Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.

08006-003 East Okoboji Beach Final Report

East Okoboji Beach was platted on April 20, 1961 and includes over 90.4 acres with 489 lots. The East Okoboji Beach project includes a complete storm water discharge system, which includes low impact development and reconstruction of the roadways in East Okoboji Beach. The East Okoboji Beach Project is an enormous project that is the first Dickinson County project to retrofit LID practices, lake-friendly storm-water drainage systems and roadway reconstruction throughout an existing sub- division. This cooperative project between DNR, Dickinson County, and EOB landowners includes engineering retention ponds, rain gardens, bio-swales and other LID practices to reduce nutrient and sediment pollutants flowing directly into East Okoboji. The nature of the problem stems back to that original plat where small lots were platted and developed without planning for storm water discharge. There was no consideration of the effects of filling in and developing over the many wetland areas existing in EOB. The scope of the problem covers the entire 90.4 acres in East Okoboji Beach, the DNR owned land and the farmed land to the east. The nature of the problem stems from storm water runoff flowing throughout the watershed and into East Okoboji Beach where it flows down self-made paths and then into East Lake Okoboji. That storm water runoff dumps nutrient and sediment pollutions directly into East Lake Okoboji. The expected result of this project is a new roadway and drainage system constructed with engineering that is intended to protect East Lake Okoboji and the land and homes in East Okoboji Beach. The benefit will be the improvement in the waters and the reduction of the siltation in the East Lake Okoboji.

East 1 St Street Interchange and I-35 Widening, From MP 94.3 to Oralabor Road, Polk County, Iowa, Project # IM-035-4(140)92--13-77, Environmental Assessment and Section 4(f) De Minimis Impact Finding, 2015

From Proposed Action: "The proposed action consists of reconstructing the East 1st Street/I-35 interchange with a Diverging Diamond interchange, widening I-35 from four (4) lanes to six (6) lanes, and widening East 1st Street from four (4) lanes to five (5) lanes from Delaware Avenue to Frisk Drive. The project also proposes to reconstruct the intersections of East 1st Street/Creekview Drive and East 1st Street/Frisk Drive."

Road Safety Audit for County Road X-37, from the Intersection of G-62 to the East Corporate Limits of Columbus City in Louisa County, Iowa, 2009

A road safety audit was conducted for a 7.75 mile section of County Road X-37 in Louisa County, Iowa. In 2006, the average annual daily traffic on this roadway was found to be 680 vehicles per day. Using crash data from 2001 to 2007, the Iowa Department of Transportation (Iowa DOT) has identified this roadway as being in the highest 5% of local rural roads in Iowa for single-vehicle runoff- road crashes. Considering these safety data, the Louisa County Engineer requested that a road safety audit be conducted to identify areas of safety concerns and recommend low-cost mitigation to address those concerns. Staff and officials from the Iowa DOT, Governor’s Traffic Safety Bureau, Federal Highway Administration, Institute for Transportation, and local law enforcement and transportation agencies met to review crash data and discuss potential safety improvements to this segment of X-37. This report outlines the findings and recommendations of the road safety audit team to address the safety concerns on this X-37 corridor and explain several selected mitigation strategies.

Variability of the radius growth at 25 years old Pinus uncinata Miller ex Mirbel in the North-East Spanish Pyrenees

It has been studied the variability of stem radial growth in four radius orientations at the age of 25 years old trees. The species was Pinus uncinata. The sampling sites, located in the North East Spanish Pyrenees belong to different plant communities. An ANOVA analysis was performed in order to find out which factors, the radio orientation, plant community of the site and tree itself are significative or have some kind of influence on the tree radial growth.

Species-specific population structure in rock-specialized sympatric cichlid species in Lake Tanganyika, East Africa.

Species richness and geographical phenotypic variation in East African lacustrine cichlids are often correlated with ecological specializations and limited dispersal. This study compares mitochondrial and microsatellite genetic diversity and structure among three sympatric rock-dwelling cichlids of Lake Tanganyika, Eretmodus cyanostictus, Tropheus moorii, and Ophthalmotilapia ventralis. The species represent three endemic, phylogenetically distinct tribes (Eretmodini, Tropheini, and Ectodini), and display divergent ecomorphological and behavioral specialization. Sample locations span both continuous, rocky shoreline and a potential dispersal barrier in the form of a muddy bay. High genetic diversity and population differentiation were detected in T. moorii and E. cyanostictus, whereas much lower variation and structure were found in O. ventralis. In particular, while a 7-km-wide muddy bay curtails dispersal in all three species to a similar extent, gene flow along mostly continuous habitat appeared to be controlled by distance in E. cyanostictus, further restricted by site philopatry and/or minor habitat discontinuities in T. moorii, and unrestrained in O. ventralis. In contrast to the general pattern of high gene flow along continuous shorelines in rock-dwelling cichlids of Lake Malawi, our study identifies differences in population structure among stenotopic Lake Tanganyika species. The amount of genetic differentiation among populations was not related to the degree of geographical variation of body color, especially since more phenotypic variation is observed in O. ventralis than in the genetically highly structured E. cyanostictus.

Jurassic and Early Cretaceous Radiolaria of the Lower Amurian Terrane: Khabarovsk region, far east of Russia

New data on biostratigraphy, sedimentology and tectonics of the Russian Far Eastern region (Lower Amurian terrane) are presented. This study shows that sedimentary sequence of the terrane consists of interbedded Radiolaria-bearing siliceous and volcaniclastic sediments spanning an interval of over 90 million years. It is shown that accumulation of radiolarian deposits on an oceanic plate was associated with alkaline (intraplate) volcanism in the Jurassic, while the plate was drifting, and with some are volcanism during the Early Cretaceous. The younger siliceous rocks contain volcaniclastic material and indicate that the studied sequence approached the trench in the Early Cretaceous (Hauterivian-Barremian) and became accreted in the late Albian-early Cenomanian. We describe and illustrate radiolarian species extracted fi om 21 samples. A taxonomic list of 194 taxa and nine plates of Jurassic-Early Cretaceous Radiolaria are presented.

The late roman pottery imports in the East of Hispania Tarraconensis

Recent studies provided new data about late Roman imports (ARS, amphorae, lamps) in the coast of Hispania Tarraconensis. Concerning urban contexts (the ancient towns of Barcino, Tarraco and others) and rural settlements, the data allow us to identify the imports and the economic trends of the region from the 4th to the late 6th /early 7th centuries. We hope this paper to be an interpretative work of synthesis about the economic relationship between town and country in Catalonia and Northern Comunidad Valenciana in the Late Antiquity.

Growth strategies of international companies in the emerging markets of South-East Europe

Työn tarkoituksena oli tutkia niitä tekijöitä jotka ovat vaikuttaneet kansainvälisten yritysten myynnin kasvuun Romaniassa, Bulgariassa, Serbiassa ja Sloveniassa. Tutkimusta varten haastateltiin neljää kansainvälisen yrityksen edustajaa sekä 16 kansainvälisen kaupan ammattilaista. Työn akateemisena viitekehyksenä käytettiin keskeisiä kansainvälisen liiketoiminnan teorioita sekä myynnin strategista viitekehystä. Johtopäätöksenä katsotaan, että menestyvillä yrityksillä on selvä kansainvälistymis-strategia, kansainvälinen organisaatio, konsultoiva myyntityyli ja resursseja investoida koulutukseen. Tarkastelun alla olevista maista etenkin Romaniasta ja Bulgarista löytyy liiketoiminta potentiaalia. Tutkimuksen johtopäätökset perustuvat laadullisiin ja määrällisiin tutkimusmenetelmiin ja ne on tarkoitettu palvemaan Tikkurila Oy:tä. Tutkimustuloksia on myös mahdollista soveltaa laajemmin samanlaisessa tutkimusympäristössä, kunhan tutkittavan liiketoimintaympäristön erityispiirteet ovat otetttu huomioon

Survival of wild adults of Ceratitis capitata (Wiedemann) under natural winter conditions in north east Spain

The overwintering of the Mediterranean fruit fly (medfly), Ceratitis capitata (Wiedemann) at the northern limits of its geographic distribution is not yet well known. With the aim of estimating the survival rate of medfly adults in northeast Spain under natural winter conditions, a two-winter-season trial was carried out. A control was carried out in a climatic chamber at 25°C. The results showed that medfly adults were unable to survive the entire winter season in the Girona area. Climatic conditions, including the daily minimum temperature, daily maximum temperature and the high rainfall, appeared to be involved in adult mortality in winter.

A General Chart of the Baltic or East Sea, including the Gulfs of Bothnia and Finland compiled from the Surveys - [Overview]

London : W. Faden 1803