911 resultados para Traffic Pattern Analysis
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The human prion gene contains five copies of a 24 nt repeat that is highly conserved among species. An analysis of folding free energies of the human prion mRNA, in particular in the repeat region, suggested biased codon selection and the presence of RNA patterns. In particular, pseudoknots, similar to the one predicted by Wills in the human prion mRNA, were identified in the repeat region of all available prion mRNAs available in GenBank, but not those of birds and the red slider turtle. An alignment of these mRNAs, which share low sequence homology, shows several co-variations that maintain the pseudoknot pattern. The presence of pseudoknots in yeast Sup35p and Rnq1 suggests acquisition in the prokaryotic era. Computer generated three-dimensional structures of the human prion pseudoknot highlight protein and RNA interaction domains, which suggest a possible effect in prion protein translation. The role of pseudoknots in prion diseases is discussed as individuals with extra copies of the 24 nt repeat develop the familial form of Creutzfeldt–Jakob disease.
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Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) have been studied for several decades and are well-known as unintentionally generated persistent organic pollutants (POPs), which pose serious health and environmental risks on a global scale1. Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/F) have similar properties and effects to PCDD/F, as they are structural analogs with all the chlorine atoms substituted by bromine atoms. PBDD/F have been found in various matrices such as air, sediments, marine products, and human adipose samples.
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Transportation Department, Office of Systems Engineering, Washington, D.C.
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Transportation Department, Office of University Research, Washington, D.C.
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National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.
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Federal Highway Administration, Washington, D.C.
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Mode of access: Internet.
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Mode of access: Internet.
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National Highway Traffic Safety Administration, Washington, D.C.
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Federal Highway Administration, Office of Research, Development, and Technology, Washington, D.C.
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Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin
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National Highway Traffic Safety Administration, Mathematical Analysis Division, Washington, D.C.
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National Highway Traffic Safety Administration, Washington, D.C.
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National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.
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National Highway Traffic Safety Administration, Washington, D.C.