Human Endogenous Retrovirus HERV-Fc1 Association with Multiple Sclerosis Susceptibility: A Meta-Analysis

Background: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods: A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results: Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: p(M-H) = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [p(M-H) = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)]. Conclusion: Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts.

Dor no Corpo ou Dor na Alma? Visões Contemporâneas sobre a Fibromialgia.

Dentro das síndromes de dor crônica, caracterizadas pela manifestação de sintomas somáticos na ausência de uma etiologia médica identificável, a fibromialgia constitui uma das categorias mais misteriosas, devido à presença de numerosos sintomas associados - tais como fadiga, perturbações do sono e alterações da memória e da concentração e pela elevada comorbidade com transtornos de ansiedade e de humor, especialmente com a depressão. Na atualidade, a fibromialgia atinge até 5% da população e afeta profundamente a qualidade de vida dos sujeitos diagnosticados, se instituindo como um importante problema de saúde pública, realidade que demanda o aumento dos estudos relativos à doença. Partindo da revisão bibliográfica das publicações cientificas sobre fibromialgia nos últimos anos (2010-2013), procurou-se alcançar uma melhor visão das abordagens contemporâneas sobre a doença em termos da sua compreensão, classificação e diagnóstico. Os resultados obtidos através desta revisão apontaram a existência de problemas inerentes à concepção da natureza ontológica e epistemológica da dor, cujas manifestações da ordem objetivo e subjetivo dor física/ dor psíquica - embaralham as categorias compreensivas que definem a visão moderna do ser humano nas suas diferentes dimensões existenciais, dificultando a construção de instrumentos de medida e de sistemas classificatórios que permitam uma abordagem mais sofisticada da fibromialgia.

Frequency of word-use predicts rates of lexical evolution throughout Indo-European history

Mark Pagel, Quentin D. Atkinson & Andrew Meade (2007). Frequency of word-use predicts rates of lexical evolution throughout Indo-European history. Nature, 449,717-720. RAE2008

Zintegrowane kształcenie przedmiotowo-językowe. Dydaktyka zadaniowa a rozwój osobistej kompetencji komunikacyjnej w warunkach półautonomii

Wydział Neofilologii

THE ART SONG OF SOUTH AMERICA: AN EXPLORATION THROUGH PERFORMANCE

The repertoire included in this dissertation was presented over the course of three recitals, The Songs of Argentina, The Songs of Brazil, Chile and Venezuela, and The Songs of Perú and Colombia. Each recital was supplemented by written program notes and English translations of the Spanish, Portuguese and Quechua texts. The selections presented in this study was chosen in an effort to pair the works of internationally renowned composers like Argentine composers Alberto Ginastera and Carlos Guastavino, and Brazilian composer Heitor Villa-Lobos, with those of lesser-known composers, including Venezuelan composer Juan Bautista Plaza, Peruvian composers Edgar Valcárcel, Theodoro Valcárcel, and Rosa Mercedes Ayarza de Morales, and Colombian composer Jaime Léon. Each composer represents a milestone in the development of art song composition in South America. All three recitals were recorded and are available on compact discs in the Digital Repository at the University of Maryland (DRUM). This dissertation was completed in May, 2011.

Scatman

Scatman, aka Andreas Grassl, knew no fear when it came to verbal acrobatics. Burn - A List of my Enemies, his column in his Bavarian High School newspaper, run for five consecutive years, hitting his targets with caustic wit and irony. The list of enemies ranged from Bavarian farms (compulsory normality) to television companies (the rule of mediocrity) to Paris Hilton (trivia domination). Before graduating from high school, Scatman finished his last column with the following sentence: ‘Please tell me, what am I supposed to conjure up as a grandiose finale for the end of this five-year series?’

Modelos de desarrollo, unificación y “desterritorialización”.

El presente estudio tiene el objetivo de ofrecer una visión general sobre los Modelos de Desarrollo y Organización Territorial desde la perspectiva de las relaciones entre el medio urbano, “rururbano” y rural, en España. Para ello, tras conocer y valorar los enfoque conceptuales y temáticos, se estudia el crecimiento urbano en nuestro país en las últimas décadas, analizando de manera pormenorizada la importancia que ha cobrado y cobra la aplicación legislativa de leyes, planes y normas, tanto en el propio crecimiento urbano como en la demanda de viviendas en las ciudades españolas y, de igual modo, la vinculación de ambas con el precio de las viviendas, relacionándolo con la problemática de la “rururbanización”, y del medio rural.

La Inteligencia Competitiva en los procesos de internacionalización empresarial: Una guía de recursos de información para la empresa española y el periodismo económico

La información se ha convertido en un recurso imprescindible para el proceso de toma de decisiones en las empresas, y elemento fundamental en el proceso de Inteligencia Competitiva. La globalización económica y la libre circulación de mercancías, bien sea dentro de estructuras supranacionales o derivados de la firma de Tratados internacionales, han aumentado el número de competidores presentes en los mercados, pero también las oportunidades para acceder a otros mercados internacionales. Este trabajo describe los recursos de información más importantes que puede necesitar una empresa en su acceso a los mercados internacionales, y que proceden tanto de organismos públicos como privados.

Cine policíaco del tardofranquismo: El thriller en el “Período Oscuro” del cine español (1969-1975)

Definición de la etapa de crisis del aparato cinematográfico franquista, llamada aquí “Período Oscuro” (1969-1975), discusión de la etiqueta de subgéneros aplicada al cinema bis de la época, y caracterización histórica del thriller español y de sus corrientes estéticas y conceptuales internas en dicho período. La acotación del período 1969-1975 es clarificada previamente ante el vacío historiográfico al respecto. Se caracteriza la crisis que tiene lugar en el “Período Oscuro”, desde su comienzo oficial en 1969, que supuso el definitivo cierre de las políticas proteccionistas emprendidas por el Director General de Cinematografía García Escudero en 1962. Después se define y discute la etiqueta de subgéneros aplicada tradicionalmente al cine español de género de bajo presupuesto. Luego, se especifican, definen y analizan las diversas categorías dentro del thriller español de 1969-1975: se trata de categorías temáticas y argumentales, estéticas, o bien relacionadas con corrientes internacionales del policíaco europeo. Por último, se extraen las conclusiones pertinentes.

Citizens’ attitudes toward public services. Satisfaction in 2009-2011

The aim of this paper is to study the recent changes on citizens’ satisfaction with the performance ofpublic services, in the period 2009-2011 in Spain. Using data from the surveys on Quality of PublicServices, developed by the Sociological Research Center jointly with the National Agency for theEvaluation of Public Services and Quality of Services, our results show that the level of satisfactionhas slightly increased, which seems to display a greater tendency to positively value public servicesduring economic retrenchment. A major determinant of high satisfaction is self-reported ideology.Besides, immigrants display higher levels of satisfaction than Spaniards.

Dynamic analysis of employment trajectories through the concept of fl exicurity

The paper presents a dynamic study of the Spanish labour market which tries to determine if it matches the characteristics of transitional labour markets from a fl exicurity approach. Employment trajectories of Spanish workers during the years 2007-2010 are studied using the Continuous Sample of Working Lives. This period covers the end of the expansion of the Spanish economy and the beginning of the current employment crisis. From the combination of the chosen topic, the approach, and the database used, this is a novel perspective in our country. The article shows evidence of the evolution of the employment and unemployment spells, the Spanish labour market turnover degree, and the diffi culties of some groups for carrying out transition between employment and unemployment. The results obtained show a labour market in which a) transitions have come to a halt, and b) there is high job insecurity.

Determining factors of the innovative behavior of cooperatives: an analysis of the case of Castilla y León

Cooperatives have a long historical experience in the Spanish economy and have demonstrated their ability to compete against traditional firms in the market. To maintain this capability, while taking advantage of the competitive advantages associated with their idiosyncrasies as social economy enterprises, they should take into consideration that the economy is increasingly globalized and increasingly knowledge-based, especially with regards to technological content. As a consequence, the innovative capacity appears to be a key aspect in order to be able to challenge competitors. This article characterizes the innovative behavior of cooperatives in the region of Castile and Leon and analyses the internal and external factors affecting their innovative performance, based on data from a survey of 581 cooperatives. The results of the empirical analysis, which is performed by multivariate binary logistic regression on various types of innovation, lead us to identify the size of the organizations, the existence of planning, the R & D activities and the human capital as the main determining factors.

Claves para el reconocimiento de la dehesa como "paisaje cultural" de Unesco

La dehesa española y su homónimo portugués (el montado) son sistemas agrosilvopastoriles mediterráneos que proyectan un paisaje excepcional y de elevados valores patrimoniales. Sobre ellos se ciernen nuevas o renovadas amenazas que comprometen su futuro, en un momento (el actual) de creciente revalorización socio-institucional de sus paisajes. Su declaración como paisaje cultural de Unesco puede constituir un potente instrumento para atajar dichas amenazas, pero requiere de la clarificación de ciertos interrogantes relacionados con las escalas. Este artículo se adentra en el valor universal excepcional de la dehesa y propone algunas claves para sustentar su posible incorporación a la Lista de Patrimonio Mundial de Unesco. El análisis se acomete a nivel de tipos de paisaje, pero se avanzan algunos criterios para la selección de ámbitos concretos y representativos susceptibles de integrar una candidatura como “bien en serie”.

International issues in education

Anxiety, negative attitudes, and attrition are all issues presented in the teaching of statistics to undergraduates in research-based degrees regardless of location. Previous works have looked at these obstacles, but none have consolidated a multilingual, multinational effort using a consistent method. Over 400 Spanish-, English-, and German-speaking undergraduate students enrolled in introductory psychology statistics courses were given the Composite Survey of Statistics Anxiety and Attitudes to determine the precursors and effects of existing problems. Results indicated that student background was heavily linked to attitudes and anxieties. The measure was supported as a viable method for more than one class or university in addressing issues in statistics education, developing interventions to improve students’ experiences, and then determining the success of those changes.

Issue salience in regional party manifestos in Spain

This article analyses the dynamics of electoral competition in a multilevel setting. It is based on a content analysis of the party manifestos of the Spanish PP and PSOE in eight regional elections held between 2001 and 2003. It provides an innovative coding scheme for analysing regional party manifestos and on that basis seeks to account for inter-regional, intra-party and inter-party differences in regional campaigning. The authors have tried to explain the inter-regional variation of the issue profiles of state-wide parties in regional elections on the basis of a model with four independent variables: the asymmetric nature of the system, the electoral cycle, the regional party systems and the organisation of the state-wide parties. Three of their hypotheses are rejected, but the stronger variations in the regional issue profiles of the PSOE corroborate the assumption that parties with a more decentralised party organisation support regionally more diverse campaigning. The article concludes by offering an alternative explanation for this finding and by suggesting avenues for further research.