Inniskillin fonds, 1970-2014, n.d.

Inniskillin Wines was founded by Karl Kaiser and Donald Ziraldo in 1975 in Niagara-on-the-Lake, Ontario. They had met the previous year, when Karl Kaiser, a winemaker and chemist, purchased some grapes from Donald Ziraldo, who owned and operated Ziraldo Nurseries. The two shared a vision of producing better quality Canadian wines and formed a partnership, with Kaiser making the wine and Ziraldo serving as company President. In 1975, they were granted a winery license by the LCBO, the first one granted since 1929. The company name Inniskillin was derived from the Inniskilling Fusilliers, an Irish regiment whose Colonel once owned the land that Ziraldo Nurseries occupied. This was the original site of the winery, although in 1978 the winery moved to the Brae Burn Estate, their current location. In 1982 the winery expanded by 50 acres with the addition of the Montague Vineyard, and another 50 acres was acquired in 1991. The Niagara-on-the-Lake vineyard produces single vineyards bottlings of Chardonnay, Pinot Noir, Merlot and Pinot Grigio/Pinot Gris. In 1984, Karl Kaiser began producing icewine from Vidal grapes frozen naturally on the vine. Inniskillin garnered international acclaim for the quality of their icewines, receiving the prestigious Grand Prix d’Honneur at VinExpo in 1991, for their 1989 Vidal icewine. This established Inniskillin as a producer of world class wines, while also raising the profile of Canadian wines in general. The company branched out their operations, first acquiring vineyards in the Napa Valley in 1989 to form Inniskillin Napa (producing wines under the Terra label), and in 1994 establishing Inniskillin Okanagan in the Okanagan Valley in British Columbia. The Napa valley venture ceased in the mid 90’s, while Inniskillin Okanagan continues to operate. In 2006, Karl Kaiser and Donald Ziraldo left Inniskillin. Kaiser retired, while Ziraldo became chair of the Vineland Research and Innovation Center (2006-2011), and remains involved in the wine industry. In 2007, Bruce Nicholson joined Inniskillin as winemaker. Nicholson continues to produce award-winning wines under the Inniskillin label, receiving the top award, the Premio Speciale Gran Award, at Vinitaly 2009 for his 2006 Gold Vidal and his 2006 Sparkling Vidal Icewine. In 2012, he received several awards for the 2008 Riesling Icewine, including gold at the International Wine and Spirits Competition in London, UK, the San Francisco International Wine Championships, and Selections Mondials des Vins Canada.

Análisis de factibilidad en la recolección y recuperación de pilas de zinc-aire para audífonos cubiertos por el POS

Debido a la latente preocupación ambiental, la nueva y futura legislación sobre el tema y la forma en que estos factores afectan a las empresas, en este trabajo realizado en la Universidad del Rosario en el primer semestre del 2011, se realizó un estudio de la factibilidad de realizar un plan post consumo para las pilas zinc-aire, referencias R10, R13, R312 y R675 que son utilizadas para los aparatos auditivos. Existe una gran cantidad de pilas zinc-aire que alcanzan el final de su vida útil semanalmente en el país y estas son potencialmente tóxicas y no-biodegradables, por lo que decidimos investigar qué tan factible podía ser hacer una recuperación eficiente de las mismas y qué beneficios podría reportar a las empresas del sector. En la investigación se descartaron opciones como la desmaterialización para venta de sus materiales y la recarga de las pilas para su re-uso, ambas debido a que aún no se cuenta con la tecnología necesaria en el continente para estas opciones. Se consideró entonces el planteamiento de un plan Post-consumo para la correcta disposición de estas pilas, para lo cual es necesario exportarla al continente Europeo. A partir del planteamiento del Plan Post-consumo se hizo un estudio de la factibilidad del mismo, logrando determinar los aspectos principales del plan, como son: Información del producto, del mercado, transporte, almacenamiento, procedimiento del reciclaje, beneficios ambientales, y los costos de llevarlo a cabo.

Impacto del proceso de eliminación del doble conteo del material importado por Carbones del Cerrejón Limited en términos de eficiencia y efectividad en el proceso de nacionalización y liberación del material

La operación de mega minería que abarca CERREJON se desarrolla bajo lo más altos estándares de seguridad y calidad, con el compromiso de entregar al mercado un excelente producto y evitando el deterioro del entorno. Uno de los puntos más fuertes de la compañía se haya en la integración de los procesos productivos entre la mina de carbón, el ferrocarril y el puerto, logrando que la operación sea eficiente y que garantice niveles altos de óptimos resultados y que los porcentajes de falla no existan o cada vez sean menores en el proceso de explotación y transporte del carbón de Colombia hacia el mundo. El departamento de MATERIALES es el punto de origen para garantizar que se desarrolle la operación, dado que el departamento tiene la gran labor de adquirir y entregar los bienes y servicios requeridos por la Compañía al más bajo costo total evaluado, en el menor tiempo posible y bajo el marco de la legislación Colombiana en el proceso de nacionalización, con un alto énfasis en el desarrollo de relaciones fuertes y sinérgicas entre todos los eslabones de la cadena. Todo el proceso del departamento se enmarca dentro de un ciclo que debe encaminarse a ser cada vez más efectivo y eficiente; de allí que se busquen opciones de mejoramiento para afinar los procesos. Para que sea posible y factible manejar una mega operación como esta se requiere afinar al máximo la red que se establece en su cadena de abastecimiento, buscando lograr un flujo de producto, información y fondos que garanticen disponibilidad del producto, para así generar una rentabilidad alta a la compañía, y controlar los costos por la operación. Dado que la cadena de suministro es susceptible a mejoras, gracias a la interacción con los proveedores, colaboradores y clientes; se pretende sacar el mejor provecho de esto, a través del análisis de la cadena actual de CERREJON; presentando una opción de mejora en uno de los eslabones del proceso productivo, esta opción ha sido contemplada desde años anteriores, pero en esta ocasión gracias a la integración de afinamientos en los sistemas de información, y la participación activa de los proveedores, se encuentra una opción viable de la eliminación de un reproceso, que garantiza eficiencia y efectividad en la agilización del ciclo de producción en CERREJON. A través de la ejecución del proyecto de reforma del conteo, se presenta la oportunidad de mejoramiento en la cadena del departamento; el proceso de reconteo en la mina, realizado posteriormente al conteo inicial en Puerto Bolívar, de los materiales que llegan importados vía marítima. El proceso de afinamiento del recibo documental en el consolidador de carga y los mayores proveedores de entrega directa (HITACHI y MCA) al transportador, genera la opción del uso de terminales portátiles, que de la mano con los ajustes documentales, permitirán que la carga sea contada y separada por localización, para enviarla vía tren a LMN, reduciendo tiempo de entrega al cliente final, los costos de remanejo al volver a contar, y los costos asociados a las entregas no oportunas de devolución de contenedores.

Evaluación de la Efectividad del Restaurante-Bar El Molino en el Campo de Percepción de Marca Usando un Sistema de Simulación Basado en Agentes

El siguiente trabajo, a partir de la identificación de los diferentes sujetos que participan en el medio ambiente donde se desenvuelve el restaurante El Molino, busca determinar cuáles podrían ser las estrategias de mercadeo más efectivas para que la imagen, concepto y servicio del restaurante, la marca en general, resulte lo más atractivas posibles para los segmentos objetivo de la empresa. Dadas las circunstancias de que es un negocio reciente, no existen datos históricos de la imagen que proyecta la marca hacia sus clientes, por lo tanto la información a partir de la cual se pretenden generar alternativas para que la marca influencie a los clientes de la manera deseada será conseguida a partir de una simulación que será obtenida de un modelo basado en agentes. Con esto lo que se busca es poder parametrizar en qué aspectos y de qué forma la empresa debe invertir para que la forma en que los clientes perciben la marca sea la deseada por el restaurante.

Consumer attitude towards purchasing intent for ready to drink orange juice and nectar

Purpose: The purpose of this paper was to evaluate the impact of some labeling aspects on the consumer intent to purchase ready to drink orange juice and nectar. Design/methodology/approach: The influence of label information on the consumer intent to purchase was evaluated by conjoint analysis using a convenience sample (n=149). A factorial design with four characteristics, price, brand, information about the product and kind of beverage, was used. Three levels were established for brand and product information, and two for price and kind of beverage. Findings: Low price, product information and market leading brand had positive impact. No preservatives/natural was the information that most influenced consumer's purchase intent. The ideal label showed the leading brand, low price and information no preservatives/natural. These results could be useful for strategic planning of consumer instruction and have important implications for Brazilian orange juice manufactures. Originality/value: Although the most widely consumed beverages in Brazil are ready to drink orange juice and nectar, it was unexpected that consumers did not know the differences between them and that kind of beverage was not an important factor for the purchase decision. © Emerald Group Publishing Limited.

Processos de ocupação nas novas fronteiras da Amazônia: o interflúvio do Xingu/ Iriri

Este trabalho apresenta os primeiros resultados do esforço conjunto de várias instituições, organizadas em torno da rede Geoma (Rede Temática de Pesquisa em Modelagem Ambiental da Amazônia) para avançar a compreensão dos novos padrões e processos de estruturação do território nas novas frentes no sul do Pará, analisando padrões de desmatamento e os processos que dão origem a esses padrões. Busca-se, aqui, produzir os subsídios necessários para o desenho de políticas públicas responsáveis, que não privilegiem um único aspecto do problema, como a abertura de estradas, por exemplo. Aponta-se, então, a partir desses primeiros resultados, que apenas uma solução integrada que procure estruturar os principais agentes e processos na cadeia produtiva seria possível para minorar os efeitos do desmatamento e nortear o desenvolvimento integrado para a região, com benefícios para a floresta e para as populações que ali vivem.

Pharmakovigilanz bei Patienten mit Phenprocoumon-Therapie : Untersuchungen zu potentiellen Interaktionen und Betreuungsqualität

Zur Verbesserung der Sicherheit und Effektivität der Phenprocoumon-Therapie wurden drei unterschiedliche Untersuchungen durchgeführt.rnZunächst wurde auf Grundlage bekannter Datenbanken und Informationsquellen zu Arznei-mittelinteraktionen (Drugdex, Abda Datenbank, Marcumar® Fachinformation, Coumarin-Interaktionsliste der Federatie van Nederlandse Trombosediensten, Review zu Warfarin-Interaktionen) eine handlungsorientierte Interaktionsdatenbank für Phenprocoumon erstellt. Dazu wurden in einer Übersichtstabelle relevante Informationen zu potentiellen Interaktionen für insgesamt 375 Arzneimittel zusammengestellt. Diese Tabelle wurde durch ein dreiköpfiges Expertenteam begutachtet und die potentiellen Interaktionspartner fünf verschiedenen Schweregraden und Stufen klinischer Relevanz zugeordnet. Für fast 50% der potentiellen Interaktionspartner wurden Handlungen als nicht erforderlich erachtet. Für die restlichen potentiellen Interaktionspartner wurden Handlungen zum klinischen Management der Interaktion in Abhängigkeit vom zeitlichen Zusammenhang mit der Phenprocoumon-Einnahme festgelegt. rnAnschließend wurde in einer Anwendungsbeobachtung der Zusammenhang zwischen der zusätzlichen Einnahme potentiell interagierender Arzneimittel (in der entwickelten Datenbank eingestuft mit dem Schweregrad „hoch“ und „sehr hoch“) und der Häufigkeit von Änderungen der Phenprocoumon-Wochendosis an 116 Patienten untersucht. Das relative Risiko für eine Dosisanpassung war bei Patienten in der Interaktions-Gruppe (n=23) signifikant erhöht (RR=1,9; p<0,001). Als weitere potentielle Einflussfaktoren stellten sich zunehmendes Alter (Alter 80-85 Jahre: RR=2; p<0,05), vielfache Komorbiditäten (4 Komorbiditäten: RR=2,1; p<0,05) und eingeschränkte Nieren- (RR=1,47; p>0,05) und Leberfunktion (RR=1,3; p>0,05) heraus.rnZur Untersuchung der Betreuungsqualität von VKA-Patienten im Thrombosedienst Mainz wurden retrospektiv die Daten von 118 Patienten ausgewertet. Als Qualitätsparameter wurden die prozentuale Häufigkeit von INR-Werten im Zielbereich, die TTR (Time in Therapeutic Range), die Dauer der NMH-Therapie, die Zeit bis zum Erreichen des Zielbereichs und der durchschnittliche Abstand zwischen zwei Kontrollterminen ermittelt. Im Median lag jeder Patient mit 73% der gemessenen INR-Werte und im individuellen Zielbereich. Die TTR betrug im Median 80%. Die Patienten benötigten 7 Tage zum Erreichen des Zielbereiches. Die NMH-Therapie wurde über 8 Tage durchgeführt. Die Patienten kamen im Median alle 11 Tage zu einem Kontrolltermin. Im Benchmark zu international publizierten Qualitätskenn-zahlen zur VKA-Therapie ist die Betreuungsqualität im Thrombosedienst Mainz als sehr gut einzustufen.rn

Confusion over live/dead stainings for the detection of vital microorganisms in oral biofilms--which stain is suitable?

BACKGROUND There is confusion over the definition of the term "viability state(s)" of microorganisms. "Viability staining" or "vital staining techniques" are used to distinguish live from dead bacteria. These stainings, first established on planctonic bacteria, may have serious shortcomings when applied to multispecies biofilms. Results of staining techniques should be compared with appropriate microbiological data. DISCUSSION Many terms describe "vitality states" of microorganisms, however, several of them are misleading. Authors define "viable" as "capable to grow". Accordingly, staining methods are substitutes, since no staining can prove viability.The reliability of a commercial "viability" staining assay (Molecular Probes) is discussed based on the corresponding product information sheet: (I) Staining principle; (II) Concentrations of bacteria; (III) Calculation of live/dead proportions in vitro. Results of the "viability" kit are dependent on the stains' concentration and on their relation to the number of bacteria in the test. Generally this staining system is not suitable for multispecies biofilms, thus incorrect statements have been published by users of this technique.To compare the results of the staining with bacterial parameters appropriate techniques should be selected. The assessment of Colony Forming Units is insufficient, rather the calculation of Plating Efficiency is necessary. Vital fluorescence staining with Fluorescein Diacetate and Ethidium Bromide seems to be the best proven and suitable method in biofilm research.Regarding the mutagenicity of staining components users should be aware that not only Ethidium Bromide might be harmful, but also a variety of other substances of which the toxicity and mutagenicity is not reported. SUMMARY - The nomenclature regarding "viability" and "vitality" should be used carefully.- The manual of the commercial "viability" kit itself points out that the kit is not suitable for natural multispecies biofilm research, as supported by an array of literature.- Results obtained with various stains are influenced by the relationship between bacterial counts and the amount of stain used in the test. Corresponding vitality data are prone to artificial shifting.- As microbiological parameter the Plating Efficiency should be used for comparison.- Ethidium Bromide is mutagenic. Researchers should be aware that alternative staining compounds may also be or even are mutagenic.

Mefloquine at the crossroads? Implications for malaria chemoprophylaxis in Europe

Since its introduction to the market in 1985, mefloquine has been used for malaria chemoprophylaxis by more than 35 million travellers. In Europe, in 2014, the European Medicines Agency (EMA) issued recommendations on strengthened warnings, prescribing checklists and updates to the product information of mefloquine. Some malaria prevention advisors question the scientific basis for the restrictions and suggest that this cost-effective, anti-malarial drug will be displaced as a first-line anti-malaria medication with the result that vulnerable groups such as VFR and long-term travellers, pregnant travellers and young children are left without a suitable alternative chemoprophylaxis. This commentary looks at the current position of mefloquine prescribing and the rationale of the new EMA recommendations and restrictions. It also describes the new recommendations for malaria prophylaxis that have been adapted by Switzerland, Germany, Austria and Italy where chemoprophylaxis use is restricted to high-risk malaria-endemic areas.

A survey of warning colours of pesticides

Pesticides are used to protect plants all over the world. Their increasing specificity has been due to utilization of differences in biochemical processes, and has been accompanied by lower human toxicity. Nevertheless cases of poisoning are still observed. While certain toxic substances are provided with characteristic dyes or pigments to facilitate easy identification, no overview of pesticide colors exists. The lack of available product information prompted us to explore the colors and dyes of pesticides registered in Germany, most of which are commercially available worldwide. A compilation of the colors and odors of 207 pesticide products is presented. While some of the substances can be identified by their physical characteristics, in other cases, the range of possibilities can be narrowed by their nature and color.

Assessment of markers of medication literacy in a US-Mexico border community

Each year an estimated 180,000 people in the United States (U.S.) die as a result of medication errors, now considered a major public health problem. If a patient cannot correctly act on information related to medication use or "Medication Literacy" there is an increased potential for error. Medication use issues are unique on the US-Mexico border because they include high rates of herbal products and medication products from Mexico as well as issues related to the preferred language (English or Spanish) of the patient. To evaluate the medication literacy in a US-Mexico border community, this retrospective study evaluates 180 subjects representing four diverse economic segments of a metropolitan US-Mexico Border community who have taken a Medication Literacy Assessment. The assessment tool has been created to understand how patients interpret medication information for prescription, over-the-counter, herbal, and Mexican medication product use, and how they problem-solve medication questions. The Medication Literacy Assessment tool specifically assesses document literacy (e.g., prescription labels), prose literacy (e.g., patient leaflets), numeracy (e.g., calculations and measurements) as well as qualitative data related to medication use practices. The main hypothesis of this study is that the ability to interpret and use medications will vary based on education, language (Spanish or English), and recruitment sites (economically diverse communities). The results will provide information to better characterize medication use in a primarily Hispanic population on the US-Mexico border and may be used to influence policy decisions regarding prescription and over-the-counter product information.^

Bank Borrowing and Financing of Medium-sized Firms in Indonesia

The improvement of financial intermediation functions is crucial for a robust banking system. When lending, banks have to cope with such problems as information asymmetry and adverse selection. In order to mitigate these problems, banks have to product information and improve their techniques of lending. During the 1998 financial crisis, Indonesia's banking system suffered severe damage and revealed that the country's banking intermediation functions did not work well. This paper examines the financial intermediation functions of banks in Indonesia and analyzes the importance of bank lending to firms. The focus is on medium-sized firms, and "relationship lending", one of the bank lending techniques, is used to examine financial intermediation in Indonesia. The results of logit regressions show that the relationship between a bank and a firm affects the probability of bank lending. The amount of borrowing and collateral are also affected by a firm's relationship with a bank. When viewed from the standpoint of relationship lending to medium-sized firms, Indonesian banks cannot be criticized for any malfunction of financial intermediation.

Drug registration and listing instruction booklet.

Mode of access: Internet.

National drug code directory.

Vols. for 1970-1972 published by the Public Health Service; 1976- by the Public Health Service, Food and Drug Administration; 1980- by the U.S. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration.

Utilising online shopping environment attributes holistically to create competitive advantage

As more consumers shop online, it becomes crucial for marketers to know how online shopping environments (OSEs) can be used to gain competitive advantage. This dissertation aims to explain theoretically how OSE attributes work together holistically to produce desirable consumer responses, applying and extending a theory from the environmental psychology literature to the online context. Firstly, the study conceptualises OSEs as virtual environments which may be perceived and experienced both cognitively and affectively through a technology-mediated interaction with a computer screen. A multi-disciplinary approach identifies key characteristics of OSEs: they involve consumers; they are more complex than their offline counterparts; they are likely first apprehended holistically; and they can elicit high levels of emotions and cognition. Secondly, the research uses a gestalt approach and extends Kaplan and Kalan’s (1982) Preference Framework, taking account of the specific characteristics of OSEs, which one visits specifically to obtain product information. The results support the proposition that OSEs are perceived in terms of their Sense-making and Exploratory attributes. Thirdly, the research explains how OSE attributes work together to produce desirable consumer responses. As hypothesised, Exploratory potential produces both Hedonic and Utilitarian value, and both kinds of value contribute to Site commitment. An unexpected result is that Sense-making potential does not produce Utilitarian value directly, but only through the mediation of Exploratory potential. The research contributes to marketing theory by: (1) identifying ways the internet has changed the nature of the shopping experience; (2) extending Kaplan and Kaplan’s Preference Framework to explain how consumers perceive OSEs holistically; (3) identifying the distinction between page-level and site-level perceptions, and (4) distinguishing between different sources of information (marketer vs. non-marketer). Managerially, the research provides a model for marketers to conceive and design retail websites whose attributes work together to create competitive advantage.