PAHs: phenanthrene, benzo[g,h,i]perylene, pyrene and benzo[a]pyrene, besides the 3-pentadecilfenol allergen (urushiol analogue) as prevalent. Occupational exposure to PAHs was confirmed by the increase of urinary 1-hydroxypyrene levels and genotoxic effects were evidenced by the increase on micronuclei and nuclear bud frequency in exfoliated buccal mucosa cells among the exposed workers. Other biomarkers of effects such as karyorrhexis, pyknotic, karyolytic, condensed chromatin and binucleated cells also have their frequencies increased when compared to an unexposed control group. The investigation of the molecular mechanisms associated with the PM organic extract showed cytotoxicity in human lung cell lines (A549) at concentrations ≥ 4 nM BaPeq. Using non-cytotoxic doses the extract was able to activate proteins involved in the DNA damage response pathway (Chk1 and p53). Moreover, the specific contribution of the four most representative PAHs in the cashew nut roasting sample showed that benzo[a]pyrene was the most efficient to activate Chk1 and p53. Finally, the organic extract was able to increase persistently the mRNA expression involved in the PAHs metabolism (CYP1A1 and CYP1B1), inflammatory response (IL-8 and TNF-α) and cell cycle arrest (CDKN1A) for DNA repair (DDB2). The high PM concentrations and its biological effects associated warn of the serious harmful effects of artisanal cashew nut roasting and urgent actions should be taken to the sustainable development of this activity.

Efeito da oxigenação hiperbárica no reparo ósseo de ratos diabéticos

The chronic state of hyperglycemia due to diabetes mellitus affects multiples organs impairing life quality. In bone, diabetes alters strength and mineral density and also suppresses the osteoblast activity, leading to an unbalanced bone healing process. Hyperbaric oxygen therapy (HBO) is suggested as an adjuvant treatment to accelerate bone repair. This study evaluated the effects of HBO in the number of mast cells and in new bone formation at the initial stage of bone repair in normoglycemic and diabetic rats. It was hypothesized that HBO treatment may improve bone repair in diabetic bone. The rats were equally divided in four groups: Control (C); Control + HBO (CH); Diabetes (D) and Diabetes + HBO (DH). Diabetes was induced by streptozotocin (65mg/kg) and femoral bone defects were created thirty days after diabetes induction in all groups. HBO initiated immediately after surgery procedure and was performed daily, for 7 days, in the CH e DH groups. Seven days after surgery, all animals were euthanized. The femur diaphyses were removed, fixated, decalcified and processed for paraffin embedding. The semi-serial histological sections obtained were stained with Hematoxylin-Eosin (HE), Mallory Trichrome and Toluidine Blue. The qualitative analysis was conducted in the histology slides stained with HE, where it was evaluated the morphological aspects of bone repair in the lesion area, observing the presence of clot, inflammatory cells, granulation tissue, type of bone tissue, morphology of bone cells, and thickness and organization of bone trabeculae. In the slides stained with Mallory Trichrome and Toluidine Blue were evaluated the percentage of new bone formation and number of mast cells, respectively. The qualitative analysis showed that the CH group presented a more advanced stage of bone repair compared to the C group, showing thicker trabeculae and greater bone filling of the lesion area. In D and DH group, the lesion area was partially filled with new bone formation tissue and presented thinner trabeculae and fewer areas associated to osteoclasts compared to control group. The histomorphometric analysis showed a significant improvement in new bone formation (p<0.001) comparing CH (38.08 ± 4.05) and C (32.05 ± 5.51); C and D (24.62 ± 2.28 and CH and DH (27.14 ± 4.21) groups. In the normoglycemic rats there was a significant increasing in the number of mast cells (p<0.05) comparing C (8.06 ± 5.15) and CH (21.06 ± 4.91) groups. In conclusion, this study showed that diabetes impaired bone repair and HBO was only able to increase new bone formation and the number of mast cells in the normoglycemic animals.