Design and Optimization of Four-dimensional Cone-beam Computed Tomography in Image-guided Radiation Therapy

The influence of respiratory motion on patient anatomy poses a challenge to accurate radiation therapy, especially in lung cancer treatment. Modern radiation therapy planning uses models of tumor respiratory motion to account for target motion in targeting. The tumor motion model can be verified on a per-treatment session basis with four-dimensional cone-beam computed tomography (4D-CBCT), which acquires an image set of the dynamic target throughout the respiratory cycle during the therapy session. 4D-CBCT is undersampled if the scan time is too short. However, short scan time is desirable in clinical practice to reduce patient setup time. This dissertation presents the design and optimization of 4D-CBCT to reduce the impact of undersampling artifacts with short scan times. This work measures the impact of undersampling artifacts on the accuracy of target motion measurement under different sampling conditions and for various object sizes and motions. The results provide a minimum scan time such that the target tracking error is less than a specified tolerance. This work also presents new image reconstruction algorithms for reducing undersampling artifacts in undersampled datasets by taking advantage of the assumption that the relevant motion of interest is contained within a volume-of-interest (VOI). It is shown that the VOI-based reconstruction provides more accurate image intensity than standard reconstruction. The VOI-based reconstruction produced 43% fewer least-squares error inside the VOI and 84% fewer error throughout the image in a study designed to simulate target motion. The VOI-based reconstruction approach can reduce acquisition time and improve image quality in 4D-CBCT.

El imaginario en la génesis del proyecto arquitectónico: La construcción de la realidad a través del mito, la utopía y la cibercultura

El término imaginario, nombra el principio y el tema central de una investigación del mundo arquitectónico, necesaria para entender las condiciones alrededor de un proceso proyectual íntimo, cargado de significaciones ideológicas y simbólicas. En diferentes interpretaciones, el inconsciente colectivo y personal, científico o social, aparece en el origen de cada pensamiento y comportamiento humano, constituyendo un universo cerrado y caótico, donde todas las ideas están en constante tensión y contradicción. Por esta razón existen nociones y construcciones lógicas y coherentes que estructuran el marco de la verisimilitud y por tanto el régimen de la realidad, mediante la verdad y la verificación. Para el proyecto arquitectónico estas configuraciones se expresan en la situación del espacio, el tiempo y el cuerpo, como elementos básicos de jerarquización de la habitabilidad y de la cohabitabilidad humana. Esta tesis pretende acotar y definir un ámbito de procesos verosímiles instalados dentro del imaginario mediante el patrimonio intangible del pensamiento mítico o utópico, donde no solamente se crean envolventes del pensamiento, de iconografía o de sociedades, sino de donde también se derivan modelos rígidos y excluyentes, desde teorías basadas en la heteronormatividad y la segregación según el sexo, el género, la clase y la capacidad dentro de la diversidad funcional. La experiencia del espacio arquitectónico ha sido tradicionalmente descrita mediante palabras e imágenes: el lógos y el símbolo han sido los grandes intermediadores entre los sujetos y el habitar. Los ámbitos cotidiano y urbano se han regido por modelos y normas absolutas aplicadas universalmente y el mundo arquitectónico se ha visto estancado en la polaridad dual, entre lo público y lo privado, el dentro y el fuera, el movimiento y el reposo, el hombre y la mujer. Si el espacio-tiempo, el cuerpo y sus interpretaciones son la base para los modelos absolutistas, universalistas y perfeccionistas que han dominado el pensamiento occidental y elaborado la noción de lo “normal” en su totalidad, restando complejidad y diversidad, en la era hipermoderna ya no tiene sentido hablar en términos que no contemplen la superposición y la contradicción de la multiplicidad caótica en igualdad y en equilibrio instable. La realidad se ha visto reinventada a través de situaciones intermedias, los lugares inbetween en los espacios, tiempos, identidades y nociones presupuestas, donde se ha tergiversado el orden establecido, afectando al imaginario. La cotidianidad ha superado la arquitectura y el tiempo ha aniquilado el espacio. La conectividad, las redes y el libre acceso a la información – allá donde los haya – componen el marco que ha permitido a los sujetos subalternos emerger y empezar a consolidarse en el discurso teórico y práctico. Nuevos referentes están apareciendo en el hiper-espacio/tiempo aumentado, infringiendo todas aquellas leyes e interpretaciones impuestas para controlar los hábitos, las conductas y las personas. La casa, la ciudad y la metrópolis al vaciarse de contenidos, han dejado de cumplir funciones morales y simbólicas. Los no-lugares, los no-space, los no-time (Amann, 2011) son las condiciones radicalmente fenoménicas que reemplazan la realidad de lo vivido y activan de forma directa a los sentidos; son lugares que excitan el cuerpo como termótopos (Sloterdijk, 2002), que impulsan el crecimiento de la economía y en gran medida la multinormatividad. Sin duda alguna, aquí y ahora se requiere un nuevo modo de emplear la palabra, la imagen y la tecnología, dentro de una temporalidad efímera y eterna simultáneamente. ABSTRACT The term imaginary marks the beginning and the main topic of this research into the architectural world, presented as the necessary condition to understand the design process in its intimate layers, loaded with ideological and symbolic meanings. Through different interpretations, the unconscious, personal and collective, scientific or social, is found in the origin of every human thought and behaviour, constituting a closed chaotic universe, where all ideas are in constant tension and contradiction. This is why there are logical and coherent notions or discursive constructions which organise the context of verisimilitude and therefore the regime of reality through truth and its verification. For the architectural project, these specific configurations are associated with space, time and body as basic elements of management and hierarchization of human habitability and co-habitability. This thesis aims to demarcate and define a field of verisimilar processes installed in the imaginary, through the intangible heritage of mythical or utopian thinking, where not only enclosures of thought, iconography or utopian ideals are created, but from where rigid and exclusive models are derived as well, from theories based on heteronormativity and segregation by sex, gender, class and functional diversity. The experience of the architectural space has been described traditionally through words and images: the language and the symbol have been intermediating between the user and his habitat. Everyday life and urban interactions have been governed by absolute, universally applied, models or standards, therefore the architectural world has been stalled in a constant dual polarity between the public and the private, the inside and the outside, the movement and the repose, the man and the woman. Certainly, if the space-time notion, along with the theorization of the body, are the basis for absolutist, universalist and perfectionist models that have dominated western thought and developed the concept of “normal” in its totality, deducting all complexity and diversity, in the hypermodern era it makes no longer sense to speak in terms that ignore the overlap and contradiction of the chaotic multiplicity that characterises equality and unstable balance. Reality has been reinvented through intermediate situations, the in-between spaces, time, identities, or other presupposed notions. The order of truth has been distorted, affecting and transforming the contemporary imaginary. Everyday practices have surpassed the architectural design and time has annihilated space. Connectivity, networks, free access to information -wherever it exists-, compose the framework that has allowed subaltern subjectivity to emerge and begin to consolidate into main theoretical and practical discourses. New models are appearing in the augmented hyper-space/ time, transgressing any rule and interpretation imposed to control habits, behaviours and people. The house, the city and the metropolis are empty of content; they no longer fulfil moral and symbolic functions. The non-places, non-space, non-time (Amann, 2011) are radically phenomenal conditions that replace the reality of the lived experience and activate the senses as places that excite the body, thermotopos (Sloterdijk, 2002), which boost economic growth and to a considerable extent the multinormativity. Undoubtedly, what is required here and now is a new way of employing the word, the image and the technology within an ephemeral yet eternal temporality.

Detecting and sorting targeting peptides wtih neural networks and support vector machines

This paper presents a composite multi-layer classifier system for predicting the subcellular localization of proteins based on their amino acid sequence. The work is an extension of our previous predictor PProwler v1.1 which is itself built upon the series of predictors SignalP and TargetP. In this study we outline experiments conducted to improve the classifier design. The major improvement came from using Support Vector machines as a "smart gate" sorting the outputs of several different targeting peptide detection networks. Our final model (PProwler v1.2) gives MCC values of 0.873 for non-plant and 0.849 for plant proteins. The model improves upon the accuracy of our previous subcellular localization predictor (PProwler v1.1) by 2% for plant data (which represents 7.5% improvement upon TargetP).

Kockázattal kiegészített Taylor-szabályok becslése Magyarországra = Estimation of risk-augmented Taylor rules for Hungary

Cikkünkben a magyar monetáris politikát vizsgáljuk olyan szempontból, hogy kamatdöntései meghozatalakor figyelembe vette-e az országkockázatot, és ha igen, hogyan. A kérdés megválaszolásához a monetáris politika elemzésének leggyakoribb eszközét használjuk: az ország monetáris politikáját leíró Taylor-szabályokat becslünk. A becslést több kockázati mérőszámmal is elvégeztük több, különféle Taylor-szabályt használva. Az érzékenységvizsgálatban az inflációhoz és a kibocsátási réshez is alkalmaztunk más, az alapspecifikációban szereplőtől eltérő mérőszámokat. Eredményeink szerint a Magyar Nemzeti Bank kamatdöntései jól leírhatók egy rugalmas, inflációs célkövető rezsimmel: a Taylor-szabályban szignifikáns szerepe van az inflációs céltól való eltérésének és - a szabályok egy része esetén - a kibocsátási résnek. Emellett a döntéshozók figyelembe vették az országkockázatot is, annak növekedésére a kamat emelésével válaszoltak. Az országkockázat Taylor-szabályba történő beillesztése a megfelelő kockázati mérőszám kiválasztása esetén jelentős mértékben képes javítani a Taylor-szabály illeszkedését. _____ The paper investigates the degree to which Hungarian monetary policy has considered country risk in its decisions and if so, how. The answer was sought through the commonest method of analysing a countrys monetary policy: Taylor rules for describing it. The estimation of the rule was prepared using several risk indicators and applying various types of Taylor rules. As a sensitivity analysis, other indicators of inflation and output gap were employed than in the base rule. This showed that the interest-rate decisions of the National Bank of Hungary can be well described by a flexible inflation targeting regime: in the Taylor rules, deviation of inflation from its target has a significant role and the output gap is also significant in one part of the rules. The decision-makers also considered country risk and responded to an increase in it by raising interest rates. Insertion of country risk into the Taylor rule could improve the models fit to an important degree when choosing an appropriate risk measure.

Studio e prototipazione di un'architettura software di alto livello per lo sviluppo di applicazioni di mixed reality su piattaforma HoloLens

La tesi si pone come obiettivo quello di realizzare un'architettura di alto livello per lo sviluppo di applicazioni dirette alla piattaforma HoloLens. Per conseguire tale risultato si è rivelata necessaria una prima parte di studio dei concetti di mixed reality, con riferimento particolare al caso specifico HoloLens, per poi dirigere l'attenzione alla comprensione dell'architettura di applicazioni olografiche. L'analisi delle API rilasciate per lo sviluppo di applicazioni HoloLens ha permesso di riscontrare varie criticità, alle quali si è posto rimedio tramite l'introduzione di un livello di astrazione, che possa consentire uno sviluppo di applicazioni ad un livello più alto. Si è poi introdotto il concetto di augmented worlds (mondi aumentati), i cui principi cardine hanno fornito le basi per la progettazione e lo sviluppo di un sistema client-server, nel quale il dispositivo HoloLens agisce come un client e la logica di controllo degli elementi del modello dell'applicazione viene gestita lato server.

Design and development of a Unity based framework for augmented worlds

The way we've always envisioned computer programs is slowly changing. Thanks to the recent development of wearable technologies we're experiencing the birth of new applications that are no more limited to a fixed screen, but are instead sparse in our surroundings by means of fully fledged computational objects. In this paper we discuss proper techniques and technologies to be used for the creation of "Augmented Worlds", through the design and development of a novel framework that can help us understand how to build these new programs.

Realtà virtuale multiutente

L’obbiettivo di questa tesi è realizzare il prototipo di un’applicazione client-server che permetta di utilizzare in remoto applicazioni in Virtual Reality, fornendo allo stesso tempo supporto alla multiutenza. L’applicazione in realtà virtuale dovrà girare sul server, dispositivo con capacità di calcolo notevolmente superiori rispetto a quelle del client. Più utenti dovranno avere la possibilità di connettersi contemporaneamente e condividere lo stesso spazio virtuale. Il client sarà, in questo caso, un’applicazione Android che si connetterà al server e avrà il compito di mostrare all'utente l’output dell’applicazione in Virtual Reality e allo stesso tempo ricevere l’input da inviare al server. Un altro obbiettivo durante lo sviluppo del prototipo è quello di realizzare una libreria che offra le funzionalità sopraelencate, facilmente integrabile in nuovi progetti o in progetti già esistenti. Utilizzando questa struttura client-server sarà possibile sviluppare applicazioni che permettano a più persone di condividere lo stesso spazio virtuale, ognuno dal proprio punto di vista, utilizzando visori e sistemi operativi diversi.

In Whose Image: The Emergence, Development, and Challenge of African-American Evangelicalism

The current era of American Christianity marks the transition from a Western, white-dominated U.S. Evangelicalism to an ethnically diverse demographic for evangelicalism. Despite this increasing diversity, U.S. Evangelicalism has demonstrated a stubborn inability to address the entrenched assumption of white supremacy. The 1970s witnessed the rise in prominence of Evangelicalism in the United States. At the same time, the era witnessed a burgeoning movement of African-American evangelicals, who often experienced marginalization from the larger movement. What factors prevented the integration between two seemingly theologically compatible movements? How do these factors impact the challenge of integration and reconciliation in the changing demographic reality of early twenty-first Evangelicalism?

The question is examined through the unpacking of the diseased theological imagination rooted in U.S. Evangelicalism. The theological categories of Creation, Anthropology, Christology, Soteriology, and Ecclesiology are discussed to determine specific deficiencies that lead to assumptions of white supremacy. The larger history of U.S. Evangelicalism and the larger story of the African-American church are explored to provide a context for the unique expression of African-American evangelicalism in the last third of the twentieth century. Through the use of primary sources — personal interviews, archival documents, writings by principals, and private collection documents — the specific history of African-American evangelicals in the 1960s and 1970s is described. The stories of the National Black Evangelical Association, Tom Skinner, John Perkins, and Circle Church provide historical snapshots that illuminate the relationship between the larger U.S. Evangelical movement and African-American evangelicals.

Various attempts at integration and shared leadership were made in the 1970s as African-American evangelicals engaged with white Evangelical institutions. However, the failure of these attempts point to the challenges to diversity for U.S. Evangelicalism and the failure of the Evangelical theological imagination. The diseased theological imagination of U.S. Evangelical Christianity prevented engagement with the needed challenge of African American evangelicalism, resulting in dysfunctional racial dynamics evident in twenty-first century Evangelical Christianity. The historical problem of situating African American evangelicals reveals the theological problem of white supremacy in U.S. Evangelicalism.

Transformative realism: reflections of reality in political avant-garde and contemporary fine art film - Spanish Labyrinth, south from Granada

A turn towards documentary modes of practice amongst contemporary fine art video and filmmakers towards the end of the 20th Century, led to moving image works that represent current social realities. This drew some comparisons of these forms of art to journalism and industrial documentary. The practical research is embodied in a single screen film that responds to recent political and ecological realities in Spain. These include the mass demonstrations that led to the occupation of Madrid’s Plaza del Sol and Spain’s in 2011 and largest recorded forest fires that spread through Andalusia in August of the following year. The film, titled Spanish Labyrinth, South from Granada, is a response to these events and also relates to political avant-garde film of the 1930’s by re-tracing a journey undertaken by three revolutionary filmmakers, Yves Allegret, René Naville and Eli Lotar, in 1931. The theoretical research for this project establishes an historical root of artists’ film that responds to current social realities, in contrast to news media, in the Soviet and European avant-garde movements of the 1920s and 1930s. The main aim of this method is to argue the status of the works that I identify, both avant-garde and contemporary, as a form of art that preceded a Griersonian definition of documentary film.

Ambienti di servizi per applicazioni in mixed reality per MS HoloLens

Nella presente tesi, dopo una prima parte dedicata all'analisi del concetto di realtà mediata e delle sue varie specializzazioni, verranno illustrati i principali dispositivi hardware presenti attualmente sul mercato, analizzandone le caratteristiche, gli aspetti innovativi e la diffusione raggiunta al momento. Si passerà quindi ad esaminare nel dettaglio il visore Microsoft HoloLens, impiegato per la realizzazione del progetto di laurea, per arrivare alla descrizione dello sviluppo di un'applicazione. Il software realizzato rappresenta un esempio di applicazione della realtà mista al campo del design di interni: verranno esaminati strumenti di sviluppo, architettura, casi d'uso e work-flow dell'applicazione. Infine verranno descritte le fasi di test, i costi di sviluppo dell'applicazione e il feedback ricevuto dagli utenti.

Augmented Dissent: The Affordances of ICTs for Citizen Protest (A Case Study of the Ukraine Euromaidan Protests of 2013-2014).

This dissertation research project uses the Euromaidan protests in Ukraine to inform and shape a theory of augmented dissent to help explain the complex ways in which protest participants guided by the political, social, and cultural contexts engage in dissent augmented by ICTs in a reality where both the physical and the digital are used in concert. The purpose of this research is to conceptualize the use and perception of ICTs in protest activity using the communicative affordances framework. Through a mixed-method research approach involving interviews with protest participants, as well as qualitative and thematic analysis of online content from social media pages of several key Euromaidan protest communities, the research project examines the role ICTs played in the information and media landscape during the Euromaidan protest. The findings of the online content analysis were used to inform the questions for the 59 semi-structured, open-ended interviews with Euromaidan protest participants in Ukraine and abroad. The research findings provide in-depth insights about how ICTs were used and perceived by protest participants, and their role as vehicles for information and civic media content. The study employs the theoretical framework of social media affordances to interpret the data gathered during the interviews and content analysis to better understand how digital media augmented citizens’ protest activity through affording them new possibilities for dissent, and how they made meaning of said protest activity as augmented by ICTs. The findings contribute towards shaping a theory of digitally augmented dissent that conceptualizes the complex relationship between citizens and ICTs during protest activity as an affordance-driven one, where online and offline tools and activity merge into a unified dissent space and extend or augment the possibilities for action in interesting, and sometimes unexpected ways. Such a conceptual model could inform broader theories about civic participation and digital activism in the post-Soviet world and beyond, as ICTs become an inseparable part of civic life.

Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice

AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular material and the generation of dystrophic neurites, thus contributing to axonal/synaptic dysfunction. In this study, we analyzed the effect of a microtubule-stabilizing compound in the progression of the disease in the hippocampus of APP751SL/PS1M146L transgenic model. METHODS: APP/PS1 mice (3 month-old) were treated with a weekly intraperitoneal injection of 2 mg/kg epothilone-D (Epo-D) for 3 months. Vehicle-injected animals were used as controls. Mice were tested on the Morris water maze, Y-maze and object-recognition tasks for memory performance. Abeta, AT8, ubiquitin and synaptic markers levels were analyzed by Western-blots. Hippocampal plaque, synaptic and dystrophic loadings were quantified by image analysis after immunohistochemical stainings. RESULTS: Epo-D treated mice exhibited a significant improvement in the memory tests compared to controls. The rescue of cognitive deficits was associated to a significant reduction in the AD-like hippocampal pathology. Levels of Abeta, APP and ubiquitin were significantly reduced in treated animals. This was paralleled by a decrease in the amyloid burden, and more importantly, in the plaque-associated axonal dystrophy pathology. Finally, synaptic levels were significantly restored in treated animals compared to controls. CONCLUSION: Epo-D treatment promotes synaptic and spatial memory recovery, reduces the accumulation of extracellular Abeta and the associated neuritic pathology in the hippocampus of APP/PS1 model. Therefore, microtubule stabilizing drugs could be considered therapeutical candidates to slow down AD progression. Supported by FIS-PI12/01431 and PI15/00796 (AG),FIS-PI12/01439 and PI15/00957(JV)

Plan de negocios Bicigo app

La gran cantidad de personas interesadas actualmente en cuidar de su salud por medio de la Bicicleta, es una tendencia que cada vez toma más fuerza y por esto, se tomara como ventaja que la ciudad de Bogotá con sus últimos alcaldes han decidió apoyar el uso de esta. Aplicación para realizar grupos de ciclistas y poder salir cualquier día de la semana acompañado de más personas por un tema de transporte pero también de ocio. El objetivo es que las personas que no utilizan la bicicleta por miedo a salir solos, puedan unirse a diferentes grupos y hacer bici paseos por la ciudad, también contemplamos el hecho de que existen personas que quieren montar bicicleta como aficionados, es decir que salen por la carreteras aledañas a la capital pero muchas veces no tienen grupo con quien rodar. Queremos para el año 2020, lograr ser una de las aplicaciones de Bicicletas más exitosa de la ciudadanía de Bogotá, siendo una de las aplicaciones que mas apoya el uso diario y deportivo de la bicicleta. Nuestra aplicación ofrece el servicio principalmente de reunir gente y hacer paseos con diferentes personas haciendo uso de las bicicletas, dentro de la ciudad como ocio y transporte se realizarían en la mañana y noches, pero así mismo realizar grupos para hacer uso de la bicicleta por carreteras, es decir más como modo profesional o aficionado. Nuestra aplicación cuenta con una interface para seleccionar el tipo de bici usuario y segundo por donde o a donde quiere dirigirse para así mismo mostrarle las rutas cercanas a él. Nuestra característica principal es la unión de diferentes grupos, personas y entidades para hacer uso de la Bicicleta, tenemos una plataforma interactiva y fácil de usar, tan fácil que cualquier persona que no esté inmersa en el mundo de los Smartphone o aplicaciones pueda aprender a usarla. Unas de las ventajas con las que cuento es que desde muy joven me ha gustado montar en bicicletas y es así como decido crear una aplicación ya que compañeros, familiares y conocidos no salían a montar bicicleta solo conmigo, preferían que fuese un grupo más grande. Así mismo cuento con 3 compañeros de la universidad Javeriana que son programadores y ellos me van a brindar apoyo con la programación de la aplicación, y una compañera cercana a mí que estudio diseño industrial y me brindara apoyo con el diseño e imagen corporativa de la aplicación. Cuento con planta física para ubicar la oficina de nuestra empresa. Esta aplicación va dirigida principalmente a los habitantes de la ciudad de Bogotá, interesados en el cuidado de su salud combinado con medio de transporte, y personas correspondientes al estrato 2 en adelante, ya que son las personas que normalmente hacen uso de la bicicleta o que son personas potenciales para empezar hacer uso de la bicicleta. . La ciudad de Bogotá cuenta con 8’037.732 habitantes y este proyecto va ser desarrollado en toda la ciudad, toca tener en cuenta que la ciudad esta mesclada entre la diferente estratificación, no dirigimos a los estratos 2 y 3 que tenga la posibilidad de tener su Bicicleta y un celular tipo Smartphone, para los estratos 4, 5 y 6 sabemos que tiene la facilidad de obtener una bicicleta y ellos son nuestro usuario potencial el cual generaríamos un cambio y tomarían su bicicleta para hacer ejercicio como ocio y como medio de transporte. En cuanto a la proyección financiera para la aplicación, como se mencionó anteriormente, contamos con una gran ventaja, ya que la inversión requerida será menor debido a la propiedad con la que cuento para llevar a cabo el proyecto. Una propiedad de 60 metros cuadrados para empezar, la cual cuenta con salas de reunión y auditorio, un parqueaderos exteriores. Al hacer la calculación se va tener en cuenta el pago de un arriendo sin importan que sea de nuestra propiedad y así poder evidenciar realmente como es el estado financiero y no subsidiarla. Por otro lado, la inversión en efectivo que se necesitara será aproximadamente de $100.000.000 que serán $50.000.000 de mis padres y el restante saldrán de mis ahorros, Javier Amortegui Babativa, los cuales serán distribuidos para adecuación de planta, equipos y sistemas $17.616.880, para publicidad y mercadeo: $30.000.000, creación de la aplicación $34.000.000, sistemas IOS + Android $421.600, Gastos de composición empresarial y bancarios $11.000.000 y por último se va tener un provisión para imprevistos por el restante $6.961.520. Nuestras proyecciones de ventas han sido basadas en aplicaciones similares con un mismo formato de lucro con el tema de bicicletas pero no con la misma idea de negocio, nuestras proyecciones de ventas estimadas serán de $20.000.000 a $25.000.000 los primeros 3 meses, mientras tomamos fuerza en el mercado.

"Portuguese Observatory of Taeniasis and Cysticercosis": A "One Health" example for epidemiological surveillance of one neglected disease in a European country

Cysticercosis results from the ingestion Taenia solium eggs directly by faecal-oral route or contaminated food or water. Human tapeworm carriers who have become infected after ingesting pork meat contaminated with cysticerci release these eggs. Cysticercosis occurs after tapeworm eggs are ingested by an intermediate host (pig or human) and then hatch, migrate, and lodge in the host's tissues, where they develop onto larval cysticerci. When they lodged in the central nervous system of humans, results in the disease condition called Neurocysticercosis (NCC), with a heterogeneous manifestations depending of the locations of cysts, number, size and their stage of evolution (1). Consequently the prognostic ranges from asymptomatic to situations leading to death in 2% to 9.8%. of cases (7) In swine’s there are few studies, but recent works have proved that animals, for the same reasons, also have neurological abnormalities, expressed by seizures, stereotypic walk in circles, chewing motions with foamy salivation included tonic muscle contractions followed by a sudden diminution in all muscle tone leading to collapse (2). Conventional domestic wastewater treatment processes may not be totally effective in inactivating parasites eggs from Taenia solium, allowing some contamination of soils and agricultural products (11). In Portugal there are some evidence of aggregation of human cysticercosis cases in specific regions, bases in ecological design studies (6). There are few information about human tapeworm carriers and social and economic factors associated with them. Success in knowledge and consequently in lowering transmission is limited by the complex network of biological and social factors that maintain the spread. Effective control of mostly zoonosis require One Health approach, after a real knowledge and transparency in the information provided by the institutions responsible for both animal and human health, allowing sustained interventions targeted at the transmission cycle's crucial nodes. In general, the model used to control, reflects a rural reality, where pigs are raised freely, poor sanitation conditions and incipient sanitary inspection. In cysticercosis, pigs are obligate intermediate hosts and so considered as first targets for control and used as sentinels to monitor environmental T. solium contamination (3). Usually environmental contamination with Taenia spp. eggs is a key issue in most of studies with landscape factors influencing presence of Taenia spp. antigens in both pigs and humans (5). Soil-related factors as well as socio-economic and behavioural factors are associated with the emergence of significant clustering human cysticercosis (4,5). However scarce studies has been produced in urban environmental and in developed countries with the finality to characterize the spatial pattern. There are still few data available regarding its prevalence and spatial distribution; Transmission patterns are likely to exhibit correlations as housing conditions, water supply, basic sanitation, schooling and birthplace of the individual or relatives, more than pigs rearing free, soil conditions (9). As a matter of fact, tapeworm carriers from endemic zones can auto-infect or transmit infection to other people or arrive already suffering NCC (as a result of travelling to or being a citizen from an endemic cysticercosis country) to a free cysticercosis country. Transmission is fecal-oral; this includes transmission through person-to-person contact, through autoinfection, or through contaminated food This has been happening in different continents as North America (5.4–18% been autochthonous), Europe and Australia (7). Recently, case reports of NCC have also emerged from Muslim countries. (10). Actually, different papers relate an epidemic situation in Spain and Portugal (7, 8). However the kind of study done does not authorize such conclusion. There are no evidence that infections were acquired in Portugal and there are not characterized the mode of transmission. Papers with these kind of information will be allow to have economic consequences resulted from artificial trade barriers with serious consequences for pig producers and pig meat trade. We need transparency in information’s that allow provide the basis to support the development and targeting of future effective control programmes (and prove we need that). So, to have a real picture of the disease, it is necessary integrate data from human, animal and environmental factors surrounding human and pig cases to characterize the pattern of the transmission. The design needs to be able to capture unexpected, and not common outcomes (routine data). We need to think “One Health” to get a genuine image of the situation.

Dietro le quinte della satira. Rapporti tra cittadini e contadini nel basso Medioevo italiano

Questa tesi indaga la relazione tra la letteratura anticontadina, fiorente in Italia a partire dalla metà del Trecento, e la realtà dei rapporti tra cittadini e contadini nel basso Medioevo italiano, con un’attenzione particolare all’area padana. Al centro dell’analisi vi sono due stereotipi satirici: il rustico ladro nei campi, che attirava su di sé l’odio feroce della classe padronale, e il villano rozzo, che mangiava alimenti poveri e del tutto estranei alla raffinata cultura alimentare cittadina. L’esame delle fonti giudiziarie, soprattutto bolognesi, conferma che l’immagine del rustico ladro aveva un saldo appiglio nella realtà, ma lo avevano anche i lamenti letterari dei contadini, riguardanti la disonestà dei padroni: vi sono infatti processi in cui i rustici riuscirono a dimostrarsi innocenti da accuse rivelatesi infondate o addirittura false. Inoltre, alcuni processi per ingiurie contro i campagnoli, insieme a episodici riferimenti in epistolari governativi e fonti normative, mostrano come il disprezzo per i villani fosse ben radicato a tutti i livelli della società cittadina. Per quanto riguarda la seconda figura – il rustico rozzo – l’esame dei libri di cucina italiani, unitamente alle descrizioni dei grandi banchetti, mostra chiaramente che non solo i prodotti, ma anche intere ricette associate in letteratura al mondo contadino rientravano nell’alimentazione delle élites: non vi era pertanto una rigida separazione tra l’ambito alimentare cittadino e quello campagnolo. La satira aveva dunque un profondo legame con la realtà, in quanto partiva sempre da un dato reale ed esprimeva un sentimento provato da una larga fascia della cittadinanza. Se ne discostava, tuttavia, quando esasperava la subalternità sociale e culturale dei contadini, negando gli evidenti aspetti di complementarità e integrazione di quel rapporto città-campagna che vedeva la prima in posizione dominante, ma la seconda tutt’altro che passiva o inerme.