15 resultados para Biblioteca nazionale centrale di Roma
em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"
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Pós-graduação em Letras - FCLAS
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Pós-graduação em Serviço Social - FCHS
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Pós-graduação em Serviço Social - FCHS
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Pós-graduação em Artes - IA
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Tendo em vista a problemática mundial com relação à degradação dos materiais plásticos e sua dispersão no meio ambiente, e diante de estudo realizado anteriormente onde se observou alterações histopatológicas e bioquímicas na próstata de animais expostos ao DBP (Di-N-Butil-ftalato) no período perinatal, este estudo teve por objetivo avaliar o potencial carcinogênico do DBP administrado desde o período fetal e após iniciação pelo MNU em um modelo de carcinogênese prostática. Ratas prenhes foram divididas em 4 grupos experimentais: 2 tratados: n=16/grupo (TDBP100 e TDBP500) e 2 controles: n=8/grupo (CN e CMNU). O grupo TDBP100 foi exposto ao DBP (100 mg/kg) e o TDBP500 a 500 mg/kg do 15º. dia de gestação (DG15) até a 21º. dia pósnatal (DPN21), enquanto que os animais controle receberam o veículo. Após o desmame, os machos foram separados e os grupos tratados e CMNU receberam dose única de MNU (50 mg/Kg, i.p.) na 6ª. semana pós-natal. Metade dos animais tratados (n=8/grupo) continuaram recebendo o DBP (DBP100+ e DBP500+) após o desmame em doses semanais até o dia do sacrifício (DPN180), enquanto os demais foram mantidos pelo mesmo período sem tratamento (DBP100- e DBP500-).Após a aplicação do MNU, os animais foram submetidos a injeções semanais de Cipionato de Testosterona (promotor) 2mg/aplicação. No dia do sacrifício, o sangue foi coletado, os órgãos reprodutores foram pesados e fragmentos do lobo ventral da próstata foram processados para inclusão em resina e Paraplast para as análises estruturais; e imunocitoquímicas para a detecção de AR e ER. Fragmentos de próstata ventral foram congelados e estocados a -80ºC e após extração das proteínas, estas foram destinadas à reação de Western Blot para avaliar a expressão das mesmas proteínas. Houve diminuição na distância anogenital nos animais DBP500 no DPN1 quando comparado com o grupo controle apontando para o efeito efetivo do DBP ...
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Coumarin is a natural active compound that can be found in many plants. The coumarins have many properties such as bronchodilator, anti-inflammatory, antioxidant, anticoagulant, antibiotics, immunomodulatory, antimicrobial and antiviral, thus, they are widely used in medical applications. More recently the coumarin derivatives have attracted the interest of many research groups in the field of new materials, for example the possibility of their use as sensitizers in dye-sensitized solar cells (DSSC) and lasers. The MCRs are defined as a process in which three or more reactants are combined in the same reaction pot, resulting in products with good structural complexity a single step, in addition to economy of atoms and selectivity and is a very important feature in modern synthetic methodology. In this work we investigated the use of niobium pentachloride as catalyst of the multicomponent reactions between phenolic derivatives, various aromatic aldehydes and β-diester derivatives in the synthesis of 4-aryl-3,4-dihydrocoumarin derivatives. The reactions were carried out at room temperature, under inert atmosphere (N2), using dichloromethane anhydrous (CH2 Cl2) as solvent, with a reaction time of most 120 hours. The products were isolated by column chromatography on silica gel and submitted to spectrometric and spectroscopic analysis. The results show that NbCl5 is an excellent agent for promoting the synthesis of 4-aryl-3,4-dihydrocoumarin derivatives through multicomponent reactions, obtaining yields varying from 45 to 95%
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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This thesis work aims to bring a better viewing on an atypical case of financial analysis. The lstituto per le Opere di Religione (IOR), commonly known as the Vatican Bank, has peculiarities according to its goals as a bank. Belonging to a Catholic religious congregation, IOR has been used to manage the resources of the church, and ensure that these resources are used for the operation of it and, also for religious works. However the financial transactions made by the bank remained secret throughout its existence until mid 2012. This feature of not providing relevant information at the local and international community brought harm. Several cases of corruption and money laundering came up, bringing scandals that cause bad looks for the religious entity. In order to interact with the international community and understanding the importance of it, the Roman Apostolic Catholic Church decides to joing the international accounting procedures (IFRS) and went on to provide yearly financial statement reports and other information from its bank from 2012 . Thus, this thesis work takes on the role of analyzing the financial statements of the IOR and present its economic and financial health from the Capital Structure ratios, liquidity and profitability in the period 2012-2014. Overall, there has been a significant reduction in indebtedness 548% in 2012 to 362% in 2014. However, such an index showing is still high. In addition, the debt profile remained bad (87.47% short-term in 2014). The Liquidity ratios, both indices fell during the analysed period. Noteworthy is that even with retractions, the indices are equal or greater than 1, which indicates financial footing able to pay off debts. Regarding profitability, in 2013 it represented atypical moment, considering the economic performance of the IOR in the investigated period. There was decrease in profits this year, which resulted in great loss of the indicators in 2013. For the previous and subsequent...
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Pós-graduação em História - FCLAS