Multi-dimensional classification of GABAergic interneurons with Bayesian network-modeled label uncertainty

Abstract Interneuron classification is an important and long-debated topic in neuroscience. A recent study provided a data set of digitally reconstructed interneurons classified by 42 leading neuroscientists according to a pragmatic classification scheme composed of five categorical variables, namely, of the interneuron type and four features of axonal morphology. From this data set we now learned a model which can classify interneurons, on the basis of their axonal morphometric parameters, into these five descriptive variables simultaneously. Because of differences in opinion among the neuroscientists, especially regarding neuronal type, for many interneurons we lacked a unique, agreed-upon classification, which we could use to guide model learning. Instead, we guided model learning with a probability distribution over the neuronal type and the axonal features, obtained, for each interneuron, from the neuroscientists’ classification choices. We conveniently encoded such probability distributions with Bayesian networks, calling them label Bayesian networks (LBNs), and developed a method to predict them. This method predicts an LBN by forming a probabilistic consensus among the LBNs of the interneurons most similar to the one being classified. We used 18 axonal morphometric parameters as predictor variables, 13 of which we introduce in this paper as quantitative counterparts to the categorical axonal features. We were able to accurately predict interneuronal LBNs. Furthermore, when extracting crisp (i.e., non-probabilistic) predictions from the predicted LBNs, our method outperformed related work on interneuron classification. Our results indicate that our method is adequate for multi-dimensional classification of interneurons with probabilistic labels. Moreover, the introduced morphometric parameters are good predictors of interneuron type and the four features of axonal morphology and thus may serve as objective counterparts to the subjective, categorical axonal features.

Multi-dimensional classification of GABAergic interneurons with Bayesian network-modeled label uncertainty

Interneuron classification is an important and long-debated topic in neuroscience. A recent study provided a data set of digitally reconstructed interneurons classified by 42 leading neuroscientists according to a pragmatic classification scheme composed of five categorical variables, namely, of the interneuron type and four features of axonal morphology. From this data set we now learned a model which can classify interneurons, on the basis of their axonal morphometric parameters, into these five descriptive variables simultaneously. Because of differences in opinion among the neuroscientists, especially regarding neuronal type, for many interneurons we lacked a unique, agreed-upon classification, which we could use to guide model learning. Instead, we guided model learning with a probability distribution over the neuronal type and the axonal features, obtained, for each interneuron, from the neuroscientists’ classification choices. We conveniently encoded such probability distributions with Bayesian networks, calling them label Bayesian networks (LBNs), and developed a method to predict them. This method predicts an LBN by forming a probabilistic consensus among the LBNs of the interneurons most similar to the one being classified. We used 18 axonal morphometric parameters as predictor variables, 13 of which we introduce in this paper as quantitative counterparts to the categorical axonal features. We were able to accurately predict interneuronal LBNs. Furthermore, when extracting crisp (i.e., non-probabilistic) predictions from the predicted LBNs, our method outperformed related work on interneuron classification. Our results indicate that our method is adequate for multi-dimensional classification of interneurons with probabilistic labels. Moreover, the introduced morphometric parameters are good predictors of interneuron type and the four features of axonal morphology and thus may serve as objective counterparts to the subjective, categorical axonal features.

Student essay attributed to William Ellery Channing, 1797 June 5

Three-page handwritten essay composed in English and attributed to Harvard undergraduate William Ellery Channing. The verso of the last page is inscribed "Channing 5 June 97." A quotation from Edward Young appears at the top of the first page: "A Competence is vital to content / Much wealth is corpulence, if not disease" and discusses the topic of affluence. The document includes edits and struck-through words.

A inserção profissional de assistentes sociais em instituições particulares de solidariedade social com resposta à senioridade: o caso do concelho da Covilhã

O presente trabalho teve como objetivo analisar a inserção das Técnicas de Serviço Social na área da senioridade. Como se trata de um estudo de caso restringe-se concelho da Covilhã. Por isso, foi realizado um estudo que tinha quatro vertentes: as Assistentes Sociais, as Instituições Particulares de Solidariedade Social e o concelho da Covilhã. No sentido de tomar mais consistente a pesquisa, foi desenvolvido um guião de entrevista e aplicado a várias profissionais inseridas nas Ipss com três valências (ERPI, SAD e CD) no concelho. Posteriormente foram analisados os resultados e comparados com dados recolhidos dos Censos, do Instituto nacional de Estatística e Pordata. O tema é bastante atual e pertinente, devido ao panorama nacional. Por um lado o aumento da Taxas de desemprego e emigração, e por outro o envelhecimento da população e o aumento dos casos sociais. Concluiu-se que, para as entrevistadas a maior dificuldade no desempenho das suas funções é a excessiva carga horária, os problemas diários associados aos idosos (Dependência física e mental, o Luto, condições desumanas) no entanto revelaram alguma facilidade e rapidez na obtenção do primeiro emprego.

A influência dos aplicativos móveis no negócio das empresas prestadoras de serviço de táxis em São Paulo: um estudo de caso

Este estudo pretende identificar as mudanças relevantes no mercado e qual o valor percebido pelos clientes e taxistas, considerando-se a inserção das empresas prestadoras de serviços de táxis da cidade de São Paulo no mundo virtual, através do uso de aplicativos. Para tanto, explanamos o conceito de cadeia de valor, incluindo cadeia de valor virtual e rede de valor, a fim de um melhor entendimento da estrutura em que se embasam as empresas desse novo ambiente, bem como explicamos os conceitos de modelo de negócio e Business Model Canvas. Com esse embasamento teórico propomos um framework com a finalidade de auxiliar o processo de extração e análise das informações que permitiram identificar as mudanças relevantes que ocorreram nesse mercado e o valor percebido pelos clientes e taxistas, fazendo uso de um estudo de caso. O tema é relevante, por se tratar de uma mudança significativa na forma como as empresas se relacionam com seus clientes e prestadores; e por permitir observar que valor agregado esse modelo tem propiciado, que fez com que cerca de 30 mil taxistas, dos 35 mil da cidade de São Paulo, optassem pelo uso de aplicativos, fazendo com que uma das empresas estudadas nessa dissertação atingisse mais de 2.5 milhões de downloads em todo o Brasil. Espera-se, com este estudo, identificar as mudanças relevantes que a inserção dos aplicativos trouxeram aos usuários e taxistas e apresentar um framework que pode ser utilizado como um facilitador na análise da cadeia de valor e cadeia de valor virtual do mercado de prestação de serviços de taxis, esclarecendo que esse modelo não é apenas um modismo ao qual se pode atribuir uma série de benefícios, mas, sim, uma tendência que está redefinindo o formato das empresas desse mercado.

Initial scientific review of cacodylic acid /

"Data research, abstracting, and collection were primarily performed by Midwest Research Institute (MRI), Kansas City, Missouri" -- p. iv

Communities of implementation

The concept of communities of practice (CoPs) has rapidly gained ground in fields such as knowledge management and organisational learning since it was first identified by Lave and Wenger (1991) and Brown and Duguid (1991). In this article, we consider a related concept that we have entitled “communities of implementation.” Communities of implementation (CoIs) are similar to communities of practice in that they offer an opportunity for a collection of individuals to support each other and share knowledge in a dynamic environment and on a topic in which they share interest. In addition, and to differentiate them from CoPs, a community of implementation extends the responsibilities of a CoP by having as its focus the implementation of a programme of change. This may well extend to designing the change programme. Thus, whereas a main purpose of a CoP is to satisfy “a real need to know what each other knows” (Skyrme, 1999) in an informal way, we argue that a main purpose of a community of implementation is to “pool individual knowledge (including contacts and ways of getting things done) to stimulate collective enthusiasm in order to take more informed purposeful action for which the members are responsible.” Individual and collective responsibility and accountability for successfully implementing the actions/change programme is a key feature of a community of implementation. Without these pressures the members might lower the priority of implementation, allowing competing priorities to dominate their attention and resources. Without responsibility and accountability, the result is likely to be (at best) an organisation which has not begun a change programme, or (at worst) an organisation which is stuck halfway through another failing initiative. To achieve these additional objectives beyond those of a CoP, the CoI needs to provide heightened support to its members. In fact often the members will collectively strategise the development and implementation of the change programme they are leading in the organisation. Other concepts similar to CoPs have appeared in the literature, for example “communities of knowing” (Boland & Tenkasi, 1995), but none have a specific focus on implementation. Perhaps the closest example of a CoI, as suggested by our definition, is reported by Karsten, Lyytinen, Hurskainen, and Koskelainen (2001) who describe a CoP in a paper machinery manufacturer which seems to have the necessary focus on implementation. The theoretical aspects of this article will explore the relationship between CoPs and CoIs, and the needs for different arrangements for a CoI. The practical aspect of this article will consist of a report on a case study of a CoI that was successful in its implementation of a programme of change that aimed to improve its organisation’s knowledge management activities. Over two years the CoI implemented a suite of complementary actions across the organisation. These actions transformed the organisation and moved it towards achieving its ‘core values’ and overall objectives. The article will explore: the activities that formed and gelled the community, the role of the community in the implementation of actions, and experiences from key members of this community on its success and potential improvements.

Recent advances in the heterogeneously catalysed aerobic selective oxidation of alcohols

The heterogeneously catalysed selective aerobic oxidation of alcohols is an important tool for the synthesis of valuable chemical intermediates and a hot topic within both academic and industrial arenas. In this mini-review, selected aspects of catalyst formulation, process operating conditions, and progress in identifying the active sites and surface reaction mechanisms notably through the application of synchrotron radiation, are highlighted. © 2010 Society of Chemical Industry.

Automatic Generation of Titles for a Corpus of Questions

This paper describes the followed methodology to automatically generate titles for a corpus of questions that belong to sociological opinion polls. Titles for questions have a twofold function: (1) they are the input of user searches and (2) they inform about the whole contents of the question and possible answer options. Thus, generation of titles can be considered as a case of automatic summarization. However, the fact that summarization had to be performed over very short texts together with the aforementioned quality conditions imposed on new generated titles led the authors to follow knowledge-rich and domain-dependent strategies for summarization, disregarding the more frequent extractive techniques for summarization.

Комбинированный Подход к Представлению Содержания и Текстового Описания Мультимедиа

В статье рассмотрена проблема семантической разницы между содержимым мультимедиа и его текстовым описанием, определяемым вручную. Предложен комбинированный подход к представлению семантики мультимедиа, основанный на объединении близких по содержанию и текстовому описанию мультимедиа в классы, содержащие обобщённые описания объектов, связей между ними и ключевых слов текстовых метаданных из некоторого тезауруса. Для формирования этих классов используются операции иерархической кластеризации и машинного обучения. Данный подход позволяет расширить область поиска и навигации мультимедиа благодаря привлечению медиа-данных, имеющих схожее содержание и текстовое описание.

Smartbook: Semantics Inside

This paper presents a vision for the future of the e-books which entails further development of technologies that will facilitate the creation and use of a new generation of "smart" books: e-books that are evolving, highly interactive, customisable, adaptable, intelligent, and furnished with a rich set of collaborative authoring and reading support services. The proposed set of tools will be integrated into an intelligent framework for collaborative book authoring and experiencing called SmartBook. The paper promotes the idea that the semantic technologies, intensively developed recently in connection with the Semantic Web initiative, can be incorporated in the book and become the key factor of making it "smarter".

The Odrysian Kingdom – a Concept of an Interactive Multimedia Application for Educational Purposes

The presentation of cultural heritage is difficult comprehensive and constantly updated topic. Researchers often focus more on the different techniques to digitize artifacts of cultural heritage. This work focuses on the overall shape and structure of future multimedia application whose specificity is determined by the topic - Odrysian kingdom. Below is presented a concept for structure and content-based information available for individual kings from Odryssae dynasty. Special attention is paid to the presentation of preserved artifacts associated with the reign of specific rulers. The main concept of multimedia application dedicated to the Odrysian kingdom, it is to be used in teaching programs related to cultural heritage and history of antiquity in universities. The aim of designers is that it can be modified easy for use in museums also.

A qualitative study of the clinical practice of graduates of a problem-based physical therapy program

The purpose of this study was to examine the perspectives of three graduates of a problem-based leaning (PBL) physical therapy (PT) program about their clinical practice. The study used the qualitative methods of observations, interviews, and journaling to gather the data. Three sessions of audiotaped interviews and two observation sessions were conducted with three exemplars from Nova Southeastern University PBL PT program. Each participant also maintained a reflective journal. The data were analyzed using content analysis. A systematic filing system was used by employing a mechanical means of maintaining and indexing coded data and sorting data into coded classifications of subtopics or themes. All interview transcripts, field notes from observations, and journal accounts were read, and index sheets were appropriately annotated. From the findings of the study, it was noted that, from the participants' perspectives, they were practicing at typically expected levels as clinicians. The attributes that governed the perspectives of the participants about their physical therapy clinical practice included flexibility, reflection, analysis, decision-making, self-reliance, problem-solving, independent thinking, and critical thinking. Further, the findings indicated that the factors that influenced those attributes included the PBL process, parents' value system, self-reliant personality, innate personality traits, and deliberate choice. Finally, the findings indicated that the participants' perspectives, for the most part, appeared to support the espoused efficacy of the PBL educational approach. In conclusion, there is evidence that the physical therapy clinical practice of the participants were positively impacted by the PBL curriculum. Among the many attributes they noted which governed these perspectives, problem-solving, as postulated by Barrows, was one of the most frequently mentioned benefits gained from their PBL PT training. With more schools adopting the PBL approach, this research will hopefully add to the knowledge base regarding the efficacy of embracing a problem-based learning instructional approach in physical therapy programs. ^

Análise textual-interativa das Cartas dos Sertões do Seridó: em busca de efeitos estético-estilísticos

This work takes as its object of study a specific set of texts, designated letters about Sertões do Seridó (interstate region in the Brazilian northeastern), written by Paulo Bezerra, whose main approach is the backcountry universe. For its unique character, mainly because of a strong poetic appeal, we infer that these letters can also contain natural phenomena related to discourse-compositional structure, which may be responsible for creating specific effects, particularly aesthetical. In order to discuss and develop the issue, we set the theoretical assumptions of Textual-Interactive Perspective whose base is the concept of language as interaction, such as verbal activity impregnated with the space-time social and historical context in which the interlocutors are related, we chose the analytical category discursive topic and analyse introduction, sequencing and change of topic mechanisms. The goal is to determine the functionality of these mechanisms, noting how correlate the structural and interactional aspects are, and how this movement can be used to explain some of the aesthetic and stylistic effects of these letters. The result shows that it is used different topic organizational patterns according to the nature of the central topic. These different mechanisms express an aesthetic intention and feature a style. This result gives rise to more general conclusions about the texts: their discursive-compositional structure is related to the creation of aesthetics and stylistics effects.

Tempo atmosférico numa perspetiva CTS através do ensino por pesquisa

O ser Humano, desde sempre tem tentado estabelecer relações entre si, o tempo e o clima, de modo a melhorar as suas condições de vida. Atualmente existem questões problema que ameaçam a humanidade, nomeadamente as alterações climáticas e o aquecimento global com vista à promoção de um Desenvolvimento Sustentável. À educação é atribuída extrema importância no desenvolvimento de uma adequada perceção da situação do planeta. Este facto levou as Nações Unidas a proclamarem, no início deste século (dezembro de 2002), a Década da Educação para o Desenvolvimento Sustentável. Um desafio internacional lançado aos países para que recorram à educação como ferramenta essencial na promoção do Desenvolvimento Sustentável. A vida nas sociedades contemporâneas é extremamente influenciada pelos desenvolvimentos científicos e tecnológicos, dependendo dos seus respetivos progressos. Como tal, a Educação Científica assume um papel fundamental na compreensão das problemáticas que o ser Humano enfrenta, assim como na sua própria consciencialização da responsabilidade na situação planetária atual. Devendo promover o desenvolvimento de cidadanias proactivas, fundamentadas e responsáveis, no sentido da mudança, numa perspetiva crítica global que garanta a sustentabilidade do planeta. Estes factos são alvo de reflexão por parte de diversas instâncias da sociedade tais como a UNESCO, comunidades nacionais e internacionais de investigação em Educação Científica, e o poder político que se espelham em propostas de reforma e de revisão curricular em diversos países. Neste contexto, a Escola, como instituição formal de Educação, toma o papel primordial de promover o Desenvolvimento Sustentável através da aquisição de conhecimentos, atitudes, valores e competências que permitam desenvolver nos alunos uma consciencialização ecológica e uma literacia científica. Com este propósito em mente surge a questão investigativa deste estudo “Como Abordar o Tempo Atmosférico numa Perspetiva CTS Através do Ensino Por Pesquisa?”. Assim, usando o laboratório mais acessível e gratuito, a Atmosfera, e recursos facilmente acessíveis para desenvolver atividades simples é apresentada uma proposta de abordagem em sala de aula para a temática “Tempo Atmosférico” em particular a “Previsão e Descrição do Tempo Atmosférico”. A Atmosfera é um fascinante laboratório de ensino, porque nela se podem estudar alguns processos físicos lecionados ao longo dos mais variados níveis de ensino nas disciplinas de Física, Química e Geografia. Na Atmosfera, podem realizar-se diversos estudos simples, que de uma forma fácil respondem a inquietantes questões relacionadas com a Previsão e Descrição do Tempo Atmosférico. Neste estudo foi desenvolvida e usada uma metodologia para construir e interpretar mapas de tempo permitindo a alunos do 3º Ciclo do Ensino Básico fazer a Previsão e Descrição do Tempo Atmosférico. Após a aplicação da estratégia para o desenvolvimento de capacidades, de criatividade, envolvimento, cidadania e de pensamento crítico, os alunos responderam a um questionário. Através do tratamento dos dados obtidos pode-se considerar que em média 97% dos alunos consideram importante ou muito importante o estudo desta temática e que tem influência no seu dia-a-dia. Verificou-se que em média, se passou de 26% de respostas cientificamente corretas ou parcialmente corretas para 83% de respostas cientificamente corretas ou parcialmente corretas, o que demostra que a estratégia proposta atingiu os seus propósitos que passavam por dinamizar e fomentar uma cultura meteorológica nas escolas e para as escolas. Salienta-se a importância da possibilidade do trabalho em rede e das suas potencialidades na motivação dos alunos dada a oportunidade de fazer diagnóstico do tempo atmosférico local e inter-regiões. Os alunos consultaram e interpretaram mapas de tempo atmosférico, usaram a Internet e compreendam a relação e a influência entre diferentes parâmetros meteorológicos. Os resultados obtidos neste estudo permitem afirmar que os alunos desenvolveram competências numa área que é uma preocupação de cada um, o diagnóstico do tempo atmosférico. Cresceu neles uma cultura meteorológica e as aprendizagens nesta temática podem transbordar para colegas, amigos, pais e toda a comunidade escolar. Assim pode considerar-se que a estratégia implementada foi promotora de mudança, de aquisição de conhecimentos e do desenvolvimento de competências numa temática tão aliciante que envolve o Desenvolvimento Sustentável. Considera-se ainda que a estratégia usada neste estudo é motivadora, aliada à dinâmica CTS e ao Ensino Por Pesquisa, com vista a ser utilizada em contexto de sala de aula. Este estudo é uma forte contribuição para o Ensino das Ciências em especial no ensino da temática Tempo Atmosférico e é uma ferramenta importante que pode e deve ser utilizada em contexto escolar pois está escrito de modo a ser consultado por profissionais de ensino, nomeadamente pelos professores de Física, Química e de Geografia de modo a promoverem o desenvolvimento de competências de literacia científica e de cidadania e contribuir para a formação de futuros cidadãos ativos e conscientes defensores da Sustentabilidade da Terra.