Characterization of cytotoxic ribonucleases: from the internalization pathway to the importance of dimeric structures

En aquesta tesi s'ha caracteritzat la ruta d'internalització de l'onconasa, una RNasa citotòxica. Els resultats indiquen que l'onconasa entra a les cèl·lules per la via dependent de clatrina i del complex AP-2. Seguidament es dirigeix als endosomes de reciclatge i es a través d'aquesta ruta que la proteïna exerceix la citotoxicitat. Per altra banda, els resultats d'aquest treball demostren que PE5, una variant citotòxica de la ribonucleasa pancreàtica humana (HP-RNasa), interacciona amb la importina  mitjançant diferents residus que tot i que no són seqüencials, es troben propers en l'estructura tridimensional d'aquesta proteïna. PM8 és una HP-RNasa amb estructura cristal·logràfica dimèrica constituïda per intercanvi de dominis N-terminals. En aquesta tesi s'han establert les condicions per estabilitzar aquest dimer en solució i també es proposa un mecanisme per la dimerització.

The Importance of Relationships for the Produced Knowledge in the Sector of Management Consulting

While the management consulting industry has been largely linked to the knowledge produced within the disciplines of strategic management in the academic field, the truth is that very little literature is produced in terms of research in this area, while the researchers focused more on a set of static techniques to be applied in the development of this field of research concerns. This article seeks to bridge this gap as well, showing by example that the consultancy sector is a true field of opportunities for the study of relationships management. This presentation is thus the aim of contributing both theoretically and empirically in the area of relationships through research in the context of management consulting, trying to visualize how the relationships are manifested in a context of high involvement and personal contact, and what’s the perception that must be taken into consideration by clients and consultants in terms of the benefits of their greater or lesser degree of involvement.

The Importance of Relationships for the Produced Knowledge in the Sector of Management Consulting

While the management consulting industry has been largely linked to the knowledge produced within the disciplines of strategic management in the academic field, the truth is that very little literature is produced in terms of research in this area, while the researchers focused more on a set of static techniques to be applied in the development of this field of research concerns. This article seeks to bridge this gap as well, showing by example that the consultancy sector is a true field of opportunities for the study of relationships management. This presentation is thus the aim of contributing both theoretically and empirically in the area of relationships through research in the context of management consulting, trying to visualize how the relationships are manifested in a context of high involvement and personal contact, and what’s the perception that must be taken into consideration by clients and consultants in terms of the benefits of their greater or lesser degree of involvement.

The importance of local museums in Portugal

The widening of the notion of heritage and the consequent redefinition of the “museological object”, the idea of community participation in the definition and management of the museological practice, museology as a development factor, the issues of interdisciplinarity, the use of “new technologies” of information and museography as an autonomous communications means, are examples of issues resulting from contemporary museological practices. If indeed museology in Portugal intends to continue to participate in international museology’s renovation process, it is evident that it must adequately (re)think theoretical and practical museology so as to meet the new demands…

The importance of direct language instruction for hearing impaired children

This paper discusses the importance of direct and intense language instruction for hearing impaired children in developing language and communication skills. The author presents a variety of activities for teacher use.

The importance of parental involvement in language acquisition and activities and techniques to enhance the home-school connection

This study discusses the importance of parental involvement in children’s language development, and the related project offers parents books and activities to assist them in developing their children’s linguistic skills.

A review of research on working memory and its importance in education of the deaf

This independent study provides an overview of working memory as it pertains to deaf and hard of hearing students.

The importance of addressing stress in parents of hearing impaired children

The focus of this study was to provide a summary of the existing literature concerning parental stress. The goal of highlighting factors that contribute to increased stress levels and the effects of stress on parents and children was to provide deaf educators with an understanding of parental stress and insight into the need for programs that minimize stress.

Banking Union: Ireland vs. Nevada, an illustration of the importance of an integrated banking system. CEPS Commentary, 18 October 2012

Despite their surprising similarities – in size and their housing booms – Ireland and the American state of Nevada sharply parted company when it came to who bore responsibility for bailing out their failed banks when the booms turned to bust. This latest Commentary by Daniel Gros vividly illustrates the importance of that difference and thus the shock-absorbing capacity of an integrated banking system and a banking union.

The Importance of Agriculture-Dominated Landscapes and Lack of Field Border Effect for Early-Succession Songbird Nest Success

In recent decades, many early-succession songbird species have experienced severe and widespread declines, which often are related to habitat destruction. Field borders create additional or enhance existing early-succession habitat on farmland. However, field border shape and the landscape context surrounding farms may influence the effectiveness of field borders in contributing to the stabilization or increase of early-succession bird populations. We examined the influence of linear and nonlinear field borders on farms in landscapes dominated by either agriculture or forests on nest success and Brown-headed Cowbird (Molothrus ater) brood parasitism of Indigo Bunting (Passerina cyanea) and Blue Grosbeak (Passerina caerulea) nests combined. Field border establishment did not affect nest survival probability and brood parasitism frequency of Indigo Bunting and Blue Grosbeak nests. Indigo Bunting/Blue Grosbeak nest success probability was more than twice as high in agriculture-dominated landscapes (39%) than in forested landscapes (17%), and brood parasitism frequency was high (33%) but did not differ between landscapes. Edges in agriculture-dominated landscapes can be higher-quality habitats for early-succession birds than edges in forest-dominated landscapes, but our field border treatments did not enhance nest success for these birds on farms in either landscape.