Safety and Efficacy of Oral Fexofenadine in Children with Seasonal Allergic Rhinitis - a Pooled Analysis of Three Studies

Allergic rhinitis is one of the most common clinical conditions in children; however, data regarding the safety of antihistamines in children with seasonal allergic rhinitis are limiting. To evaluate the safety and efficacy of fexofenadine in children with seasonal allergic rhinitis, data were pooled from three, double-blind, randomized, placebo-controlled, parallel-group, 2-week trials in children (6-11 year) with seasonal allergic rhinitis. All studies assessed fexofenadine HCl 30 mg b.i.d.; two studies included fexofenadine HCl at 15 and 60 mg b.i.d. Patients (and investigators) reported any adverse events during the trial. Physical examinations, including measurements of vital signs and laboratory tests, were performed. Efficacy assessments (total symptom score and individual symptom scores) were evaluated. Exposure to fexofenadine HCl 30 mg b.i.d. and to any fexofenadine dose exceeded 10,000 and 17,000 patient days, respectively. Incidences of adverse events, and discontinuations because of adverse events, were low and similar across treatment groups. In the placebo group, 24.4% of subjects reported adverse events compared with 24.1% for fexofenadine HCl 30 mg b.i.d., and 28.4% for all fexofenadine-treated groups. The most common adverse event overall was headache (4.3% placebo; 5.8% fexofenadine HCl 30 mg b.i.d.; and 7.2% any fexofenadine doses). Treatment-related adverse events were similar across treatment groups with no sedative effects. Fexofenadine HCl 30 mg b.i.d. was significantly superior to placebo in reducing the total symptom score and all individual seasonal allergic rhinitis symptoms, including nasal congestion (p < 0.05). Fexofenadine, at doses of up to 60 mg b.i.d., is safe and non-sedating, and fexofenadine HCl 30 mg b.i.d. effectively reduces all seasonal allergic rhinitis symptoms in children aged 6-11 years.

DOCUMENT CONTROL OF NATIONAL MAPPING AND METRIC STUDIES CHARACTERIZING NATIONAL IDENTITY AND INDIVIDUAL. I STAGE

This is a project of the School of Library, Documentation and Information of the National University, is performed to support the initiative of UNESCO to build the Memory of the World (UNESCO, 1995) and to help provide universal access to documentation. To this end, the School of Library Science students has promoted the realization of final graduation work on documentary control of domestic production. This project has the following objectives:Objectives1. Conduct mapping national documentary through the identification, analysis, organization and access to documentary heritage of Costa Rica, to contribute to the Memory of the World.2. Perform bibliometric analysis of documentary records contained in the integrated databases.This project seeks to bring undergraduate students graduating from the school, in making final graduation work on document control. Students have the opportunity to make final graduation work on the documentary production of Costa Rica on a specific theme or on a country's geographical area.Desk audits aimed at identifying the document using access points and indicate its contents to allow recovery by the user.The result is the production of a new document, other than the original, a secondary document: the bibliography. The records in the database each control documentation completed work will be integrated into a single database to be placed on the website of EBDI, for consultation of researchers and interested users.

User Studies Literature Review

User studies are a method of measurement that had been used in libraries for many years typically include user studies library circulation. These studies used are those that usually are associated with this term. However, user studies are not as simple as user studies of movement, has a broader meaning depending on what you want to evaluate.

A Visual Analytics Approach to Comparing Cohorts of Event Sequences

Sequences of timestamped events are currently being generated across nearly every domain of data analytics, from e-commerce web logging to electronic health records used by doctors and medical researchers. Every day, this data type is reviewed by humans who apply statistical tests, hoping to learn everything they can about how these processes work, why they break, and how they can be improved upon. To further uncover how these processes work the way they do, researchers often compare two groups, or cohorts, of event sequences to find the differences and similarities between outcomes and processes. With temporal event sequence data, this task is complex because of the variety of ways single events and sequences of events can differ between the two cohorts of records: the structure of the event sequences (e.g., event order, co-occurring events, or frequencies of events), the attributes about the events and records (e.g., gender of a patient), or metrics about the timestamps themselves (e.g., duration of an event). Running statistical tests to cover all these cases and determining which results are significant becomes cumbersome. Current visual analytics tools for comparing groups of event sequences emphasize a purely statistical or purely visual approach for comparison. Visual analytics tools leverage humans' ability to easily see patterns and anomalies that they were not expecting, but is limited by uncertainty in findings. Statistical tools emphasize finding significant differences in the data, but often requires researchers have a concrete question and doesn't facilitate more general exploration of the data. Combining visual analytics tools with statistical methods leverages the benefits of both approaches for quicker and easier insight discovery. Integrating statistics into a visualization tool presents many challenges on the frontend (e.g., displaying the results of many different metrics concisely) and in the backend (e.g., scalability challenges with running various metrics on multi-dimensional data at once). I begin by exploring the problem of comparing cohorts of event sequences and understanding the questions that analysts commonly ask in this task. From there, I demonstrate that combining automated statistics with an interactive user interface amplifies the benefits of both types of tools, thereby enabling analysts to conduct quicker and easier data exploration, hypothesis generation, and insight discovery. The direct contributions of this dissertation are: (1) a taxonomy of metrics for comparing cohorts of temporal event sequences, (2) a statistical framework for exploratory data analysis with a method I refer to as high-volume hypothesis testing (HVHT), (3) a family of visualizations and guidelines for interaction techniques that are useful for understanding and parsing the results, and (4) a user study, five long-term case studies, and five short-term case studies which demonstrate the utility and impact of these methods in various domains: four in the medical domain, one in web log analysis, two in education, and one each in social networks, sports analytics, and security. My dissertation contributes an understanding of how cohorts of temporal event sequences are commonly compared and the difficulties associated with applying and parsing the results of these metrics. It also contributes a set of visualizations, algorithms, and design guidelines for balancing automated statistics with user-driven analysis to guide users to significant, distinguishing features between cohorts. This work opens avenues for future research in comparing two or more groups of temporal event sequences, opening traditional machine learning and data mining techniques to user interaction, and extending the principles found in this dissertation to data types beyond temporal event sequences.

The impact of event sponsorship on children’s brand image and purchase intentions: The mediator effects of product involvement and brand familiarity

Field lab in marketing: Children consumer behaviour

Propuesta de Enseñanza-aprendizaje en Estudios Sociales para el Quinto año de Educación Básica de la escuela “Alfonso María Borrero”, año lectivo 2014-2015

El trabajo de investigación se basa en una propuesta de enseñanza-aprendizaje en Estudios Sociales basado en actividades con enfoque pedagógico crítico y constructivista aplicado en el desarrollo del tercer bloque del Quinto Año EGB, durante el periodo Lectivo 2014-2015 de la Escuela “Alfonso María Borrero.” La Educación Tradicional basada en el conductismo que se fundamenta en el uso del libro escolar y la memorización persiste en las Escuelas pese al esfuerzo del Ministerio de Educación por cambiar estas prácticas, por lo que esta propuesta busca probar que la práctica pedagógica y didáctica desde enfoques alternativos es factible pese a presiones de tiempo o exigencia en la presentación de calificaciones. Metodológicamente, se realizó un diagnóstico en el que se observaron las prácticas tradicionales; luego se organizaron dos grupos de trabajo, el primero en el que se aplicó la propuesta y el segundo que continuó con la labor normal; finalmente, se analizaron los resultados. Estos demostraron que las actividades de una propuesta constructivista y crítica alternativa a la tradicional pueden ser cumplidas en los tiempos establecidos y que los resultados académicos son mejores.

Estrategias educativas para potenciar aprendizajes significativos en Estudios Sociales de la Educación Básica Media.

En la presente investigación se desarrollan estrategias que faciliten un aprendizaje significativo en la asignatura de Estudios Sociales de la Educación Básica Media, tomando en cuenta que el proceso educativo está fundamentado en la utilización de metodologías con un memorismo mecánico, el cual no ha permitido desarrollar en los estudiantes las destrezas necesarias para enfrentar otros campos del aprendizaje. Para este trabajo se realizó una recopilación, revisión y análisis de fuentes bibliográficas, como libros físicos y digitales, artículos científicos y páginas web, relacionadas con la temática presentada, obteniendo como resultado el conocimiento y sistematización de estrategias que faciliten la construcción de aprendizajes significativos en la asignatura de Estudios Sociales.

Articulación de la gestión de riesgo a la ordenación territorial; caso de la provincia del Azuay

Este trabajo está enfocado al planteamiento y propuesta del modelo a considerar pretende abordar desde la periferia de la provincia del Azuay hacia su centro cantonal, buscando obtener un modelo mucho más cercano a una realidad general y las formas de actuación desde aquellos centros carentes de recursos hasta el mayor centro generador de los mismos. Se ha empezado abordando la problemática general de los riesgos que afectan en todo sentido a los seres humanos, que permitan definir sobre cuales se podrían actuar en la zona de estudio, para esto se determinó conceptualizaciones de territorio y riesgos como: caracterización de los fenómenos de riesgo en el Azuay en una perspectiva histórica; con énfasis en acontecimientos de magnitud en los últimos 25 años, definición de las tipologías de riesgos y conceptualizaciones de la Ordenación Territorial, para establecer la interrelación de conceptos y acciones que permita entender a la innovación como la capacidad de introducir nuevos métodos que apunten a mejorar las condiciones de competitividad del territorio, estudiando los posibles instrumentos de aplicación y la relación intrínseca con la administración pública. Finalmente se estableció un diagnóstico general de la provincia que permitió centrarse en tres fenómenos de riesgos: las fallas geológicas, las inundaciones y deslizamientos de masa, que se han convertido en los principales factores de afección. Con el marco teórico definido y el diagnostico establecido fue posible que en base a varios estudios preliminares en América Latina y Europa sobre situaciones de riesgos similares; se realice un planteamiento para enfrentar las situaciones de peligro de la Provincia, las alternativas de soluciones, de mitigaciones y prevención, que sumado a la gestión administrativa local y regional, permita establecer mecanismos estratégicos aplicables en las fases de la Ordenación Territorial. La propuesta plantea entre sus más importantes resultados: la administración responsable, ámbito temporal de validez de las acciones, establece modelos de ocupación inmediata de zonas seguras y ocupación diferida de áreas con riesgo aceptable, que hacen posible enfrentar estos fenómenos naturales y disminuir las pérdidas de vidas humanas.

A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis

Objective: Our objective was to systematically review the published observational research related to the role of oxidative-nitrosative stress in pathogenesis of dengue. Methods: We searched electronic databases (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO, LILACS via Virtual Health Library, Google Scholar) using the term: dengue, dengue virus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants, free radicals, oxidized lipid products, lipid peroxides, nitric oxide, and nitric oxide synthase. Articles were selected for review by title and abstract excluding letter, review, in vivo and in vitro studies, and duplicates studies. Selected articles were reviewed for study design, original purposes, sample size, main outcomes, methods, and oxidative-nitrosative stress markers values. Results: In total, 4,331 non-duplicates articles were identified from electronic databases searches, of which 16 were eligible for full text searching. Data from the observational studies originate from Asian countries (50%; 8/16), South American countries (31.2%; 5/16), and Central America and the Caribbean countries (18.8%; 3/16). Casecontrol study was the type of design most common in researches reviewed. The 1997 World Health Organization (WHO) dengue case classification criteria were used in all studies included in this review. Conclusions: Based on published data found in peer-reviewed literature, oxidative and nitrosative stress are demonstrated by changes in plasma levels of nitric oxide, antioxidants, lipid peroxidation and protein oxidation markers in patients with dengue infection. Additionally, elevated serum protein carbonyls and malondialdehyde levels appear to be associated with dengue disease severity.

Weaknesses in the reporting of cross-sectional studies according to the STROBE statement: the case of metabolic syndrome in adults from Peru

Introduction: The inadequate reporting of cross-sectional studies, as in the case of the prevalence of metabolic syndrome, could cause problems in the synthesis of new evidence and lead to errors in the formulation of public policies. Objective: To evaluate the reporting quality of the articles regarding metabolic syndrome prevalence in Peruvian adults using the STROBE recommendations. Methods: We conducted a thorough literature search with the terms "Metabolic Syndrome", "Sindrome Metabolico" and "Peru" in MEDLINE/PubMed, LILACS, SciELO, LIPECS and BVS-Peru until December 2014. We selected those who were populationbased observational studies with randomized sampling that reported prevalence of metabolic syndrome in adults aged 18 or more of both sexes. Information was analysed through the STROBE score per item and recommendation. Results: Seventeen articles were included in this study. All articles met the recommendations related to the report of the study’s rationale, design, and provision of summary measures. The recommendations with the lowest scores were those related to the sensitivity analysis (8%, n= 1/17), participant flowchart (18%, n= 3/17), missing data analysis (24%, n= 4/17), and number of participants in each study phase (24%, n= 4/17). Conclusion: Cross-sectional studies regarding the prevalence of metabolic syndrome in peruvian adults have an inadequate reporting on the methods and results sections. We identified a clear need to improve the quality of such studies.

Weaknesses in the reporting of cross-sectional studies according to the STROBE statement: the case of metabolic syndrome in adults from Peru

Introduction: The inadequate reporting of cross-sectional studies, as in the case of the prevalence of metabolic syndrome, could cause problems in the synthesis of new evidence and lead to errors in the formulation of public policies. Objective: To evaluate the reporting quality of the articles regarding metabolic syndrome prevalence in Peruvian adults using the STROBE recommendations. Methods: We conducted a thorough literature search with the terms "Metabolic Syndrome", "Sindrome Metabolico" and "Peru" in MEDLINE/PubMed, LILACS, SciELO, LIPECS and BVS-Peru until December 2014. We selected those who were population-based observational studies with randomized sampling that reported prevalence of metabolic syndrome in adults aged 18 or more of both sexes. Information was analysed through the STROBE score per item and recommendation. Results: Seventeen articles were included in this study. All articles met the recommendations related to the report of the study’s rationale, design, and provision of summary measures. The recommendations with the lowest scores were those related to the sensitivity analysis (8%, n= 1/17), participant flowchart (18%, n= 3/17), missing data analysis (24%, n= 4/17), and number of participants in each study phase (24%, n= 4/17). Conclusion: Cross-sectional studies regarding the prevalence of metabolic syndrome in peruvian adults have an inadequate reporting on the methods and results sections. We identified a clear need to improve the quality of such studies.

Hacia un enfoque epistemológico pluralista en los estudios de comunicación y cambio: humanismo, ciencia y ecologismo

El artículo propone una aproximación epistemológica pluralista a la investigación de las relaciones entre comunicación y cambio social. A tal fin, se parte de la propuesta de fusión epistemológica realizada por Johan Galtung para los Estudios para la Paz, tomando en cuenta, además, las particularidades del fenómeno de la comunicación. Según Galtung, la combinación del cartesianismo, del verum-factum (Vico) y del taoísmo permitiría contrarrestar los riesgos del monismo epistemológico y superar sus limitaciones. En este mismo sentido, el artículo plantea ampliar cada una de estas epistemologías en un nivel más general y abarcador (ciencia, humanidades, ecologismo holista-dialéctico), y describir su recorrido histórico para identificar las posibilidades de complementariedad y su valor para el estudio de la comunicación y el cambio.

CRI Event/Project List: 7/1/2012 thru 6/30/2013

This document is a blank template that was to be filled with 2012-13 Cuban Research Institute event and project information.

Testimonios de un Pasado Imperfecto : Vida Cotidiana de Mujeres bajo Dictadura en Valparaíso y Viña del Mar, Chile 1980-1987

Este proyecto de investigación se caracteriza como estudio histórico-etnográfica basado en estudios de casos de la vida cotidiana de nueve mujeres en Valparaíso y Viña del Mar durante la dictadura chilena, analizando el testimonio de los efectos del régimen autoritario en la vida cotidiana de estas mujeres chilenas entre 1980 y 1987. La metodología se radica firmemente en el método etnográfico con entrevistas semi-abiertas y el análisis del discurso de los relatos. En la metáfora de la arpillera (un tapiz anónimo cosido en lona ensamblado a partir de piezas de tela que muestra escenas de la vida cotidiana o protesta la dictadura de Pinochet), trozos y pedazos de experiencia se juntan en el encima de la lona de la historia para dar forma al testimonio de vida la vida cotidiana. Este proyecto se centra en tres aspectos diferentes de la relación entre el Estado autoritario y la vida cotidiana: las técnicas de gobernabilidad (macro), narraciones de silencio y miedo (micro) y trayectorias narrados (espacial), el último inspirado por el ensayo Halbwachs en caminar por la ciudad. Para cerrar, la relevancia del estudio se destaca por el intento de comprender el efecto de un estado autoritario en el sujeto femenino y las respuestas y adaptaciones que las mujeres chilenas adoptaron en la vida privada y pública mediada por la violencia y el miedo bajo dictadura. La dialéctica del acontecimiento y la rutina de la vida cotidiana bajo la dictadura se unen en las memorias narradas, mediada por el presente vivido, lo cual permite una reflexión sobre la cuestión de la alteridad en la sociedad chilena.Este proyecto de investigación se caracteriza como estudio histórico-etnográfica basado en estudios de casos de la vida cotidiana de nueve mujeres en Valparaíso y Viña del Mar durante la dictadura chilena, analizando el testimonio de los efectos del régimen autoritario en la vida cotidiana de estas mujeres chilenas entre 1980 y 1987. La metodología se radica firmemente en el método etnográfico con entrevistas semi-abiertas y el análisis del discurso de los relatos. En la metáfora de la arpillera (un tapiz anónimo cosido en lona ensamblado a partir de piezas de tela que muestra escenas de la vida cotidiana o protesta la dictadura de Pinochet), trozos y pedazos de experiencia se juntan en el encima de la lona de la historia para dar forma al testimonio de vida la vida cotidiana. Este proyecto se centra en tres aspectos diferentes de la relación entre el Estado autoritario y la vida cotidiana: las técnicas de gobernabilidad (macro), narraciones de silencio y miedo (micro) y trayectorias narrados (espacial), el último inspirado por el ensayo Halbwachs en caminar por la ciudad. Para cerrar, la relevancia del estudio se destaca por el intento de comprender el efecto de un estado autoritario en el sujeto femenino y las respuestas y adaptaciones que las mujeres chilenas adoptaron en la vida privada y pública mediada por la violencia y el miedo bajo dictadura. La dialéctica del acontecimiento y la rutina de la vida cotidiana bajo la dictadura se unen en las memorias narradas, mediada por el presente vivido, lo cual permite una reflexión sobre la cuestión de la alteridad en la sociedad chilena.