Prognostic value of vascular endothelial growth factor and hypoxia-inducible factor 1 alpha in canine malignant mammary tumors

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Detecção de Histophilus somni (Haemophilus somnus) no sêmen bovino mediante reação em cadeia pela polimerase (PCR)

The present study evaluated the use of PCR for Histophilus somni detection in bovine semen. Semen samples were experimentally infected with H. somni at dilutions ranging from 107 to 101 bacteria/mL and subjected to DNA extraction by the phenol/chloroform method, followed by PCR amplification. The amplification products were analyzed by electrophoresis in 8% acrylamide gel. The oligonucleotide primers used yielded an amplification fragment of 400 base pairs from the bacterial DNA. Positive amplification was obtained even for the 101 bacteria/mL dilution. PCR proved to be an efficient method for the detection of H. somni. The results obtained in this study have brought relevant information for the diagnosis of H. somni, justifying the need for the diagnosis of this bacterium in bulls, especially in semen samples that should be free of contamination. The PCR method has shown to be a useful tool for the quality control of semen produced in artificial insemination centers.

Abordagem terapêutica nas desordens temporo-mandibulares: técnicas de fisioterapia associadas ao tratamento odontológico

Temporomandibular disorders (TMD) are related to discomfort in the temporomandibular joint (TMJ). These diseases are multifactorial and treatment usually requires a combination of different approaches because each patient presents with different and usually complex needs. It is necessary to know how each expert should plan for a successful treatment.

Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-Acyl hydrazone subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display similar anti-inflammatory activities in vivo, although compound 4c is the most effective compound for inhibiting rat paw edema, with a reduction in the extent of inflammation of 35.9% and 52.8% at 2 and 4 h, respectively. The anti-inflammatory activity of N-acyl hydrazone derivatives was inferior to their respective parent drugs, except for compound 4c after 5 h. Ulcerogenic studies revealed that compounds 4a–e are less gastrotoxic than the respective parent drug. Compounds 4b–e demonstrated mucosal damage comparable to celecoxib. The in vivo analgesic activities of the compounds are higher than the respective parent drug for compounds 4a–b and 4d–e. Compound 4a was more active than dipyrone in reducing acetic-acid-induced abdominal constrictions. Our results indicate that compounds 4a–e are anti-inflammatory and analgesic compounds with reduced gastrotoxicity compared to their respective parent non-steroidal anti-inflammatory drugs.

El desarrollo tecnológico en la vida cotidiana: influencias sociales comprendidas por universitarios brasileños

This paper, trying to understand how society influences technological development in daily life, developed a theoretical model, translated into a Likert scale, to be applicable to Brazilians undergraduate students from Sao Paulo. The social indicators that are presented in this scale were generated from content analysis in the process of construction and presentation of qualitative results which are the goals of this article. So it is possible to point out that the sample of undergraduates students surveyed points to the government, educational and research institutions, companies and citizens, as the main social actors strictly responsible for technology choices. The result allows brief reflections on the social influence on technology choices in daily life.

Influência da sociedade no desenvolvimento tecnológico: um estudo das concepções de graduandos brasileiros do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Prone positioning attenuates TNF-alpha production in rabbits with lung injury under protective conventional mechanical ventilation (CMV)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

HMGB1 in an experimental model of acute lung injury

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Protein content of equine seminal plasma and sperm plasma membrane in subfertile stallions

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Análise matemática e estatística da produtividade de lavouras cafeeiras agroquímica e orgânica na região da alta paulista

Studies with organic systems have shown the feasibility and ecological and social sustainability of these agroecosystems, unlike the systems agrochemicals (conventional) production. Some studies have concluded that for the model agrochemical exists less interaction between the flow of internal energy, basically the crop receives all inputs to production with no increase in "energy quality" within the system, while in the organic model of production has increased interaction between different resources in the system. The current economic and ecological crisis, exposed no sustainability of the production pattern of industrialized agriculture developed in a way, showing the dependence of developed countries on imports of agricultural commodities produced in the third world, among there coffee. Given these facts, developed a survey to identify problems in the Alta Paulista region, west of São Paulo State, in relation to coffee production systems. Actually, the fundamental problem, according to the research, farmers in this region, is to choose a viable production system correctly (environmental, social and economic); agrochemical or organic. The objectives of this study were to analyze the yield of production systems and agro-chemical and organic coffee in the period from 2003 to 2007, in 30 producing properties, located in this region, in order to point the production system to produce the highest yield. According to the methodology of CONAB, data collected were recorded on spreadsheets to be used as variables in statistical analysis models and mathematics. We performed a descriptive analysis of productivity data and were used for statistical analysis tests for parametric and nonparametric analysis of variance. The mathematical analyses of the curves were prepared with Origin for Windows 6.0 software, which uses numerical methods to fit the data supplied to a function of variable parameters. Unlike conventional systems of production, the organic system showed greater viability of the production model. Furthermore, with the quantitative modeling proposal, it is possible to perform the evaluation of these types of investments, providing more security to the farmer at the time of decision.