First-principle data-driven models for assessment of motor disorders in Parkinson’s disease

Parkinson’s disease (PD) is an increasing neurological disorder in an aging society. The motor and non-motor symptoms of PD advance with the disease progression and occur in varying frequency and duration. In order to affirm the full extent of a patient’s condition, repeated assessments are necessary to adjust medical prescription. In clinical studies, symptoms are assessed using the unified Parkinson’s disease rating scale (UPDRS). On one hand, the subjective rating using UPDRS relies on clinical expertise. On the other hand, it requires the physical presence of patients in clinics which implies high logistical costs. Another limitation of clinical assessment is that the observation in hospital may not accurately represent a patient’s situation at home. For such reasons, the practical frequency of tracking PD symptoms may under-represent the true time scale of PD fluctuations and may result in an overall inaccurate assessment. Current technologies for at-home PD treatment are based on data-driven approaches for which the interpretation and reproduction of results are problematic.  The overall objective of this thesis is to develop and evaluate unobtrusive computer methods for enabling remote monitoring of patients with PD. It investigates first-principle data-driven model based novel signal and image processing techniques for extraction of clinically useful information from audio recordings of speech (in texts read aloud) and video recordings of gait and finger-tapping motor examinations. The aim is to map between PD symptoms severities estimated using novel computer methods and the clinical ratings based on UPDRS part-III (motor examination). A web-based test battery system consisting of self-assessment of symptoms and motor function tests was previously constructed for a touch screen mobile device. A comprehensive speech framework has been developed for this device to analyze text-dependent running speech by: (1) extracting novel signal features that are able to represent PD deficits in each individual component of the speech system, (2) mapping between clinical ratings and feature estimates of speech symptom severity, and (3) classifying between UPDRS part-III severity levels using speech features and statistical machine learning tools. A novel speech processing method called cepstral separation difference showed stronger ability to classify between speech symptom severities as compared to existing features of PD speech. In the case of finger tapping, the recorded videos of rapid finger tapping examination were processed using a novel computer-vision (CV) algorithm that extracts symptom information from video-based tapping signals using motion analysis of the index-finger which incorporates a face detection module for signal calibration. This algorithm was able to discriminate between UPDRS part III severity levels of finger tapping with high classification rates. Further analysis was performed on novel CV based gait features constructed using a standard human model to discriminate between a healthy gait and a Parkinsonian gait. The findings of this study suggest that the symptom severity levels in PD can be discriminated with high accuracies by involving a combination of first-principle (features) and data-driven (classification) approaches. The processing of audio and video recordings on one hand allows remote monitoring of speech, gait and finger-tapping examinations by the clinical staff. On the other hand, the first-principles approach eases the understanding of symptom estimates for clinicians. We have demonstrated that the selected features of speech, gait and finger tapping were able to discriminate between symptom severity levels, as well as, between healthy controls and PD patients with high classification rates. The findings support suitability of these methods to be used as decision support tools in the context of PD assessment.

Agents and stream data mining: a new perspective

Many organizations struggle with the massive amount of data they collect. Today, data does more than serve as the ingredients for churning out statistical reports. They help support efficient operations in many organizations, and to some extent, data provide the competitive intelligence organizations need to survive in today's economy. Data mining can't always deliver timely and relevant results because data are constantly changing. However, stream-data processing might be more effective, judging by the Matrix project.

An web content based data mining for car consumption in China

This paper introduces an incremental FP-Growth approach for Web content based data mining and its application in solving a real world problem The problem is solved in the following ways. Firstly, we obtain the semi-structured data from the Web pages of Chinese car market and structure them and save them in local database. Secondly, we use an incremental FP-Growth algorithm for mining association rules to discover Chinese consumers' car consumption preference. To find more general regularities, an attribute-oriented induction method is also utilized to find customer's consumption preference among a range of car categories. Experimental results have revealed some interesting consumption preferences that are useful for the decision makers to make the policy to encourage and guide car consumption. Although the current data we used may not be the best representative of the actual market in practice, it is still good enough for the decision making purpose in terms of reflecting the real situation of car consumption preference under the two assumptions in the context.

Software warehouse and software mining : the impact of data mining to software engineering

Automating Software Engineering is the dream of software Engineers for decades. To make this dream to come to true, data mining can play an important role. Our recent research has shown that to increase the productivity and to reduce the cost of software development, it is essential to have an effective and efficient mechanism to store, manage and utilize existing software resources, and thus to automate software analysis, testing, evaluation and to make use of existing software for new problems. This paper firstly provides a brief overview of traditional data mining followed by a presentation on data mining in broader sense. Secondly, it presents the idea and the technology of software warehouse as an innovative approach in managing software resources using the idea of data warehouse where software assets are systematically accumulated, deposited, retrieved, packaged, managed and utilized driven by data mining and OLAP technologies. Thirdly, we presented the concepts and technology and their applications of data mining and data matrix including software warehouse to software engineering. The perspectives of the role of software warehouse and software mining in modern software development are addressed. We expect that the results will lead to a streamlined high efficient software development process and enhance the productivity in response to modern challenges of the design and development of software applications.

Medical image classification using an efficient data mining technique

Data mining refers to extracting or "mining" knowledge from large amounts of data. It is an increasingly popular field that uses statistical, visualization, machine learning, and other data manipulation and knowledge extraction techniques aimed at gaining an insight into the relationships and patterns hidden in the data. Availability of digital data within picture archiving and communication systems raises a possibility of health care and research enhancement associated with manipulation, processing and handling of data by computers.That is the basis for computer-assisted radiology development. Further development of computer-assisted radiology is associated with the use of new intelligent capabilities such as multimedia support and data mining in order to discover the relevant knowledge for diagnosis. It is very useful if results of data mining can be communicated to humans in an understandable way. In this paper, we present our work on data mining in medical image archiving systems. We investigate the use of a very efficient data mining technique, a decision tree, in order to learn the knowledge for computer-assisted image analysis. We apply our method to the classification of x-ray images for lung cancer diagnosis. The proposed technique is based on an inductive decision tree learning algorithm that has low complexity with high transparency and accuracy. The results show that the proposed algorithm is robust, accurate, fast, and it produces a comprehensible structure, summarizing the knowledge it induces.

Agents and data mining: mutual enhancement by integration

This paper tells a story of synergism of two cutting edge technologies — agents and data mining. By integrating these two technologies, the power for each of them is enhanced. Integrating agents into data mining systems, or constructing data mining systems from agent perspectives, the flexibility of data mining systems can be greatly improved. New data mining techniques can add to the systems dynamically in the form of agents, while the out-of-date ones can also be deleted from systems at run-time. Equipping agents with data mining capabilities, the agents are much smarter and more adaptable. In this way, the performance of these agent systems can be improved. A new way to integrate these two techniques –ontology-based integration is also discussed. Case studies will be given to demonstrate such mutual enhancement.

Safely delegating data mining tasks

Data mining is playing an important role in decision making for business activities and governmental administration. Since many organizations or their divisions do not possess the in-house expertise and infrastructure for data mining, it is beneficial to delegate data mining tasks to external service providers. However, the organizations or divisions may lose of private information during the delegating process. In this paper, we present a Bloom filter based solution to enable organizations or their divisions to delegate the tasks of mining association rules while protecting data privacy. Our approach can achieve high precision in data mining by only trading-off storage requirements, instead of by trading-off the level of privacy preserving.

Prediction of paediatric asthma hospitalisation using data mining techniques

Research into the prevalence of hospitalisation among childhood asthma cases is undertaken, using a data set local to the Barwon region of Victoria. Participants were the parents/guardians on behalf of children aged between 5-11 years. Various data mining techniques are used, including segmentation, association and classification to assist in predicting and exploring the instances of childhood hospitalisation due to asthma. Results from this study indicate that children in inner city and metropolitan areas may overutilise emergency department services. In addition, this study found that the prediction of hospitalisaion for asthma in children was greater for those with a written asthma management plan.