970 resultados para good manipulation practices


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Aquest projecte realitza una auditoria ambiental de l’edifici de l’Àrea de Territori, Medi Ambient, Paisatge i Espai Urbà de l’Ajuntament de Sitges, com a primer pas per a la implantació d’un sistema de gestió ambiental (SGA), en acord amb el Reglament (CE) nº 761/2001, i la posterior obtenció d’un certificat de gestió i auditories ambientals (EMAS). L’auditoria s’inicia amb la identificació dels aspectes ambientals de l’edifici, mitjançant la recopilació de dades sobre consums energètics i hídrics, la estimació de la generació de residus i enquestes de mobilitat als treballadors. Aquestes dades són utilitzades per determinar els aspectes ambientals significatius i posteriorment, exposar una sèrie de propostes de millora per tal de corregir-los o minimitzar-los, com ara sistemes d’estalvi d’aigua, d’enllumenat, de producció d’electricitat i l’educació ambiental dels treballadors. Per a la implantació d’un SGA en la situació actual de l’edifici, es necessària, entre altres coses, la implantació d’un sistema de registre que arxivi els consums d’aigua, energia i generació de residus, per tal de dur un control de les despeses de cadascun dels vectors. A més, caldrà implementar un Programa de bones pràctiques ambientals en l’oficina per tal de reduir el consum elèctric, d’aigua i generació de residus, i la seva classificació per part dels treballadors.

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Some of the elements that characterize the globalization of food and agriculture are industrialization and intensification of agriculture and liberalization of agricultural markets, that favours elongation of the food chain and homogenization of food habits (nutrition transition), among other impacts. As a result, the probability of food contamination has increased with the distance and the number of “hands" that may contact the food (critical points); the nutritional quality of food has been reduced because of increased transport and longer periods of time from collection to consumption; and the number of food-related diseases due to changes in eating patterns has increased. In this context, there exist different agencies and regulations intended to ensure food safety at different levels, e.g. at the international level, Codex Alimentarius develops standards and regulations for the marketing of food in a global market. Although governments determine the legal framework, the food industry manages the safety of their products, and thus, develops its own standards for their marketing, such as the Good Agricultural Practices (GAP) programs. The participation of the private sector in the creation of regulatory standards strengthens the free trade of food products, favouring mostly large agribusiness companies. These standards are in most cases unattainable for small producers and food safety regulations are favouring removal of the peasantry and increase concentration and control in the food system by industrial actors. Particularly women, who traditionally have been in charge of the artisanal transformation process, can be more affected by these norms than men. In this project I am analysing the impcact of food safety norms over small farms, based on the case of artisanal production made by women in Spain.

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L’escola bressol és el primer centre educatiu on els infants tenen accés a l’era digital després de l’entorn familiar que és el primer que reben després del seu naixement. Aquests centres educatius també han de donar resposta a la societat digital que hi ha actualment per tal d’aconseguir un desenvolupament integral de l’infant. Per realitzar aquesta integració de les Tecnologies de la Informació i la Comunicació (TIC) al centre és important una bona formació per part dels docents i tenir clar quins són els elements que fan una bona pràctica TIC. En el present treball final de grau s’aprofundeix en les bones pràctiques educatives en l’ús de les TIC i, posteriorment, es realitza una proposta de transferència de les mateixes a una escola de nova creació.

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If adequately designed and high quality material and good construction practices are used, portland cement concrete is very durable. This is demonstrated by the oldest pavement in Iowa (second oldest in the U.S.) paved in 1904, which performed well for 70 years without resurfacing. The design thickness is an important factor in both the performance and cost of pavement. The objective of this paper is to provide a 30-year performance evaluation of a pavement constructed to determine the required design thickness for low volume secondary roadways. In 1951 Greene County and the Iowa Highway Research Board of the Iowa Department of Transportation initiated a four-mile (6.4 km) demonstration project to evaluate thicknesses ranging from 4-1/2" (11.4 cm) to 6" (15.2 cm). The project, consisting of 10 research sections, was formed pavement placed on a gravel roadbed with very little preparation except for redistribution of the loose aggregate. Eight sections were non-reinforced except for centerline tie bars and no contraction joints were used. Mesh reinforcing and contraction joints spaced at 29' 7" (9.02 m) intervals were used in two 4-1/2" (11.4 cm) thick sections. The only air entrained section was non-reinforced. The pavement performed well over its 30-year life carrying a light volume of traffic and did not require major maintenance. There was substantial cracking with average slab length varying directly with thickness. The 4-1/2" (11.4 cm) thick non-air entrained, mesh-reinforced pavement with contraction joints has performed the best.

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En la asignatura de Farmacia Galénica III y Gestión de Calidad se ha llevado a cabo una actividad de campo en el curso 2011/2012, que consistía en una visita a 4 labo-ratorios farmacéuticos autorizados (Kern Pharma, Almirall, Reig Jofré y Novartis) para ver evidencias de cumplimientos de las NCF o GMP (Normas de Correcta Fa-bricación o Good Manufacturing Practices) en el entorno profesional y real.El objetivo del estudio es evaluar la capacidad analítica de los estudiantes de 4º cur-so de farmacia en cuanto a cumplimiento de las NCF. Para el desarrollo de la activi-dad se han organizado los estudiantes en diferentes grupos con la finalidad de “auditar”. La actividad implicaba preparar un cuestionario previo, realizar la visita y elaborar el informe final. Los resultados obtenidos han sido que aproximadamente un 97,1% de los alumnos han superado esta actividad con una nota media de 8,23. Se constata que la realización de esta actividad por parte de los estudiantes comporta una mejora de la calificación final de la asignatura respecto al curso previo.

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Presentem una caracterització de la distribució espacial de la contaminació per nitrats en els aqüífers de la plana del baix Fluvià. En concret, els valors de concentració més elevats s’han observat a l’aqüífer superficial, on sobrepassen, amb escreix, els límits de potabilitat aconsellats pel RD 1138/1990. L’àrea més afectada ocupa part dels termes municipals de Vilamacolum i Torroella de Fluvià, en els quals hi predominen concentracions que oscil·len entre 50 i 200 mg × L–1. Els focus de contaminació són de tipus puntual i difús. Documentada la presència anormal de nitrats en aquest aqüífer, es planteja el correcte maneig agrícola, en vistes a una doble finalitat: d’una banda, contribuir a la planificació d’unes bones pràctiques agrícoles tenint en compte la relació entre volums de reg i aportacions de nitrogen; d’altra banda, preveure una progressiva recuperació de la qualitat de l’aqüífer, a partir de l’ús de tecnologies que integrin la ubicació d’unes zones favorables on es pugui maximitzar l’extracció del recurs contaminat, i la ubicació d’uns sòls aptes per a l’aplicació d’aquest recurs, amb uns criteris agronòmics coherents.

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El examen de una normativa para mejorar la información al consumidor plantea observaciones pragmáticas sobre buenas prácticas textuales. La orden 385/2003 de la Generalitat de Catalunya establece el tamaño mínimo de la letra en contratos para facilitar su legibilidad. La interpretación de esta normativa permite considerar el uso pragmático de la letra pequeña. Y se recoge también el ejemplo publicitario de una empresa energética que paradójicamente utiliza, en la actualidad, como recurso de prestigio la letra pequeña en documentos contractuales. GOOD TEXTUAL PRACTICES AND INTERPRETABILITY OF THE FINE PRINT IN CONTRACTS. The review of legislation to improve consumer information raises pragmatic observations on textual practices. The order 385/2003 of the Autonomous Government of Catalonia (Spain) sets the minimum font size in contracts for readability. The interpretation of these rules allows us to consider the pragmatic use of the fine print. And the paper also includes advertising from an energy company that paradoxically used as a resource for prestige the fine print in contract documents.

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Drying is a major step in the manufacturing process in pharmaceutical industries, and the selection of dryer and operating conditions are sometimes a bottleneck. In spite of difficulties, the bottlenecks are taken care of with utmost care due to good manufacturing practices (GMP) and industries' image in the global market. The purpose of this work is to research the use of existing knowledge for the selection of dryer and its operating conditions for drying of pharmaceutical materials with the help of methods like case-based reasoning and decision trees to reduce time and expenditure for research. The work consisted of two major parts as follows: Literature survey on the theories of spray dying, case-based reasoning and decision trees; working part includes data acquisition and testing of the models based on existing and upgraded data. Testing resulted in a combination of two models, case-based reasoning and decision trees, leading to more specific results when compared to conventional methods.

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This work aimed to characterize the chemical composition of samples of alcoholic beverages fermented from jabuticaba produced in five successive crops. Up to 2005 most of the results didn't meet the current legal standards for wines and there was a negative correlation between parameters such as pH and volatile acidity, pH and total acidity, volatile acidity and alcohol content (p<0.01). The implementation of Good Manufacturing Practices and must sulfitation during the 2006 harvest lowered volatile acidity and more than 60% of the samples were in accordance with legislation. Also, a significant improvement in alcohol content was found (p<0.05)

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In this paper, we present procedures for the treatment and final disposal of residual solutions containing chromium, in order to evaluate the effectiveness of chemical precipitation of the metal and the potential of the glass encapsulation technique, using broken laboratory glassware. The results demonstrated that pH-values convenient for chemical precipitation are between 10 - 11. With regard to Cr(OH)3 encapsulation, the leaching and solubilization tests allowed to classify the waste as non-dangerous and non-inert. Finally, it is pointed out that the adoption of waste management practices in universities should be encouraged, helping to train professionals skilled in good laboratory practices.

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The aim of this work was the single-laboratory validation of a quantitative method for the determination of amoxicillin residues in support of cleaning control and validation. Linearity was demonstrated between 2.5 and 17.5 μg/mL, without matrix effects. Mean recoveries ranged from 84.00 to 103.74% and the relative standard deviation under repetitivity and within-reproducibility conditions were from 0.58 to 4.20% and from 0.79 to 4.39%, respectively. The theoretical limits of detection and quantification were 0.133 and 0.442 μg/mL, respectively. The studied method was suitable for cleaning control purpose within good manufacturing practices.

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In the context of quality and good laboratory practices, the article recovers some historical data. From a specific Institutional situation (CPQBA/UNICAMP), is presented an experience of establishing and implementing a standard (NIT-DICLA-035) for good laboratory practice according to definitions of the Brazilian authority (INMETRO) responsible for regulating, monitoring, supervising and recognition in this area. The issue aims to focus on studies of pesticide residues in GLP parameters.

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Three growing systems of Arabica coffee were evaluated under the energy perspective, in the state of Espírito Santo in Brazil. The systems are conventional cultivation (CC), cultivation with good agricultural practices (CGP) and organic farming (OF). It was made a comparison of the energy flows within these three systems to show sustainable levels of each one based on production average data of several family-farming units. Therefore, we analyzed crop yield, total energy efficiency reverse (TEER), energy efficiency of ripe coffee (EERC) and non-renewable energy efficiency (NREE). OF system had values for TEER, EERC and NREE of 3.3 4.7 and 7.9 respectively. Yet CC showed values of 1.8, 1.9 and 1.6 for TEER, EERC and NREE respectively. Furthermore, CGP presented values for TEER, EERC and NREE of 0.7, 1.3 and 1.4 respectively. The highest yield was observed in CGP, reaching an amount of 1794 kg ha-1(17,455 MJ); however, this system expends more energy than it converts. Thus, over those points, OF is the most sustainable system.

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Diplomityön tavoitteena on selvittää rautatiealalla toimivien yritysten turvallisuuden hallinnan nykytilaa ja löytää keinoja sen parantamiseen. Tutkimuksen kannalta olennaisia teemoja ovat turvallisuuskulttuuri, turvallisuusjohtaminen ja turvallisuusvaatimukset. Työ tarkastelee rautatiealalla toimivia Liikenneviraston palveluntuottajayrityksiä ja heidän näkemyksiään turvallisuuden hallinnan nykytilanteesta edellä mainittujen teemojen ja työn teoriatutkimuksen avulla. Työn teoriaosuus esittelee laajasti rautatiealalla vallitsevia sääntöjä, määräyksiä, ohjeita ja standardeja. Näiden vaatimusten lisäksi teoriaosuus esittelee rautatiealan turvallisuusjohtamisjärjestelmää (TJJ), joka jaetaan turvallisuuden hallinnan osa-alueiksi. Näitä osa-alueita käytetään apuna tunnistettaessa rautatiealalla toimivien yritysten kannalta tärkeimmät turvallisuuden hallinnan osa-alueet. Työn empiirisessä osuudessa toteutetaan haastattelututkimus rautatiealalla toimiville yrityksille. Haastattelujen perusteella tunnistetaan turvallisuuden hallinnan kannalta tärkeitä kehittämiskohteita ja toimivia käytäntöjä turvallisuuteen liittyen. Näiden avulla luodaan kuva turvallisuuden nykytilasta, joka esitetään työn turvallisuusteemojen avulla. Työn tuloksena esitetään malli viidestä, rautatiealalla toimivien yritysten näkökulmasta keskeisestä, turvallisuuden hallinnan osa-alueesta. Mallia soveltamalla rautatiealalla toimivat yritykset pystyvät vastaamaan paremmin turvallisuusvaatimuksiin, kehittämään turvallisuustoimintojaan ja lisäämään koko yrityksen tietoisuutta turvallisuudesta rautatieympäristössä.

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The purpose of this study was to verify and compare the main contamination sources and the hygienic/sanitary conditions of organic honey samples of Apis mellifera from Parana River islands. Thirty-three (33) samples were analyzed between January 2005 and August 2006. Eleven (11) samples were collected by beekeepers and twenty-two (22) samples were collected and processed in accordance with ideal personal hygiene norms and good manufacturing practices. The samples underwent microbiological analysis in search of coliforms at 35 ºC and 45 ºC, as well as fungi enumeration analysis. As for fungi counting, the samples harvested by beekeepers showed values above the maximum established by Resolution nº 15/94 of Common Market Group - Mercosul. The results showed that secondary contamination sources are responsible for the reduction of organic honey quality.