Snake venomics of the Siamese Russell's viper (Daboia russelli siamensis) - Relation to pharmacological activities

The venom proteome of Daboia russelli siamensis, a snake of medical importance in several Asian countries, was analysed by 2-D electrophoresis, subsequent MS/MS and enzymatic assays. The proteome comprises toxins from six protein families: serine proteinases, metalloproteinases, phospholipases A(2), L-amino acid oxidases, vascular endothelial growth factors and C-type lectin-like proteins. The venom toxin composition correlates with the clinical manifestation of the Russell's viper bite and explains pathological effects of the venom such as coagulopathy, oedema, hypotensive, necrotic and tissue damaging effects. The vast majority of toxins are potentially involved in coagulopathy and neurotoxic effects. The predominant venom components are proteinases capable of activating blood coagulation factors and promoting a rapid clotting of the blood, and neurotoxic phospholipase A(2)s. The analysis of the venom protein composition provides a catalogue of secreted toxins. The proteome of D. r. siamensis exhibits a lower level of toxin diversity than the proteomes of other viperid snakes. In comparison to the venoms of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis, the venom from D. r. siamensis showed quantitative differences in the proteolytic, phospholipase A2, L-amino acid oxidase and alkaline phosphatase activities. (c) 2009 Published by Elsevier B.V.

O modelo keynesiano de James Meade

Este artigo reavalia o modelo simplificado da Teoria Geral de Keynes elaborado por James Meade e procura complementar alguns dos argumentos teóricos que Meade deixou apenas indicados. O artigo também responde às solicitações de Frisch a Meade, quanto à explicação do significado de estabilidade e à explicitação dos pressupostos que garantem suas conclusões. Além disso, apresenta alguns dos cálculos não desenvolvidos por Meade, e, quando necessário, suas devidas correções.

The interaction between vitamin K nutriture and warfarin administration in patients with bacterial overgrowth due to atrophic gastritis

Atrophic gastritis patients have intestinal bacterial overgrowth which could produce menaquinones. The aim of this study was to evaluate the interaction between a diet low in phylloquinone and minidoses of warfarin in subjects with and without bacterial overgrowth. Subjects with atrophic gastritis (indicated by serum pepsinogen ratio) and healthy volunteers were studied while fed a restrictive phylloquinone diet and while receiving a minidose of warfarin. Coagulation times, serum osteocalcin, serum undercarboxylated osteocalcin, plasma phylloquinone, plasma K-epoxide, plasma undercarboxylated prothrombin (PIVKA)-II and urinary gamma-carboxyglutamic acid (Gla) were measured. At baseline, there were no differences between groups for any variable measured. Comparisons between baseline and post intervention in both groups, showed significant increases in circulating levels of K-epoxide, PIVKA II and undercarboxylated osteocalcin. However, no differences were observed when comparisons were made between groups. Our data do not support the hypothesis that bacterial synthesis of menaquinones in patients with bacterial overgrowth due to atrophic gastritis confers considerable resistance to the effect of warfarin.

Tourism and environment case study of Fort James Dickenson Bay, Antigua

Includes bibliography

Diálogos entre literatura e cinema: um estudo sobre The Dead de James Joyce

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A República Federativa ampliada versus democracia popular: o contributo de James Madison para a formação do sistema republicano norte-americano

Pós-graduação em História - FCHS

Espaço e focalização em The ambassadors, de Henry James

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Propriedades e aspectos geométricos de estimadores tipo James-Stein e do estimador de Hartigan

The James-Stein estimator is a biased shrinkage estimator with uniformly smaller risk than the risk of the sample mean estimator for the mean of multivariate normal distribution, except in the one-dimensional or two-dimensional cases. In this work we have used more heuristic arguments and intensified the geometric treatment of the theory of James-Stein estimator. New type James-Stein shrinking estimators are proposed and the Mahalanobis metric used to address the James-Stein estimator. . To evaluate the performance of the estimator proposed, in relation to the sample mean estimator, we used the computer simulation by the Monte Carlo method by calculating the mean square error. The result indicates that the new estimator has better performance relative to the sample mean estimator.

A articulação das culturas humanísticas e científica por meio do estudo histórico-sociocultural dos trabalhos de James Prescott Joule: contribuições para a formação de professores universitários em uma perspectiva transformadora

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

O discurso da crítica literária universitária: sobre James Joyce e Ulysses

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

James Buchanan e a construção do consenso social

Este artigo pretende apresentar, de modo preliminar, uma exposição da teoria de James Buchanan sobre os temas relacionados a ação coletiva e as regras do processo decisorio no âmbito do Estado.

Quando gestos não políticos são políticos: a tradução brasileira de Giovanni's Room, de James Baldwin, e a questão da homossexualidade

This work is part of a research project on the role of translations of African-American literature in Brazil and their relation to issues of identity, discourse and aesthetics. It analyzes the translation, by Affonso Blacheyre, of Giovanni's room (1956), by James Baldwin, which was published in 1967 in Brazil. Baldwin is revered for his role in the Civil Rights Movement, having produced works that portray the contradictions of a democratic, but, at the same time, racist society. Giovanni's room was first rejected by his publisher for addressing homosexuality. The text displayed on the book flaps of the translation praises Baldwin's "work with language", in contrast to his anti-racism in other works. The praise of aesthetics of Giovanni's room is noteworthy, in contrast with the absence of any remarks on its critique of the marginalization of homosexuality. The focus on the aesthetics of the work corresponded to characters speaking a more formal register in the translation. Discourses on identity strengthening were less apparent in the 60s in Brazil in comparison to nowadays. The emphasis on aesthetics represented a seemingly "non-political" gesture that made it less shocking in the context of military dictatorship prevalent in the country at the time.

As concepções de função de Frege e Russell: um estudo de caso em filosofia e história da matemática

Pós-graduação em Educação Matemática - IGCE

A produção técnico-científica de James Precott Joule: uma leitura a partir da epistemologia de Ludwig Fleck

This paper aims an epistemologically analysis of the attempt of James Prescott Joule to replace the steam engine by the electric one. In this historical analysis, we use the epistemological categories: style of thinking, collective thinking, intercollective circulation of ideas and practices,Joule and other technicians in Machester received in that time financial incentives from governments and industry to replace the steam engine by the electric one, since it was in Manchester a culture of the technique of the accuracy and precision in which Joule was immersed, which allowed us to initially identify the styles of techniques thinking and experimental efficiency. However, Joule could not replace the steam engine by the electric; and the awareness of the problems faced by him, in the attempt to make such a substitution, led him to seek, through an intercollective circulation of ideas and practices, such as the studies of Faraday and Jacobi, a change of direction in his researches. According to our analysis, what happened was a change of style from a technical to a scientific thinking. In this sense, Joule began to investigate issues of a scientific nature, as the Joule’s effect and the mechanical equivalent of heat, which contributed significantly to the establishment of the principle of conservation of energy. We present here the contributions of this epistemological analysis to the discussion of questions of the nature of science in the basic education and for the training of physics teachers.