Vysočajše utverždennyj ego imperatorskim" vělistvom" požarnyj ustav" dlâ g. Vyborga, izdannyj v" Gel'singforsě 26 ânvarâ 1840 goda

Julkaistu myös suomeksi nimellä: Palo-asetus Wiipurin kaupungille. - Julkaistu myös ruotsiksi nimellä: Brandordning för Wiborgs stad.

Głosowanie elektroniczne – nowe wyzwanie dla demokracji?

The notion of democracy poses a significant challenge and problem in modern considerations on history, philosophy and politics. At present, in the face of the so-called information revolution, democracy has undoubtedly undergone profound and easily visible transformations. It can be said that the application of IT to exercise democratic power has brought about a revolution that will span a period of many years, given the different potential differing states have to spread the new technologies. The development of information and communications technology (ICT) has introduced new notions related to democracy, such as teledemocracy, technopolitics or electronic democracy (e-democracy). The subject of this paper, electronic voting (e-voting) is among the highly significant instruments of e-democracy. Electronic voting is the fulfillment of the principle of national sovereignty as it can be applied in the procedures of both indirect (e-elections) and direct (e-referendum) democracy.

Demokracja bezpośrednia a wprowadzenie praw wyborczych dla kobiet. Przykład Szwajcarii

Over the centuries, Switzerland has developed a unique and inimitable statehood that functions in peculiar geographical, social and political conditions, shaped by the tradition of exercising direct forms of power. It appears, however, that these tools of direct democracy can sometimes obstruct the changes of utmost significance for the development of modern statehood and democracy. This was the case of granting voting rights to women. Although many European and other states granted the rights to vote and stand for election to women in the 1920s and 1930s, Switzerland needed much longer to introduce this change: on the federal level, women’s suffrage was granted as late as in 1971, and the last to enjoy the right to partake in the political life of their canton were the women of Appenzell Innerrhoden, granted the right in 1990. The objective of this paper is to analyze the influence of the mechanisms of direct democracy on the introduction of voting rights for Swiss women.

Zbadanie prądu tunelowego w złączach typu metal-nadprzewodnik trypletowy dla wybranych symetrii parametru porządku

Wydział Fizyki: Zakład Teorii Ciała Stałego

Modele niepełnosprawności jako determinanty przeobrażeń struktury podażowej rynku turystycznego dostępnego dla osób niepełnosprawnych

The research aims to answer a fundamental question: which of the disability models currently in use is optimal for creating “accessible tourism-oriented” amenities, as well as more detailed problems: (1) what is disability and what determines different disability models? (2) what types of tourism market supply available for the disabled do the different disability models suggest? (3) are the disability models complementary or mutually exclusive? (4) is the idea of social integration and inclusion of people with disabilities (PWD) while on tourist trips supported of the society? Data sources comprise selected literature and results of a survey conducted using the face-to-face method and the SurveyMonkey website from May 2013 to July 2014. The surveyed group included 619 people (82% were Polish, the other 18% were foreigners from: Russia, Germany, Portugal, Slovakia, Canada, Tunisia and the United Kingdom). The research showed that the different disability models – medical, social, geographical and economic – are useful when creating the tourism supply for the PWD. Using the research results, the authors suggested a model of “diversification of tourism market supply structure available for the disabled”, which includes different types of supply – from specialist to universal. This model has practical usage and can help entrepreneurs with the segmentation of tourism offers addressed to the PWD. The work is innovative, both in its theoretical approach (the review of disability models and their practical application in creating tourism supply) and empirical values – it provides current data for the social attitude towards the development of PWD tourism. Especially the presentation of a wide range of perception of disability as well as the simple classification of tourism supply that meets the varied needs of PWD, is a particular novelty of this chapter.

Heurystyka strachu. Czy ambiwalencja lęku może być dla nas pouczająca?

The paper assumes that fear presents a certain degree of ambivalence. To say it with Hans Jonas (1903-1993), fear is not only a negative emotion, but may teach us something very important: we recognize what is relevant when we perceive that it is at stake. Under this respect, fear may be assumed as a guide to responsibility, a virtue that is becoming increasingly important, because of the role played by human technology in the current ecological crisis. Secondly, fear and responsibility concern both dimensions of human action: private-individual and publiccollective. What the ‘heuristics of fear’ teaches us, is to become aware of a deeper ambivalence, namely the one which characterizes as such human freedom, which may aim to good or bad, to self-preservation or self-destruction. Any public discussion concerning political or economic issues related with human action (at an individual or collective level) ought not to leave this essential idea out of consideration.

Edukacja w/dla wielokulturowości. Casus Singapuru

Singapore brings together representatives of different cultures. Currently, 76% of the Singapore population is Chinese, 14% - Malay, 8% Hindu. All of them (with the rest 2%) have a possibility to participate in one of the best education models in the world. However, education and other political institutions are assessed in an ambivalent way. The article will address these controversies, including the Confucian thought of self-improvement and Peranakan Chinese as an example for the hypothesis.

Dochodzenie w drodze sądowej wynagrodzenia za szkody i straty, mogące wyniknąć dla obywateli polskich przy zastosowaniu i wykonaniu regulujących obrót ziemią dekretu, ustaw i rozporządzenia o reformie rolnej

Digitalizacja i deponowanie archiwalnych zeszytów RPEiS sfinansowane przez MNiSW w ramach realizacji umowy nr 541/P-DUN/2016

Identifying Genetic Risk Factors in Canine Autoimmune Disorders

Autoimmune diseases are more common in dogs than in humans and are already threatening the future of some highly predisposed dog breeds. Susceptibility to autoimmune diseases is controlled by environmental and genetic factors, especially the major histocompatibility complex (MHC) gene region. Dogs show a similar physiology, disease presentation and clinical response as humans, making them an excellent disease model for autoimmune diseases common to both species. The genetic background of canine autoimmune disorders is largely unknown, but recent annotation of the dog genome and subsequent development of new genomic tools offer a unique opportunity to map novel autoimmune genes in various breeds. Many autoimmune disorders show breed-specific enrichment, supporting a strong genetic background. Furthermore, the presence of hundreds of breeds as genetic isolates facilitates gene mapping in complex autoimmune disorders. Identification of novel predisposing genes establishes breeds as models and may reveal novel candidate genes for the corresponding human disorders. Genetic studies will eventually shed light on common biological functions and interactions between genes and the environment. This study aimed to identify genetic risk factors in various autoimmune disorders, including systemic lupus erythematosus (SLE)-related diseases, comprising immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis arteritis (SMRA) as well as Addison s disease (AD) in Nova Scotia Duck Tolling Retrievers (NSDTRs) and chronic superficial keratitis (CSK) in German Shepherd dogs (GSDs). We used two different approaches to identify genetic risk factors. Firstly, a candidate gene approach was applied to test the potential association of MHC class II, also known as a dog leukocyte antigen (DLA) in canine species. Secondly, a genome-wide association study (GWAS) was performed to identify novel risk loci for SLE-related disease and AD in NSDTRs. We identified DLA risk haplotypes for an IMRD subphenotype of SLE-related disease, AD and CSK, but not in SMRA, and show that the MHC class II gene region is a major genetic risk factor in canine autoimmune diseases. An elevated risk was found for IMRD in dogs that carried the DLA-DRB1*00601/DQA1*005011/DQB1*02001 haplotype (OR = 2.0, 99% CI = 1.03-3.95, p = 0.01) and for ANA-positive IMRD dogs (OR = 2.3, 99% CI = 1.07-5.04, p-value 0.007). We also found that DLA-DRB1*01502/DQA*00601/DQB1*02301 haplotype was significantly associated with AD in NSDTRs (OR = 2.1, CI = 1.0-4.4, P = 0.044) and the DLA-DRB1*01501/DQA1*00601/DQB1*00301 haplotype with the CSK in GSDs (OR=2.67, CI=1.17-6.44, p= 0.02). In addition, we found that homozygosity for the risk haplotype increases the risk for each disease phenotype and that an overall homozygosity for the DLA region predisposes to CSK and AD. Our results have enabled the development of genetic tests to improve breeding practices by avoiding the production of puppies homozygous for risk haplotypes. We also performed the first successful GWAS for a complex disease in dogs. With less than 100 cases and 100 controls, we identified five risk loci for SLE-related disease and AD and found strong candidate genes involved in a novel T-cell activation pathway. We show that an inbred dog population has fewer risk factors, but each of them has a stronger genetic risk. Ongoing studies aim to identify the causative mutations and bring new knowledge to help diagnostics, treatment and understanding of the aetiology of SLE-related diseases.

Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by phyllanthus emblica, a new immunomodulator

When administered orally, Phyllanthus emblica, an excellent source of vitamin C (ascorbate), has been found to enhance natural killer (NK) cell activity and antibody dependent cellular cytotoxicity (ADCC) in syngeneic BALB/c mice, bearing Dalton's lymphoma ascites (DLA) tumor. P. emblica elicited a 2-fold increase in splenic NK cell activity on day 3 post tumor inoculation. Enhanced activity was highly significant on days 3, 5, 7 and 9 after tumor inoculation with respect to the untreated tumor bearing control. A significant enhancement in ADCC was documented on days 3, 7, 9, 11 and 13 in drug treated mice as compared to the control. An increase in life span (ILS) of 35% was recorded in tumor bearing mice treated with P. emblica. This increased survival was completely abrogated when NK cell and killer (K) cell activities were depleted either by cyclophosphamide or anti-asialo-GM, antibody treatment. These results indicate: (a) an absolute requirement for a functional NK cell or K cell population in order that P. emblica can exert its effect on tumor bearing animals, and (b) the antitumor activity of P. emblica is mediated primarily through the ability of the drug to augment natural cell mediated cytotoxicity.

Thermodynamics of SmMnO3 and SmMn2O5 phases determined by the E.M.F. method

Streszczenie angielskie: Using solid oxide galvanic cells of the type: MnO + Sm2O3 + SmMnO3 / O-2/ Ni + NiO and Mn3O4 + SmMnO3 + SmMn2O5 / O-2 / air the equilibrium oxygen pressure for three-phase equilibria described by the following reactions of formation of ternary phases: MnO + 1/2Sm2O3 + 1/4O2 = SmMnO3 1/3Mn3O4 + SmMnO3 + 1/3O2 = SmMn2O5 was determined in the temperature range from 1173 to 1450 K. From the obtained experimental data the corresponding Gibbs free energy change for above reactions of phases formation was derived: ΔG0f,SmMnO3(+/ - 250J) = -131321(+/ - 2000) + 48.02(+/ - 0:35)T / K ΔG0f,SmMn2O5(+/ - 2000 J) = -107085(+/ - 2200) + 69.74(+/ - 1:70)T / K Using obtained results and available literature data, thermodynamic data tables for the two ternary phases have been compiled from 298.15 to 1400 K. Streszczenie polskie: W pracy przedstawiono wyniki badań dotyczące własności termodynamicznych manganinów samaru, wyznaczone metodą pomiaru SEM ogniw ze stałym elektrolitem: MnO + Sm2O3 + SmMnO3 / O-2/ Ni + NiO ogniwo I Mn3O4 + SmMnO3 + SmMn2O5 / O-2 / powietrze ogniwo II oraz określono równowagowe ciśnienie parcjalne tlenu dla reakcji tworzenia SmMnO3 i SmMn2O5 w zakresie temperatur 1173�1450 K: MnO + 1/2Sm2O3 + 1/4O2 = SmMnO3 1/3Mn3O4 + SmMnO3 + 1/3O2 = SmMn2O5 Z tych danych doświadczalnych wyznaczono zależności temperaturowe energii swobodnych tworzenia powyższych manganinów samaru: ΔG0f,SmMnO3(+/ - 250J) = -131321(+/ - 2000) + 48.02(+/ - 0:35)T / K ΔG0f,SmMn2O5(+/ - 2000 J) = -107085(+/ - 2200) + 69.74(+/ - 1:70)T / K W tablicach I i II zamieszczono dane termodynamiczne dla dwóch potrójnych faz otrzymane poprzez kompilacje własnych danych doświadczalnych z danymi literaturowymi.

Uninterrupted galvanic reaction for scalable and rapid synthesis of metallic and bimetallic sponges/dendrites as efficient catalysts for 4-nitrophenol reduction

Here, we demonstrate an uninterrupted galvanic replacement reaction (GRR) for the synthesis of metallic (Ag, Cu and Sn) and bimetallic (Cu M, M=Ag, Au, Pt and Pd) sponges/dendrites by sacrificing the low reduction potential metals (Mg in our case) in acidic medium. The acidic medium prevents the oxide formation on Mg surface and facilitates the uninterrupted reaction. The morphology of dendritic/spongy structures is controlled by the volume of acid used for this reaction. The growth mechanism of the spongy/dendritic microstructures is explained by diffusion-limited aggregate model (DLA), which is also largely affected by the volume of acid. The significance of this method is that the yield can be easily predicted, which is a major challenge for the commercialization of the products. Furthermore, the synthesis is complete in 1-2 minutes at room temperature. We show that the sponges/dendrites efficiently act as catalysts to reduce 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) using NaBH4-a widely studied conversion process.

Fractal Pattern Formation In Anodic Bonding Of Pyrex Glass/Al/Si

Anodic bonding of Pyrex glass/Al/Si is an important bonding technique in micro/nanoelectromechanical systems (MEMS/NEMS) industry. The anodic bonding of Pyrex 7740 glass/Aluminum film/Silicon is completed at the temperature from 300 degrees C to 375 degrees C with a bonding voltage between 150 V and 450 V. The fractal patterns are formed in the intermediate Al thin film. This pattern has the fractal dimension of the typical two-dimensional diffusion-limited aggregation (2D DLA) process, and the fractal dimension is around 1.7. The fractal patterns consist of Al and Si crystalline grains, and their occurrences are due to the limited diffusion, aggregation, and crystallization of Si and Al atoms in the intermediate Al layers. The formation of the fractal pattern is helpful to enhance the bonding strength between the Pyrex 7740 glass and the aluminum thin film coated on the crystal silicon substrates.

Repuesta al tratamiento súper ovulatorio, con folltropin V (Análogo sintético de la FSH), en hembras bovinas donantes, de las razas Pardo Suizo y Holsteins de la finca las mercedes de la Universidad Nacional Agraria, Managua

El presente trabajo investigativo se llevo a cabo en la finca Las Mercedes, propiedad de la Universidad Nacional Agraria ubicada en el Departamento de Managua, Nicaragua, en el Km 12.5 Carretera Norte. El objetivo del estudio fue determinar si hay influencia del factor raza en la repuesta súper ovulatoria en las hembras bovinas donantes de la> razas Holsteins y Pardo Suizo sometidas al tratamiento hormonal mediante la aplicación del Folltropin V (Análogo Sintético de la Hormona Foliculoestimulante FSH).El tamallo requerido de la muestra fue d 1 O hembras donantes para cada raza en estudio ;las cuales fueron previamente seleccionados según la calidad genética de cada hembra , la edad comprendida para la selección fue de entre 3 y 5 años además se realizaron exámenes clínicos y ginecológicos para determinar si cumplían con los requisitos o parámetros de salud para realizar esta técnica de mejoramiento productivo, los datos se obtuvieron mediante el conteo de cuerpos lúteos y folículos atravez de la palpación rectal de los ovarios ;el mismo dla en que realizo la recolecta de los embriones; los cuales fueron llevados al laboratorio para ser clasificados según su estado de desarrollo y calidad posteriormente fueron transferidos y congelados . Los resultados obtenidos atravez del análisis de la respuesta súper ovulatoria, indican que hay diferencia signicativa en cuanto al numero de cuerpos híteos en la raza Pardo Suizo ya que obtuvo un promedio de 9.2 cuerpo lúteos y la raza Holsteins obtuvo un promedio de 6.9 cuerpos lúteos . Por otra parte no hubo diferencia significativa en lo que respecta al número de embriones que tuvo un promedio de 3.8 cultivados en comparación con los 3. 7 embriones de la Raza Holsteins.