Quantifica����o dos efeitos colaterais ap��s o uso do hycanthone intramuscular em pacientes com esquistossomose mansoni cr��nica

Foi avaliado o emprego de metanosulfonato de hycanthone em dose ��nica via intramuscular em pacientes esquistossom��ticos cr��nicos, nas condi����es de ambulat��rio da Se����o de Parasitoses da Prefeitura Municipal de Belo Horizonte. Estudaram-se 790 pacientes submetidos ao tratamento com 2,5 mg/k peso corporal, quantificando-se as rea����es colaterais referidas em fun����o da forma cl��nica da esquistossomose, ao sexo e �� idade dos pacientes, bem como em rela����o ao tempo de surgimento e �� dura����o de cada rea����o. Os pacientes foram tratados ap��s exame cl��nico e, em alguns casos, provas laboratoriais, sendo vetados ao tratamento ambulatorial cerca de 4% dos pacientes que buscaram o tratamento. De modo geral esta rotina tem-se mostrado bastante simples e destitu��da de maiores riscos, com mais de 12.000 tratamentos realizados sem uma ��nica rea����o grave evidenciada. Dos 790 pacientes avaliados, 37,8% n��o referiram nenhuma rea����o colateral. Dentre as rea����es detectadas, as mais freq��entes foram as n��useas, os v��mitos e as tonturas, geralmente surgindo no mesmo dia da inje����o e com desaparecimento espont��neo nas 24 ou 48 horas subseq��entes. Relativamente ��s formas cl��nicas, n��o houve diferen��as estatisticamente significativas entre o grupo h��pato-espl��nico e os demais, talvez por problemas de ordem amostra. Foi significativamente maior a freq����ncia de rea����es colaterais entre o sexo feminino, acima dos 15 anos de idade. Com rela����o aos grupos et��rios, verificou-se a ocorr��ncia significativamente maior de v��mitos entre os pacientes de 5 a 14 anos, contrastando com a predomin��ncia de tonturas e anorexia nas faixas superiores.

Protest attitudes and stated preferences: Evidence on scale usage heterogeneity

We contribute to the stated preference literature by addressing scale usage heterogeneity regarding how individuals answer attitudinal questions capturing lack of trust in institutions and fairness issues. Using a latent class model, we conduct a contingent valuation study to elicit the willingness-to-pay to preserve a recreational site. We find evidence that respondents within the same class, that is, with similar preferences and attitudes, interpret the Likert scale differently when answering the attitudinal questions. We identify different patterns of scale usage heterogeneity within and across classes and associate them with individual characteristics. Our approach contributes to better a understanding of individual behavior in the presence of protest attitudes.

A componente l��dica na sala de aula como elemento facilitador da aprendizagem

O presente relat��rio visa, num primeiro cap��tulo, descrever em que medida a componente l��dica, utilizada em ambiente de sala de aula, pode ser considerada como elemento facilitador da aprendizagem. Para tal, parte-se, para uma abordagem �� evolu����o das metodologias de ensino, sobre qual a import��ncia da comunica����o e da aprendizagem por tarefas, bem como �� defini����o de l��dico, analisando-se a sua import��ncia na aquisi����o e consolida����o de conhecimentos. Refere-se ainda o papel do docente e discente na abordagem e aplica����o da ludicidade e motiva����o na realiza����o de atividades. No segundo cap��tulo, faz-se uma apresenta����o do Agrupamento de Escolas Ibn Mucana, onde foi realizada a Pr��tica de Ensino Supervisionada e num terceiro cap��tulo faz-se refer��ncia �� observa����o e caracteriza����o da turma em que foram lecionadas as aulas pr��ticas. Por fim, no quarto cap��tulo, apresenta-se e reflete-se sobre as atividades l��dicas que foram desenvolvidas durante o per��odo de leciona����o.

Talidomida usada por pacientes com eritema nodoso hans��nico

INTRODU����O: A talidomida �� um f��rmaco utilizado atualmente no tratamento do eritema nodoso hans��nico no Brasil. M��TODOS: Estudo prospectivo para acompanhar a evolu����o cl��nica, registrar os eventos adversos e determinar as concentra����es plasm��ticas de talidomida em dose di��ria de 100mg/dia, em 20 pacientes com manifesta����es cl��nicas de eritema nodoso hans��nico, divididos em dois grupos: ap��s ou em curso da poliquimioterapia para hansen��ase. RESULTADOS: N��o foram observadas diferen��as significativas nos grupos no decorrer do estudo, tanto na evolu����o cl��nica favor��vel dos pacientes, de 70% e 90%, quanto nos eventos adversos registrados que foram tontura e sonol��ncia. Os teores plasm��ticos de talidomida em D7 e D14 foram de 0,82��0,4μg/mL e 0,79��0,3μg/mL no grupo 1 e de 0,82��0,4 e 1,55��1,0 no grupo 2, respectivamente. CONCLUS��ES: Na amostra estudada, a poliquimioterapia n��o interferiu na evolu����o cl��nica, na incid��ncia dos efeitos adversos e nos n��veis plasm��ticos de talidomida.

Online consumer behavior: The tablet shopper ��� A new kind of customer?

Tablet computers are on the rise and are increasingly superseding stationary computers in terms of modern online shopping. This paper therefore aims on understanding how tablet and website characteristics might impact online consumer behavior. The collected data resulted from focus groups and in-depth interviews conducted with a technology affine audience. It has shown that tablets indeed may have shifted shopping behavior from utilitarian towards rather recreational attributes. Discussions also revealed high customer expectations towards visited shopping websites and prevailing deficits. Thus, harnessing the concept of experiential flow is crucial. Compelling experiences are required to increase the duration of stay and consequently the likelihood of increased purchases.

Comuns: An Open-Data Provider, Explorer and Analytic Toolbox Based on FOSS

Cont��m resumo

Ecstasy intoxication: the toxicological basis for treatment

Youngsters are increasingly using 3,4 methylenedioxymethamphetamine, known as ecstasy, because it is wrongly believed that it does not induce harm. However, there are many reports of adverse effects, including acute intoxication, abuse potential, and possible neurotoxic effects. Therefore, health care providers need to promptly recognize the symptoms of systemic intoxication in order to initiate early treatment. The drug is used by the oral route for long hours during crowded dance parties. Acutely, ecstasy increases the release of serotonin and decreases its reuptake, leading to hypertension, hyperthermia, trismus, and vomiting. There is debate on whether recreational doses of ecstasy cause permanent damage to human serotonergic neurons. Ecstasy users showed a high risk of developing psychopathological disturbances. The prolonged use of ecstasy might induce dependence, characterized by tolerance and hangover. Acute ecstasy intoxication needs emergency-type treatment to avoid the dose-dependent increase in adverse reactions and in severity of complications. There are no specific antidotes to be used during acute intoxication. Supportive measures and medical treatment for each one of the complications should be implemented, keeping in mind that symptoms originate mainly from the central nervous system and the cardiovascular system.

Effects of medical therapy, alcohol, smoking, and endocrine disruptors on male infertility

Infertility affects up to 15% of the sexually active population, and in 50% of cases, a male factor is involved, either as a primary problem or in combination with a problem in the female partner. Because many commonly encountered drugs and medications can have a detrimental effect on male fertility, the medical evaluation should include a discussion regarding the use of recreational and illicit drugs, medications, and other substances that may impair fertility. With the knowledge of which drugs and medications may be detrimental to fertility, it may be possible to modify medication regimens or convince a patient to modify habits to decrease adverse effects on fertility and improve the chances of achieving a successful pregnancy. Concern is growing that male sexual development and reproduction have changed for the worse over the past 30 to 50 years. Although some reports find no changes, others suggest that sperm counts appear to be decreasing and that the incidence of developmental abnormalities such as hypospadias and cryptorchidism appears to be increasing, as is the incidence of testicular cancer. These concerns center around the possibility that our environment is contaminated with chemicals - both natural and synthetic - that can interact with the endocrine system.

O ��mbito de aplica����o material da legisla����o de prote����o de dados pessoais e o tratamento de imagem por pessoa singular

Images have gained a never before seen importance. Technological changes have given the Information Society extraordinary means to capture, treat and transmit images, wheter your own or those of others, with or without a commercial purpose, with no boundaries of time or country, without ���any kind of eraser���. From the several different ways natural persons may engage in image processing with no commercial purpose, the cases of sharing pictures through social networks and video surveillance assume particular relevance. Consequently there are growing legitimate concerns with the protection of one's image, since its processing may sometimes generate situations of privacy invasion or put at risk other fundamental rights. With this in mind, the present thesis arises from the question: what are the existent legal instruments in Portuguese Law that enable citizens to protect themselves from the abusive usage of their own pictures, whether because that image have been captured by a smartphone or some video surveillance camera, whether because it was massively shared through a blog or some social network? There is no question the one's right to not having his or her image used in an abusive way is protected by the Portuguese constitution, through the article 26th CRP, as well as personally right, under the article 79th of the Civil Code, and finally through criminal law, articles 192nd and 193rd of the Criminal Code. The question arises in the personal data protection context, considering that one's picture, given certain conditions, is personal data. Both the Directive 95/46/CE dated from 1995 as well as the LPD from 1998 are applicable to the processing of personal data, but both exclude situations of natural persons doing so in the pursuit of activities strictly personal or family-related. These laws demand complex procedures to natural persons, such as the preemptive formal authorisation request to the Data Protection National Commission. Failing to do so a natural person may result in the application of fines as high as ���2.500,00 or even criminal charges. Consequently, the present thesis aims to study if the image processing with no commercial purposes by a natural person in the context of social networks or through video surveillance belongs to the domain of the existent personal data protection law. To that effect, it was made general considerations regarding the concept of video surveillance, what is its regimen, in a way that it may be distinguishable from Steve Mann's definition of sousveillance, and what are the associated obligations in order to better understand the concept's essence. The application of the existent laws on personal data protection to images processing by natural persons has been analysed taking into account the Directive 95/46/CE, the LPD and the General Regulation. From this analysis it is concluded that the regimen from 1995 to 1998 is out of touch with reality creating an absence of legal shielding in the personal data protection law, a flaw that doesn't exist because compensated by the right to image as a right to personality, that anyway reveals the inability of the Portuguese legislator to face the new technological challenges. It is urgent to legislate. A contrary interpretation will evidence the unconstitutionality of several rules on the LPD due to the obligations natural persons are bound to that violate the right to the freedom of speech and information, which would be inadequate and disproportionate. Considering the recently approved General Regulation and in the case it becomes the final version, the use for natural person of video surveillance of private spaces, Google Glass (in public and private places) and other similar gadgets used to recreational purposes, as well as social networks are subject to its regulation only if the images are shared without limits or existing commercial purposes. Video surveillance of public spaces in all situations is subject to General Regulation provisions.

Gest��o de museus : o caso do Museu Nacional de Arqueologia

O presente trabalho pretende caraterizar o regime atual de governa����o do MNA descrevendo-o do ponto de vista dos recursos financeiros, recursos humanos, marketing e planeamento, tendo em conta a sua depend��ncia da Dire����o Geral de Patrim��nio Cultural, complementarmente pretende apresentar algumas propostas de melhoria. Desde a sua cria����o o Museu Nacional de Arqueologia, tem por objetivo representar a parte material da vida do homem portugu��s desde a pr��-hist��ria. Hoje, constitui a institui����o de refer��ncia da Arqueologia Portuguesa, ligado a outros museus, universidades e centros de investiga����o por todo o mundo. Num momento em que num n��mero crescente de pa��ses, os museus e institui����es culturais t��m de procurar fontes alternativas de financiamento, por for��a do desinvestimento por parte dos Estados, e a reduzir os gastos, incluindo restri����es ��s contrata����es de recursos humanos, coloca-se um grande desafio ��queles que gerem estas institui����es. Por um lado, val��ncias como lojas com artigos ligados ao museu e a concess��o de espa��os de restaura����o nas suas instala����es, a organiza����o de eventos tem��ticos l��dico-pedag��gicos, acompanhados de uma estrat��gia de comunica����o segmentada, contribuem para a diversifica����o e o aumento de p��blicos. Por outro lado, atividades de fundraising devem passar a ser uma pr��tica comum nestas entidades. Tudo isto, tendo sempre presente que se trata de uma entidade cultural com uma fun����o de produ����o de conhecimento e cultura, n��o devendo o Estado alhear-se desta fun����o. O Museu Nacional de Arqueologia, �� tutelado pela Dire����o Geral do Patrim��nio Cultural o que imp��e constrangimentos ao n��vel da gest��o. Embora seja poss��vel, pela dire����o do MNA, tomar decis��es relativas �� ��rea financeira, a perce����o do seu impacto n��o �� imediata. No que respeita aos recursos humanos, estamos perante um quadro qualificado, capaz de dar resposta ��s exig��ncias do funcionamento do museu, mas que pela m��dia et��ria e pelas dificuldades de contrata����o, coloca em risco o futuro. O marketing e o planeamento s��o as ��reas em an��lise que apresentam menos constrangimentos, pela depend��ncia da tutela. Os processos de marketing s��o concretizados pelos diferentes departamentos, com uma abordagem tradicional, ou seja unilateral, verificando-se pouca intera����o com os seus p��blicos. O plano de atividades �� bastante completo e �� uma boa ferramenta de gest��o no que respeita ao planeamento, assim como o planeamento de car��cter estrat��gico permite ao museu seguir uma linha de continuidade.

Os processos criativos na aprendizagem da t��cnica do violoncelo no ensino vocacional de m��sica

Relat��rio de est��gio de mestrado em Ensino de M��sica

O l��dico como estrat��gia de consolida����o e revis��o de conhecimentos na aula de L��ngua Estrangeira

Relat��rio de est��gio de mestrado em Ensino do Portugu��s no 3�� Ciclo do Ensino B��sico e no Ensino Secund��rio e de Espanhol nos Ensinos B��sico e Secund��rio

Brincar de Internet: a viv��ncia l��dica infantil em ambiente virtual

Tese de Doutoramento em Ci��ncias da Educa����o (Especialidade em Tecnologia Educativa)

Avalia����o do transporte sedimentar na bacia do rio Lima baseada em ferramentas de modela����o

Disserta����o de mestrado integrado em Engenharia Civil

Lewis Score - Prognostic value in patients with isolated small bowel Crohn's disease

Background and aims: Small bowel capsule endoscopy (SBCE) allows mapping of small bowel inflammation in Crohn���s disease (CD). We aimed to assess the prognostic value of the severity of inflammatory lesions, quantified by the Lewis score (LS), in patients with isolated small bowel CD. Methods: A retrospective study was performed in which 53 patients with isolated small bowel CD were submitted to SBCE at the time of diagnosis. The Lewis score was calculated and patients had at least 12 months of follow-up after diagnosis. As adverse events we defined disease flare requiring systemic corticosteroid therapy, hospitalization and/or surgery during follow-up. We compared the incidence of adverse events in 2 patient subgroups, i.e. those with moderate or severe inflammatory activity (LS =790) and those with mild inflammatory activity (135 = LS < 790). Results: The LS was =790 in 22 patients (41.5%), while 58.5% presented with LS between 135 and 790. Patients with a higher LS were more frequently smokers (p = 0.01), males (p = 0017) and under immunosuppressive therapy (p = 0.004). In multivariate analysis, moderate to severe disease at SBCE was independently associated with corticosteroid therapy during follow-up, with a relative risk (RR) of 5 (p = 0.011; 95% confidence interval [CI] 1.5���17.8), and for hospitalization, with an RR of 13.7 (p = 0 .028; 95% CI 1.3���141.9). Conclusion: In patients with moderate to severe inflammatory activity there were higher prevalences of corticosteroid therapy demand and hospitalization during follow-up. Thus, stratifying the degree of small bowel inflammatory activity with SBCE and LS calculation at the time of diagnosis provided relevant prognostic value in patients with isolated small bowel CD.