The Political Communication of Independent Regulatory Agencies

Since independent regulatory agencies (IRAs) became key actors in European regulatory governance in the 1990s, a significant share of policy-making has been carried out by organizations that are neither democratically elected nor directly accountable to elected politicians. In this context, public communication plays an important role. On the one hand, regulatory agencies might try to use communication to raise their accountability and thereby to mitigate their democratic deficit. On the other hand, communication may be used with the intent to steer the behavior of the regulated industry when more coercive regulatory means are unfeasible or undesirable. However, empirical research focusing directly on how regulators communicate is virtually non-existent. To fill this gap, this paper examines the public communication of IRAs in four countries (the United Kingdom, Germany, Ireland, and Switzerland) and three sectors (financial services, telecommunications, and broadcasting). The empirical analysis, based on qualitative interviews and a quantitative content analysis, indicates that the organization of the communication function follows a national pattern approach while a policy sector approach is helpful for understanding the use of communication as a soft tool of regulation.

Genomic determinants of the efficiency of internal ribosomal entry sites of viral and cellular origin

Variation in cellular gene expression levels has been shown to be inherited. Expression is controlled at transcriptional and post-transcriptional levels. Internal ribosome entry sites (IRES) are used by viruses to bypass inhibition of cap-dependent translation, and by eukaryotic cells to control translation under conditions when protein synthesis is inhibited. We aimed at identifying genomic determinants of variability in IRES-mediated translation of viral [Encephalomyocarditis virus (EMCV)] and cellular IRES [X-linked inhibitor-of-apoptosis (XIAP) and c-myc]. Bicistronic lentiviral constructs expressing two fluorescent reporters were used to transduce laboratory and B lymphoblastoid cell lines [15 CEPH pedigrees (n = 205) and 50 unrelated individuals]. IRES efficiency varied according to cell type and among individuals. Control of IRES activity has a significant genetic component (h(2) of 0.47 and 0.36 for EMCV and XIAP, respectively). Quantitative linkage analysis identified a suggestive locus (LOD 2.35) on chromosome 18q21.2, and genome-wide association analysis revealed of a cluster of SNPs on chromosome 3, intronic to the FHIT gene, marginally associated (P = 5.9E-7) with XIAP IRES function. This study illustrates the in vitro generation of intermediate phenotypes by using cell lines for the evaluation of genetic determinants of control of elements such as IRES.

Johdon palkkiojärjestelmätsuomalaisten pörssiyhtiöiden sijoittajaviestinnässä

Tutkimuksen tavoitteena on selvittää, mitä vaatimuksia suomalainen lainsäädäntö, IFRS-standardit, corporate governance - suosituksetja pörssin suositukset asettavat johdon palkkiosta tiedottamiselle ja kuinka laajasti tietoa tosiasiassa annetaan. Pörssiyhtiöiden tiedotuksen avoimuutta lähestytään tutkimalla, millaisia palkkioita ja kannustimia sekä päätöksentekotapoja on olemassa. Yhtiöiden omistuksen ja johtamisen eriytyessä syntyy päämies-agentti-ongelma. Johdon ja omistajien intressejä lähennetään palkkiojärjestelmien avulla. Palkitsemisen tarkoitus on kannustaa yrityksen johtoa toimimaan omistajan edun mukaisesti. Tutkimus on kvalitatiivinen ja tutkimusmenetelmä on deskriptiivinen: kuvailun ja luokittelun kautta pyritään analyysiin yritysten avoimuudesta palkkioiden suhteen. Tutkimus toteutettiinvertaamalla yhtiöiden Internet-sivuja ja vuosikertomuksia vuodelta 2004 määritettyihin kriteereihin. Tutkimuksen aineistona toimivat Helsingin arvopaperipörssin päälistan yhtiöt. Tutkimuksessa havaittiin, että palkkauksen muotoa tärkeämpää on palkitsemisen kokonaisuus ja siihen liittyvä päätöksenteko. Suomalaiset pörssiyhtiöt tiedottavat johdon palkkioista kohtuullisen hyvin, mutta erityisesti palkkioiden perusteista voisi kertoa tarkemminkin. Internetin tarjoamia mahdollisuuksia hyödynnetään kiitettävästi. Liike-vaihdoltaan suurimmatyritykset tiedottavat kautta linjan pienempiä tarkemmin.

Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits

BACKGROUND: Selection for increasing intramuscular fat content would definitively improve the palatability and juiciness of pig meat as well as the sensorial and organoleptic properties of cured products. However, evidences obtained in human and model organisms suggest that high levels of intramuscular fat might alter muscle lipid and carbohydrate metabolism. We have analysed this issue by determining the transcriptomic profiles of Duroc pigs with divergent phenotypes for 13 fatness traits. The strong aptitude of Duroc pigs to have high levels of intramuscular fat makes them a valuable model to analyse the mechanisms that regulate muscle lipid metabolism, an issue with evident implications in the elucidation of the genetic basis of human metabolic diseases such as obesity and insulin resistance. RESULTS: Muscle gene expression profiles of 68 Duroc pigs belonging to two groups (HIGH and LOW) with extreme phenotypes for lipid deposition and composition traits have been analysed. Microarray and quantitative PCR analysis showed that genes related to fatty acid uptake, lipogenesis and triacylglycerol synthesis were upregulated in the muscle tissue of HIGH pigs, which are fatter and have higher amounts of intramuscular fat than their LOW counterparts. Paradoxically, lipolytic genes also showed increased mRNA levels in the HIGH group suggesting the existence of a cycle where triacylglycerols are continuously synthesized and degraded. Several genes related to the insulin-signalling pathway, that is usually impaired in obese humans, were also upregulated. Finally, genes related to antigen-processing and presentation were downregulated in the HIGH group. CONCLUSION: Our data suggest that selection for increasing intramuscular fat content in pigs would lead to a shift but not a disruption of the metabolic homeostasis of muscle cells. Future studies on the post-translational changes affecting protein activity or expression as well as information about protein location within the cell would be needed to to elucidate the effects of lipid deposition on muscle metabolism in pigs.

Anàlisi del recurs pilot "cases d'infants: nou paradigma d'atenció i tractament a la infància i l'adolescència".

El treball que es presenta a continuació és una recerca aplicada, consistent en l’anàlisi descriptiva d’una mostra d’infants i adolescents de 5 a 19 anys atesos al projecte “Cases d’Infants” des del desembre de 2010 fins al juliol de 2013. Aquesta investigació pretén donar a conèixer la nova perspectiva o paradigma d’atenció a la infància i l’adolescència a Catalunya que neix de la Llei dels Drets i les Oportunitats de la Infància i l’Adolescència (LDOIA, maig de 2010): basada en la prevenció, el model sistèmic i de complexitat, la col·laboració de la família com a element de canvi, el treball en xarxa i interprofessionalitat, la participació dels infants i adolescents, i la territorialitat, principalment. Un cop feta aquesta aproximació teòrica, s’ha concretat identificant aquesta nova perspectiva al projecte pilot “Cases d’Infants” (nascut al setembre de 2010), el qual desplega les actuacions que sorgeixen d’aquesta filosofia de treball i suport. Per a elaborar aquesta recerca s’ha emprat un disseny d’investigació no experimental descriptiu, on s’han associat i comparat variables per tal d’identificar interferències en les relacions –a través de proves estadístiques-, i proposar una certa tendència i pronòstic de les característiques del perfil atès al projecte i les interferències d’algunes variables amb el recurs final de l’infant o adolescent. Finalment, s’extreuen unes conclusions en relació a la bibliografia inicial i els resultats obtinguts en l’anàlisi de la mostra estudiada.

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

BACKGROUND: Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective--their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd) (NCT01062607) aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. METHODS: WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices) in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales), adherence to treatment (DAI-10 scale and Medication Possession Ratio), quality of life (EQ-5D scale), healthcare resources, and caregiver burden (BAS scale) will be collected. Descriptive analysis with common statistics will be performed. DISCUSSION: This study will provide detailed descriptions of the management of BD in different countries, particularly in terms of clinical outcomes and resources used. Thus, it should provide psychiatrists with reliable and up-to-date information about those factors associated with different management patterns of BD. TRIAL REGISTRATION NO: ClinicalTrials.gov: NCT01062607.

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Starting from the mid-1960s, family and fertility patterns in Europe underwent fundamental changes. Social scientists have increasingly turned to intergenerational models to explain such changes. This paper deals with one important intergenerational dimension of fertility, namely the transmission of normative beliefs about childbearing choices. Normative beliefs are important determinants of fertility behavior. While norms are learnt and internalized throughout the life course, primary socialization of children within the family and role modeling are important mechanism to ensure norm transmission. Interaction with family members in adult life may reinforce the effects of early socialization and role modeling. The paper focuses on the ways in which mothers and daughters make sense of normative beliefs about childbearing. I draw on set of semi-structured interviews with childless women in reproductive ages and their mothers, collected in Italy between 2004 and 2006. First, I provide a micro-level descriptive analysis of normative beliefs about childbearing norms in mother-daughter dyads. Second, linking these descriptive analyses to the biography of specific dyads, I identify patterns of continuity and discontinuity in the social meaning of children and their fertility outcomes.

Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling.

Emerging as an important correlate of neurological dysfunction in Multiple Sclerosis (MS), extended focal and diffuse gray matter abnormalities have been found and linked to clinical manifestations such as seizures, fatigue and cognitive dysfunction. To investigate possible underlying mechanisms we analyzed the molecular alterations in histopathological normal appearing cortical gray matter (NAGM) in MS. By performing a differential gene expression analysis of NAGM of control and MS cases we identified reduced transcription of astrocyte specific genes involved in the astrocyte-neuron lactate shuttle (ANLS) and the glutamate-glutamine cycle (GGC). Additional quantitative immunohistochemical analysis demonstrating a CX43 loss in MS NAGM confirmed a crucial involvement of astrocytes and emphasizes their importance in MS pathogenesis. Concurrently, a Toll-like/IL-1β signaling expression signature was detected in MS NAGM, indicating that immune-related signaling might be responsible for the downregulation of ANLS and GGC gene expression in MS NAGM. Indeed, challenging astrocytes with immune stimuli such as IL-1β and LPS reduced their ANLS and GGC gene expression in vitro. The detected upregulation of IL1B in MS NAGM suggests inflammasome priming. For this reason, astrocyte cultures were treated with ATP and ATP/LPS as for inflammasome activation. This treatment led to a reduction of ANLS and GGC gene expression in a comparable manner. To investigate potential sources for ANLS and GGC downregulation in MS NAGM, we first performed an adjuvant-driven stimulation of the peripheral immune system in C57Bl/6 mice in vivo. This led to similar gene expression changes in spinal cord demonstrating that peripheral immune signals might be one source for astrocytic gene expression changes in the brain. IL1B upregulation in MS NAGM itself points to a possible endogenous signaling process leading to ANLS and GGC downregulation. This is supported by our findings that, among others, MS NAGM astrocytes express inflammasome components and that astrocytes are capable to release Il-1β in-vitro. Altogether, our data suggests that immune signaling of immune- and/or central nervous system origin drives alterations in astrocytic ANLS and GGC gene regulation in the MS NAGM. Such a mechanism might underlie cortical brain dysfunctions frequently encountered in MS patients.

Análisis de la responsabilidad social corporativa en empresas del mercado continuo español

En este trabajo se presenta un análisis descriptivo de la responsabilidad social corporativa, en el área medioambiental. En concreto, se estudia la información medioambiental que detallan las empresas en su Memoria normal de las cuentas anuales en relación con la que regula el PGC07. También analizamos si las empresas que siguen fielmente el PGC07 son las que más certificados medioambientales y Memorias de sostenibilidad presentan. Hemos escogido como muestra un conjunto de empresas de determinados sectores de actividad del mercado continuo español en el ejercicio 2008. Los resultados alcanzados nos permiten concluir que las empresas que tienen alguna certificación medioambiental son las que presentan más información medioambiental en su Memoria contable avalando el cambio que se está produciendo en la cultura empresarial.

Brandi osana yrityskuvaa case: Fazer (Fazerin Sininen) sekä Valio (Valiomaito)

Tutkielman tavoitteena on antaa kuva tuotebrandista osana yrityksen yrityskuvaa. Tutkimuksen pääkysymyksenä on: "Miten ja millä keinoilla yritys voi yhdistää tuotemerkkinsä brandikuvan yrityskuvaansa". Työ on kaksiosainen. Tutkimuksen kirjallisuusosassa pyritään aikaisemman tutkimustiedon perusteella rakentamaan käsitys yrityskuvasta, brandista ja niiden pohjalla vaikuttavista strategisista ratkaisuista. Tutkimuksessa esitetään malleja yritysbrandin ja tuotebrandien yhteydestä sekä käydään läpi yritys- ja tuotekuvaviestinnän keinoja. Tutkimuksessa halutaan lisäksi tuoda esille design management -ajattelutavan merkitys yhtenäisen yrityskuvan kannalta. Työn empiirinen osuus suoritettiin kvalitatiivisena casetutkimuksena kohteina Oy Fazer Ab sekä Valio Oy. Empiirinen osuus perustuu kirjalliseen materiaaliin sekä havainnointiin, joiden pohjalta tehtyjä johtopäätöksiä käytettiin hyväksi teemahaastattelujen kysymysten-asettelussa. Työ on luonteeltaan deskriptiivis-analyyttinen. Tutkimus osoitti, että yritys voi selkeästi yhdistää strategisen brandinsa osaksi yrityskuvaansa yritysbrandin ja tuotebrandin yhdistävän merkkistrategian ja eri viestintäelementtien avulla. Empiirisessä osassa selvisi, että kummassakin caseyrityksessä strategisen brandin yhteys yrityskuvaan on selkeä ja brandi ja yritys pyrkivät kohti samaa tavoitekuvaa. Fazerin strategiassa strategisen brandin ja yrityskuvan yhteyttä ei tosin enää selkeästi korosteta.

Effectiveness of a primary care-based intervention to reduce sitting time in overweight and obese patients (SEDESTACTIV): a randomized controlled trial; rationale and study design

Background: There is growing evidence suggesting that prolonged sitting has negative effects on people's weight, chronic diseases and mortality. Interventions to reduce sedentary time can be an effective strategy to increase daily energy expenditure. The purpose of this study is to evaluate the effectiveness of a six-month primary care intervention to reduce daily of sitting time in overweight and mild obese sedentary patients. Method/Design: The study is a randomized controlled trial (RCT). Professionals from thirteen primary health care centers (PHC) will randomly invite to participate mild obese or overweight patients of both gender, aged between 25 and 65 years old, who spend 6 hours at least daily sitting. A total of 232 subjects will be randomly allocated to an intervention (IG) and control group (CG) (116 individuals each group). In addition, 50 subjects with fibromyalgia will be included. Primary outcome is: (1) sitting time using the activPAL device and the Marshall questionnaire. The following parameters will be also assessed: (2) sitting time in work place (Occupational Sitting and Physical Activity Questionnaire), (3) health-related quality of life (EQ-5D), (4) evolution of stage of change (Prochaska and DiClemente's Stages of Change Model), (5) physical inactivity (catalan version of Brief Physical Activity Assessment Tool), (6) number of steps walked (pedometer and activPAL), (7) control based on analysis (triglycerides, total cholesterol, HDL, LDL, glycemia and, glycated haemoglobin in diabetic patients) and (8) blood pressure and anthropometric variables. All parameters will be assessed pre and post intervention and there will be a follow up three, six and twelve months after the intervention. A descriptive analysis of all variables and a multivariate analysis to assess differences among groups will be undertaken. Multivariate analysis will be carried out to assess time changes of dependent variables. All the analysis will be done under the intention to treat principle. Discussion: If the SEDESTACTIV intervention shows its effectiveness in reducing sitting time, health professionals would have a low-cost intervention tool for sedentary overweight and obese patients management.

ICT-YRITYKSEN MENESTYKSEN ARVIOINTI TALOUDELLISEEN INFORMAATIOON PERUSTUEN

Tutkielman tavoitteena on selvittää, miten tilinpäätösanalyysi työkaluna soveltuu ICT-yritysten menestyksen arviointiin. Samalla pyritään tilinpäätösanalyysin avulla arvioimaan Kaakkois-Suomen ICT-klusterin taloudellinen tilanne. Tutkielman teoriaosassa tutustutaan uuden talouden erityispiirteiden vaikutuksiin tilinpäätösinformaation ja tilinpäätösanalyysin tulosten tulkinnassa. Empiirinen aineisto koostuu Kaakkois-Suomen ICT-klusterin tilinpäätöksistä, joista lasketaan valitut tunnusluvut. Näiden tunnuslukujen avulla pyritään arvioimaan yritysten menestystä ja selvittämään menestykseen vaikuttavia tekijöitä taloudellisesta näkökulmasta. Tutkimus on kvalitatiivinen ja tutkimusotteeltaan deskriptiivinen eli kuvaileva ja selittävä. Tutkimustulosten mukaan tilinpäätösanalyysi ei ole riittävä työkalu ICT-yritysten menestyksen arviointiin. Sen avulla on mahdollista kerätä yrityksistä pohjatietoa, jota tulee muiden keinojen mm. yrityshaastattelujen avulla täydentää. Tilinpäätösanalyysi osoittaa, että Kaakkois-Suomen ICT-yritysten taloudellinen tilanne on keskimääräisesti hyvä, mutta tulevaisuutta on mahdoton ennustaa. Koska kyseessä ei ole tilastollinen tutkimus, eikä kohdeyritysjoukko ole riittävä, ei tuloksia voi yleistää koskemaan kaikkia toimialan yrityksiä.

An efficient total variation algorithm for super-resolution in fetal brain MRI with adaptive regularization.

Although fetal anatomy can be adequately viewed in new multi-slice MR images, many critical limitations remain for quantitative data analysis. To this end, several research groups have recently developed advanced image processing methods, often denoted by super-resolution (SR) techniques, to reconstruct from a set of clinical low-resolution (LR) images, a high-resolution (HR) motion-free volume. It is usually modeled as an inverse problem where the regularization term plays a central role in the reconstruction quality. Literature has been quite attracted by Total Variation energies because of their ability in edge preserving but only standard explicit steepest gradient techniques have been applied for optimization. In a preliminary work, it has been shown that novel fast convex optimization techniques could be successfully applied to design an efficient Total Variation optimization algorithm for the super-resolution problem. In this work, two major contributions are presented. Firstly, we will briefly review the Bayesian and Variational dual formulations of current state-of-the-art methods dedicated to fetal MRI reconstruction. Secondly, we present an extensive quantitative evaluation of our SR algorithm previously introduced on both simulated fetal and real clinical data (with both normal and pathological subjects). Specifically, we study the robustness of regularization terms in front of residual registration errors and we also present a novel strategy for automatically select the weight of the regularization as regards the data fidelity term. Our results show that our TV implementation is highly robust in front of motion artifacts and that it offers the best trade-off between speed and accuracy for fetal MRI recovery as in comparison with state-of-the art methods.

The Political Communication of Independent Regulatory Agencies

Since independent regulatory agencies (IRAs) became key actors in European regulatory governance in the 1990s, a significant share of policy-making has been carried out by organizations that are neither democratically elected nor directly accountable to elected politicians. In this context, public communication plays an important role. On the one hand, regulatory agencies might try to use communication to raise their accountability and thereby to mitigate their democratic deficit. On the other hand, communication may be used with the intent to steer the behavior of the regulated industry when more coercive regulatory means are unfeasible or undesirable. However, empirical research focusing directly on how regulators communicate is virtually non-existent. To fill this gap, this paper examines the public communication of IRAs in four countries (the United Kingdom, Germany, Ireland, and Switzerland) and three sectors (financial services, telecommunications, and broadcasting). The empirical analysis, based on qualitative interviews and a quantitative content analysis, indicates that the organization of the communication function follows a national pattern approach while a policy sector approach is helpful for understanding the use of communication as a soft tool of regulation.

Retrospective study of sonographic findings in bone involvement associated with rotator cuff calcific tendinopathy: preliminary results of a case series

Abstract Objective: The present study was aimed at investigating bone involvement secondary to rotator cuff calcific tendonitis at ultrasonography. Materials and Methods: Retrospective study of a case series. The authors reviewed shoulder ultrasonography reports of 141 patients diagnosed with rotator cuff calcific tendonitis, collected from the computer-based data records of their institution over a four-year period. Imaging findings were retrospectively and consensually analyzed by two experienced musculoskeletal radiologists looking for bone involvement associated with calcific tendonitis. Only the cases confirmed by computed tomography were considered for descriptive analysis. Results: Sonographic findings of calcific tendinopathy with bone involvement were observed in 7/141 (~ 5%) patients (mean age, 50.9 years; age range, 42-58 years; 42% female). Cortical bone erosion adjacent to tendon calcification was the most common finding, observed in 7/7 cases. Signs of intraosseous migration were found in 3/7 cases, and subcortical cysts in 2/7 cases. The findings were confirmed by computed tomography. Calcifications associated with bone abnormalities showed no acoustic shadowing at ultrasonography, favoring the hypothesis of resorption phase of the disease. Conclusion: Preliminary results of the present study suggest that ultrasonography can identify bone abnormalities secondary to rotator cuff calcific tendinopathy, particularly the presence of cortical bone erosion.