Allergic rhinitis in the child and associated comorbidities

Allergic rhinitis (AR) typically presents after the second year of life, but the exact prevalence in early life is unknown. AR affects 10-30% of the population, with the greatest frequency found in children and adolescents. It appears that the prevalence has increased in the pediatric population. As the childs` immune system develops between the 1st and 4th yr of life, those with an atopic predisposition begin to express allergic disease with a clear Th(2) response to allergen exposure, resulting in symptoms. In pediatric AR, two or more seasons of pollen exposure are generally needed for sensitization, so allergy testing to seasonal allergens (trees, grasses, and weeds) should be conducted after the age of 2 or 3 years. Sensitization to perennial allergens (animals, dust mites, and cockroaches) may manifest several months after exposure. Classification of AR includes measurement of frequency and duration of symptoms. Intermittent AR is defined as symptoms for < 4 days/wk or < 4 consecutive weeks. Persistent AR is defined as occurring for more than 4 days/wk and more than 4 consecutive weeks. AR is associated with impairments in quality of life, sleep disorders, emotional problems, and impairment in activities such as work and school productivity and social functioning. AR can also be graded in severity - either mild or moderate/severe. There are comorbidities associated with AR. The chronic effects of the inflammatory process affect lungs, ears, growth, and others. AR can induce medical complications, learning problems and sleep-related complaints, such as obstructive sleep apnea syndrome and chronic and acute sinusitis, acute otitis media, serous otitis media, and aggravation of adenoidal hypertrophy and asthma.

Measurement of IgE antibodies to shrimp tropomyosin is superior to skin prick testing with commercial extract and measurement of IgE to shrimp for predicting clinically relevant allergic reactions after shrimp ingestion

Background: Shrimp is a frequent cause of food allergy. Tropomyosin is the major allergen in shrimp, and it shares homology to tropomyosins from other crustaceans, dust mites, cockroach, and parasites. Objective: The aim of this study was to determine the value of detection of IgE to shrimp tropomyosin in the diagnosis of shrimp allergy. Methods: We have studied 35 patients with asthma, rhinitis, or both who were sensitized to Dermatophagoides pteronyssinus. All subjects underwent skin prick testing in addition to double-blind, placebo-controlled food challenges (DBPCFC); oral open challenges; or both with shrimp. Measurements of IgE to shrimp and shrimp tropomyosin were carried out by means of CAP and chimeric ELISA, respectively. Results: Oral challenges confirmed the diagnosis of shrimp allergy in 7 patients. IgE measurement to shrimp tropomyosin was positive in 71.4% of the patients with shrimp allergy. Of the 28 patients without shrimp allergy, only 7.1% (2/28) had IgE to shrimp tropomyosin compared with 25% (7/28) who had IgE to shrimp and 35.7% (10/28) who had positive skin prick test responses to shrimp. Sensitivity was similar for all 3 methods (71.4%); in contrast, specificity of IgE to shrimp tropomyosin (92.8%) was greater than that of IgE to shrimp (75%) and skin prick testing (64.2%). With regard to diagnostic efficiency, measurement of IgE to shrimp tropomyosin was superior to measurement of IgE to shrimp and skin prick testing (88.5%, 74.2%, and 65.7%, respectively). Conclusion: Use of measurements of IgE to shrimp tropomyosin provided added value to the diagnosis of shrimp allergy. (J Allergy Clin Immunol 2010;125:872-8.)

Brood cell size of Apis mellifera modifies the reproductive behavior of Varroa destructor

We undertook a field study to determine whether comb cell size affects the reproductive behavior of Varroa destructor under natural conditions. We examined the effect of brood cell width on the reproductive behavior of V. destructor in honey bee colonies, under natural conditions. Drone and worker brood combs were sampled from 11 colonies of Apis mellifera. A Pearson correlation test and a Tukey test were used to determine whether mite reproduction rate varied with brood cell width. Generalized additive model analysis showed that infestation rate increased positively and linearly with the width of worker and drone cells. The reproduction rate for viable mother mites was 0.96 viable female descendants per original invading female. No significant correlation was observed between brood cell width and number of offspring of V. destructor. Infertile mother mites were more frequent in narrower brood cells.

Host plant specificity in several species of generalist mite predators

1. Species in the genus Neoseiulus are considered to be generalist predators. with some species used in biological control programmes against phytophagous mites and insects. 2. A general survey of Neoseiulus species in inland Australia indicated that different species are associated with particular tree species. This pattern of host plant use was investigated for four Neoseiulus species (N. buxeus, N. cappari, N. brigarinus, N. eremitus) by means of a sampling programme through time and across space. 3. Each species of Neoseiulus was collected entirely or mostly from one species of tree: little or no overlap was detected despite the tree species growing in well-mixed stands. Host plant specificity thus appears to be strong in this genus. 4. Species in two other genera (Pholaseius and Australiseiulus), also considered to be predatory, showed a similar association with particular tree species. 5. The implications for the use of these predators in biological control are considerable. In particular, phytoseiid species with specific needs in terms of host plants may not be suitable for use as general purpose predators. Meeting the needs of phytoseiids through the modification of host plant attributes may be a step towards enhancing their efficacy as biological control agents.

The mitochondrial 12S gene is a suitable marker of populations of Sarcoptes scabiei from wombats, dogs and humans in Australia

We sequenced part of the mitochondrial 12S ribosomal RNA gene of 23 specimens of Sarcoptes scabiei from eight wombats, one dog and three humans. Twelve of the 326 nucleotide positions varied among these mites and there were nine haplotypes (sequences) that differed by 1-8 nucleotides. Phylogenetic analyses indicated that these mites were from two lineages: (1) mites from wombats from Victoria, Australia, and mites from the humans and dog from the Northern Territory, Australia (haplotypes 1-4, 9); and (2) mites from the humans and dog from the Northern Territory (haplotypes 5-8). Mites from the three different hosts (wombats, a dog and humans) had not diverged phylogenetically; rather, these mites had similar 12S sequences. Thus, we conclude that these mites from wombats, humans and a dog are closely related, and that they diverged from a common ancestor relatively recently. This conclusion is consistent with the argument that people and/or their dogs introduced to Australia the S. scabiei mites that infect wombats Australia. So, S. scabiei, which has been blamed for the extinction of populations of wombats in Australia, may be a parasitic mite that was introduced to Australia with people and/or their dogs. These data show that the mitochondrial 12S rRNA gene may be a suitable population marker of S. scabiei from wombats, dogs and humans in Australia.

Exotic vs endemic biocontrol agents: Would the real stratiolaelaps miles (Berlese) (Acari : Mesostigmata : Laelapidae), please stand up?

The ability of introduced organisms to invade undisturbed native habitats is a major concern in conservation biology and has resulted in a re-evaluation of the introduction of exotic biocontrol agents, especially of generalist predators. One such agent is Stratiolaelaps miles (Berlese), a predatory mite described from Italy, known from throughout the Holarctic, and apparently accidentally introduced to other areas of the world, including Australia. Initial investigations revealed that putative S. miles could be found in both disturbed and relatively pristine habitats in Queensland, Australia. However, analysis of the mitochondrial DNA of five populations showed most to be highly divergent genetically. Subsequent morphological analysis established two species groups: the lamington-group from cool-temperate to subtropical rainforests in Eastern Australia and the more eurytopic miles-group with a cosmopolitan distribution. We describe two new species from each of these complexes (Stratiolaelaps womersleyi, Stratiolaelaps lamington; Stratiolaelaps marilyn, Stratiolaelaps lorna, respectively), and resurrect Stratiolaelaps scimitus (Womersley), a species which often appears to have been confused with S. miles. Additionally, the large genetic distances among morphologically homogenous species in the miles-group suggest that the apparently cosmopolitan S. miles may be composed of a suite of cryptic species of potentially varying utility in biological control. (C) 2002 Elsevier Science (USA). All rights reserved.

Ultraviolet signals in birds are special

Recent behavioural experiments have shown that birds use ultraviolet (UV)-reflective and fluorescent plumage as cues in mate choice. It remains controversial, however, whether such UV signals play a special role in sexual communication, or whether they are part of general plumage coloration. We use a comparative approach to test for a general association between sexual signalling and either UV-reflective or fluorescent plumage. Among the species surveyed, 72% have UV colours and there is a significant positive association between UV reflectance and courtship displays. Among parrots (Psittaciformes), 68% of surveyed species have fluorescent plumage, and again there is a strong positive association between courtship displays and fluorescence. These associations are not artefacts of the plumage used in courtship displays, being generally more 'colourful' because there is no association between display and colours lacking UV reflectance or fluorescence. Equally, these associations are not phylogenetic artefacts because all results remain unchanged when families or genera, rather than species, are used as independent data points. We also find that, in parrots, fluorescent plumage is usually found adjacent to UV-reflective plumage. Using a simple visual model to examine one parrot, the budgerigar Melopsittacus undulatus, we show that the juxtaposition of UV-reflective and fluorescent plumage leads to a 25-fold increase in chromatic contrast to the budgerigar's visual system. Taken together, these results suggest that signals based on UV contrast are of special importance in the context of active sexual displays. We review briefly six hypotheses on why this may be the case: suitability for short-range signalling; high contrast with backgrounds; invisibility to predators; exploitation of pre-existing sensory biases; advertisement of feather structure; and amplification of behavioural signals.

A new mite from an arboreal ant (Formicidae : Polyrachis sp.): Myrmozercon iainkayi n. sp (Mesostigmata : Laelapidae)

Previously, two species of Myrmozercon (= Myrmonyssus) have been described from ground-nesting Australian ants in the genus Iridiomyrmex. Herein a new species, Myrmozercon iainkayi, infesting workers and alate adults of a leaf-nesting species of Polyrachis ant is described. The new species has a number of unusual or unique characters, including coxal hypertrichy (6-6-6-4 for legs I-IV, respectively), and based on the structure of its mouthparts, appears to be a haemolymph-feeding parasite.

A review of the genus Ledermuelleriopsis Willmann (Acari : Prostigmata : Stigmaeidae)

The mite family Stigmaeidae (Acari:Prostigmata) is of considerable importance in biological control, but its genera are often poorly defined and have never been subjected to cladistic analysis. Herein, we report the stigmaeid genus Ledermuelleriopsis Willmann from Australia for the first time, present a preliminary phylogenetic analysis that demonstrates that Eustigmaeus Berlese and Ledermuelleriopsis Willman are distinct, review the genus at the world level, and provide diagnostic characters of the adult females for each of the 21 known species. We also catalogue habitats, distributions and localities of holotypes. Four new species from Australia are described and illustrated: L. parvilla, sp. nov. from old dune sand, L. barbellata, sp. nov. from wet-sandy heath litter, and L. pustulosa, sp. nov. and L. claviseta, sp. nov. from dry eucalypt forest litter. A key to adult females of all known Ledermuelleriopsis species is provided. The Australian species and L. incisa Wood from New Zealand can be separated from all other members of the genus by a synapomorphy: the reduction of the number of setae on the aggenital shield to one pair. Results of a preliminary morphological cladistic analysis for those stigmaeid genera in which the larvae and adults of both sexes are known, indicate that Ledermuelleriopsis is basal to a clade containing Cheylostigmaeus Willman and Eustigmaeus.

M??dulo 3 - perspectivas y pr??cticas en el incentivo a la consciencia y conducta ??tica en el contexto de la administraci??n p??blica: curso ??tica y administraci??n p??blica en Am??rica Latina

Este trabajo se ocupa de las cuatro grandes perspectivas en que se encuadran las propuestas de refuerzo de la dimensi??n ??tica en la gesti??n p??blica; los l??mites y el alcance de los aspectos ??ticos y legales de la pr??ctica administrativa; instrumentos gerenciales y pr??cticas que ayudan el desarrollo de la consciencia ??tica

Terceiro setor e pol??ticas p??blicas

Te??ricos apontam um estreitamento nas rela????es das entidades do terceiro setor com o Estado. Esta aproxima????o, numa perspectiva internacional, est?? inserida no que se convencionou chamar crise do Estado provedor e, portanto, na busca por modelos alternativos de implementa????o de pol??ticas sociais. No ??mbito nacional, a expans??o do terceiro setor ??, em parte, fruto da redemocratiza????o do pa??s, com a prolifera????o e o amadurecimento de iniciativas da sociedade civil. Este trabalho pretende contribuir para a reflex??o sobre o contexto onde surgem e se desenvolvem essas rela????es. Parece-nos que lan??ar luz sobre a id??ia de parceria pode colaborar na compreens??o das potencialidades e limites desse modelo de coopera????o intersetorial.

Reforma administrativa e marco legal das organiza????es sociais no Brasil: as d??vidas dos juristas sobre o modelo das organiza????es sociais

O modelo brasileiro das organiza????es sociais representa uma das respostas poss??veis ?? crise do aparelho do Estado no ??mbito da presta????o dos servi??os sociais. Essas entidades s??o percebidas como uma forma de parceria do Estado com as institui????es privadas de fins p??blicos (perspectiva ex parte principe) ou, sob outro ??ngulo, uma forma de participa????o popular na gest??o administrativa (perspectiva ex parte populi). No texto s??o tematizadas as diferen??as e semelhan??as entre o marco legal das organiza????es sociais e das entidades de utilidade p??blica no Brasil, as notas distintivas entre a disciplina dos servi??os privados de interesse p??blico e dos servi??os p??blicos, bem como o que distingue juridicamente o modelo das organiza????es sociais de processos de privatiza????o e terceiriza????o. Em todos esses temas os juristas aparecem como protagonistas na determina????o dos limites do modelo das organiza????es sociais, evidenciando que processos de reforma normativa exigem, para serem eficazes, uma concomitante reforma na mentalidade dos agentes p??blicos.

Mecanismos societ??rios e contratuais de gest??o das sociedades estatais

As sociedades estatais s??o importantes organiza????es societ??rias, que podem servir ao administrador p??blico para a realiza????o de atividades econ??micas que configurem relevante interesse coletivo ou motivo de seguran??a nacional. Com a finalidade de adequarem-se aos limites de investimento p??blico e com vistas ao cumprimento do princ??pio da efici??ncia, elas podem utilizar-se de mecanismos societ??rios e contratuais de gest??o disponibilizados a empresas, sejam elas estatais ou privadas. Os movimentos societ??rios, os mecanismos de controle e partilha de controle e a ado????o das pr??ticas de governan??a corporativa s??o alternativas jur??dicas disponibilizadas aos administradores das empresas estatais. A an??lise do caso da Companhia Paranaense de Energia El??trica (Copel) ?? realizada no artigo com o prop??sito de auxiliar na visualiza????o da aplica????o de tais institutos.

A perspectiva brasileira sobre a pobreza: um estudo de caso do Programa Bolsa Fam??lia

Tendo como pano de fundo a dificuldade de definir a pobreza, este artigo visa retomar parte da discuss??o sobre o tema, utilizando como estudo de caso o Programa Bolsa Fam??lia. Inicia-se com a defini????o institucional de pobreza dada pelo soci??logo alem??o Georg Simmel passando-se, na seq????ncia, a uma abordagem mais substancial da pobreza e da rela????o entre trabalho e precariedade, desenvolvida por Robert Castel. Apresenta uma breve descri????o do funcionamento do Programa Bolsa Fam??lia e alguns aspectos relacionados aos conceitos e modos de tratamento da quest??o da renda e da educa????o, bem como da fam??lia e dos modelos familiares, baseando-se tamb??m nos resultados parciais de uma pesquisa de campo realizada nos estados da Bahia, Pernambuco, Alagoas e Goi??s. O texto trata ainda de alguns desafios administrativos na gest??o do Programa e os preconceitos morais e sociais recorrentemente veiculados em rela????o a ele. Por fim, na conclus??o, busca retomar a an??lise do Programa Bolsa Fam??lia, seus limites e desafios, defendendo a necessidade de participa????o de todos em um pacto social contra a pobreza e a desigualdade no Brasil.

A pesquisa governamental de opini??o p??blica: raz??es, limites e a experi??ncia recente no Brasil

Este trabalho discute raz??es pelas quais se deve esperar que governos representativos mantenham um programa institucionalizado de pesquisa de opini??o p??blica. O argumento divide-se em quatro se????es. Na primeira, discutem-se raz??es te??ricas e operacionais para que os governos acompanhem ao longo do tempo o comportamento de opini??es e prefer??ncias dos cidad??os. Na segunda, descrevem-se as consequ??ncias da (im)popularidade governamental, medida sint??tica e crucial da rela????o entre representantes e representados. Em seguida, uma terceira se????o aponta poss??veis fronteiras ou limites que permitiriam distinguir o escopo das pesquisas de opini??o p??blica realizadas pelos governos daquele das conduzidas com prop??sito cient??fico, mercadol??gico e, sobretudo, eleitoral. Finalmente, a quarta se????o descreve a recente experi??ncia do governo brasileiro nessa ??rea