Das Evangelium Johannis : in neu-griechischer Sprache

C.F. Spittler

Inez Garcia, woman who killed her rapist

General note: Title and date provided by Bettye Lane.

Inez Garcia, who killed her rapist at a press conference at NOW

General note: Title and date provided by Bettye Lane.

Inez Garcia, woman who killed her rapist

General note: Title and date provided by Bettye Lane.

Carpenter in front of her shop

Inscriptions: Verso: [stamped] Photograph by Freda Leinwand. [463 West Street, Studio 229G, New York, NY 10014].

Kate Millett reads from the manuscript of her book "The Basement" at the Woman's Salon

Inscriptions: Verso: [stamped] Photograph by Freda Leinwand. [463 West Street, Studio 229G, New York, NY 10014].

Lynda Schor (second from right) reads from her book "Appetites" at the Woman's Salon

Inscriptions: Verso: [stamped] Photograph by Freda Leinwand. [463 West Street, Studio 229G, New York, NY 10014].

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.

The goal of this study was to determine whether beta(1)-adrenergic receptor (AR) and beta(2)-AR differ in regulating cardiomyocyte survival and apoptosis and, if so, to explore underlying mechanisms. One potential mechanism is that cardiac beta(2)-AR can activate both G(s) and G(i) proteins, whereas cardiac beta(1)-AR couples only to G(s). To avoid complicated crosstalk between beta-AR subtypes, we expressed beta(1)-AR or beta(2)-AR individually in adult beta(1)/beta(2)-AR double knockout mouse cardiac myocytes by using adenoviral gene transfer. Stimulation of beta(1)-AR, but not beta(2)-AR, markedly induced myocyte apoptosis, as indicated by increased terminal deoxynucleotidyltransferase-mediated UTP end labeling or Hoechst staining positive cells and DNA fragmentation. In contrast, beta(2)-AR (but not beta(1)-AR) stimulation elevated the activity of Akt, a powerful survival signal; this effect was fully abolished by inhibiting G(i), G(beta gamma), or phosphoinositide 3 kinase (PI3K) with pertussis toxin, beta ARK-ct (a peptide inhibitor of G(beta gamma)), or LY294002, respectively. This indicates that beta(2)-AR activates Akt via a G(i)-G(beta gamma)-PI3K pathway. More importantly, inhibition of the G(i)-G(beta gamma)-PI3K-Akt pathway converts beta(2)-AR signaling from survival to apoptotic. Thus, stimulation of a single class of receptors, beta(2)-ARs, elicits concurrent apoptotic and survival signals in cardiac myocytes. The survival effect appears to predominate and is mediated by the G(i)-G(beta gamma)-PI3K-Akt signaling pathway.

Capital 2.0 capital formation and legal risk in a new global economic order from fiat to exit: including case studies of the proposed transatlantic trade and investment partnership between the United States and the European Union and the financing relation between the United States and the People’s Republic of China

Following the intrinsically linked balance sheets in his Capital Formation Life Cycle, Lukas M. Stahl explains with his Triple A Model of Accounting, Allocation and Accountability the stages of the Capital Formation process from FIAT to EXIT. Based on the theoretical foundations of legal risk laid by the International Bar Association with the help of Roger McCormick and legal scholars such as Joanna Benjamin, Matthew Whalley and Tobias Mahler, and founded on the basis of Wesley Hohfeld’s category theory of jural relations, Stahl develops his mutually exclusive Four Determinants of Legal Risk of Law, Lack of Right, Liability and Limitation. Those Four Determinants of Legal Risk allow us to apply, assess, and precisely describe the respective legal risk at all stages of the Capital Formation Life Cycle as demonstrated in case studies of nine industry verticals of the proposed and currently negotiated Transatlantic Trade and Investment Partnership between the United States of America and the European Union, TTIP, as well as in the case of the often cited financing relation between the United States and the People’s Republic of China. Having established the Four Determinants of Legal Risk and its application to the Capital Formation Life Cycle, Stahl then explores the theoretical foundations of capital formation, their historical basis in classical and neo-classical economics and its forefathers such as The Austrians around Eugen von Boehm-Bawerk, Ludwig von Mises and Friedrich von Hayek and most notably and controversial, Karl Marx, and their impact on today’s exponential expansion of capital formation. Starting off with the first pillar of his Triple A Model, Accounting, Stahl then moves on to explain the Three Factors of Capital Formation, Man, Machines and Money and shows how “value-added” is created with respect to the non-monetary capital factors of human resources and industrial production. Followed by a detailed analysis discussing the roles of the Three Actors of Monetary Capital Formation, Central Banks, Commercial Banks and Citizens Stahl readily dismisses a number of myths regarding the creation of money providing in-depth insight into the workings of monetary policy makers, their institutions and ultimate beneficiaries, the corporate and consumer citizens. In his second pillar, Allocation, Stahl continues his analysis of the balance sheets of the Capital Formation Life Cycle by discussing the role of The Five Key Accounts of Monetary Capital Formation, the Sovereign, Financial, Corporate, Private and International account of Monetary Capital Formation and the associated legal risks in the allocation of capital pursuant to his Four Determinants of Legal Risk. In his third pillar, Accountability, Stahl discusses the ever recurring Crisis-Reaction-Acceleration-Sequence-History, in short: CRASH, since the beginning of the millennium starting with the dot-com crash at the turn of the millennium, followed seven years later by the financial crisis of 2008 and the dislocations in the global economy we are facing another seven years later today in 2015 with several sordid debt restructurings under way and hundred thousands of refugees on the way caused by war and increasing inequality. Together with the regulatory reactions they have caused in the form of so-called landmark legislation such as the Sarbanes-Oxley Act of 2002, the Dodd-Frank Act of 2010, the JOBS Act of 2012 or the introduction of the Basel Accords, Basel II in 2004 and III in 2010, the European Financial Stability Facility of 2010, the European Stability Mechanism of 2012 and the European Banking Union of 2013, Stahl analyses the acceleration in size and scope of crises that appears to find often seemingly helpless bureaucratic responses, the inherent legal risks and the complete lack of accountability on part of those responsible. Stahl argues that the order of the day requires to address the root cause of the problems in the form of two fundamental design defects of our Global Economic Order, namely our monetary and judicial order. Inspired by a 1933 plan of nine University of Chicago economists abolishing the fractional reserve system, he proposes the introduction of Sovereign Money as a prerequisite to void misallocations by way of judicial order in the course of domestic and transnational insolvency proceedings including the restructuring of sovereign debt throughout the entire monetary system back to its origin without causing domino effects of banking collapses and failed financial institutions. In recognizing Austrian-American economist Schumpeter’s Concept of Creative Destruction, as a process of industrial mutation that incessantly revolutionizes the economic structure from within, incessantly destroying the old one, incessantly creating a new one, Stahl responds to Schumpeter’s economic chemotherapy with his Concept of Equitable Default mimicking an immunotherapy that strengthens the corpus economicus own immune system by providing for the judicial authority to terminate precisely those misallocations that have proven malignant causing default perusing the century old common law concept of equity that allows for the equitable reformation, rescission or restitution of contract by way of judicial order. Following a review of the proposed mechanisms of transnational dispute resolution and current court systems with transnational jurisdiction, Stahl advocates as a first step in order to complete the Capital Formation Life Cycle from FIAT, the creation of money by way of credit, to EXIT, the termination of money by way of judicial order, the institution of a Transatlantic Trade and Investment Court constituted by a panel of judges from the U.S. Court of International Trade and the European Court of Justice by following the model of the EFTA Court of the European Free Trade Association. Since the first time his proposal has been made public in June of 2014 after being discussed in academic circles since 2011, his or similar proposals have found numerous public supporters. Most notably, the former Vice President of the European Parliament, David Martin, has tabled an amendment in June 2015 in the course of the negotiations on TTIP calling for an independent judicial body and the Member of the European Commission, Cecilia Malmström, has presented her proposal of an International Investment Court on September 16, 2015. Stahl concludes, that for the first time in the history of our generation it appears that there is a real opportunity for reform of our Global Economic Order by curing the two fundamental design defects of our monetary order and judicial order with the abolition of the fractional reserve system and the introduction of Sovereign Money and the institution of a democratically elected Transatlantic Trade and Investment Court that commensurate with its jurisdiction extending to cases concerning the Transatlantic Trade and Investment Partnership may complete the Capital Formation Life Cycle resolving cases of default with the transnational judicial authority for terminal resolution of misallocations in a New Global Economic Order without the ensuing dangers of systemic collapse from FIAT to EXIT.

“2 Mundos”, o corpo das palavras : dramaturgia do corpo com a Cia. Mariana Muniz de Dança e Teatro

O que pode vir a ser material dramatúrgico em dança? Onde o corpo se ancora para criá-lo? Como o artista faz o trânsito deste para a pesquisa de movimento? E, por fim, como cria a dramaturgia do corpo na cena? Para responder a estas questões norteadoras desta pesquisa busquei o solo fértil de investigação da Cia. Mariana Muniz de Dança e Teatro. Para a fundamentação, descrição e análise, foi eleito o processo de remontagem de “2 Mundos”, criação coreográfica que integrou à exposição fotográfica Trajetória(s) Mariana Muniz – quem, aliás, abriu a Mostra de Fomento à Dança de São Paulo (Brasil), em 2015, com a apresentação do mesmo. Assim, parti para o acompanhamento e observação dos ensaios da artista. Utilizei-me de anotações em um caderno de campo e vídeos. Discussões, trocas e diálogo com a mesma sobre seu caminho para a criação e, posterior, remontagem do espetáculo foram de singular importância para o direcionamento do meu olhar buscador. Sentimos, ao longo do processo, a necessidade de realizar uma entrevista que apontasse, assim, maiores detalhes sobre seu caminhar para este trabalho. Encontramos quatro “práticas” que serviram de treino corporal à artista: Gerda Alexander e a Eutonia, Rudolf Steiner e seu pensamento sobre a Antroposofia que criou a Euritmia; o T`ai Chi Chuan e o Yoga. Para Mariana Muniz “entrar no lugar da criação” requer ferramentas ora da dança ora do teatro ou, ainda, de ambas. Desta forma, Grotowski, referência indicada pela artista, permitiu um rico intercâmbio entre a dança e o teatro por uma dramaturga do corpo. “2 Mundos”, cujo registro em vídeo acompanha esta dissertação, é um convite ao universo da LIBRAS (Língua Brasileira de Sinais). Para surdos e ouvintes, neste espetáculo, a palavra ganha corpo e Mariana Muniz nos oferece com delicadeza sua diferença enquanto artista do movimento.

Investigating the role and function of Tribbles 2 (TRIB2) in drug resistance within cancer

Dissertação de Mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2014

Clinical and molecular characterization of feline mammary carcinomas overexpressing HER2 proto-oncogene (FMC-HER2+) : new strategies for effective diagnostic and cancer therapy

Tese de Doutoramento em Ciências Veterinárias na Especialidade de Ciências Biológicas e Biomédicas

O conhecimento profissional do professor e as investigações matemáticas na sala de aula: Um estudo nos 1º e 2º ciclos do ensino básico

Este estudo tem como objetivo contribuir para a compreensão do conhecimento profissional do professor de Matemática envolvido no desenvolvimento de tarefas de investigação na sala de aula, focando-se em quatro questões orientadoras: (i) como é que os professores colocam em prática as tarefas de investigação, considerando a planificação e condução das aulas? (ii) que dificuldades sentem os professores no desenvolvimento de tarefas de investigação na sala de aula? (iii) como é que o conhecimento didático dos professores influencia o desenvolvimento de tarefas de investigação? (iv) como é que o conhecimento didático dos professores é influenciado pelo desenvolvimento de tarefas de investigação? A fundamentação teórica assenta sobre as duas grandes temáticas do estudo: o conhecimento profissional do professor, sendo discutida a sua natureza, estrutura e conteúdo, e as tarefas de investigação, das quais se aprofunda a natureza e a utilização em sala de aula. Apresenta-se ainda investigação empírica referente ao conhecimento profissional do professor envolvido no desenvolvimento de tarefas de investigação. O estudo assumiu uma abordagem interpretativa, concretizando-se através dois estudos de caso, um de uma professora de 1. ° Ciclo e outro de um professor de Matemática do 2. ° Ciclo do Ensino Básico. Estes professores trabalharam em colaboração com a investigadora sobre tarefas de investigação, que até aí não conheciam, planificando, lecionado e refletindo acerca de um conjunto de aulas com tarefas desta natureza. Foram recolhidos dados durante as sessões de trabalho referidas, bem como nas aulas e ainda em entrevistas realizadas a cada um dos professores. Uma leitura transversal dos casos permite retirar algumas conclusões. A possibilidade de enquadramento nos conteúdos programáticos parece ser o principal critério de seleção das tarefas por parte dos professores. Na planificação, é a inventariação dos conteúdos que a tarefa mobiliza a principal prioridade, na busca da redução do grau de incerteza relacionado com as eventuais reações dos alunos. Quanto à condução de tarefas de investigação, a fase de introdução foi a mais breve, tendo servido o objetivo de conduzir à compreensão do propósito da tarefa por parte dos alunos e também reforçar alguns aspetos metodológicos do trabalho investigativo. A fase de desenvolvimento da tarefa foi aquela a que o professor de 2. ° Ciclo atribuiu maior importância, embora também valorizada pela professora de 1. ° Ciclo. Aqui, os professores consideram que o seu papel é acompanhar e orientar o trabalho dos alunos, ajudando a ultrapassar possíveis obstáculos, mantendo uma atitude questionadora. Quanto à fase de discussão, a grande preocupação dos professores é garantir a compreensão das ideias apresentadas pelos alunos. No entanto, existem duas estratégias distintas: enquanto a professora de 1. ° Ciclo, que muito valorizou esta fase, estimula a interação aluno-aluno, atribuindo-lhes a responsabilidade de validar/rejeitar as conjeturas apresentadas, o professor de 2. ° Ciclo centra em si toda esta fase, assumindo a responsabilidade de corrigir as ideias apresentadas. O desenvolvimento de tarefas de investigação é influenciado pelo conhecimento didático, revelando-se determinantes o conhecimento dos alunos e da forma como aprendem e o conhecimento do processo instrucional. O desenvolvimento de tarefas de investigação influencia várias componentes do conhecimento didático do professor, permitindo-lhe fortalecer o seu conhecimento matemático, desenvolver um conhecimento mais completo dos alunos e da forma como aprendem. Por último, a prática letiva com tarefas de investigação fornece ao professor dados importantes de como planificar e conduzir tarefas de natureza aberta, de forma a tirar o máximo partido das suas potencialidades. ABSTRACT: This study’s aim is to contribute to the understanding of the professional knowledge of the Maths teacher, involved in the development of investigative tasks in the classroom, focusing four guiding questions: (i) how do teachers give practical way to the investigative tasks, having in mind the lesson plans and lesson execution? (ii) Which difficulties do the teachers face when developing the investigative tasks in the classroom? (iii) How does the teachers' didactical knowledge influence the development of the investigative tasks? (iv) How is the teachers' didactical knowledge influenced by the development of the investigative tasks? The theorical framework is based on two broad themes of the study: teacher's professional knowledge (discussing its nature, structure and contents) and the investigative tasks (whose nature and use in the classroom is deepened). Besides, empirical research in what concerns to the professional knowledge of the teacher involved in the development of investigative tasks is also added. The study assumed an interpretative approach, materialised through two case studies, one of a primary school teacher, the other of a preparatory school Maths teacher. The teachers worked in cooperation with the researcher on the investigative tasks, which, until then, they weren't familiar with, planning, teaching and thinking about a set of lessons with tasks of this kind. Data were collected during the work meetings, as well as in the lessons and also in interviews to each one of the teachers. A transversal appreciation of the cases allows us to draw some conclusions. The possibility of integrating the programmatic contents seems to be the main criteria for the selection of the tasks by the teachers. ln the planning, the main priority of the task is the inventory of contents, aiming to reduce the level of uncertainty in what concerns to eventual reactions of the students. ln what concerns to the conduction of the investigative tasks, the introduction phase was the shortest, fulfilling the aim of leading to the understanding of the proposal of the task by the students and also to reinforce some methodological aspects of the investigative work. The task's development phase was the one the preparatory school teacher dedicated more importance, though it was also valued by the primary school teacher. ln this aspect, the teachers consider that their role is to follow and lead the students’ work, helping them to overtake eventual obstacles, keeping the questioning attitude. ln what concerns the discussion phase, the big concern of the teachers is to reassure the understanding of the ideas presented by the students. However, there are two different strategies: while the primary school teacher, who really valued this phase, stimulates the student-student interaction, giving them the responsibility of validating/rejecting the presented conjectures; the preparatory school teacher centers around himself all this phase, assuming the responsibilities of correcting the presented ideas. The development of the investigative tasks is influenced by the didactical knowledge, and it is determinant the knowledge about the students and about the way they learn and the instructional knowledge. The development of the investigative tasks influences several components of the didactical knowledge of the teacher, allowing him/her to reinforce his mathematical knowledge, developing a more complete knowledge about the students and the way they learn. Finally, the lessons execution with investigative tasks provides the teacher with important data about how to plan and conduct open nature tasks, in order to take the biggest advantage of their potential.

Gestão de três equipas por parte do(a) treinador(a) : relatório de estágio em futebol realizado na Sociedade União 1º Dezembro, Campeonato Distrital de Juniores C da 2ª Divisão, série 7

O Futebol é a forma de desporto mais popular no Mundo, sendo praticado em todas as Nações (Reilly, 2003). Em Portugal, nenhum outro desporto atrai tantos adeptos como o Futebol. É este o desporto que movimenta mais paixões e mais dinheiro. O seu poder e influência são cada vez maiores, sendo já considerado uma importante referência do setor económico, social e cultural (Santos, 2011). E uma verdade é inegável: o Futebol joga-se praticamente em todo o lado (Ramos, 2002). O estágio profissionalizante propõe um trabalho de planeamento, intervenção e reflexão da prática profissional diária de um(a) Treinador(a) de Futebol, que vive confrontado com a necessidade constante de encontrar soluções para os mais variados problemas, com que se depara regularmente no exercício da sua profissão. O estágio foi realizado na Sociedade União 1ºDezembro no escalão de Iniciados B, arcando a signatária, pela primeira vez na carreira, a função de Treinadora Principal. Esta Equipa B competiu no Campeonato Distrital de Juniores “C” da 2ª Divisão na série 7 e no Torneio Extraordinário. O documento segue a exposição de toda a atividade desenvolvida ao longo do estágio.