Model results of ocean physical field of the reference state and the targets in NetCDF format

In a feasibility study, the potential of proxy data for the temperature and salinity during the Last Glacial Maximum (LGM, about 19 000 to 23 000 years before present) in constraining the strength of the Atlantic meridional overturning circulation (AMOC) with a general ocean circulation model was explored. The proxy data were simulated by drawing data from four different model simulations at the ocean sediment core locations of the Multiproxy Approach for the Reconstruction of the Glacial Ocean surface (MARGO) project, and perturbing these data with realistic noise estimates. The results suggest that our method has the potential to provide estimates of the past strength of the AMOC even from sparse data, but in general, paleo-sea-surface temperature data without additional prior knowledge about the ocean state during the LGM is not adequate to constrain the model. On the one hand, additional data in the deep-ocean and salinity data are shown to be highly important in estimating the LGM circulation. On the other hand, increasing the amount of surface data alone does not appear to be enough for better estimates. Finally, better initial guesses to start the state estimation procedure would greatly improve the performance of the method. Indeed, with a sufficiently good first guess, just the sea-surface temperature data from the MARGO project promise to be sufficient for reliable estimates of the strength of the AMOC.

Definición e implantación de herramientas avanzadas 3D en el diseño integrado y eficiente de sistemas HVAC en buques, desde el proyecto conceptual hasta la producción

Uno de los aspectos más complicados del diseño de sistemas HVAC en buques es la correcta evaluación de las necesidades de aire fresco y el correcto dimensionado de los conductos que suministran dicho aire y evacuan el calor generado a bordo. Contrariamente a lo que sucede en los sistemas de tuberías, las características particulares del caudal de aire hacen que el dimensionado de los conductos sea muy sensible al trazado y geometría de los mismos, por lo que para obtener un buen diseño es necesaria una relación muy estrecha y una integración bidireccional entre los cálculos y el trazado de los propios conductos en el buque. Asumida la utilización de sistemas CAD/CAM para las tareas de diseño, históricamente, aquellos que permitían modelar conductos HVAC no incluían en su alcance de suministro los aspectos de cálculo, y como consecuencia de ello, el trazado de conductos se reducía a la inclusión en el modelo 3D de circuitos y sistemas previamente calculados y dimensionados, Así, servían únicamente para calcular interferencias con otros elementos del modelo 3D y para obtener posteriormente planos de fabricación y montaje. Esto, que por sí no es poco, dejaba el diseño de sistemas HVAC pendiente de una importante interacción manual y de habituales retrabajos, ya que cualquier modificación en el trazado de los conductos, consecuencia de otras necesidades del diseño, obligaba a los diseñadores a recalcular y redimensionar los conductos en un entorno diferente al del propio sistema CAD/CAM, y volver a realizar el modelado de los mismos, reduciendo significativamente las ventajas de la utilización de un modelo 3D. Partiendo de esta situación real, y con objeto de solucionar el problema que para el diseño y la propia producción del buque se creaba, se concibió una herramienta que permitiera la definición en el modelo 3D de diagramas de ventilación, el cálculo de pérdidas de presión, el dimensionado automático de los conductos, y que toda esta información pudiera estar disponible y reutilizarse en las etapas posteriores del diseño. Con ello, los diseñadores podrían realizar su trabajo en un entorno único, totalmente integrado con el resto de disciplinas. El objeto de esta Tesis Doctoral es analizar en detalle el problema y las ineficiencias actuales del diseño de HVAC, describir la innovadora herramienta concebida para paliar estas ineficiencias, detallando las bases sobre la que se construye, y destacar las ventajas que se obtienen de su uso. La herramienta en cuestión fue concebida como una funcionalidad adicional del sistema CAD/CAM naval FORAN, referente tecnológico en el mundo del diseño y la construcción navales, y como consecuencia de ellos se llevó a cabo el desarrollo correspondiente. En la actualidad, el sistema FORAN incluye en su alcance de suministro una primera versión de esta herramienta, cuya utilidad queda avalada por el uso que de la misma hacen astilleros y oficinas técnicas en todo el mundo. Esta Tesis Doctoral es eminentemente práctica. No es un estudio teórico de dudosa aplicación, sino que tiene por objeto aportar una solución eficiente a un problema real que muchos astilleros y oficinas técnicas, incluidas los más avanzados, padecen hoy en día. No tiene otra motivación que servir de ayuda para lograr diseñar y construir mejores barcos, en un plazo más corto, y a un coste menor. Nada más, pero nada menos. ABSTRACT One of the most complicated aspects of the design of HVAC systems in shipbuilding is the correct evaluation of the fresh air needs, the correct balancing of the ducts that supply this air and evacuate the existing heat on board. In opposition to piping systems, due to the particular characteristics of the air flow, the balancing of the ducts is very sensitive to the routing and the aspect of the ducts, so the correct design requires a close interconnectivity between calculations and routing. Already assumed the use of CAD/CAM systems for design tasks, historically, those CAD/CAM systems capable of modelling HVAC ducts did not cover calculation aspects, with the result that the routing of HVAC ducts was reduced solely to the input of previously balanced circuits into the 3D Product Model for the purpose of interference checking and generation of fabrication and assembly drawings. This situation, not negligible at all, put the design of HVAC ducts very dependent on manual operations and common rework task, as any modification in the routing of the HVAC ducts, derived from design needs, obliged engineers to re-balance the ducts and eventually to re-size them independently of the CAD-CAM environment, thus annulling the advantages of the 3D Product Model. With this situation in mind, and with the objective of filling the gap created in the design and construction of the ship, it was conceived a tool allowing the definition, within the 3D Product model, of HVAC diagrams, the calculation of pressure drops, the automatic dimensioning of ducts. With this, engineers could make the complete HVAC design in a single working environment, fully integrated with the rest of the disciplines. The present Ph. D. thesis analyses in deep the existing problem and the current lack of efficiency in HVAC design, describes the innovative tool conceived to minimize it, details the basis on which the tool is built, and highlights the advantages of its use. This tool was conceived as an additional functionality of the marine CAD/CAM system FORAN, a technological reference in the shipdesign and shipbuilding industry. As a consequence, it was developed, and nowadays FORAN System includes in its scope of supply a first version of the tool, with its usefulness endorsed by the fact that it is used by shipyards and shipdesign offices all over the world. This Ph. D. thesis is on top everything, of practical nature. It is not a theoretical study with doubtful application. On the contrary, its objective is to provide with an efficient solution for solving a real problem that many shipyards and shipdesign offices, including those more advanced, suffer nowadays. It has no other motivation that to help in the process of designing and building better and cheaper ships, within a shorter deliver time. Nothing more, but nothing less.

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

In the tumor-bearing host, T cells invariably fail to induce a clinically significant antitumor immune response. Although model systems support the existence of tumor peptide antigens, the molecular interactions critical for antigen presentation by the tumor cell remain unresolved. Here, we demonstrate that human follicular lymphoma cells are highly inefficient at presenting alloantigen despite their strong expression of major histocompatibility complex and low-to-intermediate expression of some adhesion and B7 costimulatory molecules. Activation of follicular lymphoma cells via CD40 induces or up-regulates both adhesion and B7 costimulatory molecules essential to repair this defect. More importantly, once primed, alloreactive T cells efficiently recognize unstimulated follicular lymphoma cells. Thus, correction of defective tumor immunity requires not only expression of major histocompatibility complex but also sufficient expression of multiple adhesion and costimulatory molecules.

The gas target model for the Visegard 4 Region: conceptual analysis. OSW Report, May 2013

The similarity of issues and geographical proximity have led the Visegrad 4 countries (V4) to undertake closer collaboration in natural gas policy, notably by agreeing on a common security of supply strategy, including regional emergency planning, and a common implementation of the Gas Target Model (GTM) that European regulators have proposed for the medium-long term design of the EU gas market, and which has been endorsed by the Madrid Regulatory Forum. As a contribution to this collaboration, the present paper will analyse how the GTM may be implemented in the V4 region, with a view to maximize the benefits that arise from joint implementation. A most relevant conclusion of the GTM is that markets should be large enough to attract market players and investments, so that sufficient diversity of sources may be reached and market power indicators are kept below dangerous levels. In most cases, this requires physical and/or virtual interconnection of present markets, which is also useful to achieve the required security of supply standards, as envisaged in the Regulation 994/2010/EC.

Parliamentary law and rules of procedure : a manual of practical information concerning deliberative bodies; motions and their purpose and relation; voting; elections; committees; officers and debate; together with model forms and reference charts; in accordance with Robert's rules of order, revised 1915 /

Mode of access: Internet.

Conceptual plan for an interactive highway safety design model. Final report.

Federal Highway Administration, Office of Safety and Traffic Operations Research and Development, McLean Va.

Conceptual design of a regional water quality screening model /

"DOE/EV/10154-T1."

Direct and general support and depot maintenance repair parts and special tools lists : theodolite, directional; 0.002-mil graduation, 5.9 in. long telescope; detachable tribrach; w/accessories and tripod (Wild Heerbrugg model T-2-56-C-MIL), FSN 6675-682-4635 ... (Wild Heerbrugg model T-2-56-C-MIL, reference), FSN 6675-988-5225.

Includes index.

Operator, organizational, direct support, and general support maintenance manual : theodolite, directional, 0.002 mil graduation, 5.9 in. lg. telescope ... (Wild Heerbrugg models), (model T2-56-C-MIL), NSN 6675-00-682-4635 ... theodolite, directional (reference), (Wild Heerbrugg models T2-56-C-MIL ... and T2-68MIL), NSN 6675-00-988-5225.

Includes index.

A conceptual model of organized primary care and comprehensive community health services.

Mode of access: Internet.

Social-servicescape conceptual model

There is considerable evidence that environmental variables can substantially influence consumer behavior in service settings (cf. Turley and Milliman, 2000). However, research to date has focused on the effects of the physical elements (‘atmospherics’), with the social aspects (customers and service providers) of the environment largely ignored. First, we provide a review of the extant literature drawing on four major streams of research from (1) previous marketing (servicescapes); (2) environmental psychology (approach–avoidance theory, behavior setting theory); (3) social psychology (social facilitation theory); and (4) organizational behavior (affective events theory). Second, we present a new conceptual model, the ‘Social-servicescape’. In this paper we argue that the social environment and purchase occasion dictates the desired social density which influences customers’ affective and cognitive responses, including repurchase intentions. Furthermore, we argue that customers play a key role in influencing the emotions of others either positively or negatively, and this largely determines whether they intend to return to the service setting. Implications of this conceptual model for theory and practice are discussed.

A conceptual model of personalized virtual learning environments

The Virtual Learning Environment (VLE) is one of the fastest growing areas in educational technology research and development. In order to achieve learning effectiveness, ideal VLEs should be able to identify learning needs and customize solutions, with or without an instructor to supplement instruction. They are called Personalized VLEs (PVLEs). In order to achieve PVLEs success, comprehensive conceptual models corresponding to PVLEs are essential. Such conceptual modeling development is important because it facilitates early detection and correction of system development errors. Therefore, in order to capture the PVLEs knowledge explicitly, this paper focuses on the development of conceptual models for PVLEs, including models of knowledge primitives in terms of learner, curriculum, and situational models, models of VLEs in general pedagogical bases, and particularly, the definition of the ontology of PVLEs on the constructivist pedagogical principle. Based on those comprehensive conceptual models, a prototyped multiagent-based PVLE has been implemented. A field experiment was conducted to investigate the learning achievements by comparing personalized and non-personalized systems. The result indicates that the PVLE we developed under our comprehensive ontology successfully provides significant learning achievements. These comprehensive models also provide a solid knowledge representation framework for PVLEs development practice, guiding the analysis, design, and development of PVLEs. (c) 2005 Elsevier Ltd. All rights reserved.