Reflexão sobre a politica desportiva em Moçambique : diagnostico sobre as instalações desportivas da cidade de Maputo

Universidade Estadual de Campinas . Faculdade de Educação Física

Validation of an HPLC analytical method for determination of pancuronium bromide in pharmaceutical injections

Pancuronium bromide is used with general anesthesia in surgery for muscle relaxation and as an aid to intubation. A high performance liquid chromatographic method was fully validated for the quantitative determination of pancuronium bromide in pharmaceutical injectable solutions. The analytical method was performed on an amino column (Luna 150mm4.6mm, 5m). The mobile phase was composed of acetonitrile:water containing 50mmol L-1 of 1-octane sulfonic acid sodium salt (20:80v/v) with a flow rate of 1.0mL min-1 and ultraviolet (UV) detection at 210nm. The proposed analytical method was compared with that described in the British Pharmacopoeia.

Naltrexone in the treatment of male alcoholics - an effectiveness study in Singapore

Naltrexone has been demonstrated in western studies to be a useful pharmacological adjunct within treatment programmes for alcoholic patients. We report the first study of its efficacy and usefulness in an Asian region. This project was designed to allow naltrexone's performance to be assessed under routine clinical conditions but with patients selected on the basis of their being likely to comply. Following in-patient detoxification, 53 male alcohol-dependent patients admitted to the Alcohol Treatment Centre at Woodbridge Hospital, Singapore, were enrolled in a 12-week, placebo-controlled trial of naltrexone hydrochloride (50 mg/day). Subjects were randomized on a 2:1 basis, with 35 receiving naltrexone and 18 receiving placebo. Analyses identified that a higher percentage of naltrexone patients completed the study (40% vs. 22%). In the study non-completers, the dropout rate due to drinking relapse was also lower in the naltrexone group (9% vs. 43%). Of the 39 patients for whom drinking status over the trial could be ascertained, fewer naltrexone-treated patients drank (33% vs. 53%). Alcohol craving scores also showed a selective and distinct reduction in the naltrexone-treated group. Results suggest that naltrexone may be an effective and safe aid to treatment of alcohol dependent patients in Asian patients, for whom the aims are to reduce alcohol craving and drinking reinstatement, but where compliance is likely to be low.

Bariatric Surgery Reverses Natural Killer (NK) Cell Activity and NK-Related Cytokine Synthesis Impairment Induced by Morbid Obesity

Background Obesity is related to a higher rate of infections and some types of cancer. Here we analyzed the impact of obesity and weight loss induced by Roux-en-Y gastric bypass (RYGB) on immunological parameters, i.e., cytokine productions and natural killer cell function. Methods We analyzed 28 morbidly obese patients before and 6 months after RYGB. Biochemical parameters were analyzed in plasma. The percent of natural killer (NK) cells, their cytotoxicity, and the production of cytokines by peripheral blood mononuclear cells were analyzed. The percent of NK cells was determined by flow cytometry and cytokine production determined by enzyme-linked immunosorbent assay. NK cytotoxicity was determined by the lactate dehydrogenase release assay. Results The weight loss 6 months following surgery was 35.3 +/- 4.5 kg. RYGB also improves biochemical parameters. No significant difference was found in the percent of NK cells after surgery. We found an increase in the production of interferon-gamma, interleukin (IL)-12 and IL-18, but not in IL-2, 6 months after RYGB. Cytotoxic activity of NK cells was significantly enhanced 6 months after RYGB [17.1 +/- 14.7% before RYGB vs 51.8 +/- 11.3% at 6 months after, at 40: 1 effector to target cell ratio; p<0.001]. We observed significant post-surgical improvement in the cytotoxic activity curve in 22 out of 28 patients (78.6%), irrespective of the target to effector cell ratio. Conclusions The weight loss induced by RYGB modifies the production of cytokines related with NK cell function and improves its activity.

Biostatistics in Australia: Directions in the new millennium

The Biostatistics Collaboration of Australia (BCA) was formed in response to a shortage of statisticians seeking careers in the medical and health professions. The Collaboration has been successful in developing postgraduate courses (Graduate Certificate, Graduate Diploma and Masters) offered by a consortium of seven Australian Universities. These courses are available through a distance learning medium. The BCA was successful in securing funding from the Federal government to launch these courses, which commenced in March 2001. Two traineeships by the NSW Department of Health have also been awarded and a third is currently advertised. There has been close collaboration with governments, the pharmaceutical industry and research organisations to ensure that course content reflects practical problems and addresses industry needs. A second objective of the BCA is to provide ongoing workshops for practising biostatisticians to enhance professional development. These workshops serve to ring together biostatisticians from both within Australia and the Asia-Pacific region, providing a forum for discussion of current statistical thinking. (author abstract)

Controlled partial mine ventiliation recirculation trial at Mount Isa Mines

The ventilation and cooling of deep, hot mines present particular problems in Australia as a consequence of the surface climate, the size of the underground voids, the degree of mechanization and the cost of power in remote areas. A preliminary investigation of the effects of controlled partial recirculation of air was conducted in Mount Isa Mines' Deep Copper section. Gas and dust concentrations were measured in the exhaust air of the major working section to assess the potential for recirculating exhaust air to the intake airways to reduce the cost of providing an acceptable working environment in the deep parts of the mine. Studies were undertaken of airborne dust deposition in vertical airways and the efficiency of usage of the ventilation air in diluting contaminants. It was established that 45% of the respirable dust was deposited in a 130-m vertical raise and 60% of the air supplied to the section could be reused or recirculated. The first major field trial of a controlled partial recirculation system in Australia was undertaken in the light of these results and demonstrated excellent potential for significant reduction in ventilation costs. Gas and dust contaminant levels were well below the threshold limit values during the trial. It is concluded that controlled partial recirculation can be a practical, effective and safe aid to normal ventilation practice in Australian deep, hot mines.

Nem privado nem estatal: em busca de uma nova estrat??gia para a provis??o de servi??os p??blicos

A id??ia que anima este artigo ?? a de juntar argumentos que demonstrem a import??ncia de se reformar as rela????es do Estado com a sociedade para que a reforma do aparelho do Estado tenha sucesso. S??o discutidas as vantagens e desvantagens da provis??o dos servi??os p??blicos sociais por meio de organiza????es p??blicas n??o-estatais, como uma estrat??gia para superar a crise de governan??a do Estado contempor??neo e tamb??m como um caminho para reduzir a precariedade dos servi??os sociais. O esfor??o de supera????o da crise do Estado vem se traduzindo na redefini????o do modo de financiamento e da maneira de organizar a execu????o das pol??ticas p??blicas sociais, de forma a garantir efetividade na resposta ??s demandas sociais e maior efici??ncia na produ????o dos servi??os. A desestatiza????o da provis??o dos servi??os sociais coloca as sociedades democr??ticas diante do desafio de resolver como manter a responsabilidade do Estado frente ao interesse p??blico. Trata-se de responder como transitar do estatal para o p??blico, garantindo que a provis??o de servi??os p??blicos n??o dependa exclusivamente do Estado, sem que este abandone seu papel de financiador e regulador das atividades de interesse geral. O que n??o merece mais d??vidas ?? que a constitui????o de uma esfera p??blica que venha a atuar em simetria com o Estado e o mercado, como uma poss??vel solu????o duradoura e democr??tica para a produ????o de bens e servi??os sociais, atrav??s de organiza????es p??blicas n??o-estatais, passe a ser considerada como uma das principais tarefas te??ricas e pr??ticas que desafiam os atores sociais envolvidos com as quest??es da gest??o p??blica.

As novas propostas para a seguran??a p??blica no Brasil: uma an??lise comparativa dos projetos Bolsa Forma????o e Mulheres da Paz

A partir do exame qualitativo de dados e informa????es coletadas, lastreado nas teorias do ciclo de pol??ticas p??blicas, esse texto analisa duas recentes iniciativas do governo federal brasileiro na ??rea de seguran??a p??blica ??? os projetos ???Bolsa Forma????o??? e ???Mulheres da Paz???, ambos do Programa Nacional de Seguran??a P??blica com Cidadania (Pronasci). A partir da descri????o e reconstru????o hist??rica desses projetos, tentamos realizar uma compara????o entre alguns de seus principais elementos ou caracter??sticas, concatenando-os com conceitos e abordagens te??ricas, a fim de trazer conclus??es ??teis ?? an??lise e formula????o de pol??ticas p??blicas.

Financiamento e gasto público da assistência social no Município de Vitória - ES - 2005 a 2012

Trata do financiamento e do gasto público com a política de assistência social no município de Vitória - ES, nos oito anos seguintes à publicação da Política Nacional de Assistência Social 2004. Constitui-se em um estudo de caso, onde se realizou revisão bibliográfica e pesquisa documental utilizando-se como fontes de dados o Sistema Municipal Ferramenta Operacional de Controle Orçamentário, os Planos Municipais de Assistência Social, os Planos Plurianuais de Aplicação e outras leis e resoluções municipais. Apresenta considerações sobre a trajetória da assistência social, especialmente a partir da Constituição Federal de 1988. Discute aspectos da política fiscal, do orçamento público, da Lei de Responsabilidade Fiscal e do financiamento e gasto da União com a assistência social. Por fim, debruça-se sobre a experiência do Município de Vitória - ES. Neste trabalho, a assistência social é compreendida como uma das formas de intervenção estatal, no sentido de garantir as condições de reprodução da sociedade capitalista, seja contribuindo para a acumulação de capital seja respondendo as reivindicações dos trabalhadores. Como resultados desta pesquisa foi possível identificar avanços e limites no financiamento e no gasto com a política de assistência social no município, dentre os quais destacam-se, de um lado, a ampliação dos recursos da assistência social em valores reais e o protagonismo do município no financiamento da política, de outro, a manutenção e/ou redução do percentual de gastos em relação às despesas gerais do município e o insuficiente aporte de recursos para fazer avançar a assistência social na direção da ampliação e da qualificação dos serviços.

Auxílios de Estado sob a forma fiscal: O caso Açores - Proc. C-88/03

Mestrado em Fiscalidade

Consultoria de gestão operacional e gestão da formação

Relatório de estágio apresentado ao Instituto de Contabilidade e Administração do Porto para a obtenção do título de Mestre em Auditoria Orientada por Dr. Rodrigo Carvalho Coorientador: Dr. José Rui Dias

O papel da interactividade na construção da narrativa em role-playing games digitais

Dissertação apresentada à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Audiovisual e Multimédia.

Desenvolvimento de uma plataforma SIG para apoio ao controlo da segurança das grandes barragens portuguesas

Trabalho Final de Mestrado elaborado no Laboratório Nacional de Engenharia Civil (LNEC) para a obtenção do grau de Mestre em Engenharia Civil pelo Instituto Superior de Engenharia de Lisboa no âmbito do protocolo de cooperação entre o ISEL e o LNEC

A relevância da comunicação integrada no web marketing: estudo de um caso prático

Dissertação de Mestrado apresentada ao Instituto Superior de Contabilidade e Administração do Porto para a obtenção do grau de Mestre em Marketing Digital, sob orientação do Prof. Paulo Alexandre Pires

Polymerase Chain Reaction Screening for Fungemia and/or Invasive Fungal Infections in Patients with Hematologic Malignancies

INTRODUCTION: Invasive fungal infections (IFIs) are a life-threatening complication in patients with hematologic malignancies, mainly in acute leukemia patients, following chemotherapy. IFI incidence is increasing, and associated mortality remains high due to unreliable diagnosis. Antifungal drugs are often limited by inadequate antimicrobial spectrum and side effects. Thus, the detection of circulating fungal DNA has been advocated as a rapid, more sensitive diagnostic tool. PATIENTS AND METHODS: Between June 01 and January 03, weekly blood samples (1,311) were screened from 193 patients undergoing intensive myelosuppressive or immunosuppressive therapy. IFI cases were classified according to European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Fungal DNA was extracted from whole blood and amplified using polymerase chain reaction (PCR) published primers that bind to the conserved regions of the fungal 18S rRNA gene sequence. In our study, two or more consecutive positive samples were always associated with fungal disease. RESULTS: PCR screening predicted the development of IFI to be 17 days (median). This test had a specificity of 91.1% and a sensitivity of 75%. IFI incidence was 7.8%. DISCUSSION: Therefore, our results confirm the potential usefulness of PCR serial screening and the clinical applicability in everyday routine. PCR screening offers a noninvasive repeatable aid to the diagnosis of IFI.