Developing Launching Processes ��� A Case Study

New product launches are becoming more and more important to companies around the globe. Being first on the market is a good place to be, and it will mostly likely bring the best profits. Gaining that desired position requires a lot of work where cooperation inside as well as outside of the company need to be in line. This thesis discusses launching processes in a pharmaceutical firm. The topic is looked at from supply chain management's point of view where purchasing department's role is emphasized. Additionally, launching strategies related to launches are investigated and the idea of internal alignment is introduced. Moreover, the topic is examined in project and process management perspective; how with the tools of project and process management the launching processes could be improved. The main findings reveal that there are many improvement points in the current launching process. Problems in the areas of information exchange, leadership and internal alignment were discovered yet trust and confidence for the better future compound the interviewees. This study presents what are the most important factors for a successful product launch and how the current processes could be streamlined.

Purchasing and supply management capabilities in Finnish medium-sized enterprises

Purchasing and supply management (PSM) has become increasingly important for companies to survive in current highly competitive market. Increased outsourcing has extended the role of PSM, making external resource management and supplier relationships critical success factors in business. However, the recent research has mainly concentrated on large enterprises. Therefore the PSM issues related to medium-sized enterprises represent a significant research area. The thesis aims to explore the status and role of PSM in Finnish medium-sized firms, understand how strategic companies consider PSM to be, clarify what are the competence requirements for PSM professionals, and increase the understanding of PSM capabilities needed from the points view of individual competence and organisational capabilities. The study uses data that was collected in 2007 from purchasing executives at the director/CEO level representing a sample of 94 Finnish firms. 54 % of the respondent enterprises had a supply strategy. The total supply cost was on average 60 % of firms' turnover. Centralisation of PSM and outsourcing of logistics will increase in Finnish medium-sized enterprises. The findings point out that Finnish medium-sized enterprises had strategical features of PSM. However, Finnish firms have not concentrated on making strategies that relate to PSM. The elements that explain the existence of a supply strategy could be found in this study. It can be concluded from this study that there is an advantageous base for the development of strategic PSM, because nearly all the enterprises were of the opinion that PSM capabilities have an effect on business success. When reviewing the organisational capabilities, the five most important development elements were supplier relationships, both operational and strategic processes, time management, and personnel's competence. Training in internationalisation, strategic management, and communication could help to improve competences of PSM personnel.

IEA Bioenergy Task 40 ���Sustainable International Bioenergy Trade: Securing supply and demand��� Country report of Finland 2008

This study considered the current situation of biofuels markets in Finland. The fact that industry consumes more than half of the total primary energy, widely applied combined heat and power production and a high share of solid biomass fuels in the total energy consumption are specific to the Finnish energy system. Wood is the most important source of bioenergy in Finland, representing 21% of the total energy consumption in 2006. Almost 80% of the wood-based energy is recovered from industrial by-products and residues. Finland has commitment itself to maintaining its greenhouse gas emissions at the 1990 level, at the highest, during the period 2008���2012. The energy and climate policy carried out in recent years has been based on the National Energy and Climate introduced in 2005. The Finnish energy policy aims to achieve the target, and a variety of measures are taken to promote the use of renewable energy sources and especially wood fuels. In 2007, the government started to prepare a new long-term (up to the year 2050) climate and energy strategy that will meet EU���s new targets for the reduction of green house gas emissions and the promotion of renewable energy sources. The new strategy will be introduced during 2008. The international biofuels trade has a substantial importance for the utilisation of bioenergy in Finland. In 2006, the total international trading of solid and liquid biofuels was approximately 64 PJ of which import was 61 PJ. Most of the import is indirect and takes place within the forest industry���s raw wood imports. In 2006, as much as 24% of wood energy was based on foreignorigin wood. Wood pellets and tall oil form the majority of export streams of biofuels. The indirect import of wood fuels increased almost 10% in 2004���2006, while the direct trade of solid and liquid biofuels has been almost constant.

Improving the effectiveness of supply chain development work ��� an expert role perspective

This study focuses to the intersection of three sets of activities in a company: expert work, development work and supply chain management, SCM. Experts and expert work represent a set of individuals whose efficiency and impact this study is intended to improve, while development work defines the set of organizational activities to focus on. SCM as an expertise area acts as the platform on which this study is built. The study has two aims. Firstly, it aims to derive a model helping an SCM expert to increase the effectiveness of expert work in development tasks by understanding the encountered organizational situations and processes better, reflecting his/her past and future actions to organizational processes and selecting and adjusting the processes and contents of his/her work accordingly. Secondly, it aims to develop applicable approaches and methods to understand, evaluate and manage the organizational processes and situations in development work. The integrative model on approaches and methods to improve the effectiveness of development processes is split to two aggregate dimensions: technical performance of the developed solution and consumption of resources of the development process. Six potential approaches and methods aiming at helping in the management of organizational dimensions are presented in enclosed publications. The approaches focus on three subtasks of development work: decision making, implementation and change, and knowledge accumulation. The approaches and methods have been tested in case studies representing typical development processes in the area of supply chain management. As a result, four suggestions are presented. Firstly, SCM experts are advised to consider the SCM development work to be consisting of development processes. Secondly, inside these processes they should identify and evaluate the risk of difficult decision-making related to organizational factors. Thirdly, they are prompted for an active role in implementation and change, supporting the implementation through whole process. Finally, the development should be seen in a holistic view, taking into account the stage of knowledge and organizational issues related to it, and adopt a knowledge development strategy.

Contract manufacturing networks structure and supply chain management

The usual objectives that companies have for subcontracting are studied in this thesis. The case company���s objectives for contract manufacturing now and in the future are identified. The main objective of the thesis is to create a focused model for the structure and supply chain management in the contract manufacturing network. This model is made for case company���s certain profit center. The different possibilities and their advantages and disadvantages for the structure and supply chain management are examined trough a theoretical review of literature. The possibilities found are then examined from the case company���s point of view. The case company point of view is established based on the opinions of the case company���s representatives. The outcome of the thesis is that the star shaped structure with supply chain management centralized to case company would be the best choice for the case company to manage the contract manufacture network.

Antimoniais empregados no tratamento da leishmaniose: estado da arte

Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.

Degree of hermeticity of a multicompartment compliance aid: Implications for the quality of professional pharmaceutical services

A multicompartment compliance aid (MCA) is a blister-type repackaging system that aims to facilitate drug administration and thereby increase patient adherence. One of the characteristics of the MCA that should be taken into account is the moisture permeability, since this atmospheric condition is one of the most important factors that can modify the stability of medicines. In the current paper we report the moisture permeability tests performed on a MCA according to the US Pharmacopeia. This information on the suitability of the device will help pharmacists implement a high-quality professional service.

The influence of substratum type and nutrient supply on biofilm organic matter utilization in streams

We investigated the effect of benthic substratum type (sand and rocks) and nutrient supply (N and P) on biofilm structure and heterotrophic metabolism in a field experiment in a forested Mediterranean stream (Fuirosos). Rock and sand colonization and biofilm formation was intensively studied for 44 d at two stream reaches: control and experimental (continuous addition of phosphate, ammonia, and nitrate). Structural (C, N, and polysaccharide content and bacterial and chlorophyll density) and metabolic biofilm parameters (b-glucosidase, peptidase, and phosphatase enzyme activities) were analyzed throughout the colonization process. The epilithic biofilm (grown on rocks) had a higher peptidase activity at the impacted reach, together with a higher algal and bacterial biomass. The positive relationship between the peptidase activity per cell and the N content of the epilithic biofilm suggested that heterotrophic utilization of proteinaceous compounds from within the biofilm was occurring. In contrast, nutrient addition caused the epipsammic biofilm (grown on sand) to exhibit lower b-glucosidase and phosphatase activities, without a significant increase in bacterial and algal biomass. The differential response to nutrient addition was related to different structural characteristics within each biofilm. The epipsammic biofilm had a constant and high C:N ratio (22.7) throughout the colonization. The epilithic biofilm had a higher C:N ratio at the beginning of the colonization (43.2) and evolved toward a more complex structure (high polysaccharide content and low C:N ratio) during later stages. The epipsammic biofilm was a site for the accumulation and degradation of organic matter: polysaccharides and organic phosphorus compounds had higher degradation activities

Converter Supply Transformer For LVDC Distribution System

This master���s thesis is focused on optimizing the parameters of a distribution transformer with respect to low voltage direct current (LVDC) distribution system. One of the main parts of low voltage direct current (LVDC) distribution system is transformer. It is studied from several viewpoints like filtering capabilities of harmonics caused by rectifier, losses and short circuit current limiting Determining available short circuit currents is one of the most important aspects of designing power distribution systems. Short circuits and their effects must be considered in selecting electrical equipment, circuit protection and other devices.

��lykk����t l����kkeenjakoratkaisut:Liiketoimintakonseptien nykytila

��lykk��ille l����kkeenjakoratkaisuille tulee luultavasti olemaan tulevaisuudessa suuri kysynt��, sill�� asiakasm����r��t ja julkisen terveydenhuollon resurssit eiv��t kohtaa toisiaan. S��ilytt����ksemme yhteiskuntamme terveydenhuollon tason kohtuullisilla kustannuksilla on ainoana mahdollisuutena alan uudet innovaatiot. ��lykk��ill�� l����kkeenjakoratkaisuilla tarkoitetaan ��lykk��it�� l����kepakkauksia tai muita l����kint����n liittyvi�� tuotteita tai palveluja, jotka mahdollistavat teknologisen edistyksellisyyden avulla ihmisty��m����r��n v��hent��misen terveydenhuollossa. Raportti esittelee tapaustutkimuksen alustavia tuloksia, joissa on tarkoituksena tuoda esille yleiskatsaus tuotteista ja asiakaseduista. Tuotteet on kuvattu niihin liittyvien liiketoimintamallinen tarjoomien avulla. Analyysi rakentuu liiketoimintamallin nelj��n peruspilarin mukaisesti, Tuote, Asiakassuhde, Rakenne, ja Talous, jotka m����ritt��v��t mallin asiakasarvon. L��ht��kohtana liiketoimintamallien mittaamisessa on nelj�� arvon p����mittaria: tekniset, taloudelliset, palvelulliset, ja sosiaaliset attribuutit. Esimerkin avulla voidaan huomata, ett�� tarjoamaa markkinoilla on vakiintumaton. Yksi malli painotti l����kkeiden annosjakelun tehokkuutta, toinen nautittujen l����kkeiden oton valvontaa ja kolmas yritti p��rj��t�� molemmissa. Suurimmat hy��dyt voidaan n��hd��, jos pystyt����n yhdist��m����n koneellinen jakelu ��lykk��isiin jakelulaitteisiin.

Tuote- ja tilaustietojen hallinta tukkukaupan toimitusketjussa

Ty��n tavoitteena on selvitt����, millaisia tuote-ja tilaustietojen hallinnan malleja tukkukaupan toimitusketjussa on k��yt��ss��. Kaupan alan tilaus-toimitusketju on hyvin tietointensiivinen prosessi, ja siksi kiinnostava tiedon hallinnan n��k��kulmasta. Ty��ss�� perehdyt����n kolmen Suomessa toimivan caseyrityksen k��yt��nt��ihin p��ivitt��istavara- kaupan, l����ketukkukaupan ja s��hk��tarviketukkukaupan alalta. Toimitusketjun keskipisteen�� on t��ss�� ty��ss�� tukkukaupan organisaatio. Tiedon v��lityst�� tarkastellaan tukkukaupan organisaation ja sen asiakkaiden v��lill�� (B2B) ja toisaalta tukkukaupan ja sen ensimm��isen tason p����miesten / tavarantoimittajien v��lill��. Tutkimuksen keskeist�� aineistoa ovat henkil��kohtaiset haastattelut. Lis��ksi tutkimuskysymyksiin etsittiin vastauksia my��s alan kirjallisuudesta. Ty�� antaa yleiskuvaa tukkukaupan organisaatioiden tuote- ja tilaustietojen hallinnan nykytilasta ja kehityskohteista. Ty�� tarjoaa my��s vertailupohjaa tuote- ja tilaustietojen hallinnan kehitt��mist�� suunnitteleville muille organisaatioille. Kaikilla tarkastelluilla toimialoilla tuote- ja tilaustietojen hallintaa ohjaa pyrkimys kustannustehokkaaseen toimintatapaan. Tuotetietojen hallinnassa ensiarvoisen t��rke���� on tuotetiedon nopea saatavuus, luotettavuus ja virheett��myys toimialasta riippumatta. P��ivitt��istavarakaupan tuotetietojen keskitetty�� hallintaa voi perustellusti esitt���� malliksi my��s muille kaupan aloille. Yhteisty��kumppaneiden suuri m����r�� ja kasvavat tietovirrat korostavat transaktioiden prosessoinnin merkityst�� toimitusketjussa.

Development and application of spectrophotometric method for the determination of cefaclor in pharmaceutical formulations

A simple, fast and sensitive spectrophotometric method for the determination of cefaclor in pharmaceutical raw and dosage forms based on reaction with ninhydrin is developed, optimized and validated. The purple color (Ruhemenn's purple) that resulted from the reaction was stabilized and measured at 560 nm. Beer's law is obeyed in the concentration range of 4-80 ��g mL-1 with molar absorptivity of 1.42 × 10(5) L mole-1 cm-1. All variables including the reagent concentration, heating time, reaction temperature, color stability period, and cefaclor/ninhydrin ratio were studied in order to optimize the reaction conditions. No interference was observed from common pharmaceutical adjuvant. The developed method is easy to use, accurate and highly cost-effective for routine studies relative to HPLC and other techniques.

Flow-injection spectrophotometric determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T as oxidizing agent

A flow-injection (FI) spectrophotometric procedure is proposed for tetracycline (TC) and doxycycline (DXC) determination in pharmaceuticals. The method is based on the reaction of oxidation of these drugs by chloramine-T in alkaline medium producing red color products (λmax = 535 and 525 nm). Beer��s law is obeyed in the concentration range from 6.62 x 10-5 to 7.72 x 10-4 mol L-1 and 5.37 x 10-5 to 7.16 x 10-4 mol L-1 for TC and DXC, respectively. The analytical frequency was 50 h"1 and 45 h-1 for TC and DXC, respectively. The results obtained by the proposed method were in good agreement with those obtained by the official method at 95% confidence level.

Losartan potassium dissolution test for drug release evaluation in pharmaceutical capsules using HPLC and UV spectrophotometry

This work describes the development and validation of a dissolution test for 50 mg losartan potassium capsules using HPLC and UV spectrophotometry. A 2(4) full factorial design was carried out to optimize dissolution conditions and potassium phosphate buffer, pH 6.8 as dissolution medium, basket as apparatus at the stirring speed of 50 rpm and time of 30 min were considered adequate. Both dissolution procedure and analytical methods were validated and a statistical analysis showed that there are no significant differences between HPLC and spectrophotometry. Since there is no official monograph, this dissolution test could be applied for quality control routine.

Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC

A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.