Carte de la partie méridionale de la Grèce pour servir à l'intelligence de l'Histoire d'Epaminondas / Par M. Bellin, ... ; Dheulland sculp.

Échelle(s) : [1:1 682 000 environ], Lieues comunes de France de 25 au degré, 20 [= 5,2 cm]

La Carte de la Grèce ancienne suivant Hérodote, Thucydide, Xenophon, Sophian, Pausanias & autres : dressée pour l'intelligence de l'histoire grecque / Par P. Du Val, ...

Échelle(s) : [1:2 400 000 ca] Eschelle de 60 mille pas geométriques [= 4,9 cm]

Experimental and computational approaches to quantitative proteomics: status quo and outlook.

Proteomics has come a long way from the initial qualitative analysis of proteins present in a given sample at a given time ("cataloguing") to large-scale characterization of proteomes, their interactions and dynamic behavior. Originally enabled by breakthroughs in protein separation and visualization (by two-dimensional gels) and protein identification (by mass spectrometry), the discipline now encompasses a large body of protein and peptide separation, labeling, detection and sequencing tools supported by computational data processing. The decisive mass spectrometric developments and most recent instrumentation news are briefly mentioned accompanied by a short review of gel and chromatographic techniques for protein/peptide separation, depletion and enrichment. Special emphasis is placed on quantification techniques: gel-based, and label-free techniques are briefly discussed whereas stable-isotope coding and internal peptide standards are extensively reviewed. Another special chapter is dedicated to software and computing tools for proteomic data processing and validation. A short assessment of the status quo and recommendations for future developments round up this journey through quantitative proteomics.

Computational fluid dynamics of the right ventricular outflow tract and of the pulmonary artery: a bench model of flow dynamics.

OBJECTIVES: The reconstruction of the right ventricular outflow tract (RVOT) with valved conduits remains a challenge. The reoperation rate at 5 years can be as high as 25% and depends on age, type of conduit, conduit diameter and principal heart malformation. The aim of this study is to provide a bench model with computer fluid dynamics to analyse the haemodynamics of the RVOT, pulmonary artery, its bifurcation, and left and right pulmonary arteries that in the future may serve as a tool for analysis and prediction of outcome following RVOT reconstruction. METHODS: Pressure, flow and diameter at the RVOT, pulmonary artery, bifurcation of the pulmonary artery, and left and right pulmonary arteries were measured in five normal pigs with a mean weight of 24.6 ± 0.89 kg. Data obtained were used for a 3D computer fluid-dynamics simulation of flow conditions, focusing on the pressure, flow and shear stress profile of the pulmonary trunk to the level of the left and right pulmonary arteries. RESULTS: Three inlet steady flow profiles were obtained at 0.2, 0.29 and 0.36 m/s that correspond to the flow rates of 1.5, 2.0 and 2.5 l/min flow at the RVOT. The flow velocity profile was constant at the RVOT down to the bifurcation and decreased at the left and right pulmonary arteries. In all three inlet velocity profiles, low sheer stress and low-velocity areas were detected along the left wall of the pulmonary artery, at the pulmonary artery bifurcation and at the ostia of both pulmonary arteries. CONCLUSIONS: This computed fluid real-time model provides us with a realistic picture of fluid dynamics in the pulmonary tract area. Deep shear stress areas correspond to a turbulent flow profile that is a predictive factor for the development of vessel wall arteriosclerosis. We believe that this bench model may be a useful tool for further evaluation of RVOT pathology following surgical reconstructions.

Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues.

γ-Hydroxybutyric acid (GHB) is an endogenous short-chain fatty acid popular as a recreational drug due to sedative and euphoric effects, but also often implicated in drug-facilitated sexual assaults owing to disinhibition and amnesic properties. Whilst discrimination between endogenous and exogenous GHB as required in intoxication cases may be achieved by the determination of the carbon isotope content, such information has not yet been exploited to answer source inference questions of forensic investigation and intelligence interests. However, potential isotopic fractionation effects occurring through the whole metabolism of GHB may be a major concern in this regard. Thus, urine specimens from six healthy male volunteers who ingested prescription GHB sodium salt, marketed as Xyrem(®), were analysed by means of gas chromatography/combustion/isotope ratio mass spectrometry to assess this particular topic. A very narrow range of δ(13)C values, spreading from -24.810/00 to -25.060/00, was observed, whilst mean δ(13)C value of Xyrem(®) corresponded to -24.990/00. Since urine samples and prescription drug could not be distinguished by means of statistical analysis, carbon isotopic effects and subsequent influence on δ(13)C values through GHB metabolism as a whole could be ruled out. Thus, a link between GHB as a raw matrix and found in a biological fluid may be established, bringing relevant information regarding source inference evaluation. Therefore, this study supports a diversified scope of exploitation for stable isotopes characterized in biological matrices from investigations on intoxication cases to drug intelligence programmes.

Apoio à Administração, Business Intelligence. O caso Unipiaget

A memória realizada no âmbito do regulamento dos Cursos de Graduação da Universidade Jean Piaget de Cabo Verde, apresenta um estudo exaustivo sobre Sistemas de Apoio à Decisão e Businees Intelligence, mais concretamente, o estudo da sua arquitectura, os benefícios que trazem a uma organização, bem como a sua integração às estratégias empresariais, com vista ao alcance dos objectivos traçados. Ainda, apresenta um estudo de caso sobre a Unipiaget, cujas conclusões indicam que essa Universidade, ainda tem muito o que fazer para que haja uma real partilha de conhecimento extraído do seu Sistema Informação, que ao contrário de muitas empresas em Cabo Verde, é apoiada por Tecnologias de Informação e Comunicação bem actuais e capazes. A memória permitiu alcançar os objectivos preconizados no início da elaboração da mesma, sem que tenha havido sobressaltos, apesar da escassa bibliografia.

Carte de la mer Méditerranée pour servir à l'intelligence des événements politiques et des relations commerciales / A. M. Perrot géographe

Échelle(s) : [ca 1:8 533 000]

Hippocampal volume predicts fluid intelligence in musically trained people.

Recently, age-related hippocampal (HP) volume loss could be associated with a decrease in general fluid intelligence (gF). In the present study we investigated whether and how extensive musical training modulates human HP volume and gF performance. Previously, some studies demonstrated positive effects of musical training on higher cognitive functions such as learning and memory, associated with neural adaptations beyond the auditory domain. In order to detect possible associations between musical training and gF, we bilaterally segmented the HP formation and assessed the individual gF performance of people with different levels of musical expertise. Multiple regression analyses revealed that HP volume predicts gF in musicians but not in nonmusicians; in particular, bilaterally enhanced HP volume is associated with increased gF exclusively in musically trained people (amateurs and experts). This result suggests that musical training facilitates the recruitment of cognitive resources, which are essential for gF and linked to HP functioning. Musical training, even at a moderate level of intensity, can thus be considered as a potential strategy to decelerate age-related effects of cognitive decline. © 2013 Wiley Periodicals, Inc.

Business Intelligence Auxílio às organizações no processo da tomada de decisão

O presente trabalho destinada para o complemento de grau de licenciatura tem como objectivo principal analisar o auxílio de Business Intelligence (BI) às organizações na sua melhoria contínua no desempenho e qualidade de serviços, sobretudo no processo de tomada de decisão e estudo da sua existência na Cabo Verde Telecom. As tecnologias associadas a ele, nomeadamente, data warehouse, data mining e olap são primordiais para a tomada de decisão sobre as actividades estratégicas no mercado de negócios. Essas tecnologias permitem uma análise cuidada dos dados, transformando-os em informações pertinentes para a tomada de decisão nas empresas, garantindo com isto o seu crescimento no mercado.