La Economía del Cuidado en la Agenda de la Cooperación Internacional para el Desarrollo. Estudio de caso: Las políticas de los cuidados en América Latina. Una aproximación a Panamá y Uruguay.

El cuidado es una actividad indispensable en todos los hogares para la reproducción social y el bienestar en la vida diaria de las personas. La economía del cuidado hace referencia al espacio de actividades, bienes y servicios necesarios para la reproducción cotidiana de los individuos, siendo de suma importancia para el desarrollo económico de los países y el bienestar de sus poblaciones. Sin embargo, sigue siendo subvalorada por las sociedades y gobiernos de todo el mundo. El trabajo de cuidados o doméstico remunerado alcanza índices bajísimos de salarios mínimos, precarias condiciones laborales o se realiza desde la economía informal. El trabajo doméstico no remunerado es concebido por la sociedad como improductivo y vinculado a la mujer por razones de habilidades naturales de clara concepción machista. El resultado es la marginación de la mujer en las sociedades que la impide o le resta posibilidades de acceder a formación, empleo digno, ser parte de la esfera pública e incluso al sufragio.

Mètode Llisterri : Cada alumne és un món i cada món té el seu propi context

L'objecte d'aquest projecte es troba en l'aplicació d'un mètode que, atenent a les característiques individuals dels alumnes de la forma el més acurada possible i des d'una perspectiva constructivista, permeti establir uns horaris d'estudi personalitzats que mostrin a l'estudiant el temps que ha de dedicar a cada assignatura, el seu ordre i la seva durada per sessió.

Cellular delivery of pyrenyl-arene ruthenium complexes by a water-soluble arene ruthenium metalla-cage.

Three pyrenyl-arene ruthenium complexes (M(1)-M(3)) of the general formula [Ru(η(6)-arene-pyrenyl)Cl(2)(pta)] (pta = 1,3,5-triaza-7-phosphaadamantane) have been synthesised and characterised. Prior to the coordination to ruthenium, pyrene was connected to the arene ligand via an alkane chain containing different functional groups: ester (L(1)), ether (L(2)) and amide (L(3)), respectively. Furthermore, the pyrenyl moieties of the M(n) complexes were encapsulated within the hydrophobic cavity of the water soluble metalla-cage, [Ru(6)(η(6)-p-cymene)(6)(tpt)(2)(donq)(3)](6+) (tpt = 2,4,6-tri-(pyridin-4-yl)-1,3,5-triazine; donq = 5,8-dioxydo-1,4-naphthoquinonato), while the arene ruthenium end was pointing out of the cage, thus giving rise to the corresponding host-guest systems [M(n)⊂Ru(6)(η(6)-p-cymene)(6)(tpt)(2)(donq)(3)](6+) ([M(n)⊂cage](6+)). The antitumor activity of the pyrenyl-arene ruthenium complexes (M(n)) and the corresponding host-guest systems [M(n)⊂cage][CF(3)SO(3)](6) were evaluated in vitro in different types of human cancer cell lines (A549, A2780, A2780cisR, Me300 and HeLa). Complex M(2), which contains an ether group within the alkane chain, demonstrated at least a 10 times higher cytotoxicity than the reference compound [Ru(η(6)-p-cymene)Cl(2)(pta)] (RAPTA-C). All host-guest systems [M(n)⊂cage](6+) showed good anticancer activity with IC(50) values ranging from 2 to 8 μM after 72 h exposure. The fluorescence of the pyrenyl moiety allowed the monitoring of the cellular uptake and revealed an increase of uptake by a factor two of the M(2) complex when encapsulated in the metalla-cage [Ru(6)(η(6)-p-cymene)(6)(tpt)(2)(donq)(3)](6+).

Somatostatin Subtype‑2 Receptor-Targeted Metal-Based Anticancer Complexes

Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η6-bip)Os(4-CO2-pico)Cl] (bip = biphenyl, pico = picolinate) (4), [(η6-p-cym)RuCl(dap)]+ (p-cym = p-cymene) (5), and [(η6-p-cym)RuCl(imidazole-CO2H)(PPh3)]+ (6), were synthesized by using a solid-phase approach. Conjugates 35 readily underwent hydrolysis and DNA binding, whereas conjugate 6 was inert to ligand substitution. NMR spectroscopy and molecular dynamics calculations showed that conjugate formation does not perturb the overall peptide structure. Only 6 exhibited antiproliferative activity in human tumor cells (IC50 = 63 ± 2 μM in MCF-7 cells and IC50 = 26 ± 3 μM in DU-145 cells) with active participation of somatostatin receptors in cellular uptake. Similar cytotoxic activity was found in a normal cell line (IC50 = 45 ± 2.6 μM in CHO cells), which can be attributed to a similar level of expression of somatostatin subtype-2 receptor. These studies provide new insights into the effect of receptor-binding peptide conjugation on the activity of metal-based anticancer drugs, and demonstrate the potential of such hybrid compounds to target tumor cells specifically.

Estudi sociològic del lleure al món rural de Catalunya i Guatemala. L'oci a la població de 50 a 70 anys de Malla i San Juan la Laguna, semblances i diferències

L’estudi que es presenta a continuació té l’objectiu de comprendre quina és la realitat ociosa de les persones de 50 a 70 anys als municipis de Malla (Catalunya, Espanya) i de San Juan la Laguna (Sololá, Guatemala) des de la perspectiva humanista en termes de concepció i pràctica, i veure quina és la influència i la força que prenen les característiques de la societat en la qual es desenvolupa. Per tal de dur-ho a terme, primerament s’ha realitzat un procés d’aproximació respecte el concepte de l’oci, i una recerca concreta vers l’oci humanista. A partir d’aquí, s’ha fet l’estudi amb una mostra formada per deu persones del municipi de Malla i deu membres de San Juan la Laguna que es troben entre els 50 i 70 anys, i amb unes condicions econòmiques i uns estils de vida diferents. Per tal de realitzar la recerca i l’anàlisi de l’oci humanista en els contexts de Malla i San Juan la Laguna s’ha emprat una metodologia qualitativa, i s’ha utilitzat l’instrument corresponent a l’entrevista. Aquesta ha estat elaborada prenent com a marc de referència la metodologia de la Grounded Theory (Glaser y Strauss, 1967). El projecte també compte amb una vessant d’etnografia. Els resultats que s’han obtingut demostren que hi ha una presència significativa de l’oci humanista en els contexts analitzats, però que en el cas de San Juan la Laguna aquest esdevé un element en construcció.

Les percepcions sensorials, un mitjà per conèixer el món

Vivim en un món desbordat de sons, olors, imatges,.. que sovint adquirei-xen transparència en els ulls dels adults, no obstant durant la infància es posseeix una mirada molt oberta del món, però el dia a dia, les rutines i convencionalismes redueixen les percepcions que es reben de l’entorn. Tre-ballar i fer ús dels sentits desperta i situa a l’infant en posició de ser partícip del món que l’envolta i ajuda a la comprensió i expressió de tot allò que sent i percep. Mitjançant la metodologia de l’experimentació i l’art és possi-ble el desenvolupament de les percepcions sensorials, a través de les quals la ment comença a construir les seves pròpies idees del món. La sensibilitat en la manera de percebre la realitat permet obtenir noves perspectives, així com maneres d’expressar i comunicar, de forma creativa, tot allò que es percep.

Influence of the diketonato ligand on the cytotoxicities of [Ru(eta(6)-p-cymene)-(R(2)acac)(PTA)](+) complexes (PTA=1,3,5-triaza-7-phosphaadamantane)

A series of compounds of general formula [Ru(eta(6)-p-cymene) (R(2)acac)(PTA)][X] (R(2)acac = Me(2)acac, tBu(2)acac, Ph(2)acac, Me(2)acac-Cl; PTA = 1,3,5-triaza-7-phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac-Cl derivative [Ru(eta(6)-p-cymene)(Me(2)acac-Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X-ray crystallography. The tetrafluoroborate salts are water-soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence.

La Necròpolis protohistòrica de Milmanda (Vimbodí, Conca de Barberà, Tarragona) : un exemple del món funerari català durant el trànsit entre els segles VII i VI aC

La necròpolis protohistòrica de Milmanda (Vimbodí, Conca de Barberà, Tarragonès). Un exemple del món funerari català durant el trànsit entre els segles VII i VI aC és una monografia que documenta els materials que es van trobar en aquest jaciment i els posa en el context del món funerari del període ibèric antic a Catalunya.

MN 716: nova cultivar de cevada com estabilidade de produção e qualidade cervejeira

A cevada MN 716, lançada em 2004, é uma das cultivares recomendadas para cultivo com maior estabilidade de produção. Nos anos em que participou do ensaio para determinação de seu valor de cultivo e uso, apresentou excelente produtividade de grãos, com média superior a 3.000 kg ha-1, e desempenho equilibrado quanto à qualidade, com destaque para seu teor de beta-glucanas e índice enzimático. A cultivar constitui um avanço do melhoramento desse cereal no Brasil, aliando características de interesse do produtor e da indústria.

Soluble MHC-peptide complexes: tools for the monitoring of T cell responses in clinical trials and basic research.

Soluble MHC-peptide complexes, commonly known as tetramers, allow the detection and isolation of antigen-specific T cells. Although other types of soluble MHC-peptide complexes have been introduced, the most commonly used MHC class I staining reagents are those originally described by Altman and Davis. As these reagents have become an essential tool for T cell analysis, it is important to have a large repertoire of such reagents to cover a broad range of applications in cancer research and clinical trials. Our tetramer collection currently comprises 228 human and 60 mouse tetramers and new reagents are continuously being added. For the MHC II tetramers, the list currently contains 21 human (HLA-DR, DQ and DP) and 5 mouse (I-A(b)) tetramers. Quantitative enumeration of antigen-specific T cells by tetramer staining, especially at low frequencies, critically depends on the quality of the tetramers and on the staining procedures. For conclusive longitudinal monitoring, standardized reagents and analysis protocols need to be used. This is especially true for the monitoring of antigen-specific CD4+ T cells, as there are large variations in the quality of MHC II tetramers and staining conditions. This commentary provides an overview of our tetramer collection and indications on how tetramers should be used to obtain optimal results.

IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia.

IL-7, a member of the common gamma-chain family of cytokines, is essential for B and T lymphocyte development and homeostasis of mature T cell subsets. Thus, naive and memory T cells are both dependent on IL-7 for survival and homeostatic proliferation under lymphopenic conditions. In line with prior findings with IL-2, we show in this study that the biological activity of IL-7 in vivo is greatly increased by association with anti-IL-7 mAb. Under in vivo conditions, IL-7/mAb complexes displayed 50- to 100-fold higher activity than free IL-7 and induced massive expansion of pre-B cells. IL-7/mAb complexes also increased thymopoiesis in normal mice and restored thymopoeisis in IL-7-deficient mice. For mature T cells, IL-7/mAb complexes induced marked homeostatic proliferation of both naive and memory CD4(+) and CD8(+) cell subsets even under normal T cell-replete conditions. Finally, IL-7/mAb complexes were able to enhance the magnitude of the primary response of Ag-specific naive CD8(+) cells. The strong stimulatory activity of IL-7/mAb complexes could be useful for treatment of immunodeficiency and cancer.

Anévrismes complexes de l'aorte abdominale: la chirurgie ouverte est-elle obsolète [The complex aortic abdominal aneurysm: is open surgery old fashion?].

Open surgery is still the main treatment of complex abdominal aortic aneurysm. Nevertheless, this approach is associated with major complications and high mortality rate. Therefore the fenestrated endograft has been used to treat the juxtarenal aneurysms. Unfortunately, no randomised controlled study is available to assess the efficacy of such devices. Moreover, the costs are still prohibitive to generalise this approach. Alternative treatments such as chimney or sandwich technique are being evaluated in order to avoid theses disadvantages. The aim of this paper is to present the endovascular approach to treat juxtarenal aneurysm and to emphasize that this option should be used only by highly specialized vascular centres.

Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes.

We have determined high-resolution crystal structures of the complexes of HLA-A2 molecules with two modified immunodominant peptides from the melanoma tumor-associated protein Melan-A/Melanoma Ag recognized by T cells-1. The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), are modified in the second residue to increase their affinity for HLA-A2. The modified decamer is more immunogenic than the natural peptide and a candidate for peptide-based melanoma immunotherapy. The crystal structures at 1.8 and 2.15 A resolution define the differences in binding modes of the modified peptides, including different clusters of water molecules that appear to stabilize the peptide-HLA interaction. The structures suggest both how the wild-type peptides would bind and how three categories of cytotoxic T lymphocytes with differing fine specificity might recognize the two peptides.

Structures of ethylenediaminetetraacetato (3-) metal complexes. I complexes with Co, Mg and Cd metals

(I): Hexaaquacobalt(II) aqua[ethylenediaminetetraacetato(3-)]cobaltate(II) dihydrate, [Co(H2O)6][Co(C10H13N2O8)(H2O)]2.2H2O (Ibis): Hexaaquamagnesium(II) aqua[ethylenediaminetetraacetato(3-)]magnesiate(II) dihydrate, [Mg(H2O)6][Mg(C10H13N2O8)(H2O)]2.2H2O (II):Tetraaquabis{aqua[ethylenediaminetetraacetato(3-)]cadmium(II)-O-O'}Cadmium(II) tetrahydrate