The natural killer cell receptor Ly-49A recognizes a peptide-induced conformational determinant on its major histocompatibility complex class I ligand.

Natural killer (NK) cells are inhibited from killing cellular targets by major histocompatibility complex (MHC) class I molecules. In the mouse, this can be mediated by the Ly-49A NK cell receptor that specifically binds the H-2Dd MHC class I molecule, then inhibits NK cell activity. Previous experiments have indicated that Ly-49A recognizes the alpha 1/alpha 2 domains of MHC class I and that no specific MHC-bound peptide appeared to be involved. We demonstrate here that alanine-substituted peptides, having only the minimal anchor motifs, stabilized H-2Dd expression and provided resistance to H-2Dd-transfected, transporter associated with processing (TAP)-deficient cells from lysis by Ly-49A+ NK cells. Peptide-induced resistance was blocked only by an mAb that binds a conformational determinant on H-2Dd. Moreover, stabilization of "empty" H-2Dd heavy chains by exogenous beta 2-microglobulin did not confer resistance. In contrast to data for MHC class I-restricted T cells that are specific for peptides displayed MHC molecules, these data indicate that NK cells are specific for a peptide-induced conformational determinant, independent of specific peptide. This fundamental distinction between NK cells and T cells further implies that NK cells are sensitive only to global changes in MHC class I conformation or expression, rather than to specific pathogen-encoded peptides. This is consistent with the "missing self" hypothesis, which postulates that NK cells survey tissues for normal expression of MHC class I.

Liderazgo y autoeficacia en el comportamiento organizacional positivo

El objetivo que tiene este proyecto es revisar los conceptos básicos acerca de las relaciones que crean los líderes con sus colaboradores dentro de las organizaciones, dichas relaciones y vínculos pueden afectar positiva o negativamente el desempeño de sus actividades diarias dentro de una organización. Para darle inicio a la investigación se estudió como primer paso el concepto de liderazgo transformacional, capital psicológico y que componentes hacían parte de este factor. El desarrollo de la investigación se enfatizó entre el liderazgo transformacional y la autoeficacia ya que son factores claves dentro del desarrollo de las actividades organizacionales debido a que afectan claramente el capital humano de las compañías y están directamente relacionados con el crecimiento de las mismas, lo que nos llevó a preguntarnos ¿qué relación tendrá el liderazgo transformacional y la autoeficacia en la productividad de las empresas? Es aquí donde radica la importancia de esta investigación ya que el cambio de pensamiento de las organizaciones hacia un liderazgo transformacional podría lograr una maximización del desempeño del personal de trabajo en relación al objetivo de la compañía. Como conclusión llegamos a que efectivamente hay un efecto positivo en los individuos que desarrollan un capital psicológico específicamente en el factor de autoeficacia para lograr un desempeño destacable, productivo y eficiente dentro de las organizaciones.

A nation preferring visions: moving statues, apparitions and vernacular religion in contemporary Ireland

This thesis examines important issues of Irish vernacular Catholicism, Irish religious and cultural identities, the impacts of modernity plus socio-religious and economic change on traditional religiosity, sacred landscape and topophilia, religious material culture, folk and individual creativity, gender roles and expectations, and devotional subcultures through the vehicle of Marian apparitions and their aftermath in the Republic of Ireland in the late 20th and early 21st centuries. This thesis examines in detail five Irish Marian shrines as case studies; Knock shrine (Co. Mayo), Ballinspittle and Mitchelstown grottoes (Co. Cork), Mount Melleray grotto (Co. Waterford) and the Marian shrines of Inchigeela in West Cork and the attached houses of prayer. Key themes include; vernacular religious theory; the nature of Irish indigenous Catholicism; local, global and transnational trends in contemporary Irish devotional life; areas of individual creativity, fluidity and agency in Marian devotion; and the vital role and influence of material culture in and on local and individual religiosity.

The quantity and quality of worldwide new drug introductions, 1982-2003.

We examined trends in the introduction of new chemical entities (NCEs) worldwide from 1982 through 2003. Although annual introductions of NCEs decreased over time, introductions of high-quality NCEs (that is, global and first-in-class NCEs) increased moderately. Both biotech and orphan products enjoyed tremendous growth, especially for cancer treatment. Country-level analyses for 1993-2003 indicate that U.S. firms overtook their European counterparts in innovative performance or the introduction of first-in-class, biotech, and orphan products. The United States also became the leading market for first launch.

Trade unions, civil society organisations and health reforms

This article provides an analysis of resistance to neoliberalism and commodification in the public healthcare sector as seen from a trade union perspective. It uses recent research on social-movement unionism and new labour internationalism to structure a series of case studies examining resistance to different dimensions of healthcare commodification in four countries. The range of alliances trade unions are making do not fit tidily into one model, but give insights into the movement elements of trade unionism. This dimension must be strengthened, but can also be in tension with collective bargaining and other institutional processes. How to constantly reconcile these different positions is the future challenge facing trade unions.

The firm delocalization decision

In the current paper, the determinants of firm international relocation decision in twenty-six European countries during the period 2004-2014 are analyzed. We demonstrate, at light of three different but complementary theories that neoclassical, behavioural and institutional „push‟ factors have an impact in a firm decision-making process. Findings support that firm size, access to a global network, foreign capital, and negative internal growth in the workforce induce firm relocation. On the other hand, the degree of sunk assets has a negative effect on the probability of relocation. Delocalization decisions are also sector-dependent with low-tech manufacturing firms paying high salaries relocating abroad with a greater likelihood.

Breaking the cultural mould : the key to women`s career success

This white paper explores the role of organisational culture in either supporting or constraining the success of women in the workplace and investigates the benefits of gender diversity and what organisations can do to prevent ongoing gender bias.

Aquaculture effluent : impacts and remedies for protecting the environment and human health

Knowledge in the field of environmental health is growing rapidly. Within the context of external factors that define its boundaries, environmental health has evolved over time into a complex, multidisciplinary and ill-defined field with uncertain solutions. Many of the key determinants and solutions to environmental health lie outside the direct realm of health and are strongly dependent on environmental changes, water and sanitation, industrial development, education, employment, trade, tourism, agriculture, urbanization, energy, housing and national security. Environmental risks, vulnerability and variability manifest themselves in different ways and at different time scales. While there are shared global and transnational problems, each community, country or region faces its own unique environmental health problems, the solution of which depends on circumstances surrounding the resources, customs, institutions, values and environmental vulnerability. This work will contain critical reviews and assessments of environmental health practices and research that have worked in places and thus can guide programs and economic development in other countries or regions.

O padrão de acumulação brasileiro: elementos para uma caracterização da crise atual

Trata o presente estudo, da teoria geral dos Oligopólios Internacionais do ponto de vista da sua funcionalidade e estratégia global à longo prazo (crescimento da taxa de acumulação com equilíbrio financeiro) e dos possíveis limites que essa estratégia encontra a nível global e em particular no caso do Brasil. O contexto teórico geral desse trabalho envolve a reflexão crítica em torno de três aspectos fundamentais da teoria dos oligopólios internacionais, que alinhamos do seguinte modo: a) internacionalização do capital, b) seu impacto sobre a periferia e c) a administração da lei do valor e crises. Finalmente estudamos a extensão e interiorização do processo produtivo em função do financiamento interno no Brasil e os problemas gerados pela não funcionalidade orgânica entre o capital produtivo e o capital financeiro. Procuramos também verificar os limites encontrados em relação ao seu pleno desenvolvimento.

Revelando os modos de vida da Ponta do Tubarão

It is analyzed the social struggle held by locals at Barreiras, Diogo Lopes and Sertãozinho communities (Macau-RN) in order to avoid the ownership of its mangrove area to hotel managers, in 1995 and to hinder the destruction of Ilha dos Cavalos mangrove by the shrimp producers, in 2000, what led to the creation of Ponta do Tubarão Reserve of State Sustainable Development, located at Macau and Guamaré cities, northern coast of Rio Grande do Norte, respectively 180 and 200 kilometers away from Natal, created in July, 18, 2003 by the Decree State Law n. 8.349, to preserve its traditional territory and way of life. It is photographed and analyzed the developed ways of life in this Unit of Conservation, from the sociocultural category, based in pointers of the material production in the life ways as: the work, the leisure, the religion, the popular knowledge and the action of the contemporary men on the environment. In this perspective, it is considered as method strategy a sociocultural photo cartography, created to this research, and to be concretized used photographic documents, observation, interviews, documental research and bibliographic research, being an association of techniques as peculiarities of this strategy of research. It is concluded that the social struggle developed by the collective actors at Ponta do Tubarão Reserve of State Sustainable Development, is characterized as a transforming action against the global and predatory capital, for the maintenance of the environment and the traditional way of life; One also concludes that the sociocultural photo cartography is very important as a proposal of possible procedures to being used in qualitative researches, because of its analytical potentialities providing a more including vision of the sociocultural routine of the studied space, in the attempt to know and to disclose the relations lived for the citizens of the research in Social Sciences

Transnationalization and integration of production in Latin America

Includes bibliography

Globally solvable systems of complex vector fields

We consider a class of involutive systems of n smooth vector fields on the n + 1 dimensional torus. We obtain a complete characterization for the global solvability of this class in terms of Liouville forms and of the connectedness of all sublevel and superlevel sets of the primitive of a certain 1-form in the minimal covering space.

Dalle ambivalenze della Storia alla “cosmopolitical fiction”: la rappresentazione dell'alterità nel romanzo di Anita Desai

Varcare le frontiere della Storia attraverso le storie personali dei suoi personaggi ha sempre affascinato la sensibilità creatrice di Anita Desai, i cui romanzi possono essere considerati un interessante esempio di letteratura di confine, che riesce nel difficile compito di misurarsi, con eleganza e sensibilità, nella rappresentazione delle più feroci forme di marginalizzazione. Proponendo un dialogo tra alterità, che apre alle complessità storico-culturali in maniera del tutto a-ideologica e imparziale, la scrittrice indoinglese procede alla “provincializzazione” dell’India attraverso le numerose ambivalenze prodotte nelle zone frontaliere analizzate. Dalla rappresentazione della frontiera identitaria esterna, ovvero dall’ambivalente rapporto intrattenuto con il colonizzatore/ex-colonizzatore inglese, alla rappresentazione della frontiera identitaria interna, ovvero l’analisi delle contraddittorie relazioni tra le componenti etniche del subcontinente, Desai arriva infine a problematizzare storie di ambivalenti processi di marginalizzazione prodotti da mondi culturali così diversi come la Germania nazista, o gli indiani Huichol del lontano Messico, tracciando geografie culturali inedite della grande ragnatela della Storia. Desai riesce così a recuperare voci liminali spesso trascurate dalla postcolonialità stessa, per riconfigurarle in un’esplorazione profonda del comune destino dell’umanità, voci straniate e stranianti che acquisiscono un vero e proprio status di agency discorsiva, proiettando la sua scrittura verso una dimensione cosmopolitica. L’opera di Desai diventa indubbiamente un’opportunità concreta per scorgere nella differenza l’universalità di una comune umanità, vale a dire un’opportunità per vedere nell’alterità un’identità ribaltata.

La clase obrera y el proceso de reestructuración capitalista : Una reflexión en torno a la historiografía de los trabajadores durante la última dictadura militar [1976-1983]

El golpe de estado de 1976 inició en Argentina el proceso de reestructuración capitalista. La naturaleza de este fenómeno consistió en alterar la composición interna de la burguesía y modificar la relación del conjunto de ésta con la clase obrera. La feroz avanzada perpetrada por las burguesías en todo el mundo asestó un fuerte golpe contra los trabajadores haciéndolos retroceder en sus condiciones de vida y de organización. Este trabajo da cuenta de las diferentes formas en que esta ofensiva del capital sobre el trabajo ha sido analizada por el conjunto de los investigadores dedicados al tema. Si bien los trabajadores, por ser un sujeto central en la historia de las sociedades capitalistas, se asoman en la gran mayoría de los estudios sobre el El golpe de estado de 1976 inició en Argentina el proceso de reestructuración capitalista. La naturaleza de este fenómeno consistió en alterar la composición interna de la burguesía y modificar la relación del conjunto de ésta con la clase obrera. La feroz avanzada perpetrada por las burguesías en todo el mundo asestó un fuerte golpe contra los trabajadores haciéndolos retroceder en sus condiciones de vida y de organización. Este trabajo da cuenta de las diferentes formas en que esta ofensiva del capital sobre el trabajo ha sido analizada por el conjunto de los investigadores dedicados al tema. Si bien los trabajadores, por ser un sujeto central en la historia de las sociedades capitalistas, se asoman en la gran mayoría de los estudios sobre el período dictatorial, nuestro trabajo se enfocará en la historiografía dedicada específicamente a este sujeto entre 1976 y 1983, ya que posee características específicas que ameritan un estudio detallado sobre ella. Iniciaremos la exposición aportando algunos lineamientos básicos en torno al lugar ocupado por la clase obrera en la historiografía argentina sobre la década del setenta, con la intención de resaltar la relevancia y pertinencia actual de tomar a los trabajadores como objeto de estudio. En el primer capítulo presentamos la polémica desmovilización-inmovilismo vs. resistencia-oposición a través de la exposición de los trabajos de sus máximos referentes: Francisco Delich y Pablo Pozzi. En el capítulo siguiente realizamos un exhaustivo estado de la cuestión del conjunto de trabajos que se han publicado en torno a la historia de los trabajadores durante el período. En el tercer capítulo avanzamos en el análisis del debate planteado en el primer capítulo, y en el modo en que el resto de las investigaciones se posicionan dentro de él. Sostenemos que los supuestos que se encuentran en la mencionada dicotomía han condicionado la extensa mayoría de las investigaciones que se han realizado sobre el tema, y que es preciso superarla para avanzar en la comprensión del período. En el cuarto capítulo nos aproximamos al proceso de reestructuración capitalista iniciado por el gobierno militar desde el modo en que redefinió la relación al interior del bloque burgués. Finalmente, planteamos la hipótesis central de nuestro trabajo, a saber, que la dictadura transformó la relación de clases redefiniendo la relación capital-trabajo en beneficiola bibliografía para exponer el modo en que este movimiento se produjo. Hay que aclarar que el trabajo no se compondrá de una narración de la historia obrera del período, sino que realizaremos una lectura de los trabajos existentes y un análisis a través de la evidencia que estos aportan intentando ofrecer una respuesta a las limitaciones que observamos en la bibliografía