[Vier-Tages-Schlacht 1666] : [mit Porträtmedaillons von] Michiel Adriaensz De Ruyter L. Admiral von Holland, Ct. ; Ad. C . Tromp

Aus: [Relationis historicae semestralis continuatio ; 1666, Herbst]

The Tomb of Michiel de Ruyter in the Nieuwe Kerk, Amsterdam

Emanuel de Witte; 4 ft. 5/8 in.x 3 ft. 5 11/32 in.; oil on canvas

De kracht der christelijke godsdienst, in karakterschetsen uit de nederlandsche geschiedenis.

Contiene acontecimientos de la vida de los personajes holandeses: Maria van Reigersbergh, Hugo de Groot, A. Geesteranus en S. van Oostdijk, Willem Y. Bontekoe, Jacob Cats, Jan van Galen, Antoni Hambroek, Michiel Adriaansz. de Ruyter, Johan en Cornelis de Witt, Jan Camphuis, Hermanus Boerhaave, Maria Louise en haar zoon Willem IV, Onno Zwier van Haren, Jan Cabel Josephus van Speyk.

Portrait of Michiel Ophovius

Peter Paul Rubens; 3 ft. 7 57/64 in.x 2 ft. 8 31/64 in.; oil on canvas

Portrait of Aegje Hasselaer, Wife of Henrick Hooft, Michiel Jansz van Mierevelt

Michiel Jansz. van Miereveld; 2 ft. 3 7/16 in.x 1 ft. 11 5/8 in.; oil on panel

Portrait of Michiel Ophovius (1570-1637)

Peter Paul Rubens; 3 ft. 7 57/64 in.x 2 ft. 8 31/64 in.; oil on canvas

La Saint-Barthélemy devant le Sénat de Venise; relations des ambassadeurs Giovanni Michiel et Sigismondo Cavalli,

Mode of access: Internet.

Risk Profiles and Penetrance Estimations in Multiple Endocrine Neoplasia Type 2A Caused by Germline RET Mutations Located in Exon 10

Multiple endocrine neoplasia type 2 is characterized by germline mutations in RET. For exon 10, comprehensive molecular and corresponding phenotypic data are scarce. The International RET Exon 10 Consortium, comprising 27 centers from 15 countries, analyzed patients with RET exon 10 mutations for clinical-risk profiles. Presentation, age-dependent penetrance, and stage at presentation of medullary thyroid carcinoma (MTC), pheochromocytoma, and hyperparathyroidism were studied. A total of 340 subjects from 103 families, age 4-86, were registered. There were 21 distinct single nucleotide germline mutations located in codons 609 (45 subjects), 611 (50), 618 (94), and 620 (151). MTC was present in 263 registrants, pheochromocytoma in 54, and hyperparathyroidism in 8 subjects. Of the patients with MTC, 53% were detected when asymptomatic, and among those with pheochromocytoma, 54%. Penetrance for MTC was 4% by age 10, 25% by 25, and 80% by 50. Codon-associated penetrance by age 50 ranged from 60% (codon 611) to 86% (620). More advanced stage and increasing risk of metastases correlated with mutation in codon position (609-620) near the juxtamembrane domain. Our data provide rigorous bases for timing of premorbid diagnosis and personalized treatment/prophylactic procedure decisions depending on specific RET exon 10 codons affected. Hum Mutat 32:51-58, 2011. (C) 2010 Wiley-Liss, Inc.

European gendarmerie force

Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Ciência Política e Relações Internacionais, na variante de Estudos Europeus

Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial.

BACKGROUND The randomized placebo-controlled IFIGENIA-trial demonstrated that therapy with high-dose N-acetylcysteine (NAC) given for one year, added to prednisone and azathioprine, significantly ameliorates (i.e. slows down) disease progression in terms of vital capacity (VC) (+9%) and diffusing capacity (DLco) (+24%) in idiopathic pulmonary fibrosis (IPF). To better understand the clinical implications of these findings we performed additional, explorative analyses of the IFGENIA data set. METHODS We analysed effects of NAC on VC, DLco, a composite physiologic index (CPI), and mortality in the 155 study-patients. RESULTS In trial completers the functional indices did not change significantly with NAC, whereas most indices deteriorated with placebo; in non-completers the majority of indices worsened but decline was generally less pronounced in most indices with NAC than with placebo. Most categorical analyses of VC, DLco and CPI also showed favourable changes with NAC. The effects of NAC on VC, DLco and CPI were significantly better if the baseline CPI was 50 points or lower. CONCLUSION This descriptive analysis confirms and extends the favourable effects of NAC on lung function in IPF and emphasizes the usefulness of VC, DLco, and the CPI for the evaluation of a therapeutic effect. Most importantly, less progressed disease as indicated by a CPI of 50 points or lower at baseline was more responsive to therapy in this study.

Informe comparatiu del curs de formació bàsica de la policia a Europa. Els casos d'Anglaterra, Alemanya, Bèlgica, França i Holanda

L’informe que a continuació es presenta és una comparativa del Curs de formació bàsica (CFB) de cinc escoles de policia europees. Per a això hem comptat amb la col·laboració de l’Escola de la Policia Metropolitana de Londres (Anglaterra), la d’Hessen (Alemanya), la de Bèlgica, l’Escola Nacional Superior de la Policia Nacional de França i l’Acadèmia de Policia d’Holanda. Per a l’elaboració de l’informe es va utilitzar la informació de què ja disposava l’Àrea de Recerca i Cooperació Internacional de l’Institut fruit de la seva pròpia activitat i, a més, es va enviar un qüestionari a les diferents escoles.

Using a Parameterization of a Radiative Transfer Model to Build High-Resolution Maps of Typical Clear-Sky UV Index in Catalonia, Spain

To perform a climatic analysis of the annual UV index (UVI) variations in Catalonia, Spain (northeast of the Iberian Peninsula), a new simple parameterization scheme is presented based on a multilayer radiative transfer model. The parameterization performs fast UVI calculations for a wide range of cloudless and snow-free situations and can be applied anywhere. The following parameters are considered: solar zenith angle, total ozone column, altitude, aerosol optical depth, and single-scattering albedo. A sensitivity analysis is presented to justify this choice with special attention to aerosol information. Comparisons with the base model show good agreement, most of all for the most common cases, giving an absolute error within 0.2 in the UVI for a wide range of cases considered. Two tests are done to show the performance of the parameterization against UVI measurements. One uses data from a high-quality spectroradiometer from Lauder, New Zealand [45.04°S, 169.684°E, 370 m above mean sea level (MSL)], where there is a low presence of aerosols. The other uses data from a Robertson–Berger-type meter from Girona, Spain (41.97°N, 2.82°E, 100 m MSL), where there is more aerosol load and where it has been possible to study the effect of aerosol information on the model versus measurement comparison. The parameterization is applied to a climatic analysis of the annual UVI variation in Catalonia, showing the contributions of solar zenith angle, ozone, and aerosols. High-resolution seasonal maps of typical UV index values in Catalonia are presented

¶ COPIE DER BRIEVEN || VAN DEN GROOTẽ TURCK ghescreuẽ aẽ mijn Heere dẽ || grootẽ meestere van Rodes omtrẽt sint Ians misse || laetst ledẽ anno. M. ccccc. xxij. En oec eẽ Epistel vã || d' stadt vã Rodes / aẽ dat heylich Catholicke geloue. || Rodes. — [A la fin] : ¶ Dese Copie es vandẽ walsche ghetranslateert in || onsen tale Eñ is eerst gecõponeert par songneur/ dict || Bethune. herault darmes. ons ghenadichs heerẽ dẽ || Keysere Chaerles. || ¶ Gheprent Tantwerpẽ by mi Adriaen van || Bergen int gulden Missael. || ¶ Cum Priuilegio. In-4 goth. de 4 f. de 33 lignes à la page pleine, impr. en grosses lettres de forme, sign. A, mar. r. jans., tr. dor. (Trautz-Bauzonnet.)

Ladam (Nicaise). Epistel van de stadt van Rodes (1522)

Allegresse :chrestienne: +chrétienne+ de l'heureux succes des guerres de ce royaume , et de la justice de Dieu contre les rebelles au Roy... Ensemble le tombeau de Gaspar de Colligny jadis admiral de France... Par I.T.

Comprend : De guerre, paix ; Pyramide+ renversee sur la mort de Gaspar de Coligny ; Au :Roy: +Roi+ ; Ce que Dieu touche ard