Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A.

Hemoglobin and its structures have been described since the 1990s to enhance a variety of biological activities of endotoxins (LPS) in a dose-dependent manner. To investigate the interaction processes in more detail, the system was extended by studying the interactions of newly designed peptides from the γ-chain of human hemoglobin with the adjuvant monophosphoryl lipid A (MPLA), a partial structure of lipid A lacking its 1-phosphate. It was found that some selected Hbg peptides, in particular two synthetic substructures designated Hbg32 and Hbg35, considerably increased the bioactivity of MPLA, which alone was only a weak activator of immune cells. These findings hold true for human mononuclar cells, monocytes and T lymphocytes. To understand the mechanisms of action in more detail, biophysical techniques were applied. These showed a peptide-induced change of the MPLA aggregate structure from multilamellar into a non-lamellar, probably inverted, cubic structure. Concomitantly, the peptides incorporated into the tightly packed MPLA aggregates into smaller units down to monomers. The fragmentation of the aggregates was an endothermic process, differing from a complex formation but rather typical for a catalytic reaction.

Creating a customer profitability accounting model

Customer profitability accounting is a well-researched topic in the academic field, and it has been proved to posses rather undisputable benefits. However, the calculation of the customer profitabilities can be challenging, therefore the usage of the accounting is not self-explanatory in organizations. The aim of this study was to create a customer profitability accounting model for a wholesales unit in the case company to function as a sales management tool. The literature review of the study presents certain fundamental issues related to customer profitability accounting, in addition a theoretical framework for accounting model design is provided. The creation of the model was commenced by setting the requirements for it and examining the foundation of the model design, which consisted of for instance price setting and cost structure of products. This was followed by selecting approaches to the creation of the model. The result of the study was an accounting model, for which a determination of included revenues and costs was executed, along with the formulation of an allocation criteria of the costs. Lastly, the customer profitabilities were calculated in accordance with the accounting principles and the calculation logic of the model. The attained figures proved the model to provide an appropriate solution for obtaining the customer profitabilities and thus to use the accounting information as a sales management tool in for instance decision making and negotiation situations.

Asiakaslaskentatoimi pankkitoimialalla

Tutkimuksen tavoitteena on tarkastella asiakaslaskentatoimea strategisen johdon laskentatoimen osa-alueena. Tavoitteena on selvittää Suomessa toimivien pankkien julkisten strategioiden yhtäläisyyksiä ja eroavaisuuksia sekä konttoreiden johtajien näkemyksiä asiakaslaskentatoimesta. Tutkimuksen teoreettinen viitekehys rakentuu strategisen johdon laskentatoimen ja asiakaslaskentatoimen tieteellisten tutkimusten pohjalta. Tutkimuksen empiirinen osa koostuu pankkien julkisten strategioiden analysoinnista sekä konttoreiden johtajien haastatteluista. Johtopäätöksenä voidaan esittää, että asiakaslaskentatoimen teoria ja käytäntö mukailevat toisiaan hyvin pitkälti, vaikka tiettyjä ristiriitoja onkin havaittavissa. Suomen pankkiryhmät toimivat tiettyjen samankaltaisten perusperiaatteiden mukaisesti, mutta erovaisuuksia löydettiin liittyen julkiseen strategiaan, asiakastiedon tuottamiseen, asiakaslaskentatoimen menetelmiin sekä tiedon hyväksikäyttöön.

Jousikvartetto

Digitoitu 5. 9. 2007.

Kaamos

Soitinnus: jousiorkesteri.

Neljä yölaulua

Digitoitu 4. 10. 2007.

Canciones sobre poemas de F. G. Lorca

Digitoitu 4. 10. 2007.

Trionino

Soitinnus: viulu, alttoviulu, sello.

Turkkilainen rapsodia

Soitinnus: piano.

[Halllieder op. 25]

Soitinnus: lauluääni (sopraano), piano.

Puhallinkvintetto, op. 12

Digitoitu 4. 10. 2007.

Viulusonaatti : 1. osa

Soitinnus: viulu, piano.