Proyecto y lugar en la arquitectura doméstica de Jørn Utzon

En medio de un bosque danés, de altos arboles que se mueven al fuerte viento nórdico bajo el débil sol de las latitudes altas, y cargado de unos cuantos tableros de madera que consiguió de una exposición ya terminada, realizó Utzon su maqueta a escala real de su primera casa familiar en Hellebæk (1950-52) a la edad de treinta y dos años. De la misma manera que el pintor William Turner necesitó atarse a lo alto de un mástil de un barco, para vivir en directo una de las muchas tormentas que tantas y tantas veces había pintado en sus cuadros, el joven Utzon consideró indispensable introducirse dentro de la maqueta de su propia casa antes de construirla, para valorar in situ las potencialidades de aquel proyecto en relación al lugar. La obra de Jørn Utzon (1918-2008) es una arquitectura expectante y atenta del lugar donde se ubica. Jørn Utzon es un arquitecto de origen nórdico, que descubre su verdadera idiosincrasia en la cultura mediterránea, cultura en la que reside durante casi la mitad de toda su vida. Esta tesis se ha centrado en analizar exhaustivamente la relación de su arquitectura doméstica con el lugar donde se halla. Aspecto tan citado en la bibliografía existente de su obra, aunque nunca desarrollado de manera exhaustiva. El objetivo del análisis ha sido intentar encontrar invariantes o patrones que pudieran subyacer en su obra residencial en relación a ese tema. Para dicho análisis, se ha tomado una muestra suficientemente amplia de veinte viviendas o conjuntos residenciales (entre ellas sus cuatro viviendas familiares proyectadas), repartidas por cinco países (Suecia, Dinamarca, Reino Unido, España y Nueva Gales del Sur), que constituyen la tercera parte de su obra doméstica y la mitad de su obra construida residencial, así como las citas explícitas del autor sobre este tema en su obra escrita, y los planos o croquis de su obra gráfica. Como metodología de trabajo se ha recurrido a la consulta de las fuentes primarias: viajando y conociendo in-situ las casas seleccionadas en Dinamarca, Suecia, España y Australia; viviendo un mes en una de las casas (Can Lis) gracias a una beca del Gobierno danés y la Utzon Foundation; y realizando entrevistas a las personas que más cerca estuvieron del arquitecto en su entorno familiar y profesional. Asimismo, también se ha publicado parte de su contenido en medios internacionales: 4th International Utzon Symposium (7/3/2013-9/3/2014) y la página web oficial de Can Lis dependiente de la Utzon Foundation (www.canlis.dk). Las doce invariantes encontradas en relación al proyecto y lugar en los proyectos seleccionados, han sido agrupadas en torno a tres grandes elementos sobre los que Utzon constantemente reflexiona en sus escritos propios: horizonte, sol y material autóctono. Elementos que tienen su origen en la influencia que la navegación tuvo en su vida, y en su carácter espiritual y austero en lo material. La historia de Utzon es la de un nórdico, de vocación navegante, que encuentra su lugar en la cultura mediterránea, rodeado entre piedras de Marés, mientras divisa en silencio el horizonte marino en el umbral entre luz y sombra. ABSTRACT In the middle of a Danish forest, with high trees which move with the Nordic wind under the weak sun of high latitudes, and with the help of some wooden canvases acquired from an already completed exhibition, Jørn Utzon built a real-scale model of his first family house in Hellebæk (1950-52) at the age of thirty-two. In the same way that William Turner needed to be tied up on the top of a boat flagpole in order to have a first-hand experience of one of the many storms that he had depicted in his paintings so many times before, the young Utzon thought it was crucial to go into the model of his own house before building it, to evaluate in situ the potential of that project in relation to the place. Utzon’s work is architecture interested in and attentive of the place where it is situated. Jørn Utzon (1918-2008) is an architect of Nordic origin who discovered his own idiosyncrasy in the Mediterranean culture, in which he resided for half of his live. This thesis has focused on an exhaustive analysis of the relation between his domestic architecture and the place where it is located. This issue has been often cited in the existing bibliography, although it has never been exhaustively developed. The analysis objective has been to attempt to find invariants and patterns that could exist in his domestic work in relation to this subject. For this analysis, a sufficiently large sample has been selected: twenty houses or housing complexes (among others his own four family houses), distributed in five countries (Sweden, Denmark, United Kingdom, Spain and New South Wales), which constitute the third part of his domestic work, and half of his residential constructed projects, as well as Utzon’s written texts about this theme, and the drawings and sketches of his graphic work. The methodology used was based on consultation of primary sources: travelling and examining in situ the selected houses in Denmark, Sweden, Spain and Australia; living for a month in one of the houses (Can Lis) thanks to a research grant from the Danish Government and the Utzon Foundation; and interviewing people from his closest family and professional circles. Furthermore, part of the thesis has been published in international media: 4th International Utzon Symposium (7/3/2013-9/3/2014) and on the official web site of Can Lis, an Utzon Foundation subsidiary(www.canlis.dk). The twelve invariants discovered in relation to the project and the location of the selected projects, have been grouped according to three elements which Utzon continuously reflects upon in his own writings: the horizon, the sun and autochthonous material. Elements which originate from the influence that navigation had in his life, and from his spiritual and austere character. The story of Utzon is that of a Nordic person, with the vocation of a navigator, who found his place in the Mediterranean culture, surrounded with Marés stones, while silently making out the sea horizon on the threshold between light and shadow.

Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils

Calcineurin (protein phosphatase 2B) (CN) comprises a family of serine/threonine phosphatases that play a pivotal role in signal transduction cascades in a variety of cells, including neutrophils. Angiotensin II (Ang II) increases both activity and de novo synthesis of CN in human neutrophils. This study focuses on the role that intracellular redox status plays in the induction of CN activity by Ang II. Both de novo synthesis of CN and activity increase promoted by Ang II were downregulated when cells were treated with l-buthionine-(S,R)-sulfoximine, an inhibitor of synthesis of the antioxidant glutathione. We have also investigated the effect of pyrrolidine dithiocarbamate and phenazine methosulfate, which are antioxidant and oxidant compounds, respectively, and concluded that the intracellular redox status of neutrophils is highly critical for Ang II-induced increase of CN expression and activity. Results obtained in neutrophils from hypertensive patients were very similar to those obtained in these cells on treatment with Ang II. We have also addressed the possible functional implication of CN activation in the development of hypertension. Present findings indicate that downregulation of hemoxygenase-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factor NRF2. These data support and extend our previous results and those from other authors on modulation of CN expression and activity levels by the intracellular redox status.

Transcription of liver X receptor is down-regulated by 15-deoxy-Δ12,14-prostaglandin J2 through oxidative stress in human neutrophils

Liver X receptors (LXRs) are ligand-activated transcription factors of the nuclear receptor superfamily. They play important roles in controlling cholesterol homeostasis and as regulators of inflammatory gene expression and innate immunity, by blunting the induction of classical pro-inflammatory genes. However, opposite data have also been reported on the consequences of LXR activation by oxysterols, resulting in the specific production of potent pro-inflammatory cytokines and reactive oxygen species (ROS). The effect of the inflammatory state on the expression of LXRs has not been studied in human cells, and constitutes the main aim of the present work. Our data show that when human neutrophils are triggered with synthetic ligands, the synthesis of LXRα mRNA became activated together with transcription of the LXR target genes ABCA1, ABCG1 and SREBP1c. An inflammatory mediator, 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2), hindered T0901317-promoted induction of LXRα mRNA expression together with transcription of its target genes in both neutrophils and human macrophages. This down-regulatory effect was dependent on the release of reactive oxygen species elicited by 15dPGJ2, since it was enhanced by pro-oxidant treatment and reversed by antioxidants, and was also mediated by ERK1/2 activation. Present data also support that the 15dPGJ2-induced serine phosphorylation of the LXRα molecule is mediated by ERK1/2. These results allow to postulate that down-regulation of LXR cellular levels by pro-inflammatory stimuli might be involved in the development of different vascular diseases, such as atherosclerosis.

Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils

Liver X receptors (LXRs) are ligand-activated members of the nuclear receptor superfamily that regulate the expression of genes involved in lipid metabolism and inflammation, although their role in inflammation and immunity is less well known. It has been reported that oxysterols/LXRs may act as anti-inflammatory molecules, although opposite actions have also been reported. In this study, we investigated the effect of platelet-activating factor (PAF), a proinflammatory molecule, on LXRα signalling in human neutrophils. We found that PAF exerted an inhibitory effect on mRNA expression of TO901317-induced LXRα, ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, and sterol response element binding protein 1c. This negative action was mediated by the PAF receptor, and was dependent on the release of reactive oxygen species elicited by PAF, as it was enhanced by pro-oxidant treatment and reversed by antioxidants. Current data also support the idea that PAF induces phosphorylation of the LXRα molecule in an extracellular signal-regulated kinase 1/2-mediated fashion. These results suggest that a possible mechanism by which PAF exerts its proinflammatory effect is through the downregulation of LXRα and its related genes, which supports the notion that LXRα ligands exert a modulatory role in the neutrophil-mediated inflammatory response.

Oleic acid modulates mRNA expression of liver X receptor (LXR) and its target genes ABCA1 and SREBP1c in human neutrophils

Purpose: Regulation of liver X receptors (LXRs) is essential for cholesterol homeostasis and inflammation. The present study was conducted to determine whether oleic acid (OA) could regulate mRNA expression of LXRα and LXRα-regulated genes and to assess the potential promotion of oxidative stress by OA in neutrophils. Methods: Human neutrophils were treated with OA at different doses and LXR target gene expression, oxidative stress production, lipid efflux and inflammation state were analyzed. Results: We describe that mRNA synthesis of both LXRα and ABCA1 (a reverse cholesterol transporter) was induced by OA in human neutrophils. This fatty acid enhanced the effects of LXR ligands on ABCA1 and LXR expression, but it decreased the mRNA levels of sterol regulatory element-binding protein 1c (a transcription factor that regulates the synthesis of triglycerides). Although OA elicited a slight oxidative stress in the short term (15–30 min) in neutrophils, it is unlikely that this is relevant for the modulation of transcription in our experimental conditions, which involve longer incubation time (i.e., 6 h). Of physiological importance is our finding that OA depresses intracellular lipid levels and that markers of inflammation, such as ERK1/2 and p38 mitogen-activated protein kinase phosphorylation, were decreased by OA treatment. In addition, 200 μM OA reduced the migration of human neutrophils, another marker of the inflammatory state. However, OA did not affect lipid peroxidation induced by pro-oxidant agents. Conclusions: This work presents for the first time evidence that human neutrophils are highly sensitive to OA and provides novel data in support of a protective role of this monounsaturated acid against the activation of neutrophils during inflammation.

Análisis de la captura incidental en la pesquería industrial de cerco anchovetera en el litoral peruano durante el período 2003-2011

En el Perú, la pesquería más importante está dirigida al recurso anchoveta (Engraulis ringens), el cual es extraído con red de cerco, sin embargo, este arte de pesca no es 100% selectivo, generando así capturas incidentales. Esta investigación tiene como objetivo analizar cuantitativamente el efecto de la pesquería de anchoveta sobre los recursos de la fauna acompañante mediante el estudio de diferencias espacio-temporales en términos de captura y composición específica de la ictiofauna que conformó la captura incidental en todo el litoral peruano proveniente de la flota industrial durante el periodo 2003-2011. Los resultados muestran valores de captura incidental significativamente mayores en la región sur del litoral peruano a comparación de la región norte y centro, principalmente durante los años 2003 y 2006, aunque la mayor riqueza de especies fue encontrada en la región norte. Por otro lado, dentro de la composición de la captura incidental a nivel especifico destacó la presencia constante de la Caballa (Scomber japonicus), Bagre (Galeichthys peruvianus) y Múnida (Pleuroncodes monodon) en la región norte, Lorna (Sciaena deliciosa), Pejerrey (Odontesthes regia regia), y Múnida (Pleuroncodes monodon) en la región centro y Jurel (Trachurus picturatus murphyi), Caballa (Scomber japonicus), Lorna (Sciaena deliciosa), Pejerrey (Odontesthes regia regia), Múnida (Pleuroncodes monodon), Camotillo (Diplectrum conceptione) y Pampanito (Trachinotus paitensis) en la región sur. Sin embargo, los mayores volúmenes capturados se debieron a recursos costeros y fueron capturados por la flota industrial de acero en la región sur del litoral peruano.

Obras de D. Antonio Rafael Mengs ... /

Mode of access: Internet.

Ensayos biográficos,

t.I El jeneral Don José Manuel Borgoño. El coronel español Don José Ordoñez. Don Ignacio Domeyko.--t.II Don Andrés Bello. Don Carlos Bello. Don Francisco Bello. Don Juan Bello.--t.III. Don Manuel Antonio Tocornal i Grez. Don José Joaquín Vallejo.--t.IV. Don Vicente Carvallo i Goyeneche. Don García Hurtado de Mendoza i Don Alonso de Ercilla i Zúñiga. Don Gabriel Cano de Aponte. Don José Rodríguez Ballesteros. Don Rodulfo Amando Philippi. Don José Antonio Torres. Don Simón Rodríguez. Don Francisco Núñez de Pineda i Bascuñán. Don Bernardo de Vera i Pintado. La necrópolis de Don José Miguel Infante.

The Techialoyan Codices and their Number

In this article, it is proposed a brief revision of the number of Techialoyan codices. To do this, the text starts with a definition of the corpus, that it is composed of manuscripts done between the half of the 17th century and beginning of the next. Around these documents there are many doubts and it remains much to do. In this case, we present a review around the lists and catalogues to see the changes of the group through time. Our conclusion is that is necessary recount the corpus, because there are fragmented documents and others are unknowns or copies. Finally, we show our count, that leaves the number less than fifty-six documents catalogued until today.

Trabajos de documentación digital de grabados rupestres en el término municipal de Alcázar de San Juan (Ciudad Real)

[EN]In recent years, several historical rock art sites have been located in Alcazar de San. Given its fragility, one of the most important and urgent tasks being undertaken within the framework of the DIPAR research project is the documentation of these sites. Among the various techniques used to this, two stand out above the rest: the application of digital photography at night, and three-dimensional documentation.

Plan de ordenamiento territorial de la ciudad de Biblián:

Este compendio de planificación comprende el área urbana del cantón Biblián como ambiente de actuación. Durante este proceso se establecieron diversas recomendaciones en cada capítulo para establecer una respuesta sencilla a las partes que requieren mayor urgencia, como el uso de ocupación del suelo, el equipamiento, la vialidad, y la formación de un conjunto normativo que permita la actuación municipal, en actividades de prevención, control y sanción. Todos estos vinculados también a otros aspectos destacándose la demografía, la delimitación territorial, el socio-económico, la infraestructura, la vivienda, el medio ambiente, etc. El documento final se ha desarrollado en seis fases generales. Diagnóstico preliminar, plan de acciones inmediato, diagnóstico integral, prognosis la imagen objetiva, plan de ordenamiento territorial y programas y proyectos

Lagoa mirim: caracterização da pesca artesanal e composição da captura

Os ambientes aquáticos continentais da metade sul do RS são caracterizados por uma ampla planície costeira, onde destaca-se a Lagoa Mirim, com uma área total binacional (Brasil e Uruguai) de 3.750 Km². Nesta região, a pesca é uma importante atividade sócio-econômica, porém, a economia da região baseia-se no cultivo do arroz e na criação de gado. A proposta deste trabalho foi realizar um diagnóstico preliminar desta atividade na L. Mirim. A metodologia foi baseada na aplicação de formulários aos pescadores artesanais (perfil sócio-econômico e características da pesca) e na identificação das espécies que compunham a captura proveniente do desembarque pesqueiro no entorno da L. Mirim (Jaguarão, Santa Isabel e Santa Vitória do PalmarPorto e Curral Alto). Os dados de captura total de pescado foram provenientes de fontes independentes e complementares. O estudo sugere um perfil do pescador artesanal composto por 71% de indivíduos de sexo masculino, entre 20 e 65 anos de idade que costumam ficar de uma semana a quinze dias embarcados. A maioria (71%) dos pescadores artesanais entrevistados possui somente ensino fundamental e seus familiares geralmente estão envolvidos na atividade pesqueira. Foram identificados 28 locais de pesca e as principais espécies capturadas pela pesca artesanal foram: traíra Hoplias malabaricus, jundiá Rhandia aff. quelen, pintado Pimelodus maculatus, peixerei Odontesthes spp, viola-cascuda Loricariichthys anus e tambico Oligosarcus spp. A traíra foi a espécie mais representativa em peso (> 40%). Estas espécies apresentaram flutuações na composição das capturas ao longo do ano; os menores valores foram registrados entre julho e setembro (meses frios), exceto para o peixe-rei. A análise dos dados também aponta uma variação interanual dos valores totais de pescado e alguns fatores que podem estar associados à diminuição da captura são os prolongados períodos de seca na região, o uso da água na orizicultura e a falta de fiscalização da atividade pesqueira. Estudos baseados em estimativas de pescarias e conhecimento sobre a biologia das espécies capturadas podem fornecer subsídios para o correto manejo dos recursos pesqueiros, para tanto, são necessárias pesquisas que investiguem aspectos do uso sustentado das espécies de importância econômica na região e os possíveis efeitos da atividade pesqueira sobre a estrutura e a biodiversidade do ecossistema. Assim, para garantir a sustentabilidade da Lagoa Mirim, faz-se necessário envolver os pescadores artesanais e suas estratégias de pesca, em função de seus conhecimentos ecológicos, nas pesquisas que integram a elaboração das políticas públicas.

Prevalencia de ferropenia y factores de riesgo asociados en niños de 6 a 24 meses de edad en el Hospital de Girón-Azuay 2007

Se realizó un estudio transversal en el que se incluyeron 160 niños de 6 a 24 meses de edad, seleccionados aleatoriamente, en el período comprendido de abril a septiembre del 2007. Se efectuaron determinaciones de ferritina sérica mediante el método de quimioluminiscencia y Hb mediante la técnica de la cianometahemoglobina. Además a través de una encuesta se recogió la información referente a los factores de riesgo estudiados. Resultados: los principales resultados obtenidos fueron: prevalencia de ferropenia 49%, prevalencia de anemia por déficit de hierro 52.6%. Los factores de riesgo asociados a ferropenia que mostraron significancia estadística en nuestro estudio son ingesta de leche de vaca >750 ml/día RP 1.54 (IC 1.10-2.15 p=0.04) y consumo inadecuado de vegetales verdes RP 1.42 (IC 1.01-2.01 p=0.03).Conclusiones: 1. La tasa de prevalencia de ferropenia encontrada en los lactantes estudiados fue de 49%. 2. La prevalencia de anemia con ferropenia fue de 52,6%, confirmándose que la principal causa de anemia en este grupo etáreo es la carencia de hierro como se afirma a nivel mundial. 3. La determinación de ferritina sérica es una prueba útil para detectar ferropenia en etapa temprana antes del desarrollo de anemia. 4. Los factores de riesgo que mostraron asociación estadísticamente significativa con ferropenia fueron: la ingestión de leche de vaca mayor a 750 ml /día y una dieta insuficiente en vegetales verdes

“Colorir para agir”: educar pela arte, para a paz

O projeto “Colorir para agir” foi concebido e implementado com o objetivo de alertar para a problemática crescente da violência escolar e contribuir para a prevenção e diminuição das práticas agressivas de crianças em idade escolar, procurando valorizar a convivência harmoniosa entre pares. Aliando a educação não formal às artes, este programa de intervenção desenvolveu um conjunto de atividades no âmbito das artes plásticas, abrangendo 21 crianças, com idades compreendidas entre os 6 e os 13 anos de um Agrupamento de Escolas de Valongo do Vouga, no concelho de Águeda (Portugal). Estas culminaram na realização de um mural gigante pintado na parede exterior da instituição, que ficou como símbolo da não violência escolar e da educação para a paz.