Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume
| Data(s) |
01/07/2013
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| Resumo |
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase. |
| Formato |
application/pdf |
| Identificador |
http://boris.unibe.ch/53878/1/Conductier2013_NatNeurosc.pdf Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine Roger; Lakaye, Bernard; Risold, Pierre-Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis and Guyon, Alice (2013). Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature neuroscience, 16(7), pp. 845-847. Nature America 10.1038/nn.3401 <http://dx.doi.org/10.1038/nn.3401> doi:10.7892/boris.53878 info:doi:10.1038/nn.3401 info:pmid:23708141 urn:issn:1097-6256 |
| Idioma(s) |
eng |
| Publicador |
Nature America |
| Relação |
http://boris.unibe.ch/53878/ |
| Direitos |
info:eu-repo/semantics/restrictedAccess |
| Fonte |
Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine Roger; Lakaye, Bernard; Risold, Pierre-Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis and Guyon, Alice (2013). Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature neuroscience, 16(7), pp. 845-847. Nature America 10.1038/nn.3401 <http://dx.doi.org/10.1038/nn.3401> |
| Palavras-Chave | #610 Medicine & health |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |
