Unexpected signals in a system subject to kinetic proofreading

When multivalent ligands attach to IgEs bound to the receptors with high affinity for IgE on mast cells, the receptors aggregate, tyrosines on the receptors become phosphorylated, and a variety of cellular responses are stimulated. Prior studies, confirmed here, demonstrated that the efficiency with which later events are generated from earlier ones is inversely related to the dissociation rate of the aggregating ligand. This finding suggests that the cellular responses are constrained by a “kinetic proofreading” regimen. We have now observed an apparent exception to this rule. Doses of the rapidly or slowly dissociating ligands that generated equivalent levels of tyrosine-phosphorylated receptors comparably stimulated a putatively distal event: transcription of the gene for monocyte chemoattractant protein 1. Possible explanations of this apparent anomaly were explored.

Modeling and optimization of populations subject to time-dependent mutation.

It has become clear that many organisms possess the ability to regulate their mutation rate in response to environmental conditions. So the question of finding an optimal mutation rate must be replaced by that of finding an optimal mutation schedule. We show that this task cannot be accomplished with standard population-dynamic models. We then develop a "hybrid" model for populations experiencing time-dependent mutation that treats population growth as deterministic but the time of first appearance of new variants as stochastic. We show that the hybrid model agrees well with a Monte Carlo simulation. From this model, we derive a deterministic approximation, a "threshold" model, that is similar to standard population dynamic models but differs in the initial rate of generation of new mutants. We use these techniques to model antibody affinity maturation by somatic hypermutation. We had previously shown that the optimal mutation schedule for the deterministic threshold model is phasic, with periods of mutation between intervals of mutation-free growth. To establish the validity of this schedule, we now show that the phasic schedule that optimizes the deterministic threshold model significantly improves upon the best constant-rate schedule for the hybrid and Monte Carlo models.

Las poéticas explícitas de Antonio Colinas

Poets' thoughts about poetry have long been the subject of much attention. Since Classical Antiquity this has given rise to powerful reflections about literature, influencing texts which would then become part of academic discourse. However, these have also been used to help to explain or exemplify questions the academic discipline of Literary Theory have failed to address properly, since such questions related to the process of creation justifiably give attention to the writers' own experiences of such a process. Nevertheless, although the content of texts in which poets explain their own creation or specify key aspects of the literary process has been taken into account, there has not been any systematic study of the formal aspects of the discourse coming from the creator. The reason lies in the fact that the discourse of the creator takes different and variant directions that complicate its definition and distinction in relation to other kinds of similar texts. The first part, theoretical in nature, has emerged from the study of explicit poetics by numerous authors, as well as from critical bibliography. This seeks to identify common characteristics of these texts. Conversely, the second and third parts aims to find the individuality of Colinas' poetics, which manifests itself fundamentally in its content. Because of this, it is the study of the core parts of Colinas' poetic thinking expressed in the trends of his explicit poetics that will constitute a substantial part of this section of research...

Competence profile differences among graduates from different academic subject fields: implications for improving students’ education

The aim of a university education is the intellectual development of citizens, and the training of professionals for their subsequent entry into the workforce. However, this entry into the workforce, following the theoretical education usually provided by the university, implies that students have to manage this difficult transition by themselves. Society, in a continual process of transformation, requires of universities that they adjust, adapting the education they offer to comply with the demands of society and the workplace. Socio-emotional skills would seem to have influence predicting professional performance. These skills also influence job-finding and employability. Consequently, providing teachers with an education in socioemotional competences is becoming a necessary task within universities, and the majority of teaching staff consider these skills to be fundamental to the personal and socio-emotional development of students. The objective of our proposed work is to establish the characteristic profile of competences of a sample of teachers in training, and compare it with the competences profile of graduate students belonging to the fields of law sciences, social sciences, humanities, science and technology, and health. Starting from results, implications will be derived for the development of generic competences of socio-emotional type in the framework of the European Frame of Higher Education.

Tratado rápido de filosofía y otros poemas

Se presentan en “Tratado rápido de filosofía y otros poemas”, cuatro poemas seleccionados de tres poemarios escritos por Bartolomé Nieto Munuera, surcador incansable de mares de letras y sentimientos sujetos a mareas, algas y musgos: Ribera de la entropía, La estirpe del aire, y Noches de Quart Hadasht. A pesar de su prematura muerte, a este gran poeta le ha sobrado tiempo para regalarnos una obra intensa y coherente donde abundan interpretaciones saturadas de inteligencia y una estética cuya serenidad se mece dialécticamente en el pensamiento crítico regalándonos versos de una profundidad casi insondable. Nieto interpreta la realidad como la vive y la piensa dejando translucir un perfume delicado que se desprende lentamente al son de la pulcritud irredenta de este hermeneuta culto e intuitivo.

A proposal for teaching with authentic texts in order to develop social awareness in a language subject in tertiary education

The University of the 21st century has to establish links with society and prepare students for the demands of the working world. Therefore, this article is a contribution to the integral preparation of university students by proposing the use of authentic texts with social content in English lessons so that students acquire emotional and social competencies while still learning content. This article will explain how the choice of texts on global issues such as racism and gender helps students to develop skills such as social awareness and critical thinking to deepen their understanding of discrimination, injustice or gender differences in both oral and written activities. A proposal will be presented which involves using the inauguration speech from Mandela's presidency and texts with photographs of women so that students analyse them whilst utilising linguistic tools that allow them to explore a text's social dimension.

Exploring the use of cooperative activities in a language subject to develop students’ social competences at the University

Cooperative learning has been successfully implemented in the last 60 years for teaching at different educational levels including the Higher Studies due to its solid theoretical foundation, the principles it proposes and its practical applications. The purpose of this article is to offer a proposal for some cooperative activities that allow students to work in small groups in a language subject in order to learn not only contents but also putting into practice what they learn, i.e., they learn by being active. This article discusses how the said activities make it possible for students to work with the main principles of cooperative learning, i.e.: positive interdependence, face-to-face interaction, individual and group accountability, interpersonal and small-group skills and group processing. Moreover, this research will also point out that the proposed activities allow students to acquire some of the social competences required in the labour market such as leadership, conflict solving and cooperation.

Sundry extracts on the subject of the taxation of College &c., ca. 1798-1801

Notebook with brown paper cover containing handwritten extracts from the charters and related legislation of New England academic, charitable, and commercial institutions regarding their ability to hold real estate and related tax exemptions. Most of the listed documents are dated in the 1780s and 1790s. The notebook also contains extracts from "Argument in the case of Poor's rate, charged on the College of Christ & Emmanuel in the University of Cambridge 1768." The item title is transcribed from a handwritten inscription on the back cover.

Thaddeus Mason Harris' working documents regarding subject-based library catalog, ca. 1790

Thaddeus Mason Harris, who served as interim librarian of the Harvard College Library in 1787 and as its librarian from 1791 through 1793, is believed to have created these notes while helping compile the library's first printed subject-based catalog. The catalog, Catalogus Bibliothecae Harvardianae Cantabrigiae Nov-Anglorum, was published in 1790 and represented a significant change in approach to the cataloging of the library's collections, which had formerly been cataloged alphabetically. These documents, many of them on small scraps of paper, contain the titles and bibliographic information of books on a range of topics, from "Anatomici" to "Rhetorica."

Mr. Abbot's sermon at the Dudleian lecture at Harvard College in Cambridge August 29, 1764 pm: being the third in course on the important subject of Reveal'd-religion

The hand-sewn notebook contains a 27-page manuscript draft of the Dudleian lecture delivered by Hull Abbot on August 29, 1764 at Harvard College on the topic of revealed religion. The sermon begins with the Biblical text Zech. 4:6 and Rom. 10:18. The copy includes a small number of edits and struck-out words. The lecture was not printed.