La coordinaci??n de la docencia de grado en el marco del EEES : el caso de la Facultad de Ciencias Empresariales y Turismo de Ourense

Resumen tomado de la publicaci??n

SME’s Alliance Dynamics in the Mobile Marketing Industry

This paper presents a case study of the two similar sized, new, technology-based firms acting as alliance partners in the Mobile commerce industry. The analysis describes how the alliance dynamics in our case study relate to seminal research in the field of business alliance formation. Contrary to the established predictions we find that the negative influence on alliance performance described as a consequence of the dissolved routinized alliance pattern by seminal authors is not present. At the same time, the case study shows that internalization of complementary assets does not by necessity result in dissolution of the business alliance as argued from a resource and competence based perspective.

The utility of social behavior rating scales for children who are deaf and hard of hearing

This independent study provides an overview of the social-emotional and theory of mind development of children birth through high school and evaluates the utility of social-emotional rating scales in the classroom for children who are deaf and hard of hearing.

Análisis de la interpretación de inconstitucionalidad de la penalización de la homosexualidad en el Ecuador (Artículos Varios)

El trabajo analiza la interpretación desarrollada por el Tribunal Constitucional del Ecuador en la declaratoria de inconstitucionalidad del artículo del Código Penal que, hasta 1997, tipificaba como delito las relaciones homosexuales consentidas. Parte de un análisis crítico de los argumentos expuestos por los accionantes y la Presidencia de la República, para luego contrastar la teoría de los métodos de interpretación constitucional y su aplicación en la resolución del Tribunal. El artículo busca demostrar la estrecha relación entre ideología e interpretación del derecho. Sostiene que sobre la base de prejuicios homofóbicos el Tribunal propugna una igualdad abstracta desconocedora de la diversidad sexual y construye un conflicto ficticio entre el principio de igualdad aplicado a homosexuales y la protección a la familia y los menores.

Justicia comunitaria y pluralismo jurídico en América Latina: una panorámica de cuarto de siglo

Desarrollar un balance crítico del impacto del Convenio 169 de la OIT y sus repercusiones en el ámbito del pluralismo jurídico y la justicia comunitaria en América Latina constituye un desafío complejo. Durante buena parte del siglo XX, muchos países ni siquiera reconocían que a lo interno de sus territorios existían pueblos indígenas u originarios. La huella y la herida colonial simplemente estaban vigentes. La época en que se aprueba el Convenio 169 de la OIT coincide con el auge neoliberal y el multiculturalismo en la región, pero también con la emergencia a la escena política de un vigoroso movimiento indígena. ¿Ha cambiado la situación de los pueblos indígenas desde entonces hasta ahora? ¿Se han reconocido su condición de pueblos y culturas diferenciadas, y junto con ello, de sus instituciones, autoridades y prácticas de administración de justicia? ¿Ha sido suficiente impulsar cambios en el campo jurídico para afectar una matriz colonial de poder que excluye, invisibiliza y controla al mismo tiempo? Sin duda respuestas a fondo a estas y otras interrogantes rebasan por completo los alcances del presente texto. Apenas se pretende desarrollar un primer esbozo de la situación, a manera de un balance urgente. Hay algunos trabajos y estudios (algunos de ellos citados) que muestran de manera más específica el camino recorrido. La interrogante central que anima estas líneas gira en torno a, ¿cuáles son los principales avances y dificultades existentes en torno a la justicia comunitaria y el pluralismo jurídico a raíz de la ratificación y vigencia del Convenio 1609 de la OIT en algunos países de América Latina? Para responder a esta pregunta, el texto presenta una panorámica y retrospectiva, y está organizado en cinco ítems centrales: a) situación de los pueblos indígenas antes de la aprobación del Convenio 169 de 1989; b) los (principales) efectos y repercusiones generadas por la aprobación del Convenio 169 en el ámbito de la justicia comunitaria; c) las reformas constitucionales y legales, especialmente en relación al pluralismo jurídico y la justicia comunitaria; d) un repaso de algunas de la agenda de políticas públicas en torno a tema; y finalmente e) la situación de las mujeres indígenas y la justicia comunitaria.

Medusa, Antaeus, and Caesar Libycus

Although it is well known that Lucan’s Libya is a wild and threatening place, its threat is not restricted to indigenous people, places and things, such as Hannibal, Cleopatra, the Syrtes, or the desert with its catalogue of horrifying snakes. He also associates Libya with anti-Republican Romans, above all Julius Caesar, who endangers the Republic with his excessive, animalistic energy and resembles the continent where he is trapped in the final book. Although the gods as characters are removed from the world of the Bellum Civile, Lucan allows supernatural traces to linger in particular locations such as the Gallic grove in Book 3 or Thessaly in Book 6. Libya is by far the greatest of these reservoirs of frightening myth and fantasy, which do violence to the historical credibility of the narrative, just as Libya itself is presented as the origin or conduit of a number of historical characters who assault Italy and Europe. Lucan’s two mythic narratives (Antaeus in Book 4 and Medusa in Book 9) are essential parts of the hostile Libyan landscape, but in very different ways. The male Antaeus, associated with lions, is connected with a region of solid rock where he was destroyed. The female Medusa, associated with snakes, is connected with a region of shifting sands where she left a deadly, everlasting legacy. To complicate matters further, even though Medusa’s snakes represent the annihilation of the Republican self, the logic of the narrative is undermined and there is even a sympathetic subtext. As part of Libya’s historical and mythical legacy, these stories reveal that for Lucan, historical epic is linked with Republicanism, but mythical epic is in the service of dictatorship.

Inhibition of vascular smooth muscle cell proliferation by non-steroidal anti-inflammatory drugs

Abnormal vascular smooth muscle cell (VSMC) proliferation is known to play an important role in the pathogenesis of atherosclerosis, restenosis and instent stenosis. Recent studies suggest that salicylates, in addition to inhibiting cyclooxygenase activity, exert an antiproliferative effect on VSMC growth both in vitro and in vivo. However, whether all non-steroidal anti-inflammatory drugs (NSAID) exert similar antiproliferative effects on VSMCs, and do so via a common mechanism of action, remains unknown. In the present study, we demonstrated that the NSAIDs, aspirin, ibuprofen and sulindac induced a dose-dependent inhibition of proliferation in rat A10 VSMCs (IC50 = 1666 mumol/L, 937 mumol/L and 520 mumol/L, respectively). These drugs did not show significant cytotoxic effects as determined by LDH release assay, even at the highest concentrations tested (aspirin, 5000 mumol/L; ibuprofen, 2500 mumol/L; and sulindac, 1000 mumol/L). Flow cytometric analyses showed that a 48 h exposure of A10 VSMCs to ibuprofen (1000 mumol/L) and sulindac (750 mumol/L) led to a significant G1 arrest (from 68.7 +/- 2.0% of cells in G1 to 76.6 +/- 2.2% and 75.8 +/- 2.2%, respectively, p < 0.05). In contrast, aspirin (2500 mumol/L) failed to induce a significant G1 arrest (68.1 +/- 5.2%). Clearer evidence of a G1 block was obtained by treatment of cells with the mitotic inhibitor, nocodazole (40 ng/ml), for the final 24 h of the experiment. Under these conditions, aspirin still failed to induce a G1 arrest (from 25.9 +/- 10.9% of cells in G1 to 19.6 +/- 2.3%) whereas ibuprofen and sulindac led to a significant accumulation of cells in G1(51.8% +/- 17.2% and 54.1% +/- 10.6%, respectively, p < 0.05). These results indicate that ibuprofen and sulindac inhibit VSMC proliferation by arresting the cell cycle in the G1 phase whereas the effect of aspirin appears to be independent of any special phase of the cell cycle. Irrespective of mechanism, our results suggest that NSAIDs might be of benefit to the treatment of vascular proliferative disorders.

Ring-rearrangement metathesis of substituted 2-aminonorbornenes

In this report we describe the ring-rearrangement metathesis of 2-aminonorbornene derivatives. Ail efficient ruthenium-catalysed metathesis reaction Occurs with a wide range of pendent alkenes and alkynes to generate bicyclic amines and amides.

Experimental and theoretical study of the infrared spectra of BrHI- and BrDI-

Gas phase vibrational spectra of BrHI- and BrDI- have been measured from 6 to 17 mum (590-1666 cm-1) using tunable infrared radiation from the free electron laser for infrared experiments in order to characterize the strong hydrogen bond in these species. BrHI-.Ar and BrDI-.Ar complexes were produced and mass selected, and the depletion of their signal due to vibrational predissociation was monitored as a function of photon energy. Additionally, BrHI- and BrDI- were dissociated into HBr (DBr) and I- via resonant infrared multiphoton dissociation. The spectra show numerous transitions, which had not been observed by previous matrix studies. New ab initio calculations of the potential-energy surface and the dipole moment are presented and are used in variational ro-vibrational calculations to assign the spectral features. These calculations highlight the importance of basis set in the simulation of heavy atoms such as iodine. Further, they demonstrate extensive mode mixing between the bend and the H-atom stretch modes in BrHI- and BrDI- due to Fermi resonances. These interactions result in major deviations from simple harmonic estimates of the vibrational energies. As a result of this new analysis, previous matrix-isolation spectra assignments are reevaluated. (C) 2004 American Institute of Physics.

System identification of Wiener systems with B-spline functions using De Boor recursion

In this article a simple and effective algorithm is introduced for the system identification of the Wiener system using observational input/output data. The nonlinear static function in the Wiener system is modelled using a B-spline neural network. The Gauss–Newton algorithm is combined with De Boor algorithm (both curve and the first order derivatives) for the parameter estimation of the Wiener model, together with the use of a parameter initialisation scheme. Numerical examples are utilised to demonstrate the efficacy of the proposed approach.

Hankel and Toeplitz transforms on H 1: continuity, compactness and Fredholm properties

We revisit the boundedness of Hankel and Toeplitz operators acting on the Hardy space H 1 and give a new proof of the old result stating that the Hankel operator H a is bounded if and only if a has bounded logarithmic mean oscillation. We also establish a sufficient and necessary condition for H a to be compact on H 1. The Fredholm properties of Toeplitz operators on H 1 are studied for symbols in a Banach algebra similar to C + H ∞ under mild additional conditions caused by the differences in the boundedness of Toeplitz operators acting on H 1 and H 2.

Polysialic acid as a drug carrier: evaluation of a new polysialic acid–epirubicin conjugate and its comparison against established drug carriers

This paper explores the potential of polysialic acid (PSA) as a carrier for low molecular weight anticancer drugs. A PSA–epirubicin (Epi) conjugate was synthesized and compared against Epi conjugates containing established carriers, namely: N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers, poly(ethylene glycol) (PEG) and polyglutamic acid (PGA). Biological assessments in the breast cancer cell line MCF-7 and in the anthracycline resistant MCF-7/DX showed that the PSA–Epi conjugate had the highest activity (40% and 30% cell death in the two cell lines at 1 mM Epi equiv., respectively). FACS studies confirmed internalization of all conjugates by cholesterol-dependent endocytosis. PSA–Epi showed release of Epi (40% at 5 h) when incubated with lysosome extracts. In vivo evaluation showed that all conjugates had a significantly longer half-life compared to free Epi. This study also allowed an investigation on the effect of the polymeric carrier on the biological activity of a conjugate, with the biodegradability of the carrier emerging as an important feature.