Ataxia due to vertebral hemangiosarcoma with evidence of disseminated disease in a 20-year old Swiss Warmblood mare

A 20-year old Swiss Warmblood mare was referred to the Swiss Institute of Equine Medicine with a history of poor performance, coughing and ataxia and hindlimb weakness which progressed to recumbency. Lung auscultation revealed pronounced wheezing, blood work showed signs of chronic inflammation and increased bone turnover and thoracic ultrasound indicated patchy pulmonary consolidation. Cerebrospinal fluid revealed only mild, unspecific changes allowing exclusion of meningoencephalomyelitis and clinically relevant bleeding. Despite medical treatment and support in a sling the mare did not improve and was euthanized. Necropsy revealed a poorly demarcated, non-encapsulated and invasively growing mass dorsally in the musculature at the level of the forth cervical vertebra (C4) infiltrating the vertebral body and the spinal canal at the level of C1–C2. Multiple nodular, firm masses were present in all lobes of the lung and appeared to be mainly located in vessels. Histologically the masses were composed of spindle cells with marked anisocytosis, anisocaryosis, a high mitotic activity and showed invasive growth. These neoplastic cells stained positive for CD31, an endothelial cell marker, which confirmed diagnosis of a hemangiosarcoma. Definite ante mortem diagnosis of hemangiosarcoma, which is rare in horses, is challenging. Besides the vertebral localization, disseminated, locally invasive and cutaneous forms of hemangiosarcoma exist and can be either acquired or congenital. Prognosis for equine hemangiosarcoma and response to treatment are usually poor and progression of clinical signs is rapid. Vertebral hemangiosarcoma is an uncommon cause of spinal ataxia in horses.

Optimal target localization for subthalamic stimulation in patients with Parkinson disease

OBJECTIVE To further determine the causes of variable outcome from deep brain stimulation of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD). METHODS Data were obtained from our cohort of 309 patients with PD who underwent DBS-STN between 1996 and 2009. We examined the relationship between the 1-year motor, cognitive, and psychiatric outcomes and (1) preoperative PD clinical features, (2) MRI measures, (3) surgical procedure, and (4) locations of therapeutic contacts. RESULTS Pre- and postoperative results were obtained in 262 patients with PD. The best motor outcome was obtained when stimulating contacts were located within the STN as compared with the zona incerta (64% vs 49% improvement). Eighteen percent of the patients presented a postoperative cognitive decline, which was found to be principally related to the surgical procedure. Other factors predictive of poor cognitive outcome were perioperative confusion and psychosis. Nineteen patients showed a stimulation-induced hypomania, which was related to both the form of the disease (younger age, shorter disease duration, higher levodopa responsiveness) and the ventral contact location. Postoperative depression was more frequent in patients already showing preoperative depressive and/or residual axial motor symptoms. CONCLUSION In this homogeneous cohort of patients with PD, we showed that (1) the STN is the best target to improve motor symptoms, (2) postoperative cognitive deficit is mainly related to the surgery itself, and (3) stimulation-induced hypomania is related to a combination of both the disease characteristics and a more ventral STN location.

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Stunden der Andacht : ein Gebet- u. Erbauungs-Buch f. Israels Frauen u. Jungfrauen z. öffentl. u. häusl. Andacht so wie f. alle Verhältnisse d. weibl. Lebens

von Fanny Neuda geb. Schmiedl

Bericht über die Entstehung und Entwickelung des israelitischen Waisenhauses zu Paderborn

von Fanny Nathan

Andachtsbuch für israelitische Frauenzimmer : zur öffentlichen u. häuslichen Erbauung in allen Verhältnissen des weiblichen Lebens

[Fanny Neuda]

Šṭunden der andachṭ : ein gebeṭ- und erboiungsbuch fir Izraels froien u. jungfroien ...

fun Fanni Neida

Myocardial expression profiles of candidate molecules in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia compared to those with dilated cardiomyopathy and healthy controls.

BACKGROUND Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is mainly an autosomal dominant disease characterized by fibrofatty infiltration of the right ventricle, leading to ventricular arrhythmias. Mutations in desmosomal proteins can be identified in about half of the patients. The pathogenic mechanisms leading to disease expression remain unclear. OBJECTIVE The purpose of this study was to investigate myocardial expression profiles of candidate molecules involved in the pathogenesis of ARVC/D. METHODS Myocardial messenger RNA (mRNA) expression of 62 junctional molecules, 5 cardiac ion channel molecules, 8 structural molecules, 4 apoptotic molecules, and 6 adipogenic molecules was studied. The averaged expression of candidate mRNAs was compared between ARVC/D samples (n = 10), nonfamilial dilated cardiomyopathy (DCM) samples (n = 10), and healthy control samples (n = 8). Immunohistochemistry and quantitative protein expression analysis were performed. Genetic analysis using next generation sequencing was performed in all patients with ARVC/D. RESULTS Following mRNA levels were significantly increased in patients with ARVC/D compared to those with DCM and healthy controls: phospholamban (P ≤ .001 vs DCM; P ≤ .001 vs controls), healthy tumor protein 53 apoptosis effector (P = .001 vs DCM; P ≤ .001 vs controls), and carnitine palmitoyltransferase 1β (P ≤ .001 vs DCM; P = 0.008 vs controls). Plakophillin-2 (PKP-2) mRNA was downregulated in patients with ARVC/D with PKP-2 mutations compared with patients with ARVC/D without PKP-2 mutations (P = .04). Immunohistochemistry revealed significantly increased protein expression of phospholamban, tumor protein 53 apoptosis effector, and carnitine palmitoyltransferase 1β in patients with ARVC/D and decreased PKP-2 expression in patients with ARVC/D carrying a PKP-2 mutation. CONCLUSION Changes in the expression profiles of sarcolemmal calcium channel regulation, apoptosis, and adipogenesis suggest that these molecular pathways may play a critical role in the pathogenesis of ARVC/D, independent of the underlying genetic mutations.

Tooth loss, chewing efficiency and cognitive impairment in geriatric patients.

BACKGROUND Patients with dementia have poorer oral health and fewer teeth than their peers without cognitive impairment. OBJECTIVE The hypothesis of this study is that the number of natural teeth and the chewing efficiency are associated with cognitive functioning. METHODS This cross-sectional study included 29 patients diagnosed with dementia aged 75 years or older and 22 controls who were either cognitively normal (n = 19) or with mild cognitive impairment (n = 3). Neuropsychological, nutritional and dental assessments were performed. The chewing efficiency was evaluated with a two-colour mixing test. RESULTS Demented patients and controls presented with a mean of 4.9 and 6.5 teeth, respectively (n.s.). The number of natural teeth was not associated with dementia (p = 0.553). Same results were found for age (p = 0.746) and sex (p = 0.901). The chewing efficiency by visual inspection proved worse in participants with dementia than in the controls (p < 0.011) and explained 9.3% of the variance in the diagnosis of dementia. Neither dental state nor chewing efficiency was related to the nutritional state. CONCLUSION Chewing efficiency seems stronger associated with cognitive impairment than the number of teeth. Hence, in a more holistic approach for the geriatric assessment, the dental examination may be complemented by a chewing efficiency test.

Ms.Ff.F.Stoltze 3. 592 - Brief von Heinrich Stoltze an Friedrich Stoltze und Marie Stoltze

Fanny Januschek, Napoleon III, Frankfurt

Contribución a una bibliografía de Roberto Arlt basada en el material existente en la Facultad de Filosofía y Letras, UNCuyo

Teniendo en cuenta la Bibliografía anotada sobre Leopoldo Marechal que Aída Prátici y Fanny Torres, realizaron en el año 1982, el presente trabajo surge con el fin de sistematizar los diversos aportes que la crítica ha realizado en torno a la vida y obra de Roberto Arlt, existentes en la Biblioteca de la Facultad de Filosofía y Letras. Tal propuesta responde principalmente a dos objetivos. Primero, teniendo presente que la bibliografía sobre Arlt no es muy extensa, configurar un corpus de obras ubicables en nuestra Facultad, las cuales hasta el momento se encontraban dispersas o poco difundidas. Segundo, facilitar una guía para que investigadores, alumnos y lectores en general pudieran acceder de modo sencillo, rápido y preciso a este material. Siguiendo estos objetivos, se ha realizado un rastreo bibliográfico no exhaustivo, pero sí lo suficientemente amplio como para garantizar la recolección de los más importantes estudios críticos que se han escrito desde 1980 hasta el 2000.

Historia y condiciones para el desarrollo humano

"Historia y condiciones para el desarrollo humano" es un documental producido enteramente por el CICUNC y es parte de la serie "NU Miradas". El presente programa está dedicado al tema de la igualdad de derechos que deben garantizarse desde el estado, mediante la implementación de políticas sociales, que le permitan al hombre desarrollarse plenamente. El programa está divido en tres bloques en los cuales contamos con la participación de: Eduardo Giner, Silvia Ruggeri, Juan Carlos Aguiló, Fanny Salomón y María Rosa Goldar

Dos propuestas femeninas a la narrativa colombiana

Fil: Prevedello, Fanny. Universidad Nacional de Cuyo. Facultad de Ciencias Políticas y Sociales

Retour Sur "La Zona - Propiété Privée"

Quelques années après la sortie du film « La Zona – propriété privée », cet article décrypte quelques éléments de la fiction pour revenir sur les causes et les conséquences socio-urbaines du développement massif des enclaves résidentielles. Le contraste du dehors et du dedans, les stratégies d’enfermement, la constitution de communautés d’intérêts et l’entre-soi sont mis à mal par la révélation de la violence inhérente à des choix court-termistes d’habitants qui se murent pour conjurer leur peur et préserver leur confort. Entre ouverture et fermeture, il existerait un entre-deux où l’on pourrait tisser des en-communs avec les fils qui relient les mondes.