Serum Fatty Acid Binding Protein 4 (FABP4) Predicts Pre-eclampsia in Women with Type 1 Diabetes

Objective: To examine the association between fatty acid binding protein 4 (FABP4) and pre-eclampsia risk in women with type 1 diabetes.
Reesearch Design and Methods: Serum FABP4 was measured in 710 women from the Diabetes and Pre-eclampsia Intervention Trial (DAPIT) in early pregnancy and in the second trimester (median 14 and 26 weeks gestation, respectively).
Results: FABP4 was significantly elevated in early pregnancy (geometric mean 15.8 ng/mL [interquartile range 11.6–21.4] vs. 12.7 ng/mL [interquartile range 9.6–17]; P < 0.001) and the second trimester (18.8 ng/mL [interquartile range 13.6–25.8] vs. 14.6 ng/mL [interquartile range 10.8–19.7]; P < 0.001) in women in whom pre-eclampsia later developed. Elevated second-trimester FABP4 level was independently associated with pre-eclampsia (odds ratio 2.87 [95% CI 1.24, 6.68], P = 0.03). The addition of FABP4 to established risk factors significantly improved net reclassification improvement at both time points and integrated discrimination improvement in the second trimester.
Conclusions: Increased second-trimester FABP4 independently predicted pre-eclampsia and significantly improved reclassification and discrimination. FABP4 shows potential as a novel biomarker for pre-eclampsia prediction in women with type 1 diabetes.

A Arte de Governar: o exercício do poder pelo saber segundo Michael Foucault

As obras de Michel Foucault exercem influencia em várias áreas das ciências humanas. O mesmo fato se repetiu em teoria das organizações, onde as idéias foucaultianas estão sendo empregadas fundamentalmente para trazer novas luzes para as discussões sobre poder nas organizações. A despeito da influência significativa na área, não há discussões sobre como as obras de Michel Foucault estão sendo utilizadas. A presente dissertação de mestrado tem por objetivo sistematizar os estudos que utilizaram as idéias de Michel Foucault em teoria das organizações, problematizá-los e indicar alguns caminhos para o desenvolvimento desse tipo de análise. De uma forma geral, percebemos que a produção acadêmica em teoria das organizações baseadas nas obras de Michel Foucault tratam majoritariamente das disciplinas e deixam de lado outros aspectos da analítica do poder. Ademais, percebemos que há uma adoção simplificada da analítica do poder e uma junção acriteriosa de conceitos e noções oriundas de diferentes matrizes epistemológicas, além da inadequação da designação “pósmoderno” para classificar as obras de Michel Foucault e suas utilizações em teoria das organizações. Como possíveis desenvolvimentos, indicamos as possibilidades de análise que podem ser abertas na teoria das organizações pelo uso das noções de biopolítica e governamentalidade. / The works of Michel Foucault exert influence in various areas of the humanities. The same thing happened in organization theory, Foucauldian where ideas are being used primarily to bring new light to the discussions about power in organizations. Despite the significant influence in the area, there are discussions about the works of Michel Foucault are being used. This dissertation aims to systematize the studies that used the ideas of Michel Foucault in organization theory, problematize them and indicate some directions for developing this type of analysis. In general, we find that the academic production in the theory of organizations based on the writings of Michel Foucault deal mostly of disciplines and leave out other aspects of analytical power. Moreover, we realize that there is an adoption of simplified analytical power of an indiscriminate and a junction of concepts and notions from different epistemological matrices, besides the inadequacy of the term "postmodern" to classify the works of Michel Foucault and its uses in organizational theory. As possible developments, indicate the possibilities of analysis that can be opened in organization theory by using the notions of biopolitics and governmentality.

The Redox Potentials of n-type Colloidal Semiconductor Nanocrystals

Thesis (Ph.D.)--University of Washington, 2016-08

Karl-Josef Pazzini / Marianne Schuller / Michael Wimmer (Hrsg.): Lehren bildet? Vom Rätsel unserer Lehranstalten Bielefeld: transcript 2010 [Rezension]

Rezension von: Karl-Josef Pazzini / Marianne Schuller / Michael Wimmer (Hrsg.): Lehren bildet? Vom Rätsel unserer Lehranstalten Bielefeld: transcript 2010 (338 S.; ISBN 978-3-8376-1176-2)

Klaus Fröhlich-Gildhoff / Stefanie Pietsch / Michael Wünsche / Maike Rönnau-Böse (Hrsg.): Zusammenarbeit mit Eltern, Ein Curriculum für die Aus- und Weiterbildung, (Materialien zur Frühpädagogik Bd. 7) plus CD, Freiburg: Verlag FEL 2011(264 S. [...] [Sammelrezension]

Sammelrezension von: 1. Klaus Fröhlich-Gildhoff / Stefanie Pietsch / Michael Wünsche / Maike Rönnau-Böse (Hrsg.): Zusammenarbeit mit Eltern, Ein Curriculum für die Aus- und Weiterbildung, (Materialien zur Frühpädagogik Bd. 7) plus CD, Freiburg: Verlag FEL 2011 (264 S.; ISBN 978-3-932650-43-3) 2. Susanne Viernickel / Iris Nentwig-Gesemann / Henriette Harms / Sandra Richter / Stefanie Schwarz: Profis für Krippen, Curriculare Bausteine für die Aus- und Weiterbildung frühpädagogischer Fachkräfte, (Materialien zur Frühpädagogik Bd. 8) plus CD, Freiburg: Verlag FEL 2011 (210 S.; ISBN 978-3-932650-44-)

Katrin Ulrike Zaborowski / Michael Meier / Georg Breidenstein: Leistungsbewertung und Unterricht, Ethnographische Studien zur Bewertungspraxis in Gymnasium und Sekundarschule. Wiesbaden: VS Verlag für Sozialwissenschaften 2011 [Rezension]

Rezension von: Katrin Ulrike Zaborowski / Michael Meier / Georg Breidenstein: Leistungsbewertung und Unterricht, Ethnographische Studien zur Bewertungspraxis in Gymnasium und Sekundarschule, Wiesbaden: VS Verlag für Sozialwissenschaften 2011 (376 S.; ISBN 978-3-531-16808-1)

Michael Schratz / Johanna F. Schwarz / Tanja Westfall-Greiter: Lernen als bildende Erfahrung, Vignetten in der Praxisforschung, Mit einem Vorwort von Käte Meyer-Drawe und Beiträgen von Horst Rumpf, Carol Ann Tomlinson, Mike Rose u.a. Innsbruck: Studienverlag 2012 [Rezension]

Rezension von: Michael Schratz / Johanna F. Schwarz / Tanja Westfall-Greiter: Lernen als bildende Erfahrung, Vignetten in der Praxisforschung, Mit einem Vorwort von Käte Meyer-Drawe und Beiträgen von Horst Rumpf, Carol Ann Tomlinson, Mike Rose u.a., Innsbruck: Studienverlag 2012 (161 S.; ISBN 978-3706551182)

Frank-Michael Kuhlemann: Modernisierung und Disziplinierung. Sozialgeschichte des preußischen Volksschulwesens 1794-1872. (Kritische Studien zur Geschichtswissenschaft. Bd. 96.) Göttingen: Vandenhoeck & Ruprecht 1992 [Rezension]

Rezension von: Frank-Michael Kuhlemann: Modernisierung und Disziplinierung. Sozialgeschichte des preußischen Volksschulwesens 1794-1872. (Kritische Studien zur Geschichtswissenschaft. Bd. 96.) Göttingen: Vandenhoeck & Ruprecht 1992. 468 S.

Abs, Hermann Josef/Brüsemeister, Thomas/Schemmann, Michael & Wissinger, Jochen (Hrsg.). (2015). Governance im Bildungssystem. Analysen zur Mehrebenenperspektive, Steuerung und Koordination. [Rezension]

Rezension von: Abs, Hermann Josef/Brüsemeister, Thomas/Schemmann,Michael & Wissinger, Jochen (Hrsg.). (2015). Governance im Bildungssystem. Analysen zur Mehrebenenperspektive, Steuerung und Koordination.

Michael Glüer: Beziehungsqualität und kindliche Kooperations- und Bildungsbereitschaft. Eine Studie in Kindergarten und Grundschule. Wiesbaden: Springer VS 2011(484 S.) [Rezension]

Rezension von: Michael Glüer: Beziehungsqualität und kindliche Kooperations- und Bildungsbereitschaft. Eine Studie in Kindergarten und Grundschule. Wiesbaden: Springer VS 2011 (484 S.; ISBN 978-3-531-19315-1)

Unraveling the function of bacterial-type phosphoenolpyruvate carboxylase in vascular plants

Thesis (Master, Biology) -- Queen's University, 2016-09-29 20:09:46.997

Mucopolysaccharidosis Type Ii: Identification Of 30 Novel Mutations Among Latin American Patients.

In this study, 103 unrelated South-American patients with mucopolysaccharidosis type II (MPS II) were investigated aiming at the identification of iduronate-2-sulfatase (IDS) disease causing mutations and the possibility of some insights on the genotype-phenotype correlation The strategy used for genotyping involved the identification of the previously reported inversion/disruption of the IDS gene by PCR and screening for other mutations by PCR/SSCP. The exons with altered mobility on SSCP were sequenced, as well as all the exons of patients with no SSCP alteration. By using this strategy, we were able to find the pathogenic mutation in all patients. Alterations such as inversion/disruption and partial/total deletions of the IDS gene were found in 20/103 (19%) patients. Small insertions/deletions/indels (<22 bp) and point mutations were identified in 83/103 (88%) patients, including 30 novel mutations; except for a higher frequency of small duplications in relation to small deletions, the frequencies of major and minor alterations found in our sample are in accordance with those described in the literature.

Pyrimidine-5'-nucleotidase Campinas, A New Mutation (p.r56g) In The Nt5c3 Gene Associated With Pyrimidine-5'-nucleotidase Type I Deficiency And Influence Of Gilbert's Syndrome On Clinical Expression.

Pyrimidine-5'-nucleotidase type I (P5'NI) deficiency is an autosomal recessive condition that causes nonspherocytic hemolytic anemia, characterized by marked basophilic stippling and pyrimidine nucleotide accumulation in erythrocytes. We herein present two African descendant patients, father and daughter, with P5'N deficiency, both born from first cousins. Investigation of the promoter polymorphism of the uridine diphospho glucuronosyl transferase 1A (UGT1A) gene revealed that the father was homozygous for the allele (TA7) and the daughter heterozygous (TA6/TA7). P5'NI gene (NT5C3) gene sequencing revealed a further change in homozygosity at amino acid position 56 (p.R56G), located in a highly conserved region. Both patients developed gallstones; however the father, who had undergone surgery for the removal of stones, had extremely severe intrahepatic cholestasis and, liver biopsy revealed fibrosis and siderosis grade III, leading us to believe that the homozygosity of the UGT1A polymorphism was responsible for the more severe clinical features in the father. Moreover, our results show how the clinical expression of hemolytic anemia is influenced by epistatic factors and we describe a new mutation in the P5'N gene associated with enzyme deficiency, iron overload, and severe gallstone formation. To our knowledge, this is the first description of P5'N deficiency in South Americans.

Elevated Micronucleus Frequency In Patients With Type 2 Diabetes, Dyslipidemia And Periodontitis.

The over-production of reactive oxygen species (ROS) can cause oxidative damage to a large number of molecules, including DNA, and has been associated with the pathogenesis of several disorders, such as diabetes mellitus (DM), dyslipidemia and periodontitis (PD). We hypothesise that the presence of these diseases could proportionally increase the DNA damage. The aim of this study was to assess the micronucleus frequency (MNF), as a biomarker for DNA damage, in individuals with type 2 DM, dyslipidemia and PD. One hundred and fifty patients were divided into five groups based upon diabetic, dyslipidemic and periodontal status (Group 1 - poor controlled DM with dyslipidemia and PD; Group 2 - well-controlled DM with dyslipidemia and PD; Group 3 - without DM with dyslipidemia and PD; Group 4 - without DM, without dyslipidemia and with PD; and Group 5 - without DM, dyslipidemia and PD). Blood analyses were carried out for fasting plasma glucose, HbA1c and lipid profile. Periodontal examinations were performed, and venous blood was collected and processed for micronucleus (MN) assay. The frequency of micronuclei was evaluated by cell culture cytokinesis-block MN assay. The general characteristics of each group were described by the mean and standard deviation and the data were submitted to the Mann-Whitney, Kruskal-Wallis, Multiple Logistic Regression and Spearman tests. The Groups 1, 2 and 3 were similarly dyslipidemic presenting increased levels of total cholesterol, low density lipoprotein cholesterol and triglycerides. Periodontal tissue destruction and local inflammation were significantly more severe in diabetics, particularly in Group 1. Frequency of bi-nucleated cells with MN and MNF, as well as nucleoplasmic bridges, were significantly higher for poor controlled diabetics with dyslipidemia and PD in comparison with those systemically healthy, even after adjusting for age, and considering Bonferroni's correction. Elevated frequency of micronuclei was found in patients affected by type 2 diabetes, dyslipidemia and PD. This result suggests that these three pathologies occurring simultaneously promote an additional role to produce DNA impairment. In addition, the micronuclei assay was useful as a biomarker for DNA damage in individuals with chronic degenerative diseases.