An Evening of Opera Excerpts, December 4, 1965

Concert program for An Evening of Opera Excerpts, December 4, 1965

Magna Charta and Parliament 1900-1914

In 1915 plans for the celebration of the 700th anniversary of Magna Carta had to be dropped following the outbreak of the First World War. Such celebrations marked a sense of Magna Carta as an event in the history of these islands. The usage of the term Magna Carta in Parliament in the run-up to the First World War, however, shows that its granting was not seen only as a significant historical event to be memorialised. During the period from 1900, opening with war in South Africa and ending in 1914 with war throughout Europe, the Great Charter was mentioned 85 times in Parliament. As a period marked by a lengthy constitutional crisis in 1909-11 and beset with problems in Ireland and the Empire, this seems like a good case study period to choose. This short paper attempts to analyse how and why it was invoked in Parliament in the years and what these various usages tell us about how Magna Carta was understood at the time.

A Influência das Técnicas de Estúdio nas Obras Thema - Omaggio a Joyce (1958) e Laborintus 2 (1965) de Luciano Berio

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Artes Musicais

Exilados portugueses em Argel. A FPLN das origens à rutura com Humberto Delgado (1960-1965)

Tese apresentada para cumprimento dos requisitos necessários à obtenção do grau de Doutor em História Institucional e Política Contemporânea

Uma reflexão sobre o filme Persona (1965), de Ingmar Bergman

Dissertação apresentada para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Filosofia na área de especialização em Estética

O Jornalismo Político Republicano Radical. O Mundo (1900‐1907)

Tese de Doutoramento em História Contemporânea Institucional e Política de Portugal

Modelos e materiais de ensino da matemática moderna em Portugal (1950-1965)

Este artigo tem por base um estudo enquadrado no uso de materiais/modelos de ensino da Matemática na década de 60, aquando da implementação do Movimento Matemática Moderna, em Portugal. Para atingir este objectivo definimos três questões: 1) Já havia interesse no uso destes novos métodos de ensino, e consequentemente no uso de materiais diversos que levassem a uma melhor aprendizagem por parte dos alunos, antes da década de 60? 2) De que modo os professores aplicaram e usaram estes métodos/materiais na sua prática docente? E que formação tiveram? 3) Quais os métodos e materiais que os professores utilizavam nas suas aulas? O foco central deste trabalho parte da análise de dois artigos escritos na revista Labor, o primeiro em 1952 e o segundo em 1960, pelo professor António Augusto Lopes1 sobre o uso de materiais no 1º ciclo e o Laboratório de Matemática. Toda a pesquisa deste trabalho focou-se na interpretação de material fornecido pelo professor Lopes (manuscritos, relatórios, livros e fotografias, documentos do Ministério da Educação Nacional), bem como por reflexões e comentários do próprio, registadas na forma de entrevista,2 sobre o que foi o Movimento Matemática Moderna ao nível da prática docente, com recurso a novas metodologias e materiais de ensino. O período que irá ser analisado em termos cronológicos será de 1957 a 1965, isto porque é um período experimental e de mudança. A reunião de 57 da CIEAEM em Madrid é o marco histórico que irá despoletar o interesse da Comissão e de Augusto Lopes para a aplicação dos novos materiais\modelos. Apesar de só em 1965 serem criadas as primeiras turmas piloto para aplicação das metodologias e dos novos materiais\modelos preconizadas pelo MMM.

Systematic identification of genomic markers of drug sensitivity in cancer cells.

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and preclinical investigation. In aggregate, we found that mutated cancer genes were associated with cellular response to most currently available cancer drugs. Classic oncogene addiction paradigms were modified by additional tissue-specific or expression biomarkers, and some frequently mutated genes were associated with sensitivity to a broad range of therapeutic agents. Unexpected relationships were revealed, including the marked sensitivity of Ewing's sarcoma cells harbouring the EWS (also known as EWSR1)-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors. By linking drug activity to the functional complexity of cancer genomes, systematic pharmacogenomic profiling in cancer cell lines provides a powerful biomarker discovery platform to guide rational cancer therapeutic strategies.

Role of microRNAs in the pathogenesis of Ewing's sarcoma

SummaryEwing's sarcoma family tumors (ESFT) are the second most frequent cancer of bone in adolescents and young adults. ESFT are characterized by a chromosomal translocation that involves the 5' segment of the EWSR1 gene and the 3' segment of an ets transcription factor family member gene. In 85% of cases the chromosomal translocation generates the fusion protein EWSR1-FLI-1. Recent work from our laboratory identified mesenchymal stem cells (MSC) as the putative cell of origin of ESFT and characterized a CD133+ subpopulation of ESFT cells with tumor initating and self-renewal capacity, known as cancer stem cells (CSC). MicroRNAs (miRNAs) are small non-coding RNA that regulate protein expression at the post-transcriptional level by either repressing translation or destabilizing mRNA. MiRNAs participate in several biological processes including cell proliferation and differentiation. We used miRNA expression profile comparison between MSC and ESFT cell lines and CD133+ ESFT cells and CD133" ESFT cells to investigate the role of miRNAs in ESFT pathogenesis. MiRNA expression profile comparison of MSC and ESFT cell lines identified 35 differentially expressed miRNAs. Among these was down-regulation of let-7a which results, in part, by the direct repression of let-7a-l promoter by EWSR1-FLI-1. Overexpression of let-7a in ESFT cells blocked ESFT tumorigenesis through an High-motility group AT-hook2 (HMGA2)-mediated mechanism.MiRNA profiling of CD133+ ESFT and CD 133" ESFT cells revealed a broad repression of miRNAs in CD133+ ESFT mediated by down-regulation of TARBP2, a central regulator of the miRNA maturation pathway. Down-regulation of TARBP2 in ESFT cell lines results in a miRNA expression profile reminescent of that observed in CD133+ ESFT and associated with increased tumorigenicity. Enhancement of TARBP2 activity using the antibiotic enoxacin or overexpression of miRNA-143 or miRNA-145, two targets of TARBP2, impaired ESFT CSC self-renewal and block ESFT tumorigenicity. Moreover in vivo administration of synthetic let- 7a, miRNA-143 or miRNA-145 blocks ESFT tumor growth.Thus, dysregulation of miRNA expression is a key feature in ESFT pathogenesis and restoration of their expressions might be used as a new therapeutic tool.RésuméLe sarcome d'Ewing est la deuxième tumeur osseuse la plus fréquente chez l'enfant et le jeune adolescent. Le sarcome d'Ewing est caractérisé par une translocation chromosomique qui produit une protéine de fusion EWSR1-FLI-1. Des récents travaux ont identifié les cellules mésenchymateuses souches (MSC) comme étant les cellules à l'origine du sarcome d'Ewing ainsi qu'une sous-population de cellules exprimant le marqueur CD 133, dans le sarcome d'Ewing connu comme les cellules cancéreuses souches (CSC). Ces cellules ont la capacité d'initier la croissance tumorale et possèdent des propriétés d'auto-renouvellement. Les microRNAs (miRNAs) sont de petits ARN qui ne codent pas pour des protéines et qui contrôlent l'expression des protéines en bloquant la traduction ou en dégradant l'ARNm. Les miRNAs participent à différents processus biologiques comme la prolifération et la différenciation cellulaires.Le but de ce travail est d'étudier le rôle des miRNAs dans le sarcome d'Ewing. Un profil d'expression de miRNAs entre les MSC et des lignées cellulaires de sarcome d'Ewing a mis en évidence 35 miRNAs différemment exprimés. Parmi ceux-ci, la répression de let-7a est liée à la répression directe du promoteur de let-7a-l par EWSR-FLI-1. La sur-expression de let-7a dans des lignées cellulaires de sarcome d'Ewing inhibe leur croissance tumorale. Cette inhibition de croissance tumorale est régulée par la protéine high-motility group AT-hook2 (HMGA2).Un profil d'expression de miRNAs entre les cellules du sarcome d'Ewing CD133+ et CD133" montre une sous-expression d'un grand nombre de miRNAs dans les cellules CD133+ par rapport aux cellules CD133". Cette différence d'expression de miRNAs est due à la répression du gène TARBP2 qui participe à la maturation des miRNAs. La suppression de TARBP2 dans des cellules d'Ewing induit un profil d'expression de miRNAs similaire aux cellules CD133+ du sarcome d'Ewing et augmente la tumorigenèse des lignées cellulaires. De plus l'utilisation d'enoxacin, une molécule qui augmente l'activité de TARBP2 ou la sur- expression des miRNA143 ou miRNA-145 dans les CSC du sarcome d'Ewing bloque l'auto- renouvellement des cellules et la croissance tumorale. Finalement, l'administration de let-7a, miRNA-143 ou miRNA-145, dans des souris bloque la croissance du sarcome d'Ewing. Ces résultats indiquent que la dysrégulation des miRNAs participe à la pathogenèse du sarcome d'Ewing et que les miRNAs peuvent être utilisés comme des agents thérapeutiques.

La pesquería marítima peruana durante 1965

Analiza las estadísticas de la pesquería marítima peruana que publica el Instituto del Mar del Perú IMARPE y que corresponde al año 1965. Bajo las siguientes fuentes de información: inspectores de pesca, capitanías de puertos, empresas pesqueras, terminales pesqueros de Lima y Callao y Superintendencia general de Aduanas.

Informe preliminar del crucero de invierno 1965 (Mácora - Morro Sama)

Describe información acerca del desove de la anchoveta mediante la recolección de planctoncon red hansen. Así mimso, presenta investigaciones sobre la presencia de cardúmenes de peces por medio del eco-sonda y sonar, observaciones de aves y mamiferos marinos.

Informe preliminar del crucero de primavera 1965 (Cabo Blanco - Morro Sama)

Describe la exporación del mar peruano durante el crucero bío-oceanológico 6510-11, a bordo del B.A.P. Unuane, correspondiente a la estación de primavera, de acuerdo al plan operacional trazado para 1965. Básicamente las observaciones se orientan a conocer las condiciones hidrológicas presentes, los aspectos biológicos de desove de la anchoveta, distribución y concentración de cardúmenes atribuibles a anchoveta, distribución de avesguaneras y apreciaciones sobre dispersión y cantidad de organismos planctónicos.

Valor de la producción pesquera maritima peruana en 1964 y 1965

Analiza estadísticas de desembarque para determinar el valor de la producción por especies en cada puerto; para la determinación del valor dela producción por especies se contó con las fuentes de información de los inspectores de Pesca del Instituto del mar, Capitanías de Puertos, Terminales Pesqueros de Lima y Callao y Oficina Sectorial de Planificación Pesquera.

L'Oeuvre sociale (Paris. 1900)

Variante(s) de titre : L'Oeuvre sociale : revue de propagande socialiste