Proof of Concept of Impact Detection in Composites Using Fiber Bragg Grating Arrays

Impact detection in aeronautical structures allows predicting their future reliability and performance. An impact can produce microscopic fissures that could evolve into fractures or even the total collapse of the structure, so it is important to know the location and severity of each impact. For this purpose, optical fibers with Bragg gratings are used to analyze each impact and the vibrations generated by them. In this paper it is proven that optical fibers with Bragg gratings can be used to detect impacts, and also that a high-frequency interrogator is necessary to collect valuable information about the impacts. The use of two interrogators constitutes the main novelty of this paper.

Inter- and intramolecular enantioselective carbolithiation reactions

In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (-)-sparteine, to promote facial selection on a C=C bond. This is an attractive approach for the construction of new carbon-carbon bonds in an asymmetric fashion, with the possibility of introducing further functionalization on the molecule by trapping the reactive organolithium intermediates with electrophiles.

Carta enviada por Juan Alcorta Maiz a Justo Garate en 1981

1 carta (mecanografiada) ; 210x274 mm. Ubicación: Caja 1 - Carpeta 19

Carta enviada por Vicente Amezaga a Justo Garate en 1943

1 carta (manuscrita) ; 210x274mm. Ubicación: Caja 1 - Carpeta 28

A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report

Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are molecularly classified according to the abnormal prion protein (PrPSc) conformations along with polymorphism of codon 129 of the PRNP gene. Recently, a novel human disease, termed "protease-sensitive prionopathy", has been described. This disease shows a distinct clinical and neuropathological phenotype and it is associated to an abnormal prion protein more sensitive to protease digestion. Case presentation: We report the case of a 75-year-old-man who developed a clinical course and presented pathologic lesions compatible with sporadic Creutzfeldt-Jakob disease, and biochemical findings reminiscent of "protease-sensitive prionopathy". Neuropathological examinations revealed spongiform change mainly affecting the cerebral cortex, putamen/globus pallidus and thalamus, accompanied by mild astrocytosis and microgliosis, with slight involvement of the cerebellum. Confluent vacuoles were absent. Diffuse synaptic PrP deposits in these regions were largely removed following proteinase treatment. PrP deposition, as revealed with 3F4 and 1E4 antibodies, was markedly sensitive to pre-treatment with proteinase K. Molecular analysis of PrPSc showed an abnormal prion protein more sensitive to proteinase K digestion, with a five-band pattern of 28, 24, 21, 19, and 16 kDa, and three aglycosylated isoforms of 19, 16 and 6 kDa. This PrPSc was estimated to be 80% susceptible to digestion while the pathogenic prion protein associated with classical forms of sporadic Creutzfeldt-Jakob disease were only 2% (type VV2) and 23% (type MM1) susceptible. No mutations in the PRNP gene were found and genotype for codon 129 was heterozygous methionine/valine. Conclusions: A novel form of human disease with abnormal prion protein sensitive to protease and MV at codon 129 was described. Although clinical signs were compatible with sporadic Creutzfeldt-Jakob disease, the molecular subtype with the abnormal prion protein isoforms showing enhanced protease sensitivity was reminiscent of the "protease-sensitive prionopathy". It remains to be established whether the differences found between the latter and this case are due to the polymorphism at codon 129. Different degrees of proteinase K susceptibility were easily determined with the chemical polymer detection system which could help to detect proteinase-susceptible pathologic prion protein in diseases other than the classical ones.

The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers

Background: The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (polymorphism Val158 Met) as a risk factor for Alzheimer's disease (AD) and mild cognitive impairment of amnesic type (MCI), and its synergistic effect with the apolipoprotein E gene (APOE). A total of 223 MCI patients, 345 AD and 253 healthy controls were analyzed. Clinical criteria and neuropsychological tests were used to establish diagnostic groups. The DNA Bank of the University of the Basque Country (UPV-EHU) (Spain) determined COMT Val158 Met and APOE genotypes using real time polymerase chain reaction (rtPCR) and polymerase chain reaction (PCR), and restriction fragment length polymorphism (RFLPs), respectively. Multinomial logistic regression models were used to determine the risk of AD and MCI. Results: Neither COMT alleles nor genotypes were independent risk factors for AD or MCI. The high activity genotypes (GG and AG) showed a synergistic effect with APOE epsilon 4 allele, increasing the risk of AD (OR = 5.96, 95% CI 2.74-12.94, p < 0.001 and OR = 6.71, 95% CI 3.36-13.41, p < 0.001 respectivily). In AD patients this effect was greater in women. In MCI patients such as synergistic effect was only found between AG and APOE epsilon 4 allele (OR = 3.21 95% CI 1.56-6.63, p = 0.02) and was greater in men (OR = 5.88 95% CI 1.69-20.42, p < 0.01). Conclusion: COMT (Val158 Met) polymorphism is not an independent risk factor for AD or MCI, but shows a synergistic effect with APOE epsilon 4 allele that proves greater in women with AD.

Cogeneración de procesos en el desarrollo de una práctica escultórica

96 p. : il.

^(18)O/^(16)O and D/H studies on the interactions between heated meteoric ground waters and igneous intrusions: Western San Juan Mountains, Colorado and the Isle of Skye, Scotland

Detailed oxygen, hydrogen and carbon isotope studies have been carried out on igneous and metamorphic rocks of the Stony Mountain complex, Colorado, and the Isle of Skye, Scotland, in order to better understand the problems of hydrothermal meteoric water-rock interaction.

The Tertiary Stony Mountain stock (~1.3 km in diameter), is composed of an outer diorite, a main mass of biotite gabbro, and an inner diorite. The entire complex and most of the surrounding country rocks have experienced various degrees of ¹⁸O depletion (up to 10 per mil) due to interaction with heated meteoric waters. The inner diorite apparently formed from a low-¹⁸O magma with δ¹⁸O ≃ +2.5, but most of the isotopic effects are a result of exchange between H₂O and solidified igneous rocks. The low-¹⁸O inner diorite magma was probably produced by massive assimilation and/or melting of hydrothermally altered country rocks. The δ¹⁸O values of the rocks generally increase with increasing grain size, except that quartz typically has δ¹⁸O = +6 to +8, and is more resistant to hydrothermal exchange than any other mineral studied. Based on atom % oxygen, the outer diorites, gabbros, and volcanic rocks exhibit integrated water/rock ratios of 0.3 ± 0.2, 0.15 ± 0.1, and 0.2 ± 0.1, respectively. Locally, water/rock ratios attain values greater than 1.0. Hydrogen isotopic analyses of sericites, chlorites, biotites, and amphiboles range from -117 to -150. δD in biotites varies inversely with Fe/Fe+Mg, as predicted by Suzuoki and Epstein (1974), and positively with elevation, over a range of 600 m. The calculated δD of the mid-to-late-Tertiary meteoric waters is about -100. Carbonate δ¹³C values average -5.5 (PDB), within the generally accepted range for deep-seated carbon.

Almost all the rocks within 4 km of the central Tertiary intrusive complex of Skye are depleted in ¹⁸O. Whole-rock δ¹⁸O values of basalts (-7. 1 to +8.4), Mesozoic shales (-0.6 to + 12.4), and Precambrian sandstones (-6.2 to + 10.8) systematically decrease inward towards the center of the complex. The Cuillin gabbro may have formed from a ¹⁸O-depleted magma (depleted by about 2 per mil); δ¹⁸O of plagioclase (-7.1 to + 2.5) and pyroxene (-0.5 to + 3.2) decrease outward toward the margins of the pluton. The Red Hills epigranite plutons have δ¹⁸O quartz (-2.7 to + 7.6) and feldspar (-6.7 to + 6.0) that suggest about 3/4 of the exchange took place at subsolidus temperatures; profound disequilibrium quartz-feldspar fractionations (up to 12) are characteristic. The early epigranites were intruded as low-¹⁸O melts (depletions of up to 3 per mil) with δ¹⁸O of the primary, igneous quartz decreasing progressively with time. The Southern Porphyritic Epigranite was apparently intruded as a low-¹⁸O magma with δ¹⁸O ≃ -2.6. A good correlation exists between grain size and δ¹⁸O for the unique, high-¹⁸O Beinn an Dubhaich granite which intrudes limestone having a δ¹⁸O range of +0.5 to +20.8, and δ¹³C of -4.9 to -1.0. The δD values of sericites (-104 to -107), and amphiboles, chlorites, and biotites (-105 to -128) from the igneous rocks , indicate that Eocene surface waters at Skye had δD ≃ -90. The average water/rock ratio for the Skye hydrothermal system is approximately one; at least 2000 km³ of heated meteoric waters were cycled through these rocks.

Thus these detailed isotopic studies of two widely separated areas indicate that (1) ¹⁸O-depleted magmas are commonly produced in volcanic terranes invaded by epizonal intrusions; (2) most of the ¹⁸O-depletion in such areas are a result of subsolidus exchange (particularly of feldspars); however correlation of δ¹⁸O with grain size is generally preserved only for systems that have undergone relatively minor meteoric hydrothermal exchange; (3) feldspar and calcite are the minerals mos t susceptible to oxygen isotopic exchange, whereas quartz is very resistant to oxygen isotope exchange; biotite, magnetite, and pyroxene have intermediate susceptibilities; and (4) basaltic country rocks are much more permeable to the hydrothermal convective system than shale, sandstone, or the crystalline basement complex.

Tarjetas de Navidad enviadas por Vicente Botella Altube a Justo Garate entre 1981 y 1990

2 postales de Navidad (manuscritas) ; entre 140x110mm y 210x160mm

Ganadores del certamen literario de Ciencia Ficción Alberto Magno 2007-2010

La traición de Judas (Joaquín Revuelta Candón, 15ª edición 2003: 1er Premio). - Lemmings (Ignacio Sanz Vallas, 15ª edición 2003: 2º Premio) - Mar de Titanes (José Manuel González Rodríguez, 15ª edición 2003: Premio UPV). - No habrá vergüenza en mi derrota (Juan Luis López Aranguren, 16ª edición 2004: 1er Premio). - Sobre los inmortales (Ezequiel Dellutri, 16ª edición 2004: 2º Premio). - Tximeleta mezularia (Gotzone Barandika, 16ª edición 2004: Premio UPV). - Argos (José Antonio Cotrina Gómez, 17ª edición 2005: 1er Premio). - Las lágrimas de Caín (Juan Luis López Aranguren, 17ª edición 2005: 2º Premio). - Las dudas de Job (José Manuel González Rodríguez, 17ª edición 2005: Premio UPV). - Una larga descendencia (Santiago García Albás, 18ª edición 2006: 1er Premio). - La apuesta faustiana (Vladimir Hernández Pacín, 18ª edición 2006: 2º Premio)

Kasu eta komunztaduraren gainean

Eccentric agreement (Ken Hale). - Datibo sintagmen izaera sintaktikoaren inguruan: eztabaidarako oinarrizko zenbait datu (Pablo Albizu). - Person and number inflection in Basque (Karlos Arregi). - The role of verbal agreement in licensing null arguments (Arantzazu Elordieta). - On the position of verbal agreement markets (Andrés Enrique Arias). - Absolutibo komunztaduradun ergatiboak, absolutibo komunztaduradun datiboak: ergatiboaren lekualdatzetik datiboaren lekualdatzera (Beatriz Fernández). - Objektu-komunztadura XIX eta XX. Mendeetako euskal gramatiketan. Ricardo Gómez. - The German present participle (Martin Haiden). - A brief description of some agreement restrictions (Javier Ormazabal & Juan Romero).

X Seminario sobre Aspectos Jurídicos de la Gestión Universitaria

Índice: Bloque I (coordinadora: María Isabel Bonachera Ledro): - A. Evolución histórica del doctorado (Daniel Pastor Javaloyes). - B. Análisis de las principales novedades del RD 99/2011, de 28 de enero, por el que se regulan las enseñanzas oficiales de Doctorado (Araceli García Sánchez). - C. Análisis de la adaptación normativa en materia de estudios de Doctorado llevada a cabo por las universidades tras el Real Decreto 99/2011, de 28 de enero (Amaya Rosa Ruiz-Alejos). - D. Las escuelas de Doctorado. Nueva estructura de soporte de los estudios de doctorado (María Isabel Bonachera Ledro). - E. Aproximación a la organización de los estudios de Doctorado en el entorno EEES (Manuel Fabián Martín-Arroyo). - Anexo I. Reglamento de régimen interno de la Escuela de Doctorado de la Universidad de Cantabria (EDUC). Bloque II. Educación y formación superior: puntos de encuentro (coordinadora: Ana I. Caro Muñoz): - 1. Encuadre normativo de la correspondencia de enseñanzas: educación superior, formación profesional y enseñanzas artísticas superiores (Elena de la Fuente García). - 2. Convergencias en la consecución del EEES, el EEI y el Proceso de Copenhague (José Plana Plana). - 3. Realidades y perspectivas de los entornos de formación superior (Juan Cayón Peña). - 4. Análisis de una experiencia: universidad privada y formación profesional (Fernando Lostao Crespo). - 5. Diseño y evaluación de competencias: definición, clasificación y perfiles competenciales (David Martínez Victorio). - 6. Envejecimiento activo: educación a lo largo de la vida (Ana I. Caro Muñoz). Bloque III. La gestión de recursos humanos en las universidades y sus implicaciones jurídicas (coordinador: Fernando Palencia Herrejón): - Introducción (Fernando Palencia Herrejón). - 1. Incidencia de los Decretos leyes 20/2011 y 3/2012 en la gestión de personal de las universidades (Beatriz Vozmediano Ares). - 2. Tres aspectos de la aplicación del EBEP a las universidades (Elena Martínez Nieto). - 3. El régimen jurídico del personal directivo profesional (Juan Eduardo González González). - 4. Sobre la negociación colectiva (María de Rivera Parga). 5. La evaluación del desempeño (Jesús Lobato de Ruiloba). 6. El desarrollo legislativo del EBEP en las Comunidades Autónomas (M.ª Mercedes Sánchez Castillo). Bloque IV. Propiedad intelectual e industrial: desafíos (coordinador: Emiliano Garmendia Ferrer): - 1. Propiedad intelectual, propiedad industrial, conocimiento y su protección: - 1.1. Notas sobre la propiedad intelectual, la propiedad industrial, el conocimiento científico y su protección (Emiliano Garmendia Ferrer). - 1.2. Normativa específica de protección de determinadas invenciones (Elena Meaños Melón). - 1.3. La gestión colectiva en el sector del libro: entidades de gestión colectiva de derechos de autor y las universidades (Miguel Ángel Davara F. de Marcos). - 2. Algunas producciones en el ámbito universitario: - 2.1. La actividad del Personal de Administración y Servicios: programas de ordenador y bases de datos (Soledad Béthencourt Zamora). - 2.2. Tesis Doctorales y Propiedad Intelectual (Isabel-Cecilia del Castillo). - 3. Ejemplos a partir de las nuevas tecnologías: - 3.1. El e-book. Implicaciones jurídicas para las universidades de un nuevo modelo de aprendizaje (Soledad Béthencourt Zamora). - 3.2. La difusión de obras de la propiedad intelectual» Susana Martínez Fernández). - 4. Los Agentes de la creación del conocimiento en la Universidad: - 4.1. Los agentes universitarios de la creación del conocimiento (Elena Meaños Melón). - 4.2. La incidencia de la Ley de Economía Sostenible y de la Ley de la Ciencia en el tratamiento de autor en las universidades públicas (Jerónimo D. Reynés Vives). - 5. La transferencia de los resultados de la investigación: - 5.1. El tratamiento de la transferencia en las Leyes de Economía Sostenible y de la Ciencia (Carlos A. Gómez Otero). - 5.2. La transferencia inversa (Javier Such Martínez). - 5.3. Naturaleza jurídica de los negocios relativos a la propiedad intelectual e industrial. La problemática de los sistemas de adjudicación al amparo de la Ley de Economía Sostenible y de la Ley de la Ciencia, la Tecnología y la Innovación (Carlos A. Gómez Otero). - 5.4. La valorización y gestión de la transferencia. El caso UNIVALUE (Jerónimo D. Reynés Vives). - Ponencia final: La reforma laboral de 2012. RDL 3/2012, de 10 de febrero, de medidas urgentes para la reforma del mercado laboral (Garbiñe Biurrun Mancisidor). - Comunicación: El nuevo marco normativo de las prácticas académicas externas de los estudiantes universitarios (Josep Moreno Gené).

El pintor navarro Juan Ochoa de Arín (1600-1652) y su producción en Gipuzkoa

Investigación realizada dentro del Programa de Formación y Perfeccionamiento de Personal Investigador del Gobierno Vasco (2010-2013).

Juan Antonio de Zamacola: vida, obra y concepción esteticomusical

Tesis doctoral originalmente defendida en la Universidad de Deusto el 29-09-2000