Using integrated metamodeling to define OO design patterns with object-z and UML

Three important goals in describing software design patterns are: generality, precision, and understandability. To address these goals, this paper presents an integrated approach to specifying patterns using Object-Z and UML. To achieve the generality goal, we adopt a role-based metamodeling approach to define patterns. With this approach, each pattern is defined as a pattern role model. To achieve precision, we formalize role concepts using Object-Z (a role metamodel) and use these concepts to define patterns (pattern role models). To achieve understandability, we represent the role metamodel and pattern role models visually using UML. Our pattern role models provide a precise basis for pattern-based model transformations or refactoring approaches.

Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements

Aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) has been used to describe the histological lesion associated with metal-on-metal (M-M) bearings. We tested the hypothesis that the lymphoid aggregates, associated with ALVAL lesions resemble tertiary lymphoid organs (TLOs). Histopathological changes were examined in the periprosthetic tissue of 62 M-M hip replacements requiring revision surgery, with particular emphasis on the characteristics and pattern of the lymphocytic infiltrate. Immunofluorescence and immunohistochemistry were used to study the classical features of TLOs in cases where large organized lymphoid follicles were present. Synchrotron X-ray fluorescence (XRF) measurements were undertaken to detect localisation of implant derived ions/particles within the samples. Based on type of lymphocytic infiltrates, three different categories were recognised; diffuse aggregates (51%), T cell aggregates (20%), and organised lymphoid aggregates (29%). Further investigation of tissues with organised lymphoid aggregates showed that these tissues recapitulate many of the features of TLOs with T cells and B cells organised into discrete areas, the presence of follicular dendritic cells, acquisition of high endothelial venule like phenotype by blood vessels, expression of lymphoid chemokines and the presence of plasma cells. Co-localisation of implant-derived metals with lymphoid aggregates was observed. These findings suggest that in addition to the well described general foreign body reaction mediated by macrophages and a T cell mediated type IV hypersensitivity response, an under-recognized immunological reaction to metal wear debris involving B cells and the formation of tertiary lymphoid organs occurs in a distinct subset of patients with M-M implants. © 2013 Mittal et al.

Identifying the ICT challenges of the agri-food sector to define the architectural requirements for a future internet core platform

This paper discussed the specific challenges of the agri-food sector in the light of research carried out in the Smart-AgriFod project. Using questionnaires and focus groups, our research identified as number of business needs and drivers which enable the identification of suitable Future Internet technologies across the three sub-domains of Smart Farming, Smart Agri-logistics, and Smart Food Awareness. The universal need for information access and the importance of standards to enable this lead us to propose an integrated scenario for end to end information access from farm to fork. We conclude by discussing wider implications of such developments especially for climate change and urbanisation.

A Geometrical Interpretation to Define Contradiction Degrees between Two Fuzzy Sets

For inference purposes in both classical and fuzzy logic, neither the information itself should be contradictory, nor should any of the items of available information contradict each other. In order to avoid these troubles in fuzzy logic, a study about contradiction was initiated by Trillas et al. in [5] and [6]. They introduced the concepts of both self-contradictory fuzzy set and contradiction between two fuzzy sets. Moreover, the need to study not only contradiction but also the degree of such contradiction is pointed out in [1] and [2], suggesting some measures for this purpose. Nevertheless, contradiction could have been measured in some other way. This paper focuses on the study of contradiction between two fuzzy sets dealing with the problem from a geometrical point of view that allow us to find out new ways to measure the contradiction degree. To do this, the two fuzzy sets are interpreted as a subset of the unit square, and the so called contradiction region is determined. Specially we tackle the case in which both sets represent a curve in [0,1]2. This new geometrical approach allows us to obtain different functions to measure contradiction throughout distances. Moreover, some properties of these contradiction measure functions are established and, in some particular case, the relations among these different functions are obtained.

Use of tritium and helium to define groundwater flow conditions in Everglades National Park

The concentrations of tritium (3H) and helium isotopes (3He and4He) were used as tracers of groundwater flow in the surficial aquifer system (SAS) beneath Everglades National Park (ENP), south Florida. From ages determined by 3H/3He dating techniques, groundwater within the upper 28 m originated within the last 30 years. Below 28 m, waters originated prior to 30 years before present with evidence of mixing at the interface. Interannual variation of the 3H/3He ages within the upper 28 m was significant throughout the 3 year investigation, corresponding with varying hydrologic conditions. In the region of Taylor Slough Bridge, younger groundwater was consistently detected below older groundwater in the Biscayne Aquifer, suggesting preferential flow to the lower part of the aquifer. An increase in 4He with depth in the SAS indicated that radiogenic 4He produced in the underlying Hawthorn Group migrates into the SAS by diffusion. Higher Δ4He values in brackish groundwaters compared to fresh waters from similar depths suggested a possible enhanced vertical transport of4He in the seawater mixing zone. Groundwater salinity measurements indicated the presence of a wide (6–28 km) seawater mixing zone. Comparison of groundwater levels with surface water levels in this zone indicated the potential for brackish groundwater discharge to the overlying Everglades surface water.

Hispanics: Does Our Language (Spanish) Define Who We Are?

Use of the pan-ethnic denomination Hispanic to refer to Spanishspeakers assumes a homogeneous group. Hispanics literally constitute 20 national origins with different characteristics and idiosyncrasies. Because individuals’ national origin may influence their traditions, customs, values, and beliefs, differences in nationality should be considered in designing research.

How do Akwesasne Mohawk People Define their Cultural Identity?

This paper focuses on the cultural identity of the St. Regis Akwesasne Mohawk Indians. First, it will explain my rational for choosing to examine the cultural identity of this particular group followed by the objectives of the research. The paper will give some history and background on the Akwesasne Mohawks. It will review the literature on cultural identity specifically focusing on the identity of Native People. Next, will be a review of the interviews conducted followed by an analysis and discussion of the data. Finally, the paper will conclude with some educational implications based on the research.

Conjuring Canadas: Historians and the Quest to Define a Canadian Nation and its Past, 1920-1967

This dissertation examines the various ways in which Canadian historical researchers confronted the “Canada question,” namely the challenge of defining the basis of a unified national community. In doing so, it follows the scholarship and activities of a network of historians and intellectuals centred on the Canadian Historical Review, a quarterly publication founded in 1920. This study examines their scholarship with the aim of identifying not only the various solutions they posed to the problem, but also the philosophical undercurrents that informed their reasoning in the process. It also traces the rise of a rival network in the Revue d’histoire de l’Amérique française, a French-language historical publication founded in 1947 that by its very existence posed a significant challenge to the definition of the nation at the core of the Canadian Historical Review. This dissertation argues that the network bound together by the Review was engaged in a hegemonic project, one that sought to present a particular definition of Canada through a historical narrative that rested upon a liberal logic. Yet the greatest sustained challenge they faced in this endeavour emerged from Francophone historical scholars, who, although proposing vastly different Canadas to those imagined at the Canadian Historical Review, came under the sway of a number of liberal currents of thought as well. A detailed summary of the key traits of these liberal Canadas is found in the conclusion.

The ins of the striatum: Utilizing chemogenetics to define the contribution of cortical and thalamic afferents during addiction behaviors

Thesis (Ph.D.)--University of Washington, 2016-08

Agenda do Legislativo: quem define? E-

Analisa a relação entre os Poderes Executivo e Legislativo Brasileiro, comparando os requisitos de relevância e urgência dispostos no art. 62 da Constituição de 1988, levando-se em conta o desenho constitucional, a repercussão e o desempenho institucional diante da separação dos Poderes e do checks and balances na administração pública.

The New Bottom Line: Black Women Cultural Entrepreneurs Re-Define Success in The Connected Economy

Black women cultural entrepreneurs are a group of entrepreneurs that merit further inquiry. Using qualitative interview and participant observation data, this dissertation investigates the ways in which black women cultural entrepreneurs define success. My findings reveal that black women cultural entrepreneurs are a particular interpretive community with values, perspectives and experiences, which are not wholly idiosyncratic, but shaped by collective experiences and larger social forces. Black women are not a monolith, but they are neither disconnected individuals completely devoid of group identity. The meaning they give to their businesses, professional experiences and understandings of success are influenced by their shared social position and identity as black women. For black women cultural entrepreneurs, the New Bottom Line goes beyond financial gain. This group, while not uniform in their understandings of success, largely understand the most meaningful accomplishments they can realize as social impact in the form of cultural intervention, black community uplift and professional/creative agency. These particular considerations represent a new paramount concern, and alternative understanding of what is typically understood as the bottom line. The structural, social and personal challenges that black women cultural entrepreneurs encounter have shaped their particular perspectives on success. I also explore the ways research participants articulated an oppositional consciousness to create an alternative means of defining and achieving success. I argue that this consciousness empowers them with resources, connections and meaning not readily conferred in traditional entrepreneurial settings. In this sense, the personal, social and structural challenges have been foundational to the formation of an alternative economy, which I refer to as The Connected Economy. Leading and participating in The Connected Economy, black women cultural entrepreneurs represent a black feminist and womanist critique of dominant understandings of success.

Distribution patterns of endemic flora to define hotspots on Hispaniola

Nineteen areas on the island of Hispaniola (Haiti and the Dominican Republic) were studied with the aim of determining the distribution pattern of the endemic flora in these areas, and their variability with altitude. The main concentration of endemic species occurs in mountains with a medium altitude and in certain mountain sites (palaeo-islands), which coincide with hotspots; a lower number of endemics are found in low-lying areas (coldspots), due to the degradation of their habitats. A total of 1,582 endemic species were studied and were distributed in 19 areas. The whole island is of outstanding interest for its richness in endemics; it has 2,050 endemic species, representing 34.16% of its total flora. The territory in the study is home to 1,284 genera of which 31 are endemic to the island, including monotypical genera such as Tortuella abietifolia Urb. & Ekman, and endemic genera such as Hottea, containing seven endemic species. The sites with the highest rate of endemics are area A16 in the central range with a total of 440 endemic species, of which 278 are exclusive to the territory; and the Sierra de Bahoruco, la Selle, La Hotte and Tibur on in area A12, where we found 699 plants of which 482 are endemic and exclusive to the area; and A13 with 173 and 129 respectively. This work highlights the exceptional floristic diversity in endemic species and genera and analyses their distribution patterns as a tool for conservation in this area of the world, whose high endemicity rate makes it one of the most significant hotspots in the Caribbean.

Applied genomics to monitor the genetic diversity and integrity of honey bee (Apis mellifera) populations and define sustainable strategies to benefit the beekeeping sector

Honey bees are considered keystone species in ecosystem, the effect of harmful pesticides for the honey bees, the action of extreme climatic waves and their consequence on honey bees health can cause the loss of many colonies which could contribute to the reduction of the effective population size and incentive the use of non-autochthonous queens to replace dead colonies. Over the last decades, the use of non-ligustica bee subspecies in Italy has increased and together with the mentioned phenomena exposed native honey bees to hybridization, laeding to a dramatic loss of genetic erosion and admixture. Healthy genetic diversity within honey bee populations is critical to provide tolerance and resistance to current and future threatening. Nowadays it is urgent to design strategies for the conservation of local subspecies and their valorisation on a productive scale. In this Thesis we applied genomics tool for the analysis of the genetic diversity and the genomic integrity of honey bee populations in Italy are described. In this work mtDNA based methods are presented using honey bee DNA or honey eDNA as source of information of the genetic diversity of A. mellifera at different level. Taken together, the results derived from these studies should enlarge the knowledge of the genetic diversity and integrity of the honey bee populations in Italy, filling the gap of information necessary to design efficient conservation programmes. Furthermore, the methods presented in these works will provide a tool for the honey authentication to sustain and valorise beekeeping products and sector against frauds.