Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients

PURPOSE: To investigate the impact of alcohol intoxication and withdrawal on the course of social phobia and panic disorder. METHOD: A group of 41 alcoholic inpatients undergoing detoxification therapy were interviewed using the SCID-I (DSM-IV) and questions to detect fluctuations in the course of social phobia and panic disorder as a function of the different phases in alcohol dependence (intoxication, withdrawal, and lucid interval). RESULTS: Only 1 (2.4%) patient presented panic disorder throughout life, and 9 (21.9%) had panic attacks during alcohol intoxication or during the withdrawal syndrome. Sixteen (39%) alcoholic patients showed social phobia with onset prior to drug use. However, drinking eventually became unable to alleviate social phobia symptoms or worsened such symptoms in 31.2% of social-phobic patients. While patients with social phobia reported a significant improvement in psychiatric symptoms during alcohol intoxication, patients experiencing panic attacks worsened significantly during intoxication. In the withdrawal phase, patients with social phobia tended to have more and more intense phobic symptoms. CONCLUSION: Our findings indicate that the impact of alcohol intoxication is different for social phobia as compared to panic disorder, at first decreasing the social-phobic symptoms but later aggravating them. In panic disorder, the impact of intoxication by alcohol is more harmful, at least in the short term.

Socio-demographic correlates of physical activity of European adults: A cross-sectional study from the European Social Survey

ABSTRACT - Background: From a public health perspective, the study of socio-demographic factors related to physical activity is important in order to identify subgroups for intervention programs. Purpose: This study also aimed to identify the prevalence and the socio-demographic correlates related with the achievement of recommended physical activity levels. Methods: Using data from the European Social Survey round 6, physical activity and socio-demographic characteristics were collected from 39278 European adults (18271 men, 21006 women), aged 18-64 years, from 28 countries in 2012. Meeting physical activity guidelines was assessed using World Health Organization criteria. Results: 64.50% (63.36% men, 66.49% women) attained physical activity recommended levels. The likelihood of attaining physical activity recommendations was higher in age group of 55-64 years (men: OR=1.22, p<0.05; women: OR=1.66, p<0.001), among those who had completed high school (men: OR=1.28, p<0.01; women: OR=1.26, p<0.05), among those who lived in rural areas (men: OR=1.20, p<0.001; women: OR=1.10, p<0.05), and among those who had 3 or more people living at home (men: OR=1.40, p<0.001; women: OR=1.43, p<0.001). On the other hand, attaining physical activity recommendations was negatively associated with being unemployed (men: OR=0.70, p<0.001; women: OR=0.87, p<0.05), being a student (men: OR=0.56, p<0.001; women: OR=0.64, p<0.01), being a retired person (men: OR=0.86, p<0.05) and with having a higher household income (OR=0.80, p<0.001; women: OR=0.81, p<0.01). Conclusion: This research helped clarify that, as the promotion of physical activity is critical to sustain health and prevent disease, socio-demographic factors are important to consider when planning the increase of physical activity.

Design of bio-inspired ionic liquids for protein stabilisation

Ionic Liquids (ILs) consist in organic salts that are liquid at/or near room temperature. Since ILs are entirely composed of ions, the formation of ion pairs is expected to be one essential feature for describing solvation in ILs. In recent years, protein - ionic liquid (P-IL) interactions have been the subject of intensive studies mainly because of their capability to promote folding/unfolding of proteins. However, the ion pairs and their lifetimes in ILs in P-IL thematic is dismissed, since the action of ILs is therefore the result of a subtle equilibrium between anion-cation interaction, ion-solvent and ion-protein interaction. The work developed in this thesis innovates in this thematic, once the design of ILs for protein stabilisation was bio-inspired in the high concentration of organic charged metabolites found in cell milieu. Although this perception is overlooked, those combined concentrations have been estimated to be ~300 mM among the macromolecules at concentrations exceeding 300 g/L (macromolecular crowding) and transient ion-pair can naturally occur with a potential specific biological role. Hence the main objective of this work is to develop new bio-ILs with a detectable ion-pair and understand its effects on protein structure and stability, under crowding environment, using advanced NMR techniques and calorimetric techniques. The choline-glutamate ([Ch][Glu]) IL was synthesized and characterized. The ion-pair was detected in water solutions using mainly the selective NOE NMR technique. Through the same technique, it was possible to detect a similar ion-pair promotion under synthetic and natural crowding environments. Using NMR spectroscopy (protein diffusion, HSQC experiments, and hydrogen-deuterium exchange) and differential scanning calorimetry (DSC), the model protein GB1 (production and purification in isotopic enrichment media) it was studied in the presence of [Ch][Glu] under macromolecular crowding conditions (PEG, BSA, lysozyme). Under dilute condition, it is possible to assert that the [Ch][Glu] induces a preferential hydration by weak and non-specific interactions, which leads to a significant stabilisation. On the other hand, under crowding environment, the [Ch][Glu] ion pair is promoted, destabilising the protein by favourable weak hydrophobic interactions , which disrupt the hydration layer of the protein. However, this capability can mitigates the effect of protein crowders. Overall, this work explored the ion-pair existence and its consequences on proteins in conditions similar to cell milieu. In this way, the charged metabolites found in cell can be understood as key for protein stabilisation.

A indústria de defesa na cooperação Brasil-Portugal

The global dynamics of alliances are strongly determined by the level of cooperation among states. This cooperation can be embodied in various aspects, but the level of defense and security cooperation becomes usually more doctrinal and lasting. By the nature of sovereignty that instills in the bilateral relationship, cooperation at defense and security level can leverages other forms of cooperation. The circumstances and relational balance between Brazil and Portugal seem to evolve towards distancing opportunities, despite they are culturally and institutionally untainted. The economic dynamics, the strategic projection in global sustainability terms, the scale and ambition of Brazilian regional leadership, contrasts with the actual context of Portugal, distancing himself both on the stage where they operate. On the other hand, the historical and cultural roots, the language, the affinity of the peoples of CPLP and some opportunities for economic niches, trend to attract both countries. The condition of Portugal in NATO and Europe, coupled with the ability to export technical and human resources to value-added for Brazil, seems also to become approaching factors. On the balance of these dynamics, there is a set of exogenous factors (economic, external global relations matrix, regional stability, among others), which are not always controlled by any of both countries. These factors call for strong capacity for foresight analysis and decision making, with the inherent risk. There is cooperation vectors that are not apparently penalized by geographic distance, or by the difference of realities. Among these vectors we shall highlight synergies in technological niches, highly tradable goods and, mostly, using the domain of dual technologies. The thirteen niches herein identified are: Monitoring, Navigation, Command and Control, Electronics, Optoelectronics, Communication and remote sensing, Information Technologies, Flight Simulation, Specialized Training, Fiber Optic Sensors, Materials Engineering, Nanotechnology and Communications. Cumulating with identified opportunities in traditional relational framework, both countries are growing (in geography and economic terms) into the Atlantic, making it a central element in the bilateral approach. By being at the same time a growing stage of disputes and which stability tends to be threatened, it will be done an analysis of these synergistic vectors, superimposed on the impact on Atlantic securitization process.

Contribuição ao conhecimento dos Odonatos da Estação Ecológica de Maracá - Roraima.

Estudou-se a fauna odonatológica da Estação Ecológica de Maracá, no Estado de Roraima, com base em material coletado nas matas e campos de sua parte oriental. Foram coletadas 61 espécies das quais 3 são novas para a ciência (Epipleoneura, Leptobasisa. Lestes) e serão descritas em outro trabalho e 8 constituem novos registros para a fauna brasileira (Aeolagrion demerarum, Argia pulla, Hetaerina mortua, Hetaerina westfalli, Meta leptobasis manicaria., Neoneura denticulata, Neoneura gaida, Protoneura amatoria). Verificou-se que as espécies de grande distribuição geográfica, geralmente mais comuns, pre-dominam nas áreas de savana, enquanto nas matas predominam as de distribuição geográfica mats restrita. Os resultados ressaltam a grande semelhança que existe entre a fauna de Maracá e a da Venezuela.

Palhetas simples: técnicas de manutenção para aplicação na interpretação e pedagogia do clarinete

Relatório de estágio de mestrado em Ensino da Música

Estratégias pedagógicas na aprendizagem da emissão de som no clarinete: respiração, material e metodologias de estudo

Relatório de estágio de mestrado em Ensino de Música

On the occurrence of cyanolipids In Paullinia carpopodea cambess And P. cupana Kunth seed oils

Paullinia carpopodea seed oil contains 70% type Icyanolipids with cyanogenetic properties, as proven by chemical and spectrometric techniques. P. cupana seed oil also contains cyanogenic type I cyanolipids, according to its 1Ή-NMR spectrum. The existing controversy in the literature about the presence and/or type of cyanolipids in P. cupana seed oil is probably due to the low amount of these compounds (0.2%) in the seeds.

Ocorrência de dois citotipos em Serrasalmus spilopleura Kner, 1858 (characiformes, serrasalmidae) da região de confluência dos Rios Negro e Solimões, Amazonas, Brasil

Descreve-se pela primeira vez o cariótipo de exemplares de S. spilopleura da Amazônia Central. Todos os indivíduos analisados apresentaram número diplóide igual a 60 cromossomos, em conformidade com os dados da espécie obtidos em indivíduos da bacia do Paraná-Paraguai. No entanto, dois citótipos foram encontrados em simpatria na região de confluência dos rios Negro e Solimões, os quais não estão relacionados a heteromorfismo sexual. Além disso, os dois citótipos da Amazônia diferem dos três anteriormente descritos em exemplares do Paraná-Paraguai. A presença de distintos citótipos encontrados em simpatria e alopatria para S. spilopleura nos leva a sugerir que, ou essa espécie apresenta uma ampla heterogeneidade cariotípica ou existe um complexo de espécies cuja morfologia é muito semelhante.

Compêndio do clarinete: um contributo para a sistematização dos recursos técnicos e expressivos no nível secundário do ensino vocacional

Relatório de estágio de mestrado em Ensino da Música

Os processos criativos na aprendizagem da técnica do violoncelo no ensino vocacional de música

Relatório de estágio de mestrado em Ensino de Música

Indicadores de "Hidricidade" como ferramenta de avaliação da eficiência urbana

One of the biggest challenges for urban space planners is to conciliate the indispensable demands of life with the forms of occupation of the territory. Among these demands is water. Population growth and urban sprawl are challenging water availability. Thus, it is important to evaluate development trends to predict future scenarios, enabling guide preventive actions and decision making. It is essential to have a practical and direct tool that allows us to transmit the necessary information. The objective of this study is to present a method for evaluating the urban efficiency in the process of city expansion and the availability of water supply. To do so, the indicators will be defined, called indicators of "hidricidade". As a result, it is expected to be obtained a direct and practical tool, that is going to allow to transmit the necessary information to the harmonic urban process planning, applicable to medium size Brazilian cities, allowing decision making as a guarantee of water supply and urban sprawl.

Ocorrência de Hylettus seniculus (Germar,1824) (Coleoptera: Cerambycidae), em pomares cítricos de Roraima, Brasil, e alternativas de controle

A produção citrícola no estado de Roraima é limitada por alguns fatores, dentre os quais as pragas ocupam destaque especial. Nos últimos anos uma nova praga vem causando danos em vários pomares no Estado. Este trabalho objetivou identificar esta nova praga bem como descrever os principais sintomas e danos, visando a correta recomendação para o seu controle. Ramos e troncos infestados com o inseto, oriundos de vários pomares foram coletados e colocados em gaiolas teladas. Após a emergência, os espécimes foram mortos e acondicionados em frascos contendo álcool a 70% e conduzidos para o Centro de Identificação de Insetos Fitófagos da UFPR, Curitiba-PR, para a identificação. O inseto foi identificado como Hylettus seniculus (Germar,1824)(Coleoptera:Cerambycidae),até então não citado como espécie de importância econômica para a citricultura de Roraima. Atribuiu-se sua ocorrência ao manejo fitossanitário inadequado dos pomares de citros; plantios velhos e abandonados; e a existência de hospedeiros florestais. Fatores estes considerados como favoráveis à proliferação e disseminação do inseto nos pomares.

Implementation and comparison of different switching techniques for shunt active power filters

This paper presents a comparison between three switching techniques that can be used in three-phase four-wire Shunt Active Power Filters (SAPFs). The implemented switching techniques are: Periodic-Sampling (PS), Triangular Carrier Pulse-Width Modulation (TC-PWM) and Space Vector PWM (SVPWM). The comparison between them is made in terms of the compensated currents THD%, implementation complexity, necessary CPU time and SAPF efficiency. To perform this comparison are presented and analyzed several experimental results, obtained with a 20 kVA Shunt Active Power Filter prototype, specially developed for this purpose. The control system of the developed SAPF is based in the p-q Theory with a grid synchronization algorithm p-PLL.