Advanced aspects of radiation protection in the use of particle accelerators in the medical field

In this work, the well-known MC code FLUKA was used to simulate the GE PETrace cyclotron (16.5 MeV) installed at “S. Orsola-Malpighi” University Hospital (Bologna, IT) and routinely used in the production of positron emitting radionuclides. Simulations yielded estimates of various quantities of interest, including: the effective dose distribution around the equipment; the effective number of neutron produced per incident proton and their spectral distribution; the activation of the structure of the cyclotron and the vault walls; the activation of the ambient air, in particular the production of 41Ar, the assessment of the saturation yield of radionuclides used in nuclear medicine. The simulations were validated against experimental measurements in terms of physical and transport parameters to be used at the energy range of interest in the medical field. The validated model was also extensively used in several practical applications uncluding the direct cyclotron production of non-standard radionuclides such as 99mTc, the production of medical radionuclides at TRIUMF (Vancouver, CA) TR13 cyclotron (13 MeV), the complete design of the new PET facility of “Sacro Cuore – Don Calabria” Hospital (Negrar, IT), including the ACSI TR19 (19 MeV) cyclotron, the dose field around the energy selection system (degrader) of a proton therapy cyclotron, the design of plug-doors for a new cyclotron facility, in which a 70 MeV cyclotron will be installed, and the partial decommissioning of a PET facility, including the replacement of a Scanditronix MC17 cyclotron with a new TR19 cyclotron.

X rays from laser-plasma accelerators

Uno dei maggiori obiettivi della ricerca nel campo degli acceleratori basati su interazione laser-plasma è la realizzazione di una sorgente compatta di raggi x impulsati al femtosecondo. L’interazione tra brevi impulsi laser e un plasma, a energie relativistiche, ha recentemente portato a una nuova generazione di sorgenti di raggi x con le proprietà desiderate. Queste sorgenti, basate sulla radiazione emessa da elettroni accelerati nel plasma, hanno in comune di essere compatte, produrre radiazione collimata, incoerente e impulsata al femtosecondo. In questa tesi vengono presentati alcuni metodi per ottenere raggi x da elettroni accelerati per interazione tra laser e plasma: la radiazione di betatrone da elettroni intrappolati e accelerati nel cosiddetto “bubble regime”, la radiazione di sincrotrone da elettroni posti in un ondulatore convenzionale con lunghezza dell’ordine dei metri e la radiazione ottenuta dal backscattering di Thomson. Vengono presentate: la fisica alla base di tali metodi, simulazioni numeriche e risultati sperimentali per ogni sorgente di raggi x. Infine, viene discussa una delle più promettenti applicazioni fornite dagli acceleratori basati su interazione tra laser e plasma: il Free-electron laser nello spettro dei raggi x, capace di fornire intensità 108-1010 volte più elevate rispetto alle altre sorgenti.

Particle Accelerators and Detectors for medical Diagnostics and Therapy

This Habilitationsschrift (Habilitation thesis) is focused on my research activities on medical applications of particle physics and was written in 2013 to obtain the Venia Docendi (Habilitation) in experimental physics at the University of Bern. It is based on selected publications, which represented at that time my major scientific contributions as an experimental physicist to the field of particle accelerators and detectors applied to medical diagnostics and therapy. The thesis is structured in two parts. In Part I, Chapter 1 presents an introduction to accelerators and detectors applied to medicine, with particular focus on cancer hadrontherapy and on the production of radioactive isotopes. In Chapter 2, my publications on medical particle accelerators are introduced and put into their perspective. In particular, high frequency linear accelerators for hadrontherapy are discussed together with the new Bern cyclotron laboratory. Chapter 3 is dedicated to particle detectors with particular emphasis on three instruments I contributed to propose and develop: segmented ionization chambers for hadrontherapy, a proton radiography apparatus with nuclear emulsion films, and a beam monitor detector for ion beams based on doped silica fibres. Selected research and review papers are contained in Part II. For copyright reasons, they are only listed and not reprinted in this on-line version. They are available on the websites of the journals.

On the automatic integration of hardware accelerators into FPGA-based embedded systems

This paper proposes an automatic framework for the seamless integration of hardware accelerators, starting from an OpenMP-based application and an XML file describing the HW/SW partitioning. It extends a fully software architecture by generating and integrating the cores, along with the proper interfaces, and the code for scheduling and synchronization. Experimental results show that it is possible to validate different solutions only by varying the input code.

MURA summer study reports on design and utilization of high-energy accelerators.

Abstracts in English.

Effect of nuclear radiation on organic materials, specifically magnet insulations in high-energy accelerators /

"March 1965."

Proceedings of a Conference on Neutrons from Electron Medical Accelerators : proceedings of a conference held at the National Bureau of Standards, Gaithersburg, Maryland, April 9-10, 1979 /

Includes bibliographical references.

The synthesis and mechanism of action of organic accelerators of the sulphur vilcanisation of rubber

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The application of low energy accelerators to analysis problems

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Constructive Synthesis of Memory-Intensive Accelerators for FPGA From Nested Loop Kernels

Field-programmable gate arrays are ideal hosts to custom accelerators for signal, image, and data processing but de- mand manual register transfer level design if high performance and low cost are desired. High-level synthesis reduces this design burden but requires manual design of complex on-chip and off-chip memory architectures, a major limitation in applications such as video processing. This paper presents an approach to resolve this shortcoming. A constructive process is described that can derive such accelerators, including on- and off-chip memory storage from a C description such that a user-defined throughput constraint is met. By employing a novel statement-oriented approach, dataflow intermediate models are derived and used to support simple ap- proaches for on-/off-chip buffer partitioning, derivation of custom on-chip memory hierarchies and architecture transformation to ensure user-defined throughput constraints are met with minimum cost. When applied to accelerators for full search motion estima- tion, matrix multiplication, Sobel edge detection, and fast Fourier transform, it is shown how real-time performance up to an order of magnitude in advance of existing commercial HLS tools is enabled whilst including all requisite memory infrastructure. Further, op- timizations are presented that reduce the on-chip buffer capacity and physical resource cost by up to 96% and 75%, respectively, whilst maintaining real-time performance.

Laser-Driven Ion Accelerators: State of the Art and Applications

Laser-plasma based accelerators of protons and heavier ions are a source of potential interest for several applications, including in the biomedical area. While the potential future use in cancer hadrontherapy acts as a strong aspirational motivation for this research field, radiobiology employing laser-driven ion bursts is alreadyan active field of research. Here we give a summary of the state of the art in laser driven ion acceleration, of the main challenges currently faced by the research inthis field and of some of the current and future strategies for overcoming them.

Particle Trajectory Computation for Accelerators and Related Technologies

This work reports an alternative method for single non-relativistic charged particle trajectory computation in 2D electrostatic or magnetostatic fields. This task is approached by analytical computation of particle trajectory, by parts, considering the constant fields within each finite element. This method has some advantages over numerical integration ones: numerical miscomputation of trajectories, and stability problems can be avoided. Among the examples presented in this paper, an interesting alternative approach for positive ion extraction from cyclotrons is shown, using strip-foils. Other particle optics devices can benefit of a method such the one proposed in this paper, as beam bending devices, spectrometers, among others. This method can be extended for particle trajectory computation in 3D domains.

HPC Accelerators with 3D Memory

After a decade evolving in the High Performance Computing arena, GPU-equipped supercomputers have con- quered the top500 and green500 lists, providing us unprecedented levels of computational power and memory bandwidth. This year, major vendors have introduced new accelerators based on 3D memory, like Xeon Phi Knights Landing by Intel and Pascal architecture by Nvidia. This paper reviews hardware features of those new HPC accelerators and unveils potential performance for scientific applications, with an emphasis on Hybrid Memory Cube (HMC) and High Bandwidth Memory (HBM) used by commercial products according to roadmaps already announced.